Zhengzhou, China
Zhengzhou, China

Zhengzhou University , colloquially known in Chinese as Zhèngdà is a public university located in Zhengzhou, Henan, People's Republic of China.It has the largest area of any university in China at 4,328,688 square meters. Wikipedia.


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Zhu X.-L.,Zhengzhou University | Wang Y.,Nanyang Technological University | Du X.,Shanghai University
Optimal Control Applications and Methods | Year: 2014

This paper studies the problem of stability analysis for continuous-time systems with two additive time-varying delay components. By taking the independence and the variation of the additive delay components into consideration, more general type of Lyapunov functionals are defined. Together with a tighter estimation of the upper bound of the cross-product terms derived from the derivatives of the Lyapunov functionals, less conservative delay-dependent stability criteria are established in terms of LMIs. Combining with a reciprocally convex combination technique, the newly obtained stability conditions are also less complex. Two numerical examples are given to illustrate the effectiveness and the significant improvement of the proposed method. © 2013 John Wiley & Sons, Ltd.


Dang Y.,Peking University | Dang Y.,Zhengzhou University | Zhang C.,Peking University | Zhu Y.,Zhengzhou University
Clinical Interventions in Aging | Year: 2015

In the developed world, age-related macular degeneration (AMD) is one of the major causes of irreversible blindness in the elderly. Although management of neovascular AMD (wet AMD) has dramatically progressed, there is still no effective treatment for nonneovascular AMD (dry AMD), which is characterized by retinal pigment epithelial (RPE) cell death (or dysfunction) and microenvironmental disruption in the retina. Therefore, RPE replacement and microenvironmental regulation represent viable treatments for dry AMD. Recent advances in cell biology have demonstrated that RPE cells can be easily generated from several cell types (pluripotent stem cells, multipotent stem cells, or even somatic cells) by spontaneous differentiation, coculturing, defined factors or cell reprogramming, respectively. Additionally, in vivo studies also showed that the restoration of visual function could be obtained by transplanting functional RPE cells into the subretinal space of recipient. More importantly, clinical trials approved by the US government have shown promising prospects in RPE transplantation. However, key issues such as implantation techniques, immune rejection, and xeno-free techniques are still needed to be further investigated. This review will summarize recent advances in cell transplantation for dry AMD. The obstacles and prospects in this field will also be discussed. © 2015 Dang et al.


Weng S.,Guangdong University of Technology | Chu S.-C.,University of South Australia | Cai N.,Guangdong University of Technology | Zhan R.,Zhengzhou University
Journal of Information Hiding and Multimedia Signal Processing | Year: 2013

By employing invariant relation between the mean value of the first (n - 1) pixels and the last one pixel (also called the remaining pixel) for every image block containing n pixels, a new reversible watermark scheme capable of mostly carrying 2n-3 bits into one n-sized image block in a single embedding process is presented in this paper. First, the mean value of the first (n - 1) pixel is calculated. Next, the difference value between the last one pixel and this obtained mean value is applied to distinguish which classification (i.e., smooth or complex sub-block) any sub-block belongs to. Consequently, it is determined to embed (n - 2) bits or 2(n - 2) bits into each sub-block according to its final classification results. And meanwhile, the mean value is reapplied to predict this last one pixel. 1-bit watermark is embedded into this last one pixel in accordance with the magnitude of prediction-error value. By multi-employing invariability of the mean value of (n-1) pixels, the embedding rate can approach to (2 - 3/n) bpp (bit per pixel) for a single embedding process. Meanwhile, the embedding distortion is greatly controlled by embedding more bits into smooth image blocks and fewer bits into the other blocks with complex texture. Experimental results reveal the proposed scheme is effective. © 2013.


Yan Y.,Zhengzhou University | Yan Y.,Nanjing Southeast University | Meng Q.,National University of Singapore | Wang S.,National University of Singapore | Guo X.,Nanjing Southeast University
Transportation Research Part C: Emerging Technologies | Year: 2012

The time control point strategy is often adopted by bus operators in China and Singapore to provide more reliable transit service. It is thus important to design a schedule, in which bus drivers should devote their efforts to catch up a scheduled arrival time at a predetermined time control point on a bus route because passengers can definitely benefit from a reliable bus route schedule. This paper first proposes a novel reliable bus route schedule design problem by taking into account the bus travel time uncertainty and the bus drivers' schedule recovery efforts. It proceeds to develop a robust optimization model for the proposed problem, which aims to minimize the sum of the expected value of the random schedule deviation and its variability multiplied by a weighting value. A Monte Carlo simulation based solution method is subsequently designed to solve the robust optimization model. Finally, a numerical example based on a real bus route in Suzhou city of China is carried out to demonstrate the strength of the robust optimization model. We find that the optimal scheduled travel time (or slack time) depends on bus drivers' schedule recovery behavior and on decision makers' scheduling philosophies. © 2012 Elsevier Ltd.


Xie X.,Huazhong University of Science and Technology | Yue D.,Huazhong University of Science and Technology | Yue D.,Nanjing University of Posts and Telecommunications | Zhu X.,Zhengzhou University
IEEE Transactions on Fuzzy Systems | Year: 2014

This paper is concerned with further studies on the control synthesis of discrete-time nonlinear systems in the Takagi - Sugeno (T-S) fuzzy form. To do this, a novel slack variable technique is presented by developing some useful matrix equalities, which are homogenous polynomially parameter-dependent on both the current-time normalized fuzzy weighting functions and the past-time normalized fuzzy weighting functions. Under the framework of homogenous matrix polynomials, the algebraic properties of both the current-time normalized fuzzy weighting functions and the past-time normalized fuzzy weighting functions are collected for the first time into sets of united collection matrices. Consequently, the relaxation quality of control synthesis of discrete-time T-S fuzzy systems is improved, i.e., the convergence of asymptotically necessary and sufficient stabilization conditions is further sped up. Finally, a numerical example is provided to illustrate the effectiveness of the proposed result. © 1993-2012 IEEE.


Ren J.L.,Zhengzhou University | Chen C.,Zhengzhou University | Liu Z.Y.,Shanghai University | Li R.,Beihang University | Wang G.,Shanghai University
Physical Review B - Condensed Matter and Materials Physics | Year: 2012

Changes in intermittent serrated flow behavior during plastic deformation of Zr 64.13Cu 15.75Ni 10.12Al 10, a representative glassy metal with characteristic ductility, in response to variant strain rates and temperatures were examined. The influence of strain rates and environmental temperatures on the stress-time sequence of the plastic strain regime was investigated using comprehensive dynamical, statistical, and multifractal analyses. Three distinct spatiotemporal dynamical regimes were explored. Under small strain rates or high temperatures, the time-stress sequence exhibited a chaotic behavior. Conversely, under large strain rates or low temperatures, a transition to the self-organized critical state was observed. In addition to chaotic time series and statistical analysis, multifractal analysis was also applied to study the crossover between these two unique plastic dynamic transitions. This plastic dynamical behavior was elucidated based on the interactions between shear avalanches in the glassy metal. © 2012 American Physical Society.


Wang F.,Zhengzhou University
Shuili Fadian Xuebao/Journal of Hydroelectric Engineering | Year: 2012

In this paper, an optimal model is developed to simulate the year-end water level of a multi-year regulating storage reservoir in a cascade reservoirs system. This model considers power market environments and long-term scheduling of power generation, and is solved with a co-evolution differential evolution algorithm. Its effectiveness and reliability are verified through an application to the Wujiang cascade reservoirs. This study provides a theoretical basis for calculation of optimal scheduling of the cascade reservoirs in power market environments.


Bai Y.-F.,Zhengzhou University | Xu T.-B.,Zhengzhou University | Luong J.H.T.,University College Cork | Cui H.-F.,Zhengzhou University
Analytical Chemistry | Year: 2014

A planar boron-doped diamond (BDD) electrode was treated with KOH and functionalized with 3-aminopropyltriethoxysilane (APTES) to serve as a biosensing platform for biomolecule immobilization with glucose oxidase (GOx) as a test model. The free amino groups of GOx and APTES were cross-linked by glutaraldehyde (X), a bifunctional chemical to form a stable enzyme layer (GOx-X-APTES) on BDD. Micrographs obtained by scanning electron microscopy revealed that a mesoporous structure uniformly covered the BDD surface. Cyclic voltammetry of GOx immobilized showed a pair of well-defined redox peaks in neutral phosphate buffer solution, corresponding to the direct electron transfer of GOx. The apparent heterogeneous electron transfer rate constant of the immobilized GOx was estimated to be 8.85 ± 0.47 s-1, considerably higher than the literature reported values. The determination of glucose was carried out by amperometry at -0.40 V, and the developed biosensor showed good reproducibility and stability with a detection limit of 20 μM. Both ascorbic and uric acids at normal physiological conditions did not provoke any signals. The dynamic range of glucose detection was further extended by covering the enzyme electrode with a thin Nafion layer. The Nafion/GOx-X-APTES/ BDD biosensor showed excellent stability, a detection limit of 30 μM, a linear range between 35 μM and 8 mM, and a dynamic range up to 14 mM. Such analytical performances were compared favorably with other complicated sensing schemes using nanomaterials, redox polymers, and nanowires. The APTES-functionalized BDD could be easily extended to immobilize other redox enzymes or proteins of interests. © 2014 American Chemical Society.


Li Y.,Zhengzhou University | Li Y.,University of Oslo | Zhou Y.,University of Oslo | Danbolt N.C.,University of Oslo
Journal of Histochemistry and Cytochemistry | Year: 2012

Glutamate transporters (GLT-1, GLAST, EAAC1) limit the actions of excitatory amino acids. Because a disturbed transporter operation can cause or aggravate neurological diseases, transporters are of considerable neuropathological interest. Human samples, however, are seldom obtained fresh. Here, we used mice brains to study how fast glutamate transporters are degraded after death. Immunoblots showed that terminal GLT-1 epitopes (within residues 1-26 and 518-573) had mostly disappeared after 24 hr. GLAST termini (1-25 and 522-543) degraded slightly slower. In contrast, epitopes within central parts of GLT-1 (493-508) and the EAAC1 C-terminus (510-523) were readily detectable after 72 hr. The decline in immunoreactivity of the GLT-1 and GLAST termini was also seen in tissue sections, but proteolysis did not happen synchronously in all cells. At 24 hr, scattered cells remained strongly immunopositive, while the majority of cells were completely immunonegative. GLAST and GLT-1 co-localized in neocortical tissue, but at 12 hr, many GLAST-positive cells had lost the GLT-1 termini. The uneven disappearance of labeling was not observed with the antibodies to GLT-1 residues 493-508. The immunoreactivity to this epitope correlated better with the reported glutamate uptake activity. Thus, postmortem delay may affect epitopes differently, possibly causing erroneous conclusions about relative expression levels. © The Author(s) 2012.


Ding J.,Zhengzhou University
2012 International Conference on Systems and Informatics, ICSAI 2012 | Year: 2012

The SLA auto-management technology is an emerging research field and it is important for the construction of next generation computing environment under the background of SOA and cloud computing. In this paper, we at first review 28 recent works focused on SLA management and analyze the requirements of SLA auto-management, and then we define a complete lifecycle for SLA auto-management, and discuss details of every stage in that lifecycle, at last, we propose a research agenda towards the establishment of SLA contract for service compositions. © 2012 IEEE.


Zhang J.,Zhengzhou University | Critchley L.A.H.,Chinese University of Hong Kong | Huang L.,Peking University
British Journal of Anaesthesia | Year: 2015

Background Different mathematical approaches are used to calculate arterial pulse pressure wave analysis (PPWA) cardiac output. The CardioQ-Combi is a research oesophageal Doppler (COODM) monitor that includes these five fundamental PPWA algorithms. We compared these PPWA cardiac output readings to COODM and suprasternal USCOM Doppler (COUS) over a range of cardiac output values induced by dopamine infusion in patients undergoing major surgery. USCOM acted as a control. Methods Serial sets of cardiac output data were recorded at regular intervals as cardiac output increased. Formulae included: cardiac output calculated form systemic vascular resistance (COMAP), pulse pressure (COPP), Liljestrand-Zander formula (COLZ), alternating current power (COAC) and systolic area with Kouchoukos correction (COSA). The reference method for comparisons was COODM. Statistical methods included: Scatter plots (correlation), Bland-Altman (agreement) and concordance (trending) and polar (trending). Results From 20 patients 255 sets of cardiac output comparative data were collected. Mean cardiac output for each method ranged between 5.0 and 5.5 litre min-1. For comparisons between COUS and the five PPWA algorithms with COODM: Correlation was best with COUS (R2=0.81) followed by COLZ (R2=0.72). Bias ranged between 0.1 and 0.5 litre min-1. Percentage error was lowest with COUS (26.4%) followed by COLZ (35.2%), others (40.7 to 56.3%). Concordance was best with COUS (92%), followed by COLZ (71%), others (64 to 66%). Polar analysis (mean(standard deviation)) were best with COUS (-2.7 (21.1)), followed by COLZ (+4.7 (26.6). Conclusions The Liljestrand-Zander PPWA formula was most reliable compared with oesophageal Doppler in major surgical patients under general anaesthesia, but not better than USCOM. © 2015 The Author.


Duan G.,Zhengzhou University | Yao M.,Zhengzhou University | Ma Y.,Peking University | Zhang W.,Beijing Academy of Education science
Psychiatry Research | Year: 2014

Perinatal and background risk factors for autism were identified in a cohort of autistic children in Zhengzhou, China, to formulate preventative and treatment strategies for high-risk families. In this case-control study, children were screened for suspected autism using the Autism Behavior Checklist (ABC) and diagnosed according to DSM-IV and the Childhood Autism Rating Scale (CARS). We collected perinatal histories and clinical data of 286 confirmed autistic children treated at the Third Affiliated Hospital Children's Psychological Clinic of Zhengzhou University from 2011 to 2013. The control group consisted of 286 healthy children from area kindergartens. Maternal age>30 years, parental introversion as measured by the Eysenck Personality Questionnaire, low level of parental education, smoking, abortion threat, pregnancy complications, maternal illness during pregnancy, maternal mental health, family history of mental illness, neonatal jaundice, birth asphyxia, premature rupture of the fetal membrane, and gestational age<37 weeks were significantly higher in the autism group. These factors were significantly correlated with behavioral symptoms as measured by ABC scores (Kendall rank correlation). Birth asphyxia, neonatal jaundice, maternal age, parental introversion, family history of mental illness, abortion threat, premature delivery, and smoking were identified as independent risk factors by multivariate logistic regression. © 2014 Elsevier Ireland Ltd.


Kuo H.-Y.,National Chiao Tung University | Pan E.,Zhengzhou University
Journal of Applied Physics | Year: 2011

Rayleigh's formalism is generalized for the evaluation of the effective material properties in multicoated circular fibrous multiferroic composites. The derived solution is applied to the special three-phase composite in which coated fibers are embedded in a matrix. For composites made of piezoelectric (BaTiO3) and piezomagnetic (CoFe2O4 or Terfenol-D) phases, we find that the magnetoelectric effect in the composite made of CoFe2O4 coated BaTiO3 in matrix Terfenol-D is five times larger than that in the composite made of BaTiO 3 coated Terfenol-D in matrix CoFe2O4. Furthermore, in each case, with appropriate coating to the circular fiber, the magnetoelectric effect in the coated composites can be enhanced by more than one order of magnitude as compared to the corresponding noncoating composite. © 2011 American Institute of Physics.


