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Gonese E.,Centers for Disease Control and Prevention | Mushavi A.,Ministry of Health and Child Care Zimbabwe | Mungati M.,Ministry of Health and Child Care Zimbabwe | Mhangara M.,Ministry of Health and Child Care Zimbabwe | And 7 more authors.
BMC Infectious Diseases | Year: 2016

Background: Prevention of mother-to-child transmission of HIV (PMTCT) programs collect socio-demographic and HIV testing information similar to that collected by unlinked anonymous testing sero-surveillance (UAT) in antenatal settings. Zimbabwe evaluated the utility of PMTCT data in replacing UAT. Methods: A UAT dataset was created by capturing socio-demographic, testing practices from the woman's booking-card and testing remnant blood at a laboratory from 1 June to 30 September 2012. PMTCT data were collected retrospectively from ANC registers. UAT and PMTCT data were linked by bar-code labels that were temporarily affixed to the ANC register. A questionnaire was used to obtain facility-level data at 53 sites. Results: Pooled HIV prevalence was 15.8% (95% CI 15.3-16.4) among 17,349 women sampled by UAT, and 16.3% (95% CI 15.8%-16.9%) among 17,150 women in PMTCT datasets for 53 sites. Pooled national percent-positive agreement (PPA) was 91.2%, and percent-negative agreement (PNA) was 98.7% for 16,782 women with matched UAT and PMTCT data. Based on UAT methods, overall median prevalence was 12.9% (Range 4.0%-19.4%) among acceptors and refusers of HIV test in PMTCT compared to 12.5% ((Range 3.4%-19.5%) among acceptors in ANC registers. There were variations in prevalence by site. Conclusion: Although, there is no statistical difference between pooled HIV prevalence in UAT compared to PMTCT program, the overall PPA of 91.2% and PNA of 98.7% fall below World Health Organisation (WHO) benchmarks of 97.6% and 99.6% respectively. Zimbabwe will need to strengthen quality assurance (QA) of rapid HIV testing and data collection practices. Sites with good performance should be prioritised for transitioning. © 2016 Gonese et al.

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