Zimmer Orthobiologics Inc.

Austin, TX, United States

Zimmer Orthobiologics Inc.

Austin, TX, United States
SEARCH FILTERS
Time filter
Source Type

Patent
Zimmer Orthobiologics Inc. | Date: 2017-06-07

A fresh tissue allograft having at least one tissue portion maintained above a predetermined temperature to reduce the rate of cell death. A storage media having at least one free-radical scavenger is applied to the allograft to further slow the rate of cell death.


Patent
Zimmer Orthobiologics Inc. | Date: 2012-03-23

The invention provides a composition including isolated small living tissue particles, a method of making the tissue particles, and a method of using the composition to ameliorate a tissue defect. The tissue particles are composed of cells and their associated extracellular molecules and are sized, in certain embodiments, to be smaller than about 1 mm. Another aspect of the inventive tissue particles is the large percentage of viable cells. In certain embodiments, the tissue particles are made from cartilage and the composition may also contain additives such as adhesives, solutions, and bioactive agents.


Patent
Zimmer Orthobiologics Inc. | Date: 2012-04-16

Provided herein are preparations for repairing enchondral or osteochondral defects (4) by implantation, said preparations comprising a cartilage element (A) and optionally a bone element (B) which is connected to the cartilage element (A). The cartilage element (A) can contain cells during the implantation or is populated after the implantation with cells migrating from surrounding tissue. The aim is to better equip the cartilage element (A) of one such preparation for integration into the surrounding tissue and/or for an easy-to-achieve, primary stability. To this end, said cartilage element is not homogeneously embodied but has different characteristics in a peripheral and/or basal region (2, 3) to those in a central region (3). Said differing characteristics (A) relate to the structure and/or composition of the matrix used and/or to the cells established in the matrix, and are not used to prevent the migration of cells into the preparation from the surrounding tissue.


Patent
Zimmer Orthobiologics Inc. | Date: 2011-06-30

A hydrogel composition is formed from a natural polymer derivative having a plurality of cross-linkable units depending therefrom, and a synthetic polymer derivative having a plurality of cross-linkable units depending therefrom, said natural and synthetic polymer derivatives having hydrolysable units disposed between the polymer backbone of said derivative and at least some of said cross-linkable units. The use of a combination of natural and synthetic polymers provides for biodegradability of the hydrogel, along with mechanical properties such as strength and elasticity.


Patent
Zimmer Orthobiologics Inc. | Date: 2011-06-30

A hydrogel-forming composition is formed from a protein polymer derivative having a plurality of cross-linkable units depending therefrom, and a non-protein polymer derivative having a plurality of cross-linkable units depending therefrom, said non-protein polymer derivatives having hydrolysable units disposed between the polymer backbone of said derivative and at least some of said cross-linkable units. The use of a combination of protein and non-protein polymers provides for biodegradability of the hydrogel by hydrolysis of the hydrolysable units and/or enzymatic degradation of the proteins, along with mechanical properties such as strength and elasticity.


Patent
Zimmer Orthobiologics Inc. | Date: 2013-07-26

The invention provides a composition including isolated small living tissue particles, a method of making the tissue particles, and a method of using the composition to ameliorate a tissue defect. The tissue particles are composed of cells and their associated extracellular molecules and are sized, in certain embodiments, to be smaller than about 1 mm. Another aspect of the inventive tissue particles is the large percentage of viable cells. In certain embodiments, the tissue particles are made from cartilage and the composition may also contain additives such as adhesives, solutions, and bioactive agents.


Patent
Zimmer Orthobiologics Inc. | Date: 2011-06-30

A hydrogel-forming composition is provided that comprises an extracellular matrix protein, hyaluronic acid, and a thermosensitive biocompatible polymer such as methylcellulose. The hydrogels can provide a therapeutic effect; further, the hydrogels may comprise an optional therapeutic agent such as cells or a pharmaceutical composition. The composition may be injected to an area in need of treatment by the therapeutic agent. The composition may form a gel at about 37 C., such that the gel maintains the therapeutic agent in the area of the body in need of such treatment.


Patent
Zimmer Orthobiologics Inc. | Date: 2012-03-21

Medical devices for cutting and suturing biological tissue generally include a shaft and first and second guide members each including a first portion coupled to the shaft at a first location and a second portion coupled to the shaft at a second location. The first portions are movable along the shaft relative to the second portions, and the first and second guide members define an arcuate profile and are configured to flex in response to such movement. When used to cut tissue, the medical device may further include a blade positioned between the first and second guide members. When used to suture tissue, one or more suture guides may be provided on the first guide member for directing a suture needle through tissue proximate the first guide member. Methods of repairing and replacing a meniscus using the medical devices are also provided.


Patent
Zimmer Orthobiologics Inc. | Date: 2011-11-15

A bone void filler composition is described containing an acidic mineral component that contains a calcium source and a phosphate source or a lower alkyl carboxylate source; an osteoinductive component that contains demineralized bone; and a three-dimensional, osteoconductive biologically acceptable carrier component that contains a collagenous material. The bone void filler composition may be in the form of a sponge or in the form of a paste or putty used to form a sponge or is obtained from particulated sponge, or that forms after a sponge is rehydrated. A pre-mixed bone void filler composition is described containing the acidic mineral component or the lower alkyl carboxylate source; the osteoinductive component; and a biologically acceptable carrier component that contains a liquid carrier. Methods of making and using the compositions are also described. The ratio of demineralized bone component to acidic mineral component may range from about 0.5:1 to about 80:1.


Patent
Zimmer Orthobiologics Inc. | Date: 2010-03-29

A biocompatible synthetic bone growth composition comprising a fibrillar collagen component and a calcium phosphate component. The composition is formed into particles, and then formed into a unitary article that may be provided at the site of a skeletal defect. An osteoinductive component may be further added, either before or after forming the unitary article. The composition may be formulated as a paste or putty and facilitates bone growth and/or repair.

Loading Zimmer Orthobiologics Inc. collaborators
Loading Zimmer Orthobiologics Inc. collaborators