Tian F.,Zhengzhou University | Yourek G.,DL Biotech United States | Shi X.,Shanghai University | Yang Y.,Shanghai University
Biochimica et Biophysica Acta - Reviews on Cancer | Year: 2014

Wilms tumor recapitulates the development of the kidney and represents a unique opportunity to understand the relationship between normal and tumor development. This has been illustrated by the findings that mutations of Wnt/β-catenin pathway-related WT1, β-catenin, and WTX together account for about one-third of Wilms tumor cases. While intense efforts are being made to explore the genetic basis of the other two-thirds of tumor cases, it is worth noting that, epigenetic changes, particularly the loss of imprinting of the DNA region encoding the major fetal growth factor IGF2, which results in its biallelic over-expression, are closely associated with the development of many Wilms tumors. Recent investigations also revealed that mutations of Drosha and Dicer, the RNases required for miRNA generation, and Dis3L2, the 3'-5' exonuclease that normally degrades miRNAs and mRNAs, could cause predisposition to Wilms tumors, demonstrating that miRNA can play a pivotal role in Wilms tumor development. Interestingly, Lin28, a direct target of miRNA let-7 and potent regulator of stem cell self-renewal and differentiation, is significantly elevated in some Wilms tumors, and enforced expression of Lin28 during kidney development could induce Wilms tumor. With the success in establishing mice nephroblastoma models through over-expressing IGF2 and deleting WT1, and advances in understanding the ENU-induced rat model, we are now able to explore the molecular and cellular mechanisms induced by these genetic, epigenetic, and miRNA alterations in animal models to understand the development of Wilms tumor. These animal models may also serve as valuable systems to assess new treatment targets and strategies for Wilms tumor. © 2014 Elsevier B.V.


Zhang L.,Peking University | Zhang W.-H.,Zhengzhou University | Wang P.-Y.,Peking University
Obesity Facts | Year: 2011

Objective: This study aims to estimate the up-to-date prevalence of overweight/obesity in the suburban area of Beijing, China, and its associations with hypertension, diabetes, dyslipidemia, and metabolic syndrome (MetS). Methods: A cross-sectional survey in 19,003 suburban adults was carried out in Beijing, 2007. Overweight and obesity class 1, 2, and 3 were defined as a body mass index (BMI) of 25.0-29.9, 30.0-34.9, 35.0-39.9, and ≥ 40 kg/m 2, respectively. Results: The age-standardized prevalence of overweight/obesity was 31.9% in the study. With increasing BMI, the prevalence of hypertension, diabetes, dyslipidemia, and MetS also increased. With normal body weight as reference, the adjusted odds ratio (95% confidence interval) of hypertension for overweight and obesity class 1-3 was 2.5 (2.2-2.7), 3.1 (2.8-3.4), 3.6 (3.1-4.3), and 4.5 (4.0-5.2), respectively. The same trend was observed for diabetes and MetS. For dyslipidemia, however, participants with obesity class 2 had the highest odds ratio. Conclusion: The prevalence of hypertension, diabetes, dyslipidemia, and MetS increases with increasing BMI. Overweight/obesity is an important risk factor for these diseases. To reduce the social burden of these obesity-related diseases, effective strategies for the prevention of overweight/obesity should be implemented. Copyright © 2011 S. Karger AG, Basel.


Xu H.W.,Shanghai University | Xu H.W.,Shanghai JiaoTong University | Yu S.Q.,Zhengzhou University | Mei C.L.,Zhengzhou University | Li M.H.,Shanghai University
Stroke | Year: 2011

Background and Purpose-The association of autosomal-dominant polycystic kidney disease (ADPKD) with intracranial aneurysm (ICAN) is well known but little is known about the characteristics of ICAN in ADPKD. The purpose of this study was to investigate the prevalence and characteristics of ICAN in ADPKD. Methods-We screened 355 patients with ADPKD (mean age, 46.5±13.2 years; range, 7 to 87 years) with 3-dimensional time-of-flight MR angiography. Size, location, and morphology of aneurysms were assessed. The prevalence and characteristics of ICAN in patients with ADPKD were evaluated. Patients with ICAN found by MR angiography and moderate renal function subsequently were recommended to undergo digital subtraction angiography for comparison. Results-The prevalence of ICAN in ADPKD was 12.4% (95% CI, 8.95% to 15.82%) with an equal gender distribution. The prevalence increased as age increased, reaching a peak value of 23.3% (95% CI, 16.85 to 29.75%) in the 60- to 69-year age group. The prevalence of ICAN in patients with ADPKD with a positive family history of hemorrhagic stroke or ICAN was higher than patients with ADPKD lacking such family history (relative risk, 1.968; 95% CI, 1.57 to 2.67). The mean diameter of ICAN was 3.85±3.25 mm. The most frequent site of ICAN was the internal carotid artery. The result of digital subtraction angiography of 15 patients with 18 ICANs and moderate renal function corresponded to the detection of MR angiography. Conclusion-The characteristics of ICAN in patients with ADPKD were different from some previous reports. Systematic screening of ICAN with 3-dimensional time-of-flight MR angiography is recommended for patients with ADPKD, particularly for adult patients (±30 years) or patients with a positive family history of hemorrhagic stroke or ICAN. © 2010 American Heart Association, Inc.


Hou L.,China Pharmaceutical University | Hou L.,Zhengzhou University | Yao J.,China Pharmaceutical University | Zhou J.,China Pharmaceutical University | Zhang Q.,Peking University
Biomaterials | Year: 2012

Amphiphilic low molecular weight heparin-all-trans-retinoid acid (LHR) conjugate, as a drug carrier for cancer therapy, was found to have markedly low toxicity and to form self-assembled nanoparticles for simultaneous delivery of paclitaxel (PTX) and all-trans-retinoid acid (ATRA) in our previous study. In the present study, PTX-loaded LHR nanoparticles were prepared and demonstrated a spherical shape with particle size of 108.9 nm. Cellular uptake analysis suggested rapid internalization and nuclear transport of LHR nanoparticles. In order to investigate the dynamic behaviors and targeting ability of LHR nanoparticles on tumor-bearing mice, near-infrared fluorescent (NIFR) dye DiR was encapsulated into the nanoparticles for ex vivo optical imaging. The results indicated that LHR nanoparticles could enhance the targeting and residence time in tumor site. Furthermore, in vivo biodistribution study also showed that the area under the plasma concentration time curve (AUC (0→inf)) values of PTX and ATRA for PTX-loaded LHR nanoparticles in tumor were 1.56 and 1.62-fold higher than those for PTX plus ATRA solution. Finally, PTX-loaded LHR nanoparticles demonstrated greater tumor growth inhibition effect in vivo without unexpected side effects, compared to PTX solution and PTX plus ATRA solution. These results suggest that PTX-loaded LHR nanoparticles can be considered as promising targeted delivery system for combination cancer chemotherapy to improve therapeutic efficacy and minimize adverse effects. © 2012 Elsevier Ltd.


Cheng P.-S.,Chinese University of Hong Kong | Marivel S.,Chinese University of Hong Kong | Zang S.-Q.,Zhengzhou University | Mak T.C.W.,Chinese University of Hong Kong
Crystal Growth and Design | Year: 2012

Nine silver(I) complexes bearing the phenylethynide ligand and different ancillary anions, namely, double salts AgC≡CPh•AgNO 3 (1), 2AgC≡CPh•AgNO 3 (2), [Ag 5(C≡CPh) 4(DMSO) 2]X [X = BF 4 (3A), ClO 4 (3B), PF 6 (3C), AsF 6 (3D), SbF 6 (3E)], 2AgC≡CPh•5AgO 2CCF 3•4DMSO (4), and a triple salt 10AgC≡CPh•2AgOTf•AgNO 3•3DMSO (5), have been synthesized and shown to possess coordination frameworks that are assembled with the supramolecular synthon Ph-C≡C⊃Ag n (n = 3, 4, 5). Different argentophilic layers are found in nitrate complexes 1 and 2, which are crystallized from water and mixed water/DMSO, respectively. Difficulty was encountered in growing quality crystals of complexes 3A-3E, 4, and 5 bearing weakly coordinating anions, but DMSO proved to be a good solvent for crystallization by functioning as a coligand. The isostructural compounds 3A-3E exhibit the same type of pseudohexagonal packing of infinite silver columns, with the ancillary anionic component filling the intervening space and linking adjacent columns via weak hydrogen bonds. Three-dimensional supramolecular frameworks based on similar packing of silver chains and columns, respectively, are found in double salt 4 and triple salt 5. © 2012 American Chemical Society.


He D.,Wuhan University | Wang D.,Peking University | Wu S.,Zhengzhou University
Information Technology and Control | Year: 2013

Recently, Chen et al. [B. Chen, W. Kuo, L. Wuu, A secure password-based remote user authentication scheme without smart cards, Information Technology and Control 41(1) (2012) 53-59] proposed a secure password-based remote user authentication scheme without smart cards and claimed that their scheme could withstand various attacks. Although Chen et al.'s scheme has many benefits, we find that it is vulnerable to the device stolen attack and the privileged insider attack. We also find that their scheme does not support perfect forward secrecy and no key control. Therefore, we propose an improved scheme to overcome weaknesses and maintain the benefits of the original scheme.


Alvarez M.,University of California at Davis | Sun K.,University of California at Davis | Sun K.,Zhengzhou University | Murphy W.J.,University of California at Davis
Blood | Year: 2016

Natural killer (NK) cells exist as subsets based on expression of inhibitory receptors that recognize major histocompatibility complex I (MHCI) molecules. NK cell subsets bearing MHCI binding receptors for self-MHCI have been termedas "licensed" and exhibitahigher ability to respond to stimuli. In the context of bone marrow transplantation (BMT), host licensed-NK (L-NK) cells have also been demonstrated to be responsible for the acute rejection of allogeneic and MHCI-deficient BM cells (BMCs)in mice after lethal irradiation. However, the role of recipient unlicensed-NK (U-NK) cells has not been well established with regard to allogeneic BMC resistance. After NK cell stimulation, the prior depletion of host L-NK cells resulted in a marked increase of donor engraftment compared with the untreated group. Surprisingly, this increased donor engraftment was reduced after total host NK cell depletion, indicating that U-NK cells can actually promote donor allogeneic BMC engraftment. Furthermore, direct coculture of U-NK cells with allogeneic but not syngeneic BMCs resulted in increased colonyforming unit cell growth in vitro, which was at least partially mediated by granulocyte macrophage colony-stimulating factor (GM-CSF) production. These data demonstrate that host NK cell subsets exert markedly different roles in allogeneic BMC engraftment where host L- and U-NK cells reject or promote donor allogeneic BMC engraftment, respectively. © 2016 by The American Society of Hematology.


Liang Z.,Zhengzhou University | Xue W.,Shanghai University | Lin K.,Shanghai University | Gong H.,Shanghai University
Organic Letters | Year: 2014

Methylation of unactivated alkyl halides and acid chlorides under Ni-catalyzed reductive coupling conditions led to efficient formation of methylated alkanes and ketones using methyl p-methyl tosylate as the methylation reagent. Moderate to excellent coupling yields as well as excellent functional group tolerance were observed under the present mild and easy-to-operate reaction conditions. © 2014 American Chemical Society.


Patent
Zhengzhou University | Date: 2010-04-21

The present invention provides 2-fluorine-4-substituted-nucleoside analogues or their pro-drugs or 5-phosphate esters (including the pro-drugs of the 5-phosphate esters), preparation methods and uses thereof. The compounds have the general formula as follows:_(3), CH, N_(3), CCH;R = H, F;X = F, OH, NH_(2);Y = H, CH_(3), F, OH, NH_(2) The compounds are used in the synthesis of drugs for the treatment of virus infection, especially for the treatment of HBV, HCV or HIV infection.


Copper-mediated selective mono- or diaryloxylation of benzamides has been achieved by using 2-aminopyridine 1-oxide as a new and removable N,O-bidentate directing group. The reaction system shows a broad substrate scope and provides a straightforward way for the synthesis of mono- and diaryloxylated benzoic acids. © 2014 American Chemical Society.


News Article | December 8, 2016
Site: www.eurekalert.org

A diet rich in magnesium may reduce the risk of diseases including coronary heart disease, stroke and type-2 diabetes according to a new meta-analysis published in the open access journal BMC Medicine. This analysis of the evidence on dietary magnesium and health outcomes is the largest to date, involving data from more than one million people across nine countries. The researchers, from Zhejiang University and Zhengzhou University in China, found that people in the highest category of dietary magnesium consumption had a 10% lower risk of coronary heart disease, 12% lower risk of stroke and a 26% lower risk of type-2 diabetes compared to those in the lowest category. Their results also indicate that an extra 100mg per day of dietary magnesium could also reduce risk of stroke by 7% and type-2 diabetes by 19%. Dr Fudi Wang, lead author from the School of Public Health at Zhejiang University, said: "Low levels of magnesium in the body have been associated with a range of diseases but no conclusive evidence has been put forward on the link between dietary magnesium and health risks. Our meta-analysis provides the most up-to-date evidence supporting a link between the role of magnesium in food and reducing the risk of disease." Dr Wang added: "The current health guidelines recommend a magnesium intake of around 300mg per day for men and 270mg per day for women. Despite this, magnesium deficiency is relatively common, affecting between 2.5% and 15% of the general population. Our findings will be important for informing the public and policy makers on dietary guidelines to reduce magnesium deficiency related health risks." Magnesium is vital for human health and normal biological functions including glucose metabolism, protein production and synthesis of nucleic acids such as DNA. Diet is the main source of magnesium as the element can be found in foods such as spices, nuts, beans, cocoa, whole grains and green leafy vegetables. In this analysis, data from 40 epidemiological studies covering a period from 1999 to 2016 were used to investigate associations between dietary magnesium and various diseases. In all the studies, levels of dietary magnesium were determined using a self-reported food frequency questionnaire or a 24-hour dietary recall. As the levels of magnesium used to define categories varied widely between the studies, the researchers performed a dose-response analysis for the effect of each 100mg per day increase of dietary magnesium. This meta-analysis involves observational studies meaning that it is not possible to rule out the effect of other biological or lifestyle factors influencing the results. It is also not possible to determine if magnesium is directly responsible for reducing disease risk. However, the large size of this analysis provides robust data that were stable when adjusting for gender and study location. The authors state that their findings reinforce the notion that increased consumption of magnesium rich foods could be beneficial for overall health. 1. Research article: Dietary magnesium intake and risk of cardiovascular disease, type 2 diabetes, and allcause mortality: A dose-response meta-analysis of prospective cohort studies Fudi Wang et al. BMC Medicine 2016 During embargo period please contact Matthew Lam for the full article. After the embargo lifts, the article will be available at the journal website here: https:/ Please name the journal in any story you write. If you are writing for the web, please link to the article. All articles are available free of charge, according to BioMed Central's open access policy. 2. With an ethos of transparency and accessibility, BMC Medicine is an open access, open peer-reviewed general medical journal publishing outstanding and influential research in all areas of clinical practice, translational medicine, public health, policy, and general topics of interest to the biomedical research community. As the flagship medical journal of the BMC series, we also publish stimulating debates and reviews as well as unique forum articles and concise tutorials. 3. BioMed Central is an STM (Science, Technology and Medicine) publisher which has pioneered the open access publishing model. All peer-reviewed research articles published by BioMed Central are made immediately and freely accessible online, and are licensed to allow redistribution and reuse. BioMed Central is part of Springer Nature, a major new force in scientific, scholarly, professional and educational publishing, created in May 2015 through the combination of Nature Publishing Group, Palgrave Macmillan, Macmillan Education and Springer Science+Business Media. http://www.


