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Zhu P.,Huazhong University of Science and Technology | Yan F.,Zhongshan Hospital of Hubei Province | Yang Z.,Huazhong University of Science and Technology | Meng L.,Huazhong University of Science and Technology | Ao Q.,Huazhong University of Science and Technology
Oncology Letters | Year: 2013

Metanephric adenoma (MA) and Wilms' tumor (WT) are two distinct types of renal tumors. Composite MA and WT of the kidney are extremely rare. Here, a rare case of composite MA and WT of the kidney in a 36-year-old male is described. MA and WT each have their own histopathological features, respectively, and they focally share morphological similarities, which can be a diagnostic challenge. Immunohistochemistry is useful in the differential diagnosis of MA and WT. The histopathological features and differential diagnosis of the composite tumor are emphasized here to promote a better and broader understanding of this less understood subject.

Guo J.,Zhongshan Hospital of Hubei Province
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery | Year: 2012

To compare and analyse the efficiency of the low-temperature plasma radiofrequency and the traditional method in tonsillectomy. Sixty-four patients with chronic tonsillitis were randomly divided into group A (39 cases) and group B (25 cases). Patients in the group A were treated with traditional method tonsillectomy while patients in the group B were treated with low-temperature plasma radio frequency tonsillectomy. Analysed differences in operation time, blood loss, and postoperative pain as well as the incidence of postoperative between two groups. There were significant differences in operative time, blood loss, and postoperative pain (P < 0.05) between two groups, but there was no obvious difference in the incidence of postoperative bleeding (P > 0.05). Low-temperature plasma radiofrequency tonsillectomy is a safer method and has many superiorities including shorter operative time, less blood loss, quicker recovery of postoperative pain compared with traditional tonsillectomy.

Su T.,Huazhong University of Science and Technology | Yan F.,Zhongshan Hospital of Hubei Province | Zhu P.,Huazhong University of Science and Technology
Diagnostic Pathology | Year: 2014

Background: Metanephric neoplasms comprised a spectrum of kidney tumors containing renal epithelial or stromal cells or both, including metanephric adenoma, metanephric stromal tumor, and metanephric adenofibroma. The majority of cases were benign; only one case of " metanephric adenosarcoma" had been reported in the English literature.History: We present the case of a 69-year-old man who developed a neoplasm composed of renal epithelial component identical to metanephric adenoma combined with malignant spindle-cell stroma. The epithelial component was positive for CD57, AE1/AE3, but negative for WT-1, CD56, SYN, and CgA; whereas the sarcomatous component was negative for epithelial markers, SMA, Caldesmon, MyoD1, Myogenin, and S-100; and positive for vimentin, CD10, and WT1 focally. No specific sarcoma differentiation was apparent in the stroma by immunohistochemistry, and no SYT-SS18 rearrangement or BRAF mutation was detected by molecular analysis.A diagnosis of metanephric adenosarcoma was made because of the morphological features and immunohitochemistry and molecular pathology analysis.Clinical significance: We believe that metanephric adenosarcoma should be in the expanded spectrum of metanephric neoplasia as a malignant stromal variant.Conclusions: We report a rare case of metanephric adenosarcoma with immunohistochemistry and molecular analysis and emphasize the histopathologic features and differential diagnosis of the rare lesion to promote a better and broader understanding of this less understood subject.Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_179. © 2014 Su et al.; licensee BioMed Central Ltd.

Zhao Z.,Tianjin Medical University | Li Y.,The Peoples Hospital of Liao Cheng | Liu S.,Zhongshan Hospital of Hubei Province | Fu W.,Tianjin Medical University
Tumor Biology | Year: 2014

Gastric cancer (GC) is a highly malignant cancer with increasing incidence and mortality worldwide. Serum Helicobacter pylori CagA antibody has been widely reported to play an important role in diagnosing GC. However, published data on this subject are inconclusive. Therefore, we performed a meta-analysis to evaluate the sensitivity and specificity of serum H. pylori CagA antibody in the diagnosis of GC. We conducted a comprehensive search to identify eligible related studies, in which the pooled sensitivity, specificity, diagnostic odds ratio (DOR), and summary receiver operating characteristic (SROC) curves could be determined. A total of 12 studies including 1,524 cases and 3,324 controls who fulfilled all of the inclusion criteria were included for analysis. The summary estimates for serum H. pylori CagA antibody in the diagnosis of GC in these studies were pooled sensitivity 0.71 (95 % CI 0.69-0.73), specificity 0.40 (95 % CI 0.39-0.42), DOR 2.11 (95 % CI 1.55-2.8), and the area under the curve was 0.636. Our meta-analysis showed that serum H. pylori CagA antibody should not be used for detecting GC. © 2014 International Society of Oncology and BioMarkers (ISOBM).

Tong Z.,Wuhan University | Liu W.,Wuhan University | Yan H.,Zhongshan Hospital of Hubei Province | Dong C.,Tsinghua University
Immunology | Year: 2015

Interleukin-17 (IL-17) is a cytokine with critical functions in multiple autoimmune diseases. However, its roles in type I diabetes and the underlying mechanisms remain to be fully elucidated. In the current study, we investigated the impact of IL-17 deficiency on streptozotocin (STZ) -induced diabetes. Il-17-/- mice exhibited attenuated hyperglycaemia and insulitis after STZ treatment compared with control mice. The Il-17-/- mice had fewer CD8+ cells infiltrating the pancreas than wild-type controls after STZ injection. Wild-type mice showed increased percentage and number of splenic CD8+ cells and decreased Gr1+ CD11b+ myeloid-derived suppressor cells (MDSC) after STZ treatment, but Il-17-/- mice maintained the percentages and numbers of splenic CD8+ cells and MDSC, suggesting that IL-17 is implicated in STZ-induced cellular immune responses in the spleen. We further purified the MDSC from spleens of STZ-treated mice. Il-17-/- MDSC showed increased ability to suppress CD8+ cell proliferation in vitro compared with wild-type MDSC. Transfer of MDSC to diabetic mice showed that MDSC from Il-17-/- mice could ameliorate hyperglycaemia. Moreover, recipients with MDSC from Il-17-/- mice had a decreased percentage of CD8+ cell in the spleen compared with recipients with MDSC from wild-type mice. These data suggest that IL-17 is required in splenic MDSC function after STZ delivery. In summary, our study has revealed a pathogenic role of IL-17 in an STZ-induced diabetes model with important implications for our understanding of IL-17 function in autoimmune diseases. © 2015 John Wiley & Sons Ltd.

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