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Niu J.,Hebei Medical University | Jiang L.,Hebei Medical University | Guo W.,Hebei Medical University | Shao L.,Zhuhai Entry Exit Inspection and Quarantine Bureau | And 2 more authors.
PLoS ONE | Year: 2013

Background:Contradictory results have been reported regarding the association between leptin level and breast cancer. Therefore, a meta-analysis was performed to investigate this issue.Methods:Published literature from PubMed and the Chinese National Knowledge Infrastructure (CNKI) Database was retrieved. This study was performed based on different cases and control groups. The combined effect (d̄) with 95% confidence interval (CI) was calculated using fixed-effects or random-effects model analysis.Results:Overall, the mean serum leptin level of case groups was significantly higher than that of control groups. A) For 9 studies comparing breast cancer cases and healthy controls the combined effect d̄ 0.58 with 95% CI (0.48, 0.68). B) For 4 studies comparing premenopausal breast cancer cases and healthy controls the d̄ was 0.32 (0.12, 0.52). C) For 5 studies comparing postmenopausal cases and healthy controls the d̄ was 0.65 (0.46, 0.84). D) For 4 studies comparing breast cancer cases and breast benign controls the d̄ was 0.38 (0.17, 0.59). E) For 2 studies comparing premenopausal breast cancer cases and breast benign controls the d̄ was 0.33 (-0.25, 0.91). F) For 6 studies comparing postmenopausal breast cancer cases and breast benign controls the d̄ was 0.39 (0.19, 0.60). G) For 4 studies comparing lymph node metastasis positive cases and negative controls the d̄ was 0.72 (0.45, 1.00). H) For 3 studies comparing breast benign cases and healthy controls the d̄ was 0.71 (0.41, 1.01).Conclusion:This meta-analysis suggests that leptin level plays a role in breast cancer and has potential for development as a diagnostic tool. © 2013 Niu et al. Source


Jiang M.,China Agricultural University | Li H.,MAE Wellful Industries Co. | Li L.,Zhuhai Entry Exit Inspection and Quarantine Bureau | Peng K.,China Agricultural University | Wang S.,China Agricultural University
Nongye Gongcheng Xuebao/Transactions of the Chinese Society of Agricultural Engineering | Year: 2015

The mechanic performance of ejecting pneumatic fire extinguisher is determined by the following parameters: air speed at funnel exit, outfire range and ejecting stability; and the second and third parameters depend on the fire extinguishing agent pellet's velocity on funnel exit and the amount of fire extinguishing agent pellets detained in the funnel when extinguisher is working. In this research, the CFD-DEM coupling model was adopted to simulate the working process of ejecting pneumatic fire extinguisher, and the type of 6MF-30 pneumatic extinguisher was used to test the reliability of the coupling model. The funnel throat angle X1, the adding position of fire extinguishing agent X2, and the funnel length X3 were selected as the influencing factors, and total 23 experiments were conducted by the simulation model under the quadratic orthogonal rotation design. The virtual tunnel was designed according to the tunnel equipped to 6MF-30 pneumatic extinguisher. The virtual fire extinguishing agent pellets were found on the EDEM interface, coupled to the original CFD by Lagrangian model. The pretest results showed that this model had strong convergence which was proved by its stable airflow performance when running at the time of 0.2-0.25 s, and stable pellet number when running at 0.34 s. The air velocity at exit calculated by the CFD-DEM coupling model was similar to the theoretical value. It could be found that the number of aggregating virtual pellets detained in the region between the air tunnel and the fire extinguishing agent's channel was consistent with the result of research by other scholars. The simulating experiment data were exported for analyzing. The average velocity in axial direction on each point at funnel exit was read by Fluent, and after subtracting the average value 197.550, the deviation data of the 23 experiments were got and selected as the outlet wind velocity (index Y1). The max virtual pellet velocities in axial direction monitored by EDEM within 0-0.4 s of all experiments were selected as the spouting velocity (index Y2). The vertical coordinates of every virtual pellet at 0.37, 0.38, 0.39, 0.4 s in all experiments were read by EDEM, and 'countif' function was used to calculate the number of virtual pellet located in the tunnel (as assessment index Y3) when working. After the significant test and the variance analysis, the regression equation building was done by using SAS9.1. The result showed that the fire extinguishing agent pellet's velocity on funnel exit and the amount of fire extinguishing agent pellets detained in the funnel were significantly correlated to the three factors (P<0.0001, P<0.001 respectively), but the air speed at funnel exit had no correlation with these factors. By using response surface method combined with weighting method, the optimal aggregative index could be obtained under the condition that the funnel throat angle was 20°, the adding position of fire extinguishing agent was 140 mm and the funnel length was 700 mm. Under this condition, the efficiency of ejecting pneumatic fire extinguisher was mostly improved. The virtual test designed by the optimized parameters showed that the fire extinguishing agent pellet's velocity on funnel exit increased to 41.24 m/s, and the number of fire extinguishing agent pellets detained in the funnel decreased to 209. The verify test of the physical prototype indicated that the optimized parameters could improve the working effect of ejecting pneumatic fire extinguisher, which was manifested in extending the outfire range by 2.15 m, reducing the possibility of reburning and shortening the outfire time by 1.7 s. ©, 2015, Chinese Society of Agricultural Engineering. All right reserved. Source