Qin Q.,Zhengzhou University | Qin Q.,Zhongyuan University of Technology | Zhang R.,Zhengzhou University | Zhang R.,Zhengzhou Institute of Aeronautical Industry Management
Electrochimica Acta | Year: 2013

The conical nanotube structure of polyaniline (PANI) was facilely synthesized on indium tin oxide (ITO) conducting polyethylene terephthalate (PET) substrates via electrochemical polymerization method. The tubular morphology of PANI was confirmed by SEM and TEM images. It was observed that one side of PANI conical nanotube was a sharp closed tip, and the other was a circular open tube. In addition, the nanosheets, nanofibers and nanorods of PANI were observed by SEM with polymerization potentials varying from 2.0 V to 2.6 V. The resulting materials were also characterized by four-probe instrument, FTIR, cyclic voltammetry, and photoelectric measurement. Then the results showed that the optimal efficiency of dye sensitized solar cell (DSSC) with flexible PANI/ITO-PET counter electrode at 2.4 V reached to 0.86%, owing to the unique conical nanotube structure, excellent photoelectric property and high electrochemical activity of this PANI electrode. Therefore, the PANI/ITO-PET electrode can be applied as promising flexible electrode materials for DSSCs. © 2012 Elsevier Ltd. All Rights Reserved.


Xu D.,Zhengzhou University | Xu Q.,Zhengzhou University | Wang K.,Zhengzhou University | Chen J.,University of Wollongong | Chen Z.,Zhengzhou University
ACS Applied Materials and Interfaces | Year: 2014

A hierarchical high-performance electrode with nanoacanthine-style polyaniline (PANI) deposited onto a carbon nanofiber/graphene oxide (CNF/GO) template was successfully prepared via an in situ polymerization process. The morphology analysis shows that introducing one-dimensional (1D) CNF could significantly decrease/inhibit the staking of laminated GO to form an open-porous CNF/GO architecture. Followed with in situ facial deposition of PANI, the as-synthesized PANI modified CNF/GO exhibits three-dimensional (3D) hierarchical layered nanoarchitecture, which favors the diffusion of the electrolyte ions into the inner region of active materials. The hierarchical free-standing electrodes were directly fabricated into sandwich structured supercapacitors using 1 M H2SO4 as the electrolyte showing a significant specific capacitance of 450.2 F/g at the voltage scan rate of 10 mV/s. The electrochemical properties of the hierarchical structure can be further improved by a reduction procedure of GO before the deposition of PANI. © 2013 American Chemical Society.


Wang J.,Zhengzhou University | Fan C.,Zhengzhou University | Ding P.,Zhengzhou Institute of Aeronautical Industry Management | He J.,Zhengzhou University | And 5 more authors.
Optics Express | Year: 2012

A broad-band perfect absorber composing a two-dimensional periodic metal-dielectric-metal sandwiches array on dielectric/metal substrate is designed and numerically investigated. It is shown that the nearly-perfect absorption with a bandwidth of about 50 nm in visible region can be achieved by overlapping of two plasmon resonances: One originating from the coupling of electric dipoles between adjacent unit cells and another arising from magnetic dipole plasmon resonances. A capacitor-inductor circuit description is introduced to explain the dependence of resonance frequencies and band-width on geometrical parameters. © 2012 Optical Society of America.


Cai Y.,Japan international Research Center for Agricultural science | Yang J.,Hainan University | Pang H.,Zhengzhou University | Kitahara M.,RIKEN
International Journal of Systematic and Evolutionary Microbiology | Year: 2011

Three strains of lactic acid bacteria, designated NJ 317 T, NJ 414 and NJ 415, were isolated from the outer leaves of Chinese cabbages (Brassica rapa L. var. glabra Regel) and characterized taxonomically. The strains were Gram-reaction-positive, catalase-negative, facultatively anaerobic cocci that did not produce gas from glucose and formed L-lactic acid. The major fatty acids were C 18:1ω9c, C 16:0, C 14:0 and summed feature 10. Morphological, physiological and phylogenetic data indicated that the strains belonged to the genus Lactococcus. These strains shared similar phenotypic characteristics and exhibited DNA relatedness values>96.6%to each other, indicating that they represent a single species. The DNA G+C contents of the three strains were 42.1- 42.5 mol%. 16S rRNA gene sequences of the novel strains were determined and aligned with those of other species of the genus Lactococcus. On the basis of phylogenetic analysis the three strains grouped with other members of the genus Lactococcus. Lactococcus lactis and Lactococcus garvieae were the most closely related species, sharing a sequence similarity value of 94.4% with the three strains. Ribotyping patterns, however, revealed that these strains were well-separated from reference strains of species of the genus Lactococcus and DNA-DNA hybridization studies indicated that the novel strains had low levels (<20.2%) of DNA relatedness with reference strains of L. lactis, L. garvieae and other type strains of previously described species, showing that they represent a different species. Based on this evidence, strains NJ 317 T, NJ 414 and NJ 415 represent a novel species of the genus Lactococcus, for which the name Lactococcus fujiensis sp. nov. is proposed. The type strain is NJ 317 T (=JCM16395 T =CGMCC 1.10453 T). © 2011 IUMS.


Wang Z.,Zhengzhou University | Wang H.,North China University of Water Conservancy and Electric Power | Liu J.,Zhengzhou University | Zhang Y.,Zhengzhou University
Desalination | Year: 2014

Polyethersulfone ultrafiltration hybrid membrane containing halloysite nanotubes grafted with 2-methacryloyloxyethyl phosphorylcholine (HNTs-MPC) was prepared via phase inversion method for the purpose of enhancing the antifouling property of the membrane. HNTs-MPC were synthesized by chemical modification of HNTs with MPC via reverse atom transfer radical polymerization (RATRP). The performance and morphology of the membranes were characterized by water contact angle and SEM. The hybrid membrane was shown to be more hydrophilic with a higher pure water flux. The thickness of the thin separating layer on the top tended to decrease with the addition of HNTs-MPC. The BSA adsorption experiment indicated that the adsorption amounts of bovine serum albumin (BSA) on the membrane were dramatically decreased. BSA ultrafiltration experiment also showed that the antifouling ability of the membrane with the addition of HNTs-MPC was better than the pure PES membrane. Meanwhile, the long term ultrafiltration experiment showed that the hybrid membrane had an ideal stability. © 2014 Elsevier B.V.


Wang J.,Zhengzhou University | Yuan B.,Zhengzhou University | Yuan B.,North China University of Water Conservancy and Electric Power | Fan C.,Zhengzhou University | And 4 more authors.
Optics Express | Year: 2013

A novel planar plasmonic metamaterial for electromagnetically induced transparency and slow light characteristic is presented in this paper, which consists of nanoring and nanorod compound structures. Two bright modes in the metamaterial are induced by the electric dipole resonance inside nanoring and nanorod, respectively. The coupling between two bright modes introduces transparency window and large group index. By adjusting the geometric parameters of metamaterial structure, the transmittance of EIT window at 385 THz is about 60%, and the corresponding group index and Q factor can reach up to 1.2 × 103 and 97, respectively, which has an important application in slow-light device, active plasmonic switch, SERS and optical sensing. © 2013 Optical Society of America.


Mills K.T.,Tulane University | Xu Y.,Tulane University | Xu Y.,Shanghai JiaoTong University | Zhang W.,Zhengzhou University | And 5 more authors.
Kidney International | Year: 2015

Chronic kidney disease (CKD) is a major risk factor for end-stage renal disease, cardiovascular disease, and premature death. Here we estimated the global prevalence and absolute burden of CKD in 2010 by pooling data from population-based studies. We searched MEDLINE (January 1990 to December 2014), International Society of Nephrology Global Outreach Program-funded projects, and bibliographies of retrieved articles and selected 33 studies reporting gender- and age-specific prevalence of CKD in representative population samples. The age-standardized global prevalence of CKD stages 1-5 in adults aged 20 and older was 10.4% in men (95% confidence interval 9.3-11.9%) and 11.8% in women (11.2-12.6%). This consisted of 8.6% in men (7.3-9.8%) and 9.6% in women (7.7-11.1%) in high-income countries, and 10.6% in men (9.4-13.1%) and 12.5% in women (11.8-14.0%) in low- and middle-income countries. The total number of adults with CKD was 225.7 million (205.7-257.4 million) men and 271.8 million (258.0-293.7 million) women. This consisted of 48.3 million (42.3-53.3 million) men and 61.7 million (50.4-69.9 million) women in high-income countries, and 177.4 million (159.2-215.9 million) men and 210.1 million (200.8-231.7 million) women in low- and middle-income countries. Thus, CKD is an important global-health challenge, especially in low- and middle-income countries. National and international efforts for prevention, detection, and treatment of CKD are needed to reduce its morbidity and mortality worldwide. © 2015 International Society of Nephrology.


Zhao B.,Zhengzhou University | Shao G.,Zhengzhou University | Fan B.,Zhengzhou University | Zhao W.,Zhengzhou University | And 2 more authors.
Physical Chemistry Chemical Physics | Year: 2014

In this work, amorphous TiO2 and SiO2-coated Ni composite microspheres were successfully prepared by a two-step method. The phase purity, morphology, and structure of composite microspheres are characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectroscopy (EDS), thermogravimetric analysis (TGA), and transmission electron microscopy (TEM). Due to the presence of the insulator SiO2 shell, the core-shell Ni-SiO2 composite microspheres exhibit better antioxidation capability than that of pure Ni microspheres. The core-shell Ni-SiO2 composite microspheres show the best microwave absorption properties than those of pure Ni microspheres and Ni-TiO2 composites. For Ni-SiO2 composite microspheres, an optimal reflection loss (RL) as low as -40.0 dB (99.99% absorption) was observed at 12.6 GHz with an absorber thickness of only 1.5 mm. The effective absorption (below -10 dB, 90% microwave absorption) bandwidth can be adjusted between 3.1 GHz and 14.4 GHz by tuning the absorber thickness in the range of 1.5-4.5 mm. The excellent microwave absorption abilities of Ni-SiO2 composite microspheres are attributed to a higher attenuation constant, Debye relaxation, interface polarization of the core-shell structure and synergistic effects between high dielectric loss and high magnetic loss. This journal is © the Owner Societies.


Hejun Y.,Anyang University, South Korea | Zheng Y.,Zhengzhou University
Journal of Convergence Information Technology | Year: 2012

H ∞ Mean-square Exponentially Stable Control problem of uncertain networked control systems with stochastic network induced delay and data packet dropout is concerned in this paper. The stochastic delay and data packet dropout are viewed as equivalent delay which is viewed as a binary switching sequence satisfying interval Bernoulli distribution. Then a new networked control systems model is obtained. Based on the Lyapunov stability theory, and with the linear matrix inequality approach, a sufficient condition is presented to design the H ∞ controller which make the networked control systems be mean-square exponentially stable. A numerical example is provided to demonstrate the validity of the proposed design approach.


Fu J.,Zhengzhou University | Xu Q.,Zhengzhou University | Chen J.,Zhengzhou University | Chen Z.,Zhengzhou University | And 2 more authors.
Chemical Communications | Year: 2010

Uniform carbon spheres with hollow core and porous shell structures were controllably fabricated through carbonizing fine core/shell particles of polystyrene/cross-linked poly(cyclotriphosphazene-co-4,4′- sulfonyldiphenol), obtained by a simple template approach. © 2010 The Royal Society of Chemistry.


Chang Z.-L.,Zhengzhou University | Li D.-D.,Beijing University of Posts and Telecommunications
IEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences | Year: 2014

In this paper, one new class of quaternary generalized cyclotomic sequences with the period 2pq over F4 is established. The linear complexity of proposed sequences with the period 2pq is determined. The results show that such sequences have high linear complexity. Copyright © 2014 The Institute of Electronics, Information and Communication Engineers.


Wang Z.,Zhengzhou University | Huang X.,Shanghai JiaoTong University | Zheng Q.,Shanghai JiaoTong University
ANZ Journal of Surgery | Year: 2012

Background: Conventional laparoscopic cholecystectomy (CLC) is now accepted as the gold standard surgical treatment for gallbladder stone disease. Single-incision laparoscopic technology has recently been introduced into laparoscopic clinical practice in order to reduce the invasiveness of this procedure. A meta-analysis of randomized clinical trials (RCTs) was performed to compare single-incision laparoscopic cholecystectomy (SICL) and CLC. Methods: Medline, Embase, ISI Web of Knowledge CPCI-S and the Cochrane Library were searched and the methodological quality of the included trials was evaluated. Outcomes evaluated were adverse events, conversion rate, post-operative hospital stay, blood loss, post-operative pain, total wound length, operative time and wound satisfaction score. Results were pooled in meta-analyses as odds ratio and weighted mean differences (WMD). Results: Five RCTs on 264 patients qualified for the meta-analysis, 139 being allocated to SILC and 125 to CLC. There was no significant difference between SICL and CLC for adverse events, conversion rate, post-operative hospital stay, blood loss, post-operative pain and total wound length; however, operative time was significantly longer in SICL than in CLC (WMD 7.72 (95% confidence interval (CI): 1.38-14.07)min; P = 0.02, χ2 P = 0.02, I2 = 69%). Furthermore, wound satisfaction score was significantly higher in SICL than in CLC (WMD 1.40 (95% CI: 1.19-1.61)min; P < 0.00001, χ2 P = 0.19, I2 = 42%). Conclusion: SILC may be superior to CLC in terms of cosmetic outcome, but not in operative time. Currently, SILC is a safe procedure for proper patients in experienced surgeons. © 2012 The Authors. ANZ Journal of Surgery © 2012 Royal Australasian College of Surgeons.


Wu S.,Zhengzhou University | Wu S.,University of Chinese Academy of Sciences | Pu Q.,Tongji University | Wang S.,Beijing University of Posts and Telecommunications | He D.,Wuhan University
Information Sciences | Year: 2012

We revisit the communication-efficient three-party password authenticated key exchange protocol recently proposed by Chang et al. We show it is insecure against partition attacks, whereby the adversary can guess the correct password off-line. Thereafter we propose an enhanced protocol that can resist the attack described and yet is quite efficient. Furthermore, we prove its security in a widely accepted model. © 2012 Elsevier Inc. All rights reserved.


Wang J.,Zhengzhou University | Fan C.,Zhengzhou University | He J.,Zhengzhou University | Ding P.,Zhengzhou Institute of Aeronautical Industry Management | And 2 more authors.
Optics Express | Year: 2013

Double Fano resonant characteristics are investigated in planar plasmonic structure by embedding a metallic nanorod in symmetric Ushaped split ring resonators, which are caused by a strong interplay between a broad bright mode and narrow dark modes. The bright mode is resulted from the nanorod electric dipole resonance while the dark modes originate from the magnetic dipole induced by LC resonances. The overlapped dual Fano resonances can be decomposed to two separate ones by adjusting the coupling length between the nanorod and U-shaped split ring resonators. Fano resonances in the designed structure exhibit high refractive-index sensing sensitivity and figure of merit, which have potential applications in single or double-wavelength sensing in the near-infrared region. © 2013 Optical Society of America.


