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Hangzhou, China

Hu Z.,Zhepang University | Liu Q.,Zhepang University | Liu Q.,CAS Shanghai State Key Laboratory of Transducer Technology | Zhang Y.,Zhepang University | And 4 more authors.
Chinese Journal of Sensors and Actuators | Year: 2010

A continuous monitoring technique based on electrical cell-substrate impedance sensor was demonstrated for measuring physiological changes of endothelial cell line ECV304. The response mainly reflected the resistant changes as a result of cell adhesion and spreading. Cell impedance as a frequency and time function was analyzed based on the interdigitated electrode model to extract some guidelines for optimization design of impedance sensor. Finally, preliminary experiments were carried out to analyze cytotoxicity of toxicant on the vessel cells by monitoring the impedance time functions. The results demonstrated this sensor to be a rapid, online, label-free approach on mornitoring toxicant.

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