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Qu G.,Ocean University of China | Yue X.,Ocean University of China | An F.,Peoples Hospital of Zhucheng | Dai S.,Yantai University | And 2 more authors.
Zhongguo Zhongyao Zazhi

Objective: To investigate chemical constituents contained in Salvia castanea. Method: The compounds were separated and purified by silica gel, macroporous resin, RP-C18 and Sephadex LH-20 column chromatography. The structures were identified on the basis of physicochemical property and spectral data. Result: Nineteen compounds were separated and identified as tanshinone IIA (1), tanshinone IIB (2), hydroxytanshinone IIA (3), tanshinone I(4), dihydrotanshinone I(5), cryptotanshinone (6), neotanshinone A(7), neotanshinone B(8), tanshinoldehyde(9), przewaquinone A(10), przewaquinone B(11), sugiol(12), caffeic acid(13), rosmarinci acid(14), ethyl rosmarinate(15), lithospermic acid(16), pro-lithospermic acid(17), protocatechualdehyde (18), and danshensu(19). Conclusion: Compounds 2, 3, 7-13 and 15-19 were separated from S. castanea for the first time. Source

Cao Y.,Central University of Costa Rica | Wang Z.,Peoples Hospital of Zhucheng | Gu J.,Central University of Costa Rica | Hu F.,Central University of Costa Rica | And 5 more authors.
BioMed Research International

Many studies have investigated the association between hormonal and reproductive factors and thyroid cancer risk but provided contradictory and inconclusive findings. This review was aimed at precisely estimating this association by pooling all available epidemiological studies. 25 independent studies were retrieved after a comprehensive literature search in databases of PubMed and Embase. Overall, common hormonal factors including oral contraceptive and hormone replacement therapy did not alter the risk of thyroid cancer. Older age at menopause was associated with weakly increased risk of thyroid cancer in overall analysis (RR = 1.24, 95% CI 1.00-1.53, P = 0.049); however, longer duration of breast feeding was related to moderately reduced risk of thyroid cancer, suggested by pooled analysis in all cohort studies (RR = 0.7, 95% CI 0.51-0.95, P = 0.021). The pooled RR in hospital-based case-control studies implicated that parous women were more susceptible to thyroid cancer than nulliparous women (RR = 2.30, 95% CI 1.31-4.04, P = 0.004). The present meta-analysis suggests that older age at menopause and parity are risk factors for thyroid cancer, while longer duration of breast feeding plays a protective role against this cancer. Nevertheless, more relevant epidemiological studies are warranted to investigate roles of hormonal and reproductive factors in thyroid carcinogenesis. © 2015 Yijuan Cao et al. Source

Zhao Y.-B.,Southern Medical University | Zhang S.-H.,Peoples Hospital of Zhucheng | Zhang J.-R.,Southern Medical University
Journal of Practical Oncology

Objective: To investigate the expressions of ER, PR and EphA2 in breast cancers and their clinical significance. Methods: The expressions of ER, PR and EphA2 were detected in 130 cases of breast career by immunohistochemistry S-P method. Results: (1) The positive rates of expressions of ER, PR and EphA2 were 63.1%, 58.4% and 72.3%, respectively. (2) No significant association of expression of ER and PR was noted with age, histological types, tumor size, lymphatic metatasis and clinical stages. (3) The expression of EphA2 was related to clinical stages and lymphatic metatasis(P < 0.05), but not to age, tumor size and histological types(P > 0.05). (4) The positive rate of expression of EphA2 in the group with the positive expression of ER and PR was lower than that in the group with negative expression of ER and PR(P < 0.05). Conclusions: ER, PR and EphA2 are related with the occurrence and development of breast cancer. The combined detection of ER, PR and EphA2 can help to predict the clinical and pathologic characteristics of breast career, which is an important index to guide treatment. ER, PR and EphA2 are predictive factors for breast cancer. Source

Zhang R.,Peoples Hospital of Zhucheng
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery

To investigate the expressions of EphrinB2 and VEGF in nasopharyngeal carcinoma and their relationships with clinic pathological factors. The expressions of EphrinB2 and VEGF in 136 cases of nasopharyngeal carcinomas, and 20 cases of nasopharyngitis tissues were detected by SP method immunohistochemistry. 1) The positive rates of EphrinB2 and VEGF were 63.2% and 67.6% respectively in 136 cases of nasopharyngeal carcinomas. Their positive rate in nasopharyneal carcinoma tissues was significantly higher than those in nasopharyngitis tissues (P<0.01). 2) Intensity of the expression of EphrinB2 and VEGF protein was related to lymphnodes metabasis, cranial nerve palsy, basalis encroachment, clinical stage respectively (P<0.01). 3) The expression of EphrinB2 in nasopharyngeal carcinoma tissues and was positively correlated with VEGF (P< 0.01). Ephrinbeta2 and VEGF may play important roles in invasiveness, metastasis and angiogenesis of nasopharyngeal carcinoma. There may be certain inter regulation mechanism between them and they are hoped to become new biologic parameters to judge the pathogenesis, development and prognosis of nasopharyngeal carcinoma and to guide the treatment. Source

Xia L.,Peoples Hospital of Zhucheng | Wang H.,Weifang Peoples Hospital | Sun Y.,Weifang Medical University | Pang J.,Weifang Peoples Hospital
International Journal of Clinical and Experimental Medicine

Although important for advanced life support and critical care, mechanical ventilation frequently caused ventilator-induced lung injury (VILI), manifesting a severe impact on survival rate. As the new generation of immunosuppressant, efalizumab was studied on a VILI model in rats to elucidate the protective function against damage and possible mechanisms. SD rats were randomly enrolled into control, VILI model, IgG control, glucocorticoid and efalizumab treated groups (N=15 each). The VILI model was generated by mechanical ventilation. In the experimental group, 2.5 mg/kg efalizumab was applied before mechanical ventilation. The total number of nuclear cells and neutrophils in bronchoalveolar lavage fluid (BALF) were counted, and the expressions of tumor necrosis factor (TNF)-α and interleukin (IL)-8 were also determined. Real-time PCR and Western blotting were also employed to detect the expression levels of SP-A gene and protein. Both nuclear cell and neutrophil numbers were significantly increased in VILI model group (P<0.05). The intervention by efalizumab decreased inflammatory cell number, as well as impeding the levels of cytokines such as TNF-α and IL-8 (P<0.05 in all cases). In VILI and IgGgroups, mRNA levels of SP-A gene were significantly decreased (P<0.05) but were potentiated by the addition of efalizumab or glucocorticoid. SP-A proteins had consistent distribution patterns as those of mRNA did. Efalizumab protects lung tissues from VILI via decreasing the activation and infiltration of inflammatory cells, inhibiting inflammatory factor release and facilitating expression of surfactant proteins. © 2016, E-Century Publishing Corporation. All rights reserved. Source

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