Wang C.-H.,Zhengzhou University | Liu M.,Henan Jiaozuo Teachers College | Niu Y.-Y.,Zhengzhou University
Inorganica Chimica Acta | Year: 2015

Cation-templated self-assembly of 1,n-bis(4-methylpyridine)alkane cations (n = 3-7) with CuSCN was studied and a series of new polymeric thiocyanate frameworks were obtained: {(bmpp)[Cu2Br2(SCN)2]}n (1), {(bmpt)[Cu2(SCN)4]}n (2), {(bmppt)[Cu2(SCN)4]}n (3), {(bmph)[Cu4(SCN)6]}n (4), {(bmphp)[Cu2(SCN)4]}n (5), (n = 3, bmpp; n = 4, bmpt; n = 5, bmppt; n = 6, bmph; n = 7, bmphp). The structures consist of 1-2D frameworks with the dications trapped within host network cavities. Compounds 1, 2, 3 and 5 possess the infinite two-dimensional polypseudorotaxane anion networks. Compound 4 has a novel 1D chain structure which looks like lotus root. The results demonstrate that the side chain of methyl substituent plays an important role in the fabrication of polypseudorotaxane structures. Furthermore, solid UV-Vis spectra, photoluminescence and photocatalytic properties at ambient temperature were also investigated. © 2015 Elsevier B.V.


Wan Y.-D.,Zhengzhou University | Sun T.-W.,Zhengzhou University | Liu Z.-Q.,Zhengzhou University | Zhang S.-G.,Zhengzhou University | And 2 more authors.
Chest | Year: 2016

BACKGROUND: Corticosteroids are an option in the treatment of community-Acquired pneumonia (CAP). However, the benefits and adverse effects of corticosteroids, especially in severe CAP, have not been well assessed. METHODS: PubMed, Embase, and Cochrane library databases from inception to May 2015 were searched. Randomized controlled trials (RCTs) and cohort studies that evaluated use of corticosteroids in adult patients with CAP were included. The quality of outcomes was evaluated using Grading of Recommendations Assessment, Development and Evaluation methodology. The Mantel-Haenszel method with random-effects modeling was used to calculate pooled relative risks (RRs) and 95% CIs. RESULTS: Nine eligible RCTs (1,667 patients) and six cohort studies (4,095 patients) were identified. The mean corticosteroid dose and treatment duration were 30 mg/day methylprednisolone for 7 days. Corticosteroids did not have a statistically significant effect on mortality (RR, 0.72; 95% CI, 0.43-1.21; evidence rank, low) in patients with CAP and patients with severe CAP (RCTs: RR, 0.72; 95% CI, 0.43-1.21; evidence rank, low; cohort studies: RR, 1.00; 95% CI, 0.86-1.17 ). Corticosteroids treatment was associated with a decreased risk of ARDS (RR, 0.21; 95% CI, 0.08-0.59) and may reduce lengths of hospital and ICU stay, duration of IV antibiotic treatment, and time to clinical stability. Corticosteroids were not associated with increased rates of adverse events. CONCLUSIONS: Short-Term treatment with corticosteroids is safe and may reduce the risk of ARDS, shortening the length of the disease in patients with CAP. Copyright © 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.


Arias H.R.,Midwestern University | Gu R.-X.,Shanghai JiaoTong University | Feuerbach D.,Novartis | Guo B.-B.,Zhengzhou University | And 2 more authors.
Biochemistry | Year: 2011

The pharmacological activity of a series of novel amide derivatives was characterized on several nicotinic acetylcholine receptors (AChRs). Ca 2+ influx results indicate that these compounds are not agonists of the human (h) α4β2, α3β4, α7, and α1β1- AChRs; compounds 2-4 are specific positive allosteric modulators (PAMs) of hα7 AChRs, whereas compounds 1-4, 7, and 12 are noncompetitive antagonists of the other AChRs. Radioligand binding results indicate that PAMs do not inhibit binding of [ 3H]methyllycaconitine but enhance binding of [ 3H]epibatidine to hα7 AChRs, indicating that these compounds do not directly, but allosterically, interact with the hα7 agonist sites. Additional competition binding results indicate that the antagonistic action mediated by these compounds is produced by direct interaction with neither the phencyclidine site in the Torpedo AChR ion channel nor the imipramine and the agonist sites in the hα4β2 and hα3β4 AChRs. Molecular dynamics and docking results suggest that the binding site for compounds 2-4 is mainly located in the inner β-sheet of the hα7-α7 interface, -12 Å from the agonist locus. Hydrogen bond interactions between the amide group of the PAMs and the hα7 AChR binding site are found to be critical for their activity. The dual PAM and antagonistic activities elicited by compounds 2-4 might be therapeutically important. © 2011 American Chemical Society.


Li G.-N.,Zhengzhou University | Li G.-N.,National Taiwan University | He X.-G.,Shanghai JiaoTong University | He X.-G.,National Taiwan University | He X.-G.,National Tsing Hua University
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2015

We study a class of models for neutrino mass matrix in Type-II seesaw with A4 family symmetry. The resulting neutrino mass matrix can be naturally made to respect a μ-τ exchange plus CP conjugate symmetry (GLS) with the CP violating phase δ and the mixing angle θ23 predicted to be ±π/2 and π/4, respectively. When GLS is explicitly broken by complex Yukawa couplings, the model predictions for δ and θ23 can be significantly modified. Should future experiments indeed determine θ23 and δCP away from the GLS limit values, one then had to consider models with broken GLS. We study several simple scenarios to show how the modifications arise when GLS is broken and how future experiments can test this class of models. © 2015 The Authors.


Huang W.L.,Zhengzhou Institute of Aeronautical Industry Management | Cheng Z.X.,Zhengzhou University
IEEE Transactions on Dielectrics and Electrical Insulation | Year: 2010

Flashover occurring under repetitive pulsed voltage perhaps may not happen at the first pulse of applied repetitive pulses. Thus, studies of flashover stressing time (FST) are important to comprehend the flashover mechanism under nanosecond-pulsed voltage. In our experiments, the pulsed power source was SPG200, based on semiconductor opening switch (SOS). Solid dielectrics employed were polymethyl methacrylate (PMMA) and polyamide 1010, and liquid dielectric was transformer oil. The dispersion of FST was statistically large at invariable or variable voltage amplitude and frequency of repetitive pulses. Furthermore, the dispersion of FST decreased, and concurrently, the odds of that flashover arising at the first pulse of repetitive pulses increased, with the increase in the voltage amplitude of repetitive pulses whose frequency was invariably retained. The flashover tended to occur at the tail of the pulse waveform, and the mean value of FST was found to gradually reduce. Moreover, the extent of reduction was prominently decreased after about 200 Hz, when the pulse frequency increased, which simultaneously restricted the variation of the voltage amplitude of the applied repetitive pulses. Thus, it was demonstrated that longer FST is the ultimate factor, which induces lower flashover field strength under repetitive nanosecond pulses. © 2010 IEEE.


Suijun W.,Zhengzhou University | Zhen Y.,Shanghai JiaoTong University | Ying G.,Zhengzhou University | Yanfang W.,Zhengzhou University
Biochemical and Biophysical Research Communications | Year: 2014

Glucose-stimulated insulin secretion (GSIS) is essential for the control of metabolic fuel homeostasis and its impairment is a key element in the failure of β-cells in type 2 diabetes. Trans-caryophyllene (TC), an important constituent of the essential oil of several species of plants, has been reported to activate the type 2 cannabinoid receptor (CB2R). The effects of TC on GSIS are still unknown. Our results demonstrate that administration of TC in MIN6 cells promotes GSIS in a dose dependent manner. However, inhibition of CB2R by a specific inhibitor or specific RNA interference abolished the effects of TC on GSIS, which suggests that the effects of TC on GSIS are dependent on activation of CB2R. Further study demonstrated that treatment with TC leads to the activation of small G protein Arf6 as well as Rac1 and Cdc42. Importantly, Arf6 silencing abolished the effects of TC on GSIS, which suggests that Arf6 participates in mediating the effects of TC on GSIS. We conclude from these data that TC has a novel role in regulating GSIS in pancreatic β-cells. © 2014 Elsevier Inc. All rights reserved.


Chang Z.,Zhengzhou University | Wen Q.,Beijing University of Posts and Telecommunications
Chinese Journal of Electronics | Year: 2011

New properties and methods about the linear complexity and the k-error linear complexity of binary 2n-periodic sequences are provided. Using Games-Chan algorithm and new method, we give some new results about k-error linear complexity, and the method to count the number of critical error sequences is also provided.


Dong W.,Zhengzhou University | Feng L.,Minhang District Central Hospital | Xie Y.,Minhang District Central Hospital | Zhang H.,Minhang District Central Hospital | Wu Y.,Shanghai JiaoTong University
Cancer Science | Year: 2011

LMX1A is epigenetically inactivated in cervical cancer. However, the expression and methylation status of LMX1A in gastric cancer tissues remains unknown. In the present study, we found that the expression of LMX1A was significantly decreased in gastric cancer tissues compared with normal tissues. A statistically significant inverse association was found between the LMX1A methylation status and expression of LMX1A in tumor tissues (P=0.008). Restoration of LMX1A induced cell apoptosis and suppressed anchorage-independent growth, suggesting LMX1A may be a potential biomarker for gastric cancer. © 2010 Japanese Cancer Association.


Gao F.,Anyang University, China | Yuan Z.,Zhengzhou University | Yuan F.,Anyang University, China
Advances in Information Sciences and Service Sciences | Year: 2011

This paper investigates the finite-time control problem for networked control systems (NCSs) with time-varying delays. The finite-time controller via state feedback is proposed to guarantee the finitetime boundedness and finite-time stabilization of the resulting closed loop system for all admissible disturbances and unknown time-delays. Based on Lyapunov stability theory, sufficient conditions that ensure finite-time performance of networked control systems are derived. The control criterion is formulated in the form of linear matrix inequalities and the designed finite-time stabilization controller is described as a feasibility one. The presented results are extended to networked control systems. With time-varying delay. Numerical example illustrates the feasibility of the developed approaches.


Shi D.,Zhengzhou University | Wang C.,North China University of Water Conservancy and Electric Power
International Journal of Computer Mathematics | Year: 2011

The main aim of this paper is to develop a new low-order non-conforming mixed finite-element method to solve the second-order elliptic problems on rectangular meshes. The convergence analysis is presented and the optimal error estimates are derived with the lowest regularity of the exact solution. Numerical results which coincide with our theoretical analysis show that this element indeed has very good convergence behaviour. © 2011 Taylor & Francis.


Lv P.,Zhengzhou University | Lin X.Z.,Shanghai JiaoTong University | Chen K.,Zhengzhou University | Gao J.,Zhengzhou University
European Radiology | Year: 2012

Objective To assess image quality and diagnostic accuracy of monochromatic imaging from spectral CT in patients with small HCC (≤3 cm). Methods Twenty-seven patients with 31 HCC underwent spectral CT to generate conventional 140-kVp polychromatic images (group A) and monochromatic images with energy levels from 40 to 140 keV (group B) during the late arterial phase (LAP) and the portal venous phase (PVP). Two-sample t tests compared the tumour-to-liver contrastto- noise ratio (CNR) and mean image noise. Lesion detection for LAP, reader confidence and readers' subjective evaluations of image quality were recorded. Results Highest CNRs in group B were distributed at 40, 50 and 70 keV. Higher CNR values and lesion conspicuity scores (LCS) were obtained in group B than in group A (CNR 3.36± 2.07 vs. 1.47±0.89 in LAP; 2.29±2.26 vs. 1.58±1.75 in PVP; LCS 2.82, 2.84, 2.63 and 2.53 at 40-70 keV, respectively, vs. 1.95) (P<0.001). Lowest image noise for group B was at 70 keV, resulting in higher image quality than that in group A (4.70 vs. 4.07; P<0.001). Conclusion Monochromatic energy levels of 40-70 keV can increase detectability in small HCC and this increase might not result in image quality degradation. © European Society of Radiology 2012.


Chen Q.-J.,Zhengzhou University | Zhang M.-Z.,Zhengzhou University | Wang L.-X.,Charles Sturt University
Cellular Physiology and Biochemistry | Year: 2010

Aims: The ginsenoside Rg3 (Rg3) inhibits xenograft growth and angiogenesis in tumors mainly via down-regulates VEGF expression. This study was designed to investigate the mechanisms by which Rg3 down-regulates VEGF expression. Methods: MTT assay was performed to investigate the effect of Rg3 on the growth of human esophageal carcinoma cell line Eca-109 and 786-0 cells under normoxic and hypoxic conditions. ELISA was used to detect VEGF protein secreted by the cells under normoxic and hypoxic conditions. Real-time quantitative reverse transcriptase polymerase chain reaction and Western blotting were used to detect gene expression and protein synthesis. Results: Rg3 inhibited Eca-109 and 786-0 cell proliferation and induced a significant reduction in VEGF mRNA under hypoxia conditions. Rg3 treatment inhibited hypoxia-induced expression HIF-1α, COX-2 and NF-κB under normoxic and hypoxic conditions. Treatment with Rg3 reduced the hypoxia-induced phosphorylation of STAT3 in a dose-dependent manner in the both cell lines. Rg3 treatment also inhibited the phosphorylation of ERK1/2 and JNK induced by hypoxia. Conclusions: Rg3 targets hypoxia-induced multiple signaling pathways to down-regulate VEGF expression in cancer cells. These actions may contribute to the overall efficacy of Rg3 against tumor angiogenesis and growth. Copyright © 2010 S. Karger AG, Basel.


Deng D.,Luoyang Normal University | Liu L.,Anyang University, China | Ji B.-M.,Luoyang Normal University | Yin G.,Luoyang Normal University | And 2 more authors.
Crystal Growth and Design | Year: 2012

Solvothermal reactions of Pb(Ac) 2 with a new flexible 1,3-bis(4-pyridyl-3-cyano)propane (1, BPCP) ligand under different synthesis conditions via an in situ ligand transformation reaction produced three true coordination polymorphs, namely, [PbL 2-] n (for 2 and 3) and [Pb 3L 2- 3] n (4), as well as their polymorphic framework [(Pb 2L 2-)·2H 2O] n (5) (H 2L = 1,3-bis(4-pyridyl-3-carboxyl) propane). These compounds were characterized by elemental analysis, IR, TG, PXRD, and single-crystal X-ray diffraction. In these compounds, the L 2-ligand exhibits different coordination conformations and modes tuned by different synthesis conditions, including reaction temperature, cooling rate, and additive, and constructs various architectures by bridging a variety of building units. Polymorphs 2 and 3 display a 3D framework with 1D channels built up from dinuclear ringlike [Pb 2L 2- 2] units and dinuclear semi-ring-like [Pb 2L 2-] units, respectively. Polymorph 4 also features a 3D architecture constructed from dinuclear ringlike [Pb 2L 2- 2] units interlinked by the L 2- ligand. Interestingly, the framework of 4 is big enough to allow the other net to penetrate to form a 2-fold interpenetrating framework with a trinodal (3,6,10)-connected topology with a point symbol of (4 3)(4 4·6 10·8)(4 8·6 24·8 9·10 4). For 5, there exists two kinds of dinuclear ringlike [Pb 2L 2- 2] units. These [Pb 2L 2- 2] units are interconnected by Pb atoms to afford a 2D undulant network that is further connected by the hydrogen-bonding interactions and weak interactions to afford a 3D supramolecular network. In addition, the photoluminescence properties of 1-5 and the H 2L ligand in the solid state at room temperature were also investigated. © 2012 American Chemical Society.