Mo Q.H.,Zhuhai Entry Exit Inspection and Quarantine Bureau
Nan fang yi ke da xue xue bao = Journal of Southern Medical University | Year: 2010

To develop a 96-microwell plate DNA diagnostic chip for simultaneous detection of 9 major foodborne bacteria. Type-specific PCR primers labeled with biotin and oligonucleotide probes were designed according to the conservative genes of 9 major foodborne bacteria Staphylococcus aureus, Salmonella spp., Escherichia coli O157:H7 (Stx1 and Stx2), Shigella spp., Listeria monocytogenes, Bacillus cereus, Yersinia enterocolitica, Vibrio cholerae and Vibrio parahaemolyticus. A one-tube multiplex PCR system for simultaneous amplification of these bacteria was established, and the DNA probes were spotted and immobilized in the wells of the plate in 5x5 array format. Stable hybridization system between PCR products and oligonucleotide probes in the microwell was established after condition optimization. Alkaline phosphatase-conjugated streptavidin and NBT/BCIP were used to detect the hybridized PCR products. Twenty standard bacteria strains were used to validate the 96 microwell plate DNA diagnostic chip and highly specific and stable experiment results were obtained. Using this chip assay, the causal pathogen Staphylococcus aureus was identified within 12 h after the sampling from an incident of food poisoning, and the result was consistent with that obtained using conventional bacterial culture and biochemical identification. The novel 96 microwell plate DNA diagnostic chip allows rapid, accurate, automated and high-throughput bacterial detection and is especially valuable for quick response to such public health emergencies as food poisoning. Source


Chen H.-B.,Guiyang Medical University | Lian G.-S.,Zhuhai Entry Exit Inspection and Quarantine Bureau | Zhang C.-L.,Guiyang Medical University
Zootaxa | Year: 2011

This paper provides the first checklist of the subgenus Montisimulium Rubtsov, 1974 of genus Simulium from China, which lists 24 Chinese species including 19 known species and 5 new species, S. (M.) xinzhouense sp. nov., S. (M.) polyprominulum sp. nov., S. (M.) schizostylum sp. nov., S. (M.) luliangense sp. nov. and S. (M.) wulaofengense sp. nov., were collected from Shanxi Province, China. Keys to the species of S. (Montisimulium) known to occur in China are also provided. Copyright © 2011 - Magnolia Press. Source


Zhang Z.,Jinan University | Chen C.,Zhuhai Entry Exit Inspection and Quarantine Bureau | Li Z.,Jinan University | Wu Y.-H.,Jinan University | Xiao X.-M.,Jinan University
World Journal of Gastroenterology | Year: 2014

Hepatitis B is a major health concern in the Asia-Pacific region, and is endemic in China, Southeast Asia, and Africa. Chronic hepatitis B virus (HBV) infection may cause hepatic cirrhosis and liver cancer. It is estimated that there are more than 350 million chronic HBV carriers worldwide, of whom approximately one quarter will die of chronic hepatitis B-related liver diseases. HBV is transmitted horizontally through blood and blood products or by sexual transmission, and vertically from mother to infant. Perinatal infection is the predominant mode of transmission in countries with a high prevalence of hepatitis B surface antigen (HBsAg) carriage, and perinatal transmission leads to high rates of chronic infection. Therefore, it is important to prevent the mother-to-child transmission (MTCT) of HBV. Research has shown that pregnant women with high HBV DNA levels have an increased risk of MTCT. However, most of the obstetrics guidelines do not make a distinction between pregnant women with high HBV DNA levels and those who are HBsAg positive only. This review addresses the management of pregnant women with high levels of HBV viremia, in terms of antiviral therapy, use of hepatitis B immunoglobulin (HBIG), the combined application of hepatitis B vaccine and HBIG, choice of delivery mode and feeding practices. © 2014 Baishideng Publishing Group Inc. All rights reserved. Source

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