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Zhoushan, China

To evaluate the effect of positive end expiratory pressure on the bronchoalveolar lavage fluid (BALF) in pulmonary surfactant (PS) of patient during one lung ventilation anesthesia. Patients undergoing Bullae resection were anesthetized with treatment (n = 12) or control (n = 12) combined anesthesia. Total phospholipid (TPL), saturated phosphatidylcholine (SatPC) and total protein (TP) in the bronchoalveolar lavage fluid (BALF) were measure. The ratio of SatPC/TPL% and SatPC/TP% represented the activity of PS. The thoracic surgery pulmonary surfactant significantly reduced, PEEP can prevent the decrease, but with decreased cardiac output. The end-expiratory pressure breathing can maintain the level of pulmonary surfactant to protect lung function.


Li H.-B.,Zhoushan Hospital Zhoushan | Zhang Y.,Zhoushan Hospital Zhoushan | Gao B.-B.,Zhoushan Hospital Zhoushan | Fu H.-Q.,Zhoushan Hospital Zhoushan | Deng J.-H.,Zhoushan Hospital Zhoushan
National Medical Journal of China | Year: 2010

Objective: To evaluate the effect of positive end expiratory pressure on the bronchoalveolar lavage fluid (BALF) in pulmonary surfactant (PS) of patient during one lung ventilation anesthesia. Methods: Patients undergoing Bullae resection were anesthetized with treatment (n = 12) or control (n = 12) combined anesthesia. Total phospholipid (TPL), saturated phosphatidylcholine(SatPC) and total protein(TP) in the bronchoalveolar lavage fluid(BALF) were measure. The ratio of SatPC/TPL% and SatPC/TP% represented the activity of PS. Results: The thoracic surgery pulmonary surfactant significantly reduced, PEEP can prevent the decrease, but with decreased cardiac output. Conclusion: The end-expiratory pressure breathing can maintain the level of pulmonary surfactant to protect lung function. Copyright © 2012 by the Chinese Medical Association.

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