Wang Y.,Tsinghua University | Wang Y.,Pacific Northwest National Laboratory | Li Z.,Pacific Northwest National Laboratory | Li Z.,Zhengzhou University | And 5 more authors.
Analytical Chemistry | Year: 2013

Nucleotides, for example, adenosine-5′-triphosphate (ATP) and guanosine-5′-triphosphate (GTP), are primary energy resources for numerous reactions in organisms including microtubule assembly, insulin secretion, ion channel regulation, and so on. In order to advance our understanding of the production and consumption of nucleoside triphosphates, a versatile sensing platform for simultaneous visualization of ATP, GTP, adenosine derivates, and guanosine derivates in living cells has been built up in the present work based on graphene oxide nanosheets (GO-nS) and DNA/RNA aptamers. Taking advantage of the robust fluorescence quenching ability, unique adsorption for single-strand DNA/RNA probes, and efficient intracellular transport capacity of GO-nS, selective and sensitive visualization of multiple nucleoside triphosphates in living cells is successfully realized with the designed aptamer/GO-nS sensing platform. Moreover, GO-nS displays good biocompatibility to living cells and high protecting ability for DNA/RNA probes from enzymatic cleavage. These results demonstrate that the aptamers/GO-nS-based sensing platform is capable of selective, simultaneous, and in situ detection of multiple nucleotides, which hold a great potential for analyzing other biomolecules in living cells. © 2013 American Chemical Society.


Dong W.,Zhengzhou University | Wang L.,Zhengzhou University | Shen R.,Shanghai JiaoTong University
Digestive Diseases and Sciences | Year: 2013

Background: Our previous study has shown that MYO5B is downregulated in gastric cancer. However, the mechanism by which the expression of MYO5B was inhibited remains unknown. Methods: Inspection of the human MYO5B locus uncovered a large and dense CpG island within the 5′ region of this gene. Methylation-specific PCR (MSP) and bisulfite sequencing (BSP) were used for determination of MYO5B promoter methylation in gastric cancer cell lines and gastric cancer samples. Involvement of histone H3 methylation in those cell lines were examined by ChIP assay. Results: The densely methylated MYO5B promoter region was confirmed by MSP and BSP. Enhanced gene expression was detected when the cells were treated with the DNA-demethylating agent 5-aza-2′-deoxycytidine (DAC) and trichostatin A (TSA), a histone deacetylase inhibitor. Knockdown of MYO5B expression in gastric cancer cells expressing endogenous MYO5B inhibits HGF-stimulated MET degradation, concomitant with sustained c-MET levels and signaling. Conclusion: The results of our study showed for the first time that MYO5B is epigenetically silenced in gastric cancer cells by aberrant DNA methylation and histone modification. Inactivation of MYO5B expression in gastric cancer cells expressing endogenous MYO5B inhibits HGF-stimulated MET degradation, concomitant with sustained c-MET levels and signaling. © 2013 Springer Science+Business Media New York.


Xing Y.,Anyang University, South Korea | Liu D.,Zhengzhou University | Zhang L.-P.,Anyang University, South Korea
Desalination | Year: 2010

Ethylenediaminetetraacetic dianhydride (EDTAD) modified sugarcane bagasse (SB) was prepared, and characterized by Fourier transform infrared spectroscopy (FTIR). Due to the presence of a large number of carboxyl groups, the adsorption capacity of the EDTAD-modified SB (EDTAD-SB) for Methylene Blue (MB) showed a significant increase compared with SB. The maximum adsorption capacity was 115.3mgg -1 for MB, according to the Langmuir equation. Kinetic studies showed better correlation coefficients for a pseudo-second-order kinetic model, confirming that the sorption rate was controlled by a chemisorption process. Photocatalytic regeneration of spent EDTAD-SB using UV/TiO 2 is effective. Further, the regenerated EDTAD-SB exhibits 85% efficiency for subsequent adsorption cycle with MB aqueous solutions. © 2010 Elsevier B.V.


Tang Y.,Zhengzhou University | Ma D.,Anyang University, China | Chen W.,Zhengzhou University | Dai X.,Zhengzhou University
Sensors and Actuators, B: Chemical | Year: 2015

The stable configuration, electronic structure, magnetic property, and catalytic activity of single-atom Co catalyst on graphene substrates are investigated using the first-principles calculations. In contrast to the pristine graphene, a vacancy defect in graphene strongly stabilizes the Co atom and makes it more positively charged, which helps to facilitate the adsorption of O2 molecule and alleviate the CO poisoning of catalyst, since the larger adsorption energy of O2 gains more transferred electrons from Co-graphene substrates as compared with that of the CO molecule. Besides, the anchored Co atom and adsorbed gas molecules can regulate the electronic structure and magnetic property of graphene substrates. Moreover, the sequential processes of CO oxidation on the Co-embedded graphene system have lower energy barrier (0.42 eV) by the Langmuir-Hinshelwood (LH) reaction (CO + O2 → OOCO) and is followed by the Eley-Rideal (ER) reaction with smaller energy barrier of 0.19 eV (CO + Oads → CO2). The results provide valuable guidance on selecting the catalyst of low cost and high activity to fabricate graphene-based materials, and the atomic-scale catalyst supported on graphene would be potential for gas sensors, spintronics and catalytic electrode in fuel cells. © 2015 Elsevier B.V.


Yao H.,Anyang University, China | Yuan Z.,Zhengzhou University
International Journal of Advancements in Computing Technology | Year: 2012

The problem of exponential stability control for nonlinear stochastic networked control systems is considered in this paper. A model of nonlinear networked control systems with stochastic delays is derived by using the T-S method. The networked induced delays are assumed to satisfy some stochastic characteristics. Corresponding to the probability of the delays taking value in different interval, a stochastic variable satisfying Bernoulli distribution is introduced. With the Lyapunov stability theorem, a exponential stability condition and a state feedback controller design method are given. All the conditions are expressed in terms of LMI. Finally, a numerical example is given to demonstrate the validity of the results.


Guo H.,Zhengzhou University | Li Q.,Shanghai JiaoTong University | Li W.,Zhengzhou University | Zheng T.,Zhengzhou University | And 2 more authors.
Molecular and Cellular Biochemistry | Year: 2014

MicroRNAs play critical roles in the development and progression of non-small cell lung cancer (NSCLC). miR-96 acts as an oncogene in some malignancies, while its role in NSCLC is unclear. Here, we validated that miR-96 was significantly increased in both human NSCLC tissues and cell lines. Inhibition of miR-96 expression remarkably reduced cell proliferation, colony formation, migration, and invasion of NSCLC cells. Reversion-inducing-cysteine- rich protein with kazal motifs (RECK) was identified as a target of miR-96 in NSCLC cells. In addition, the expression of RECK was found to be negatively correlated with the expression of miR-96 in NSCLC tissues. Our data suggest that miR-96 might promote the growth and motility of NSCLC cells partially by targeting RECK. © 2014 Springer Science+Business Media New York.


Yuzhu W.,North China University of Water Conservancy and Electric Power | Shubin W.,Zhengzhou University | Yinxia W.,North China University of Water Conservancy and Electric Power
Acta Mathematica Scientia | Year: 2012

In this article, regularity criteria for the 3D magnetohydrodynamic equations are investigated. Some sufficient integrability conditions on two components or the gradient of two components of u + B and u - B in Morrey-Campanato spaces are obtained. © 2012 Wuhan Institute of Physics and Mathematics.


Akinleye A.,New York Medical College | Iragavarapu C.,New York Medical College | Furqan M.,University of Iowa | Cang S.,Zhengzhou University | Liu D.,Zhengzhou University
Oncotarget | Year: 2015

Pancreatic cancer is relatively insensitive to conventional chemotherapy. Therefore, novel agents targeting dysregulated pathways (MAPK/ERK, EGFR, TGF-β, HEDGEHOG, NOTCH, IGF, PARP, PI3K/AKT, RAS, and Src) are being explored in clinical trials as monotherapy or in combination with cytotoxic chemotherapy. This review summarizes the most recent advances with the targeted therapies in the treatment of patients with advanced pancreatic cancer.


Pei L.,Zhengzhou University | Wang Q.,Beihang University | Shi H.,Zhengzhou University
Nonlinear Dynamics | Year: 2011

In this paper, we modify the original physiological model of artificial pancreas by introducing the insulin secretion time delay. The non-resonant double Hopf bifurcation is analyzed by the Center Manifold Theorem and Normal Form Method. Numerical results supporting the theoretical analysis are presented in some typical parameter regions. It is shown that the critical value of technological delay and the area of death island of the non-resonant double Hopf bifurcation in the modified model are far less than those in the original model. This implies that when the secretion delay appears, the smaller technological delay can induce the double Hopf bifurcation. In addition, the region IV with complex coexisting bi-stability also decreases sharply. Furthermore, the rich dynamics such as various period, quasi-period and chaotic behaviors are found when some key parameters are changed. The obtained results can have important theoretical guidance for the diagnosis and treatment of diabetes patients. © 2010 Springer Science+Business Media B.V.


Qin Y.-L.,Nanjing Southeast University | Wang F.,Dalian Medical University | Li T.-X.,Zhengzhou University | Ding W.,Nanjing Southeast University | And 3 more authors.
Journal of the American College of Cardiology | Year: 2016

Background Thoracic endovascular aortic repair (TEVAR) has been used in patients with uncomplicated type B acute aortic dissection (B-AAD) to reduce late morbidity and mortality. The outcomes of comparisons between TEVAR and best medical treatment (BMT) on patients with uncomplicated type B-AAD are inconsistent in the published reports. Objectives This study sought to further clarify the early and long-term (11-year) outcomes of TEVAR in patients with uncomplicated type B-AAD compared with those with BMT treatment. Methods Between February 2003 and August 2014, 338 patients with uncomplicated type B-AAD were retrospectively identified in 3 tertiary medical centers. Information about baseline characteristics was collected from medical records. Images were retrieved from the imaging archiving system, and the thrombosis status of the false lumen and extent of the dissection were evaluated via computed tomography angiography. Early and late outcomes were recorded and analyzed. Results TEVAR procedures were performed on 184 patients (TEVAR group) and BMT for 154 patients (BMT group). Early events and 30-day mortality were not significantly different between the 2 groups. Patients receiving BMT had significantly higher aortic-related adverse events compared with those in the TEVAR group (p = 0.025). All-cause mortality with TEVAR was significantly lower than that of BMT (p = 0.01). Conclusions This study confirmed the feasibility of TEVAR for uncomplicated type B aortic dissection in the acute setting with fewer aortic-related adverse events and a lower mortality rate compared with BMT. © 2016 American College of Cardiology Foundation


Chen J.Y.,Zhengzhou University | Heyliger P.R.,Colorado State University-Pueblo | Pan E.,Zhengzhou University | Pan E.,University of Akron
Journal of Sound and Vibration | Year: 2014

In this paper, we study the free vibration of multilayered magneto-electro-elastic plates under combined clamped/free lateral boundary conditions using a semi-analytical discrete-layer approach. More specifically, we use piecewise continuous approximations for the field variables in the thickness direction and continuous polynomial approximations for those within the plane of the plate. Group theory is further used to isolate the nature of the vibrational modes to reduce the computational cost. As numerical examples, two cases of the lateral boundary conditions combined with the clamped and free edges are considered. The non-dimensional frequencies and mode shapes of elastic displacements, electric and magnetic potentials are presented. Our numerical results clearly illustrate the effect of the stacking sequences and magneto-electric coupling on the frequencies and mode shapes of the anisotropic magneto-electro-elastic plate, and should be useful in future vibration study and design of multilayered magneto-electro-elastic plates. © 2014 Elsevier Ltd.


Zeng R.-C.,Shandong University of Science and Technology | Zeng R.-C.,CAS Shenyang Institute of Metal Research | Hu Y.,Shandong University of Science and Technology | Guan S.-K.,Zhengzhou University | And 2 more authors.
Corrosion Science | Year: 2014

The effects of anions in saline solutions on the corrosion behaviour of magnesium alloy AZ31 were investigated using hydrogen evolution, pH and potentiodynamic measurements. The results demonstrated that adding bicarbonate and sulphate ions to saline solution accelerated the corrosion, whereas hydrogen phosphate and dihydrogen phosphate retarded the corrosion and decreased the open-circuit potentials. A model involving the magnesium hydroxide and magnesium carbonate film formation mechanism was proposed. The change in the solution pH over time did not reflect the corrosion rates of the magnesium alloys due to the influence of anions. © 2014 Elsevier Ltd.


Yan H.-S.,Nanjing Southeast University | Xue C.-G.,Nanjing Southeast University | Xue C.-G.,Zhengzhou University
Expert Systems with Applications | Year: 2012

This paper deals with an approach to the automatic construction and optimization of the knowledge mesh (KM) based on the user's function requirements. Once a KM multiple set operation expression is obtained, a new KM can be inferred from the expression by the developed KM-based inference engine and transformed into its corresponding KMS (knowledgeable manufacturing system) software automatically by the developed automatic program construction software so as to realize the self-reconfiguration of the KMS. Thus, the automatic construction and optimization of a KM multiple set operation expression is equivalent to the automatic construction and optimization of its corresponding KM and KMS software. To explore the automatic construction and optimization of the new KM by the user's function requirements, an automatic construction procedure of a KM aiming at the user's maximum function-satisfaction is proposed. Firstly, the fuzzy function-satisfaction degree relationships of the users' requirements for the KM functions are defined, and so are the multiple fuzzy function-satisfaction degrees of the relationships. Secondly, operations (union, intersection and minus) on both fuzzy and multiple fuzzy function-satisfaction degrees are proposed and clarified, along with the proof that there exists a one-to-one mapping between the KM multiple set operation expression and the KM-function-satisfaction degree expression. Then, the optimization model of the KM multiple set operation expression is constructed and proved to be very NP-hard. And finally, the KM multiple set operation expression is optimized by the hybrid genetic-tabu algorithm, with the steps of the KM's automatic construction presented in detail as well. Based upon the above, the KM's automatic construction and optimization are illustrated by an actual KM example which corresponds to the management information system (MIS) software used in a vehicle body plant. The proposed approach proves to be very effective. © 2011 Elsevier Ltd. All rights reserved.


Zhang C.,Peking Union Medical College | Yuan Y.,Zhengzhou Health School | Qiu C.,Guang Dong Food and Drug Vocational College | Zhang W.,Zhengzhou University
Obesity Surgery | Year: 2014

Literature search was performed for bariatric surgery from inception to September 2013, in which the effects of laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic sleeve gastrectomy (LSG) on body mass index (BMI), percentage of excess weight loss (EWL%), and diabetes mellitus (DM) were compared 2 years post-surgery. A total of 9,756 cases of bariatric surgery from 16 studies were analyzed. Patients receiving LRYGB had significantly lower BMI and higher EWL% compared with those receiving LSG (BMI mean difference (MD)=-1.38, 95 % confidence interval (CI)=-1.72 to -1.03; EWL% MD=5.06, 95 % CI=0.24 to 9.89). Improvement rate of DM was of no difference between the two types of bariatric surgeries (RR=1.05, 95 % CI=0.90 to 1.23). LRYGB had better long-term effect on body weight, while both LRYGB and LSG showed similar effects on DM. © 2014 Springer Science+Business Media.


