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San Mateo, CA, United States

Apger J.,East Carolina University | Reubens M.,East Carolina University | Henderson L.,East Carolina University | Gouge C.A.,East Carolina University | And 3 more authors.
Genetics | Year: 2010

DNA replication and the correct packaging of DNA into different states of chromatin are both essential processes in all eukaryotic cells. High-fidelity replication of DNA is essential for the transmission of genetic material to cells. Likewise the maintenance of the epigenetic chromatin states is essential to the faithful reproduction of the transcriptional state of the cell. It is becoming more apparent that these two processes are linked through interactions between DNA replication proteins and chromatin-associated proteins. In addition, more proteins are being discovered that have dual roles in both DNA replication and the maintenance of epigenetic states. We present an analysis of two Drosophila mutants in the conserved DNA replication protein Mcm10. A hypomorphic mutant demonstrates that Mcm10 has a role in heterochromatic silencing and chromosome condensation, while the analysis of a novel C-terminal truncation allele of Mcm10 suggests that an interaction with Mcm2 is not required for chromosome condensation and heterochromatic silencing but is important for DNA replication. Copyright © 2010 by the Genetics Society of America. Source

Masloski P.,ZS Associates
Medical Device and Diagnostic Industry | Year: 2010

The medical device companies are reexamining their sales channels to reduce costs and improve efficiency. The cost-cutting ideas include substituting traditional field sales roles with more effective channels or changing to less-expensive sales roles than the use of field representatives. The new sales models include the key account manager (KAM) model, field support specialist (FSS) model, and inside sales (IS) representative model. The implementation of models offers several benefits to the company and enables to generate revenues. The successful KAM program requires a person with advanced business skills in negotiation, strategy, pricing, presentation, analytics and teamwork. KAM can also be quite effective when implementing value-added programs or reaching high-level decision-makers such as business development programs that help hospitals build profitable service areas or that implement long-term cost-saving technologies such as peripherally inserted central catheters or infection-control devices. Source

Mathias A.,ZS Associates
Journal of Medical Marketing | Year: 2011

The FDA has mandated Risk Evaluation and Mitigation Strategy programs to manage risks associated with drugs. REMS programs comprise elements to assure safe use (ETASUs), and companies need to implement some (least restrictive) to all ETASUs (most restrictive) required by the FDA . Implementing ETASUs can require companies to perform a number of different activities from better educating customers and end-users to continuous monitoring of customers and end-users for risk of adverse events. In performing activities required for ETASUs, companies need to acquire, create and manage signifi cant amounts of data on their customers, end-users, product use, distribution and so on. If effectively done, these data can be married with other data from customer relationship management, marketing campaigns and so on to create a business intelligence goldmine to support and enhance marketing and sales effectiveness, and business operations. © SAGE Publications, 2011. Source

Bhattacharya B.,Indian Institute of Technology Kharagpur | Chatterjee A.,Virginia Polytechnic Institute and State University | Agrawal G.,ZS Associates | Mondal A.,Nuclear Power Corporation of India
Nuclear Engineering and Design | Year: 2013

Partial safety factors (PSFs) used in reliability-based design are intended to account for uncertainties in load, material and mathematical modeling while ensuring that the target reliability is satisfied for the relevant class of structural components in the given load combination and limit state. This paper describes the methodology in detail for developing a set of optimal reliability-based PSFs for the design of prestressed concrete inner containment shells in Indian NPPs under Main Steam Line Break (MSLB)/Loss of Coolant Accident (LOCA) conditions at two performance levels in flexure: cracking and collapse. The methodology follows current design practices in the country, accounts for uncertainties in loads and material properties and dependence among capacities and demands, develops the limit states from first principles, explicitly lays down the target reliabilities and criteria for PSF optimization. The optimization of the PSFs is based on reliability indices for each representative group of components obtained from importance sampling and a local linear response surface fit. A detailed numerical example on a typical 220 MWe Indian PHWR demonstrating the methodology is provided. © 2013 Elsevier B.V. Source

Chressanthis G.A.,Temple University | Khedkar P.,ZS Associates | Jain N.,ZS Associates | Poddar P.,ZS Associates | Seiders M.G.,Astrazeneca
Journal of Clinical Hypertension | Year: 2012

The authors explored to what extent important medical decisions by practitioners can be influenced by pharmaceutical representatives and, in particular, whether restricting such access could delay appropriate changes in clinical practice. Medical practices were divided into four categories based on the degree of sales representative access to clinicians: very low, low, medium, and high from a database compiled by ZS Associates called AccessMonitor (Evanston, IL) used extensively by many pharmaceutical companies. Clinical decisions of 58,647 to 72,114 physicians were statistically analyzed using prescription data from IMS Health (Danbury, CT) in three critical areas: an innovative drug for type 2 diabetes (sitagliptin), an older diabetes drug with a new Food and Drug Administration-required black box warning for cardiovascular safety (rosiglitazone), and a combination lipid therapy that had reported negative outcomes in a clinical trial (simvastatin+ezetimbe). For the uptake of the new diabetes agent, the authors found that physicians with very low access to representatives had the lowest adoption of this new therapy and took 1.4 and 4.6 times longer to adopt than physicians in the low- and medium-access restriction categories, respectively. In responding to the black box warning for rosiglitazone, the authors found that physicians with very low access were4.0 times slower to reduce their use of this treatment than those with low access. Likewise, there was significantly less response in terms of changing prescribing to the negative news with the lipid therapy for physicians in more access-restricted offices. Overall, cardiologists were the most responsive to information changes relative to primary care physicians. These findings emphasize that limiting access to pharmaceutical representatives can have the unintended effect of reducing appropriate responses to negative information about drugs just as much as responses to positive information about innovative drugs. © 2012 Wiley Periodicals, Inc. Source

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