Zibo, China
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Yin X.-Q.,Shandong Academy of Sciences | Yin X.-Q.,Zibo Center Hospital | Li M.,Zibo Center Hospital
Chinese Journal of Cancer Prevention and Treatment | Year: 2012

To evaluate the expression of HIF-1α and VEGF in malignant fibrous histiocoma (MFH) tissues and analyze the association of the two factors with several clinical and pathological characteristics, and patients' survival. Paraffin-embedded tissue samples were retrospectively collected from 52 MFH patients, who received surgical resection or biopsy from 01-01-2004-to 01-01-2007 in Shandong cancer Hospital. The expression of HIF-1α and VEGF were examined by immunohistochemistry method. The rerelationship between the expression of HIF-1α and VEGF and survival was analyzed. Expression of HIF-1α and VEGF were positively observed in 67.31% (35/52) and 73.08% (38/52) among the patients respectively. The HIF-1α status was significantly associated with tumor stage (χ2=4.282, P=0.039). VEGF status were significantly associated with histologic grade and tumor stage (χ2 values were 5.450 and 5.020, P values were 0.020 and 0.025). Patients with negative expression of HIF-1α had a significantly better 5 year os (51.43%) than those with positive expression (76.47%, χ2=4.234, P=0.040). Patients with negative expression of VEGF had a significantly better 5 year os (50.00%) than those with positive expression (85.71%, χ2=7.323, P=0.007). The clinical stage and the expression of HIF-1α were independent prognosticfacts shown by Cox proportional hazard model. HIF-1α can be used as biomarkers indicating tumors in advanced stage and independently implied poor prognosis in patients with MFH.


Liu Z.,Qingdao University | Liu Z.,Zibo Center Hospital | Wang X.-M.,Zibo Center Hospital | Jia T.-F.,Zibo Center Hospital | And 6 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2015

Background: Studies indicate the immediate early response gene 3 (IER3) is involved in many biological processes. Recently, it was discovered that IER3 plays an important role in tumorigenesis and tumor progression. Thus it may be a valuable biomarker in tumor. This study was designed to investigate the expression status of IER3 in primary hepatocarcinoma (PHC) and correlation with clinicopathological parameters. Materials and Methods: Real-time PCR was performed to evaluate the expression levels of IER3 in 62 pathologically diagnosed human PHC specimens. Results: A statistically significant association was disclosed between the expression of IER3 and P53 mutant protein (short for P53), Ki-67, EGFR and the biggest diameter, differentiation grade of tumor. Conclusions: This work is the first to shed light on the potential clinical usefulness of IER3, as an efficient tumor biomarker in PHC.


Wang Q.,Shandong University | Gao C.,Shandong University | Wang H.,Shandong University | Lang L.,Guangdong Provincial Institute of Public Health | And 2 more authors.
PLoS ONE | Year: 2013

Background: This study estimated the effects of ambient temperature and relative humidity on hospital admissions for ischemic stroke during 1990-2009 in Jinan, China. Methods: To account for possible delayed effects and harvesting effect, we examined the impact of meteorological factors up to 30 days before each admission using a distributed lag non-linear model; we controlled for season, long-term trend, day of week and public holidays in the analysis. Stratified analyses were also done for summer and winter. Results: A total of 1,908 ischemic stroke hospital admissions were observed between 1990 and 2009. We found a strong non-linear acute effect of daily temperatures on ischemic stroke hospital admission. With the mean temperature 15°C as the reference, the relative risk (RR) was 1.43 (95% confidence interval (CI): 1.10-1.85) for 0°C daily temperature on the same day, and 0.43 (95% CI: 0.31-0.59) for 30°C daily temperature on the same day, respectively. The effect of ambient temperature was similar in summer and winter. No significant association was observed between relative humidity and ischemic stroke hospitalization. Conclusions: Low temperature might be a risk factor for ischemic stroke, and high temperature might be protective factor of ischemic stroke occurrence in Jinan, China. © 2013 Wang et al.

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