Guan W.,China Agricultural University | Li Z.,China Agricultural University | Zhang H.,China Agricultural University | Hong H.,Zhengzhou University | And 3 more authors.
Journal of Chromatography A | Year: 2013

Amine modified graphene is successfully synthesized via a one-pot solvothermal reaction between graphene oxide and ammonia water, methylamine or n-butyl amine. The presence of amine groups in graphene is identified by Fourier-transform infrared spectrometry, X-ray photoelectron spectroscopy and an X-ray diffractometer. The ability of amine modified graphene to cleanup fatty acids and other interfering substances from acetonitrile extracts of oil crops has been evaluated. It is found that the resulting CH3NH-G exhibits the best performance in interfering substances removal. Meanwhile, a multi-residue method is validated on 28 representative pesticide residues in four oil crops (rapeseed, peanut, sesame seeds and soybean). This method is based on modified QuEChERS sample preparation with CH3NH-G as reversed-dispersive solid phase extraction material and liquid chromatography-tandem mass spectrometry. Use of matrix-matched standards provides acceptable results for most pesticides with overall average recoveries between 70.5 and 100% and consistent RSDs<13%, except for pymetrozine, thidiazuron and diuron. In any case, this method still meets the 0.1-8.3μg/kg detection limit needs for most pesticides and may be used for qualitative screening applications, in which any identified pesticides can be quantified and confirmed by a more intensive method that achieves >70% recovery. © 2013 Elsevier B.V.


Liu Z.,Monash University | Yan Y.,Zhengzhou University | Yan Y.,Nanjing Southeast University | Qu X.,Griffith University | Zhang Y.,Nanjing Southeast University
Transportation Research Part C: Emerging Technologies | Year: 2013

When a bus is late and behind schedule, the stop-skipping scheme allows the bus vehicle to skip one or more stops to reduce its travel time. The deadheading problem is a special case of the stop-skipping problem, allowing a bus vehicle to skip stops between the dispatching terminal point and a designated stop. At the planning level, the optimal operating plans for these two schemes should be tackled for the benefits of bus operator as well as passengers. This paper aims to propose a methodology for this objective. Thus, three objectives are first proposed to reflect the benefits of bus operator and/or passengers, including minimizing the total waiting time, total in-vehicle travel time and total operating cost. Then, assuming random bus travel time, the stop-skipping is formulated as an optimization model minimizing the weighted sum of the three objectives. The deadheading problem can be formulated via the same minimization model further adding several new constraints. Then, a Genetic Algorithm Incorporating Monte Carlo Simulation is proposed to solve the optimization model. As validated by a numerical example, the proposed algorithm can obtain a satisfactory solution close to the global optimum. © 2013 Elsevier Ltd.


An X.,New York Blood Center | An X.,Zhengzhou University | Schulz V.P.,Yale University | Li J.,New York Blood Center | And 8 more authors.
Blood | Year: 2014

We recently developed fluorescence-activated cell sorting (FACS)-based methods to purify morphologically and functionally discrete populations of cells, each representing specific stages of terminal erythroid differentiation. We used these techniques to obtain pure populations of both human and murine erythroblasts at distinct developmental stages. RNA was prepared from these cells and subjected to RNA sequencing analyses, creating unbiased, stage-specific transcriptomes. Tight clustering of transcriptomes from differing stages, even between biologically different replicates, validated the utility of the FACS-based assays. Bioinformatic analyses revealed that there were marked differences between differentiation stages, with both shared and dissimilar gene expression profiles defining each stage within transcriptional space. There were vast temporal changes in gene expression across the differentiation stages, with each stage exhibiting unique transcriptomes. Clustering and network analyses revealed that varying stage-specific patterns of expression observed across differentiation were enriched for genes of differing function. Numerous differences were present between human and murine transcriptomes, with significant variation in the global patterns of gene expression. These data provide a significant resource for studies of normal and perturbed erythropoiesis, allowing a deeper understanding of mechanisms of erythroid development in various inherited and acquired erythroid disorders. © 2014 by The American Society of Hematology.


Gyekis J.P.,Pennsylvania State University | Yu W.,Peking Union Medical College | Dong S.,Zhengzhou University | Wang H.,Shandong University | And 3 more authors.
American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics | Year: 2013

Major depressive disorder (MDD) is a complex psychiatric condition with strong genetic predisposition. The association of MDD with genetic polymorphisms, such as Val66Met (rs6265), in the brain derived neurotrophic factor (BDNF), have been reported in many studies and the results were conflicting. In this study, we performed a systematic literature search and conducted random-effects meta-analysis to evaluate genetic variants in BDNF with MDD. A gene-based analysis was also conducted to investigate the cumulative effects of genetic polymorphisms in BDNF. A total of 28 studies from 26 published articles were included in our analysis. Meta-analysis yielded an estimated odds ratio (OR) of 0.96 (95% CI: 0.89-1.05; P=0.402) for Val66Met (rs6265), 0.83 (95% CI: 0.67-1.04; P=0.103) for 11757C/G, 1.16 (95% CI: 0.74-1.82; P=0.527) for 270T/C, 1.03 (95% CI: 0.18-5.75; P=0.974) for 712A/G and 0.98 (95% CI: 0.85-1.14; P=0.831) for rs988748. The gene-based analysis indicated that BDNF is not associated with MDD (P>0.21). Our updated meta- and novel gene-based analyses provide no evidence of the association of BDNF with major depression. © 2012 Wiley Periodicals, Inc.


Akinleye A.,New York Medical College | Chen Y.,New York Medical College | Chen Y.,Xiamen University | Mukhi N.,New York Medical College | And 3 more authors.
Journal of Hematology and Oncology | Year: 2013

Small molecule inhibitors targeting dysregulated pathways (RAS/RAF/MEK, PI3K/AKT/mTOR, JAK/STAT) have significantly improved clinical outcomes in cancer patients. Recently Bruton's tyrosine kinase (BTK), a crucial terminal kinase enzyme in the B-cell antigen receptor (BCR) signaling pathway, has emerged as an attractive target for therapeutic intervention in human malignancies and autoimmune disorders. Ibrutinib, a novel first-in-human BTK-inhibitor, has demonstrated clinical effectiveness and tolerability in early clinical trials and has progressed into phase III trials. However, additional research is necessary to identify the optimal dosing schedule, as well as patients most likely to benefit from BTK inhibition. This review summarizes preclinical and clinical development of ibrutinib and other novel BTK inhibitors (GDC-0834, CGI-560, CGI-1746, HM-71224, CC-292, and ONO-4059, CNX-774, LFM-A13) in the treatment of B-cell malignancies and autoimmune disorders. © 2013 Akinleye et al.; licensee BioMed Central Ltd.


Das A.,New York Medical College | Liu D.,New York Medical College | Liu D.,Zhengzhou University
Experimental Hematology and Oncology | Year: 2015

Target specific oral anticoagulants (dabigatran, rivaroxaban, apixaban, and edoxaban) are changing the landscape of anticoagulation. The major drawback is the absence of an effective antidote for severe bleedings and/or prior to procedures. Currently there are a few promising antidotes undergoing clinical trials. This review summarized the latest development in idarucizumab, andexanet alpha and PER977. © 2015 Das and Liu.


Akinleye A.,New York Medical College | Avvaru P.,New York Medical College | Furqan M.,New York Medical College | Song Y.,Zhengzhou University | And 2 more authors.
Journal of Hematology and Oncology | Year: 2013

Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that regulate diverse cellular processes including proliferation, adhesion, survival, and motility. Dysregulated PI3K pathway signaling occurs in one-third of human tumors. Aberrantly activated PI3K signaling also confers sensitivity and resistance to conventional therapies. PI3K has been recognized as an attractive molecular target for novel anti-cancer molecules. In the last few years, several classes of potent and selective small molecule PI3K inhibitors have been developed, and at least fifteen compounds have progressed into clinical trials as new anticancer drugs. Among these, idelalisib has advanced to phase III trials in patients with advanced indolent non-Hodgkin's lymphoma and mantle cell lymphoma. In this review, we summarized the major molecules of PI3K signaling pathway, and discussed the preclinical models and clinical trials of potent small-molecule PI3K inhibitors. © 2013 Akinleye et al.; licensee BioMed Central Ltd.


Zuo W.,Peking Union Medical College | Zhang W.,Zhengzhou University | Han N.,Peking Union Medical College | Chen N.-H.,Peking Union Medical College
CNS Neuroscience and Therapeutics | Year: 2015

Summary: Aims: Compound IMM-H004 (7-hydroxy-5-methoxy-4-methyl-3-[4-methylpiperazin-1-yl]-2H-chromen-2-one) is a new synthetic derivative of coumarin, and previous studies showed that it exhibited antioxidant and neuroprotective roles in focal cerebral ischemia. However, we know little about the compound's function in transient global ischemia. This study is to investigate whether compound IMM-H004 can protect against transient global ischemic injury. Methods: Four-vessel occlusion (4VO) rat model was induced for a 20-min occlusion and different times of reperfusion to mimic transient global cerebral ischemia. IMM-H004 (3, 6, 9 mg/kg) or Edaravone (6 mg/kg) was administered after 30 min of reperfusion. Morris water maze tests were used to estimate the ability of spatial learning and memory. Nissl staining, TUNEL assay and Immunoblot for Bax/Bcl-2 and activated caspase-3 were used to detect hippocampal neuron injury. Immunoblot for PSD-95 and synapsin 1, and electron microscopy were used to observe synaptic function. Results: Compared with vehicle group, IMM-H004 significantly improved the spatial learning performance and exhibited less CA1 neurons loss. The expressions of Bax/Bcl-2 and activated caspase-3 were decreased. IMM-H004 also ameliorated synaptic structure, decreased PSD-95 and increased synapsin 1 expression. Conclusion: These findings suggested that IMM-H004 exerted neuroprotective role in global ischemia by reducing apoptosis and maintaining the integrity of synaptic structure. © 2015 John Wiley & Sons Ltd.


Cang S.,Henan Province Peoples Hospital | Iragavarapu C.,New York Medical College | Savooji J.,New York Medical College | Song Y.,Zhengzhou University | Liu D.,Zhengzhou University
Journal of Hematology and Oncology | Year: 2015

With the advent of new agents targeting CD20, Bruton's tyrosine kinase, and phosphoinositol-3 kinase for chronic lymphoid leukemia (CLL), more treatment options exist than ever before. B-cell lymphoma-2 (BCL-2) plays a major role in cellular apoptosis and is a druggable target. Small molecule inhibitors of BCL-2 are in active clinical studies. ABT-199 (venetoclax, RG7601, GDC-0199) has been granted breakthrough designation by FDA for relapsed or refractory CLL with 17p deletion. In this review, we summarized the latest clinical development of ABT-199/venetoclax and other novel agents targeting the BCL-2 proteins. © 2015 Cang et al.


Ma M.-L.,Zhengzhou University | Qin J.-H.,Zhengzhou University | Ji C.,Zhengzhou University | Xu H.,Zhengzhou University | And 5 more authors.
Journal of Materials Chemistry C | Year: 2014

A novel porous metal-organic framework, {[Zn2(L)·H 2O]·3H2O·3DMAc·NH2(CH 3)2}n (Zn(ii)-MOF), was synthesized under solvothermal conditions using a flexible multicarboxylic acid (H5L = 3,5-bis(1-methoxy-3,5-benzene dicarboxylic acid)benzoic acid). Zn(ii)-MOF contains 1D nanotubular channels of 13.8 Å × 16.4 Å and exhibits a rare 5-connected vbk net with a Schläfli symbol of {4 5.65} topology. Notably, Zn(ii)-MOF can adsorb toluidine blue fast and effectively, and trap lanthanide ions such as Eu3+ and Tb3+ to sensitize their emissions in the solid state through a Ln3+-exchanged approach. Furthermore, we successfully obtained white light emitting materials. © 2013 The Royal Society of Chemistry.


Wang F.,Zhengzhou University | Wang F.,Monash University
Nuclear Physics B | Year: 2011

In the GmSUGRA scenario with the higher-dimensional operators containing the GUT Higgs fields, we systematically studied the supersymmetry breaking scalar masses, SM fermion Yukawa coupling terms, and trilinear soft terms in the E6 SUSY GUT model where the gauge symmetry is broken down to the SO(10)×U(1) gauge symmetry, SU(3)C×SU(3)L×SU(3)R gauge symmetry, SU(6)×SU(2)a (a=L,R,X) gauge symmetry, flipped SU(5) gauge symmetry etc. In addition, we considered the scalar and gaugino mass relations, which can be preserved from the GUT scale to the electroweak scale under one-loop RGE running, in the SU(3)C×SU(3)L×SU(3)R model arising from the E6 model. With such relations, we may distinguish the mSUGRA and GmSUGRA scenarios if we can measure the supersymmetric particle spectrum at the LHC and ILC. © 2011 Elsevier B.V.


Patent
High-Tech, Zhengzhou Granlen Pharmatech Ltd. and Zhengzhou University | Date: 2013-07-17

The present invention relates to the field of pharmacochemistry. Disclosed are fluorinated and azido-substituted pyrimidine nucleoside derivatives, and preparation methods and uses thereof. The structural formula is as shown (I). These compounds can be used for preparing medicaments for treating diseases such as tumors and viral infections, and can be used separately or in combination with other medicaments. The compounds also have effective activity against diseases such as tumors and viral infections, while having few side effects, and thus have potential application value.


Yang Z.,Jilin University | Fang X.,Jilin University | Pei X.,Zhengzhou University | Li H.,Zhengzhou University
Genetic Testing and Molecular Biomarkers | Year: 2013

Inherited functional single-nucleotide polymorphisms (SNPs) in DNA repair genes may influence the capability of DNA repair and contribute to the risk of breast cancer. We therefore performed a case-control study to investigate the association of three in excision repair cross-complimentary group 1 (ERCC1) and three in xeroderma pigmentosum complementation group F (XPF) with the risk of breast cancer. Genotyping of ERCC1 (rs2298881, rs3212986, and rs11615) and XPF (rs2276465, rs6498486, and rs2276466) was performed in a 384-well plate format on the MassARRAY® platform. Odds ratios and their corresponding 95% confidence intervals were used to assess the effect of each SNP on breast cancer risk. The ERCC1 rs11615 variant A/A genotype was associated with increased breast cancer risk in codominant, dominant, and recessive models, and XPF rs6498486 variant C/C genotype carriers have a significantly increased breast cancer risk in codominant, dominant, and recessive models. Individuals with both the ERCC1 rs11615 A allele and XPF rs6498486 C allele had a heavy increased risk of breast cancer compared to double wild-type homozygotes. The present study shows that the ERCC1 rs11615 and XPF rs6498486 polymorphisms are associated with breast cancer risk in a Chinese population. Further large-scale studies are required to elucidate whether these ERCC1 and XPF SNPs interact with environmental factors in the development of breast cancer. © Copyright 2013, Mary Ann Liebert, Inc. 2013.


Jia H.,Zhengzhou University | Jia H.,Zhengzhou Kindergarten Teachers College | Li Y.,Zhengzhou University | Xiong Z.,Zhengzhou University | And 2 more authors.
Dalton Transactions | Year: 2014

Five metal-organic frameworks, namely, [Mn3(H 2DMPhIDC)2(HDMPhIDC)2(bpp)]n (H 3DMPhIDC = 2-(3,4-dimethylphenyl)-1H-imidazole-4,5-dicarboxylic acid, bpp = 1,3-di(4-pyridyl)propane) (1), [Pb4(DMPhIDC) 2(OH)2]n (2), [Cd(HDMPhIDC)(en)]n (en = ethylenediamine) (3), [Cu3(HDMPhIDC)3(Py) 3]n (Py = pyridine) (4) and {[Zn2(HDMPhIDC) 2(Phen)2]2·H2O}n (Phen = 1,10-phenanthroline) (5) have been hydro(solvo)thermally synthesized and structurally characterized by single-crystal X-ray diffraction, elemental and thermal analyses and IR spectra. Polymer 1 displays a 3D noninterpenetrated framework with 1D open channels. Polymer 2 exhibits a stepped (4,4,4,4,6,6)-connect 2D topology. Polymer 3 is a left-handed helix chain. Polymers 4 and 5 arrange the 3D supramolecular networks containing a 1D corrugated chain via π⋯π stacking or hydrogen bond interactions. In these MOFs, the imidazole dicarboxylate ligand shows various coordination modes and strong coordination ability. Furthermore, the solid-state luminescent properties of the polymers have also been discussed. © 2014 The Royal Society of Chemistry.


