Time filter

Source Type

Zhujiang, China

Duan J.J.,Fengxian Central Hospital | Zhou T.,Fengxian Central Hospital | Chen X.,Zhujiang Hospital | Wang Y.,Fengxian Central Hospital | And 2 more authors.
European Review for Medical and Pharmacological Sciences | Year: 2012

Objectives: Efficacy and toxicity of the drug are mainly determined by physicochemical properties and pharmacological effects of its own. In addition, they are also affected by other factors, such as gender, age, genetic character, pathophysiological status, mood states and so on. The paper aims to study whether mood disorder alters drug metabolism process through the pharmacokinetic research on some clinically important anticancer drugs in depression model rats. Materials and Methods: The depression model rats were built by exposing to chronic unpredicted mild stresses (CUMS) for 8 weeks. 36 female Sprague-Dawley (SD) rats were randomized into model group and control group. In each group, 18 rats were randomized into 2 subgroups: 5-fluorouracil (5-FU) subgroup and cyclophosphamide (CP) subgroup which were given a certain doses of 5-FU and CP. The blood samples were collected at different time points and plasma drug concentration were respectively assayed by high performance liquid chromatography (HPLC) for 5-FU and high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) for CP. Pharmacokinetic parameters were processed with DAS software. Results: There were significant differences in the pharmacokinetic parameters of 5-FU and CP between in depression model rats group and in the normal control group (p < 0.05), except t 1/2α (p > 0.05) for CP pharmacokinetics in depression model rats group and in the normal control rats group, with the value of those was 0.07 and 0.09 h. Conclusions: Depression mood disorder might alter drug metabolism process.

Zhang Y.,Nanfang Hospital | Li L.,Zhujiang Hospital | Wang J.,Nanfang Hospital | Li Z.-H.,Nanfang Hospital | Shi Z.-J.,Nanfang Hospital
Knee Surgery, Sports Traumatology, Arthroscopy | Year: 2013

Purpose: To undertake a meta-analysis of randomized controlled trials to determine whether routine use of a tourniquet is a better choice for knee arthroscopic procedures. Methods: Randomized controlled trials which evaluated the application of a tourniquet were selected, gathering information about arthroscopic visualization and operative time. The random-effects meta-analysis was performed using relative risk calculated from the raw data. Results: A total of five eligible studies were selected in this meta-analysis with 471 participants. There was no significant difference in visualization or operative time between the tourniquet and the non-tourniquet group. Conclusions: There is insufficient evidence to support the hypothesis that patients would benefit from routinely applying a tourniquet. The use of a tourniquet did not show any advantage to arthroscopic procedures. Level of evidence: Therapeutic randomized controlled trials, Level I. © 2012 Springer-Verlag.

Zhu X.-Y.,Shenyang Northern Hospital | Qin Y.-W.,Changhai Hospital | Han Y.-L.,Shenyang Northern Hospital | Zhang D.-Z.,Shenyang Northern Hospital | And 7 more authors.
EuroIntervention | Year: 2013

Aims: To assess the immediate and long-term outcomes of transcatheter closure of ventricular septal defect (VSD) in combination with percutaneous coronary intervention (PCI) in patients with VSD complicating acute myocardial infarction (AMI). Methods and results: Data were prospectively collected from 35 AMI patients who underwent attempted transcatheter VSD closure and PCI therapy in five high-volume heart centres. All the patients who survived the procedures were followed up by chest x-ray, electrocardiogram and echocardiography. Thirteen patients underwent urgent VSD closure in the acute phase (within two weeks from VSD) while the others underwent elective closure at a median of 23 days from VSD occurrence. The percentage of VSD closure device success was 92.3% (36/39) and procedure success was 91.4% (32/35). The incidence of in-hospital mortality was 14.3% (5/35). At a median of 53 months follow-up, only two patients died at 38 and 41 months, respectively, and other patients' cardiac function tested by echocardiography improved significantly compared to that evaluated before discharge. Conclusion: The combination of transcatheter VSD closure and PCI for treating VSD complicating AMI is safe and feasible and is a promising alternative to surgery in patients with anatomically suitable VSD and coronary lesion.

Zhang Y.,Nanfang Hospital | Li L.,Zhujiang Hospital | Shi Z.-J.,Nanfang Hospital | Wang J.,Nanfang Hospital | Li Z.-H.,Nanfang Hospital
European Journal of Orthopaedic Surgery and Traumatology | Year: 2013

Background and purpose: Femoral head necrosis (FHN) is a debilitating disease which seriously affects the patients' quality of life, especially the young. The porous tantalum rod has the advantages of high volumetric porosity, low modulus of elasticity, and excellent osteoinduction, with exceptional biocompatibility and safety record in clinical application, which makes it an ideal choice for FHN patients. However, there has not been a systematic analysis for its efficacy and safety. Methods: This meta-analysis of six randomized controlled trials and controlled clinical trials with 256 participants was performed to investigate the efficacy and safety of porous tantalum rod, by means of comparing with vascularized or non-vascularized bone grafting. Results: Porous tantalum has its advantages in functional evaluation of Harris Hip Score, with a significant lower incidence of femoral head collapse. The surgical blood loss is low and the operative time is short with no increase in complication rate. Interpretation: Our preliminary analysis provided that the porous tantalum rod was a less invasive method and was effective and well tolerant for early-stage FHN patients. Further specially designed clinical trials for long-term follow-up and socioeconomic assessment are needed before a final determination. © 2012 Springer-Verlag.

Liu X.Y.,Zhujiang Hospital
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology | Year: 2011

To explore the role of miR-223 in the acute rejection after kidney transplantation. 33 patients who received kidney transplantation in our hospital within a year were collected and 12 of them appeared acute rejection within 1 month after surgery. In all the patients, the peripheral blood miR-223 level was collected and detected by blind arrangements. Furthermore, PBMCs from healthy volunteers were also collected and stimulated by PHA and then miR-223 level was measured. In the peripheral blood cell, the miR-223 was increased 2 times after acute rejection, as well as 3. 76 times after PHA treatment.Furthermore, using miR-223 predicts AR had a specificity of 90% and sensitivity of 92%. The miR-223 may have significant role in the acute rejection of kidney transplantation.

Discover hidden collaborations