Wang F.,Zhengzhou University | Wang F.,CAS Institute of Theoretical Physics
Nuclear Physics B | Year: 2014

We calculate the gravitational contributions to φ4 theory with general Rξ gauge-fixing choice and find that the result is gauge independent. Based on weak coupling expansion of gravity and ignoring the possible higher dimensional operators from "integrating out" the impact of gravity, we study the impacts of gravitational effects on vacuum stability. New contributions to the beta function of scalar quartic coupling λ by gravitational effects can modify the RGE running of λ near the Planck scale. Numerical calculations show that the lower bound of higgs mass requiring absolutely vacuum stability can be relaxed for almost 0.6 to 0.8 GeV depending on the choice of top quark mass. © 2014 The Authors.


Kobakhidze A.,University of Sydney | Wang F.,Zhengzhou University | Wu L.,Nanjing Normal University | Wu L.,University of Sydney | And 3 more authors.
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2016

The top and bottom seesaw model, which extends the top seesaw in order to accommodate a 125 GeV Higgs boson, predicts vector-like top/bottom partners and these partners can be bounded to form several neutral and charged singlet composite scalars by some new strong dynamics. In this letter, we use such a singlet scalar to interpret the 750 GeV diphoton resonance. This singlet scalar is dominantly produced through the gluon fusion process induced by the partners and its diphoton decay is induced by both the partners and the charged singlet scalars. We show that this scenario can readily account for the observed 750 GeV diphoton signal under the current LHC constraints. Further, this scenario predicts some other phenomenology, such as a strong correlation between the decays to γγ, Zγ and ZZ, a three-photon signal from the associate production of a singlet scalar and a photon, as well as some signals from the partner cascade decays. These signals may jointly allow for a test of this framework in future 100 TeV hadron collider and ILC experiments. © 2016 The Authors.


Wang F.,Zhengzhou University | Wang F.,CAS Institute of Theoretical Physics | Wu L.,University of Sydney | Yang J.M.,CAS Institute of Theoretical Physics | And 2 more authors.
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2016

We propose to interpret the 750 GeV diphoton excess in deflected anomaly mediation supersymmetry breaking scenarios, which can naturally predict couplings between a singlet field and vector-like messengers. The CP-even scalar component (S) of the singlet field can serve as the 750 GeV resonance. The messenger scale, which is of order the gravitino scale, can be as light as Fφ~O(10) TeV when the messenger species NF and the deflection parameter d are moderately large. Such messengers can induce the large loop decay process S→γγ. Our results show that such a scenario can successfully accommodate the 125 GeV Higgs boson, the 750 GeV diphoton excess and the muon g-2 without conflicting with the LHC constraints. We also comment on the possible explanations in the gauge mediation supersymmetry breaking scenario. © 2016 The Author(s).


Zhang L.,Tsinghua University | Zhang L.,Zhengzhou University | Li C.,Tsinghua University | Liu A.,Tsinghua University | Shi G.,Tsinghua University
Journal of Materials Chemistry | Year: 2012

Graphene oxide/polypyrene (GO/PPr) composite films were prepared by electrochemical co-deposition of GO and PPr from the organic electrolyte of propylene carbonate (PC). The effects of the GO content in the electrolyte and the deposition charge density on the formation of GO/PPr composite films were studied. Blending with GO improved the mechanical properties of the powdery PPr and gave the composite a continuous and porous morphology with an uninterrupted conducting phase. A chemoresistor-type vapor sensor based on the GO/PPr composite film demonstrated a fast, linear and reversible response to toluene with a high normalized sensitivity of 9.87 × 10 -4 ppm -1. The mechanism of sensing the organic vapors with the GO/PPr composite film was also discussed. © The Royal Society of Chemistry 2012.


Wang F.,Zhengzhou University | Wang F.,CAS Institute of Theoretical Physics | Wang W.,Beijing University of Technology | Wang W.,CAS Institute of Theoretical Physics | Yang J.M.,CAS Institute of Theoretical Physics
European Physical Journal C | Year: 2014

We recalculate the two-loop beta functions for three gauge couplings taking into account all low energy threshold corrections in split supersymmetry (split-SUSY) which assumes a very high scalar mass scale (Formula presented.). We find that in split-SUSY with a gaugino mass unification assumption and with a large (Formula presented.) the gauge coupling unification requires a lower bound on the gaugino mass. Combined with the constraints from the dark matter relic density and direct detection limits, we find that split-SUSY is very restricted and for dark matter mass below 1 TeV the allowed parameter space can be fully covered by XENON-1T(2017). © 2014, The Author(s).


Liu Y.,Zhengzhou University | Li J.,Zhengzhou University of Light Industry | Ding Q.,Tsinghua University | Chu B.,University of Oxford
International Journal of Electrical Power and Energy Systems | Year: 2012

Using the Hamiltonian function method, this paper investigates the coordinated control of the synchronous generator and static var compensator (SVC) in power systems with constant power loads. First, via a proper variable transformation and pre-feedback control, the dissipative Hamiltonian realization of the power system is completed. Then, based on the obtained dissipative Hamiltonian realization, an energy-based coordinated stabilization controller is constructed. The guaranteed L 2 performance property of the closed loop system is analyzed as well. Simulation results indicate that the proposed coordinated control scheme can effectively improve both the transient stability and voltage regulation performance of the power system. © 2012 Elsevier Ltd. All rights reserved.


Kong K.L.,University of Hong Kong | Kwong D.L.W.,University of Hong Kong | Chan T.H.-M.,University of Hong Kong | Law S.Y.-K.,University of Hong Kong | And 5 more authors.
Gut | Year: 2012

Background: To understand the involvement of micro- RNA (miRNA) in the development and progression of oesophageal squamous cell carcinoma (ESCC), miRNA profiles were compared between tumour and corresponding non-tumour tissues. Methods: miRCURY LNA array was used to generate miRNA expressing profile. Real-time quantitative PCR was applied to detectthe expression of miR-375 in ESCC samples and its correlation with insulin-like growth factor 1 receptor (IGF1R). Methylation-specific PCR was used to study the methylation status in the promoter region of miR-375. The tumour-suppressive effect of miR-375 was determined by both in-vitro and in-vivo assays. Results: The downregulation of miR-375 was frequently detected in primary ESCC, which was significantly correlated with advanced stage (p=0.003), distant metastasis (p<0.0001), poor overall survival (p=0.048) and disease-free survival (p=0.0006). Promoter methylation of miR-375 was detected in 26 of 45 (57.8%) ESCC specimens. Functional assays demonstrated that miR-375 could inhibit clonogenicity, cell motility, cell proliferation, tumour formation and metastasis in mice. Further study showed that miR-375 could interact with the 39-untranslated region of IGF1R and downregulate its expression. In clinical specimens, the expression of IGF1R was also negatively correlated with miR-375 expression (p=0.008). Conclusions: This study demonstrates that miR-375 has a strong tumour-suppressive effect through inhibiting the expression of IGF1R. The downregulation of miR-375, which is mainly caused by promoter methylation, is one of the molecular mechanisms involved in the development and progression of ESCC.


Lu Q.-F.,Zhengzhou University | Xie J.-J.,CAS Lanzhou Institute of Modern Physics | Xie J.-J.,Lanzhou University | Xie J.-J.,CAS Institute of Theoretical Physics | Li D.-M.,Zhengzhou University
Physical Review C - Nuclear Physics | Year: 2014

Nucleon pole contribution in the pp→ppK+K- reaction below the threshold of the production of the φ meson is studied within the effective Lagrangian approach. It is assumed that the K-p final state originates from the decay of the hyperons Λ(1115) and Λ(1405). In addition to the pp final state interaction (FSI) parametrized using the Jost function, we have also considered the K+K- FSI with the techniques of the chiral unitary approach, where the scalar mesons f0(980) and a0(980) were dynamically generated. Hence, the contributions from scalar mesons f0(980) and a0(980) occur through the K+K- FSI. It is shown that the available experimental data are well reproduced, especially the total cross sections and the invariant mass distributions of pp and K+K-. Furthermore, different forms of the couplings (pseudoscalar and pseudovector) for the πNN interaction and different strengths for the proton-proton FSI are also investigated. It is found that the contributions from hyperons Λ(1115) and Λ(1405) are different between these two kinds of couplings. On the other hand, the effects of the proton-proton FSI can be adjusted by the cutoff parameters used in the form factors. © 2014 American Physical Society.


Liu Y.,Zhengzhou University | Cai Q.,Tsinghua University | Li H.,Tsinghua University | Zhang J.,Zhengzhou University
Journal of Applied Polymer Science | Year: 2013

A novel synthesis route for mesoporous carbon (MC) nanosheets were developed using halloysite nanotubes (HNTs), a type of natural clay that is structurally and chemically similar to mineral kaolinite, as inorganic matrix and using polypyrrole (PPy) as carbon precursor by a template-like method. First, PPy/HNT hybrids were prepared by in situ oxidative polymerization. Carbon (C)/HNT hybrids were further obtained by pyrolysis of the PPy/HNT hybrids. MC was obtained after the removal of inorganic template by hydrochloric acid/hydrofluoric acid mixture at the end. Both the C/HNT and the MC were characterized by Fourier transform infrared spectroscopy analysis, X-ray diffraction, Raman spectra measurement, and high-resolution transmission electron microscopy. The MC was also characterized with specific surface area (BET). The results showed that the MC obtained was almost amorphous carbon. The increase in the ratio of [HNTs template]/[pyrrole monomer] led to an increase in the BET-specific surface area. © 2012 Wiley Periodicals, Inc.


Fan Y.,Zhengzhou University | Zhang X.,Zhengzhou University | Liu Y.,Zhengzhou University | Cai Q.,Tsinghua University | Zhang J.,Zhengzhou University
Materials Letters | Year: 2013

Mn3O4/graphene nanocomposite with the structure of Mn3O4 nanoparticles anchored on graphene sheets was synthesized using a facile in situ one-pot hydrothermal method. The growth of Mn3O4 nanoparticles and the reduction of graphene oxide occurred simultaneously during this hydrothermal process. Hexagonal flake-like Mn3O4 nanoparticles were found well-dispersed on graphene sheets. Cyclic voltammetry (CV), galvanostatic charge-discharge (GCD) and electrochemical impedance spectroscopy (EIS) measurements were used to assess the electrochemical properties of Mn3O4/graphene nanocomposite. The Mn3O4/graphene nanocomposite exhibited a specific capacitance of 171 F g-1 in 1 M Na2SO 4 aqueous electrolyte and a good rate property. The results showed that the Mn3O4/graphene nanocomposite could be used as electrode material for high performance supercapacitors. © 2013 Published by Elsevier B.V.


Wang F.,Zhengzhou University | Wang F.,CAS Institute of Theoretical Physics
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2015

We propose to introduce general messenger-matter interactions in the deflected anomaly mediated SUSY breaking scenario. The most general form for the resulting soft parameters is derived. New interference terms between the GMSB type and AMSB type contributions are the unique feature of this scenario. Messenger-matter interactions involving sleptons can be used to solve the tachyonic slepton problem and naturally lead to positive slepton masses regardless of the sign of deflection parameter. Besides, due to the new contributions, large |At| that will not trigger color-breaking stop VEV are also possible in this scenario, thus can easily give the 125 GeV higgs which was discovered by LHC. This type of deflected AMSB scenario need very few messenger species, thus can avoid possible non-perturbative gauge couplings below the GUT scale (or Landau pole below the Planck scale). © 2015 The Author.


Wang F.,Zhengzhou University | Wang F.,CAS Institute of Theoretical Physics | Wang W.,Beijing University of Technology | Yang J.M.,CAS Institute of Theoretical Physics
Journal of High Energy Physics | Year: 2015

Abstract: From generalized gravity mediation we build a SUGRA scenario in which the gluino is much heavier than the electroweak gauginos at the GUT scale. We find that such a non-universal gaugino scenario with very heavy gluino at the GUT scale can be naturally obtained with proper high dimensional operators in the framework of SU(5) GUT. Then, due to the effects of heavy gluino, at the weak scale all colored sparticles are heavy while the uncolored sparticles are light, which can explain the Brookhaven muon g − 2 measurement while satisfying the collider constraints (both the 125 GeV Higgs mass and the direct search limits of sparticles) and dark matter requirements. We also find that, in order to explain the muon g − 2 measurement, the neutralino dark matter is lighter than 200 GeV in our scenario, which can be mostly covered by the future Xenon1T experiment. © 2015, The Author(s).


Wang F.,Zhengzhou University | Wang F.,CAS Institute of Theoretical Physics | Wang W.,Beijing University of Technology | Yang J.M.,CAS Institute of Theoretical Physics
Journal of High Energy Physics | Year: 2015

Abstract: We propose to split the sparticle spectrum from the hierarchy between the GUT scale and the Planck scale. A split supersymmetric model, which gives non-universal gaugino masses, is built with proper high dimensional operators in the framework of SO(10) GUT. Based on a calculation of two-loop beta functions for gauge couplings (taking into account all weak scale threshold corrections), we check the gauge coupling unification and dark matter constraints (relic density and direct detections). We find that our scenario can achieve the gauge coupling unification and satisfy the dark matter constraints in some part of parameter space. We also examine the sensitivity of the future XENON1T experiment and find that the currently allowed parameter space in our scenario can be covered for a neutralino dark matter below about 1.0 TeV. © 2015, The Author(s).


Zhang B.-J.,Central Hospital of Xinxiang City | Gong H.-Y.,Xinxiang Medical University | Zheng F.,Xinxiang Medical University | Liu D.-J.,Zhengzhou University | Liu H.-X.,Henan Provincial Chest Hospital
International Journal of Clinical and Experimental Pathology | Year: 2014

Introduction: MicroRNAs (miRNAs) are noncoding RNAs that regulate multiple cellular processes during cancer progression. MiR-335 has recently been identified to be involved in tumorigenesis of several cancers such as ovarian cancer and gastric cancer. However, the regulation of miR-335 in esophageal squamous cell carcinoma (ESCC) has not been reported yet. Methods: Expression of miR-335 in tumor and their normal matched tissues was determined by quantitative real-time PCR in 67 ESCC patients and its association with overall survival of patients was analyzed by statistical analysis. Results: The expression level of miR-335 was reduced in malignant tissue samples in comparison to normal matched tissue (P < 0.05). It was also proved that miR-335 expression was associated with ESCC histological grade, lymph node metastasis, tumor stage and clinical stage (P < 0.05). In addition, the Kaplan-Meier survival curves revealed that low miR-335 expression was associated with poor prognosis in ESCC patients. Multivariate analysis showed that miR-335 expression was an independent prognostic marker of overall survival of ESCC patients. Conclusions: The study proves for the first time that miR-335 is down regulated in a majority of ESCC patients. Our results indicate that miR-335 expression is an independent prognostic factor for patients with esophageal cancer, which might be a potential valuable biomarker for ESCC.


Fan Y.,Zhengzhou University | Liu Y.,Zhengzhou University | Cai Q.,Tsinghua University | Zhang J.,Zhengzhou University
Synthetic Metals | Year: 2012

PPy (polypyrrole)/CTAB (cetyltrimethylammonium bromide) intercalated graphene sheets nanocomposites (PPy/CGN) were prepared via in situ oxidative polymerization of pyrrole in the presence of CTAB intercalated graphene. The morphology and structure of samples were investigated by FE-SEM (field-emission scanning microscope), TEM (transmitting electron microscopy), UV-vis (ultraviolet and visible spectrum), FT-IR (Fourier transform infrared spectrum), XRD (X-ray diffraction), TGA (thermogravimetric analysis), and four-probe electrical conductivity measurements. The results showed that for the PPy/CGN nanocomposites, the disordered structure of CGN disappeared and CGN existed in the form of individual graphene sheet or stacked layers in PPy matrix. The graphene serves as a support material for nano-sized PPy particles. The CGN covered with PPy nanoparticles were confirmed by FE-SEM and TEM. The electrical conductivity of the PPy/CGN nanocomposite achieved 12.06 S/cm for the PPy/CGN-5 sample. © 2012 Elsevier B.V.


Wang J.,Tsinghua University | Li H.,CAS Institute of Genetics and Developmental Biology | Han Z.,Tsinghua University | Zhang H.,Tsinghua University | And 5 more authors.
Nature | Year: 2015

Phytosulfokine (PSK) is a disulfated pentapeptide that has a ubiquitous role in plant growth and development. PSK is perceived by its receptor PSKR, a leucine-rich repeat receptor kinase (LRR-RK). The mechanisms underlying the recognition of PSK, the activation of PSKR and the identity of the components downstream of the initial binding remain elusive. Here we report the crystal structures of the extracellular LRR domain of PSKR in free, PSK-and co-receptor-bound forms. The structures reveal that PSK interacts mainly with a β-strand from the island domain of PSKR, forming an anti-β-sheet. The two sulfate moieties of PSK interact directly with PSKR, sensitizing PSKR recognition of PSK. Supported by biochemical, structural and genetic evidence, PSK binding enhances PSKR heterodimerization with the somatic embryogenesis receptor-like kinases (SERKs). However, PSK is not directly involved in PSKR-SERK interaction but stabilizes PSKR island domain for recruitment of a SERK. Our data reveal the structural basis for PSKR recognition of PSK and allosteric activation of PSKR by PSK, opening up new avenues for the design of PSKR-specific small molecules. © 2015 Macmillan Publishers Limited.


Zhang S.,Zhengzhou University | Kan Q.-C.,Zhengzhou University | Xu Y.,Zhengzhou University | Zhang G.-X.,Thomas Jefferson University | Zhu L.,Zhengzhou University
Mediators of Inflammation | Year: 2013

Dysfunction of the blood-brain barrier (BBB) is a primary characteristic of experimental autoimmune encephalomyelitis (EAE), an experimental model of multiple sclerosis (MS). Matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae Flave, has been recently found to suppress clinical EAE and CNS inflammation. However, whether this effect of MAT is through protecting the integrity and function of the BBB is not known. In the present study, we show that MAT treatment had a therapeutic effect comparable to dexamethasone (DEX) in EAE rats, with reduced Evans Blue extravasation, increased expression of collagen IV, the major component of the basement membrane, and the structure of tight junction (TJ) adaptor protein Zonula occludens-1 (ZO-1). Furthermore, MAT treatment attenuated expression of matrix metalloproteinase-9 and -2 (MMP-9/-2), while it increased the expression of tissue inhibitors of metalloproteinase-1 and -2 (TIMP-1/-2). Our findings demonstrate that MAT reduces BBB leakage by strengthening basement membrane, inhibiting activities of MMP-2 and -9, and upregulating their inhibitors. Taken together, our results identify a novel mechanism underlying the effect of MAT, a natural compound that could be a novel therapy for MS. © 2013 Su Zhang et al.


Fan J.,Wuhan University of Technology | Fan J.,Zhengzhou University | Zhao L.,Wuhan University of Technology | Yu J.,Wuhan University of Technology | Liu G.,CAS National Center for Nanoscience and Technology
Nanoscale | Year: 2012

TiO 2-based composite nanotubes, based on an in situ template dissolution method, were one-step fabricated in a mixed aqueous solution of ammonium hexafluorotitanate and boric acid using ZnO nanorods as templates, and then the samples were calcined at different temperatures. The photocatalytic activity of the samples was evaluated by photocatalytic decoloration of Methyl Orange (MO) aqueous solution at ambient temperature under UV light. The results showed that the prepared sample possessed nanoscale tubular morphology with a wall thickness of ca. 30-50 nm, inner diameters of ca. 50-150 nm and lengths of ca. 400-2000 nm. The calcined samples exhibited excellent stabilization of the anatase phase in a wide temperature range of 300-800 °C. The un-calcined and calcined samples possessed hierarchically macro-mesoporous structures. The sample calcined at 600 °C exhibited the highest photocatalytic activity, corresponding to the maximal formation rate of OH on the photocatalyst. This is attributed to the improvement of anatase TiO 2 crystallization, the formation of multi-phase structures including anatase, cubic Zn 2TiO 4, hexagonal ZnTiO 3 and cubic ZnTiO 3, and the presence of hierarchically macro-mesoporous structures. This journal is © 2012 The Royal Society of Chemistry.


Zhao W.-M.,Zhengzhou University | Chen X.-L.,Zhengzhou University | Yuan J.-W.,Henan University of Technology | Qu L.-B.,Henan University of Technology | And 3 more authors.
Chemical Communications | Year: 2014

A novel and efficient silver catalyzed decarboxylative direct C2-alkylation of benzothiazoles with carboxylic acids for the synthesis of 2-alkyl benzothiazoles was developed. © 2014 The Royal Society of Chemistry.


Zhang F.,Zhengzhou University | Wang L.,Zhengzhou University | Zhang C.,Zhengzhou University | Zhao Y.,Zhengzhou University | Zhao Y.,Xiamen University
Chemical Communications | Year: 2014

1,2-Dideoxy-2-C-diphenylphosphinylglycopyranosides were first synthesized by the novel Mn(ii)-air promoted reaction of diphenylphosphine oxide with various glycals in high yields with excellent regio- and stereoselectivities, which was clarified as a radical addition reaction controlled by the oxygen of vinyl ether. © 2014 The Royal Society of Chemistry.


Li Z.,Nanchang Hangkong University | Liu W.,Zhengzhou University | Yi X.,Henan Mechanical Electrical Secondary School
Jixie Gongcheng Xuebao/Journal of Mechanical Engineering | Year: 2011

Combining the features of both local mean decomposition(LMD) and blind source separation, an underdetermined blind source separation method based on local mean decomposition is proposed. In this method, the observed signals are decomposed into a series of production functions(PF) by the LMD method, these PF and original observed signals then constitute new observed signals, and they undergo whitening process and joint approximate diagonalization, thus obtaining the estimate of source signals. This method can effectively overcome the deficiencies in the traditional mechanical fault source separation method, i.e. the traditional method is restricted to nongaussian, stationary and mutually independent source signals, and the number of observations is assumed to be more than the number of sources. The simulation result shows that the proposed method is effective, and obtains more satisfactory separation quality than the traditional blind source separation method based on time-frequency distribution, it can effectively process the underdetermined blind source separation of non-stationary signal mixtures. Finally the proposed method is applied to the separation of mixed faults of rolling bearing, and the result further verifies its effectivity. © 2011 Journal of Mechanical Engineering.


Yang F.,Central China Normal University | Yang F.,Wuhan Textile University | Yan N.-N.,Central China Normal University | Huang S.,Central China Normal University | And 3 more authors.
Journal of Physical Chemistry C | Year: 2012

Zn-doped CdS nanoarchitectures with different Zn content are synthesized by a simple hydrothermal method with water as the only solvent. The prepared samples are characterized by X-ray powder diffraction, scanning electron microscopy, UV-vis diffuse reflectance spectra, Brunauer-Emmett-Teller measurement, and X-ray photoelectron spectroscopy, while the photocatalytic activities are tested by photocatalytic degradation of rhodamine-B under visible-light irradiation. The results show that CdS with small amount of Zn doping can lead to an enhanced photocatalytic activity. Zn-doped CdS sample derived at 160 °C for 12 h with the molar ratio of Zn/Cd = 1:10 exhibits the best photocatalytic activity, which is much higher than that of pure CdS. Moreover, there is almost no loss of photocatalytic activity after four cycles of repeated experiments. So, Zn 2+ doping indeed improves the photocatalytic activity and stability of CdS. Theoretical calculation indicates that Zn doping into a CdS crystal lattice can result in the shift of the valence band of CdS to a positive direction. It may lead to its higher oxidative ability than pure CdS, which is important for organic pollutant degradation under visible-light irradiation. Furthermore, the low formation energy for Zn-doped CdS systems demonstrates that the stability of CdS with Zn 2+ doping can be improved. Experimentally and theoretically, this study will be useful for the improvement of photocatalytic activity and stability of CdS through the method of metal ion doping. © 2012 American Chemical Society.


Feng M.,Zhengzhou University | Zhang F.-B.,Zhengzhou University | Deng H.-R.,Sun Yat Sen University
Endocrine | Year: 2013

The polymorphism +49A/G in the cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) gene has been implicated in susceptibility to Hashimoto's thyroiditis (HT), but the findings are not clear-cut. This study aimed to investigate the association between CTLA-4 polymorphisms and HT risk using an updated meta-analysis. A meta-analysis was carried out of 14 previous studies that investigated the CTLA-4 +49A/G polymorphism and HT risk. +49A/G was associated with a significantly increased HT risk in both allele analysis and all genetic models (allele analysis: G vs. A: P < 0.001, OR = 1.379, 95 % CI = 1.244-1.529). Subgroup analysis by ethnicity showed a significantly increased HT risk with the G allele and all other genetic models in the Asian subgroup (P < 0.001). In the Caucasian subgroup, no significant association was detected between the CTLA-4 +49 G allele and HT, or in the genetic model analysis (P = 0.05). This gene-based analysis indicates that the cumulative effect of the +49A/G polymorphism in CTLA-4 is associated with HT in Asians, but appears to have no effect on HT in Caucasians. © 2013 Springer Science+Business Media New York.


Xu J.,Wuhan University of Technology | Wang G.,Wuhan University of Technology | Fan J.,Zhengzhou University | Liu B.,Wuhan University of Technology | And 2 more authors.
Journal of Power Sources | Year: 2014

Dye-sensitized solar cells (DSSCs) were fabricated by using g-C3N4 modified TiO2 nanosheets (CTS) as photoanode materials in this research. A thin layer of g-C3N4 was coated on the surface of TiO2 nanosheets by simply heating the mixture of TiO2 nanosheets and urea, which led to the formation of TiO2@g-C3N4 nanosheet heterostructure. The experimental results showed that the photoelectric conversion efficiency of DSSCs was obviously improved after modified by g-C3N4. The measurements of I-V characteristic indicated that the introduction of g-C3N4 could increase both the open circuit voltage and short-circuit photocurrent density. Along with the analysis of electrochemical impedance spectroscopy, it is considered that the thin layer of g-C3N4 can act as the blocking layer for electron backward recombination with electrolyte, which can be used as the functional material to increase the DSSC performance. © 2014 Elsevier B.V.


Yang X.,Harvard University | Yang X.,Zhengzhou University | Lyer A.K.,Northeastern University | Lyer A.K.,Wayne State University | And 5 more authors.
Scientific Reports | Year: 2015

Development of multidrug resistance (MDR) is an almost universal phenomenon in patients with ovarian cancer, and this severely limits the ultimate success of chemotherapy in the clinic. Overexpression of the MDR1 gene and corresponding P-glycoprotein (Pgp) is one of the best known MDR mechanisms. MDR1 siRNA based strategies were proposed to circumvent MDR, however, systemic, safe, and effective targeted delivery is still a major challenge. Cluster of differentiation 44 (CD44) targeted hyaluronic acid (HA) based nanoparticle has been shown to successfully deliver chemotherapy agents or siRNAs into tumor cells. The goal of this study is to evaluate the ability of HA-PEI/HA-PEG to deliver MDR1 siRNA and the efficacy of the combination of HA-PEI/HA-PEG/MDR1 siRNA with paclitaxel to suppress growth of ovarian cancer. We observed that HA-PEI/HA-PEG nanoparticles can efficiently deliver MDR1 siRNA into MDR ovarian cancer cells, resulting in down-regulation of MDR1 and Pgp expression. Administration of HA-PEI/HA-PEG/MDR1 siRNA nanoparticles followed by paclitaxel treatment induced a significant inhibitory effect on the tumor growth, decreased Pgp expression and increased apoptosis in MDR ovarian cancer mice model. Our findings suggest that CD44 targeted HA-PEI/HA-PEG/MDR1 siRNA nanoparticles can serve as a therapeutic tool with great potentials to circumvent MDR in ovarian cancer. © 2015 Macmillan Publishers Limited.


Lei Y.,Xuchang University | Lei Y.,Zhengzhou University | Jia H.,Xuchang University | He W.,Xuchang University | And 6 more authors.
Journal of the American Chemical Society | Year: 2012

P3HT:Ag2S hybrid solar cells with broad absorption from the UV to NIR band were directly fabricated on ITO glass by using a room temperature, low energy consumption, and low-cost soft-chemical strategy. The resulting Ag2S nanosheet arrays facilitate the construction of a perfect percolation structure with organic P3HT to form ordered bulk heterojunctions (BHJ); without interface modification, the assembled P3HT:Ag2S device exhibits outstanding short-circuit current densities (Jsc) around 20 mA cm-2. At the current stage, the optimized device exhibited a power conversion efficiency of 2.04%. © 2012 American Chemical Society.


Wang S.-Z.,Zhengzhou University | Chen Y.,Sun Yat Sen University | Lin H.,Sun Yat Sen University | Chen L.,Sun Yat Sen University
World Journal of Urology | Year: 2010

Objectives: To prospectively compare stress response to laparoscopic and open radical cystectomy by the measurement of humoral mediators and the incidence of systemic inflammatory response syndrome (SIRS). Methods: Thirty-eight patients undergoing radical cystectomy were prospectively assessed. Blood samples were obtained from all patients before surgery, during surgery, 72 h after surgery. Serum levels of interleukin (IL)-6 and interferon (IFN)-γ were measured using an enzyme-linked immunosorbent assay. We also investigated the incidence and duration of SIRS in the two groups. Results: The two groups had comparable perioperative variables except for less estimated blood loss in the laparoscopic group. The IL-6 levels increased during and after surgery in the two groups (P < 0.001). However, the IL-6 levels in the laparoscopic group were significantly lower than those in the open group during and after surgery (P = 0.006, P < 0.001). The incidence of SIRS was 57.1% in the laparoscopic group and 79.2% in the open group (P = 0.149). The mean duration of SIRS was 1.4 days in the laparoscopic group and 2.8 days in the open group (P = 0.032). The IFN-γ levels decreased, but there was no difference in the two groups over the entire period assessed. Multivariate analysis demonstrated that the group (laparoscopic versus open) was the only influencing factor on the levels of IL-6 and the duration of SIRS. Conclusions: Our study suggests that the laparoscopic group is markedly less stressful and it has a shorter duration of SIRS than the open group. © 2010 Springer-Verlag.


Zhan Y.,Zhengzhou University | Zhou X.,Zhengzhou University | Zhou X.,Henan Xinlianxin Chemical Fertilizer Co. | Fu B.,Zhengzhou University | Chen Y.,Zhengzhou University
Journal of Hazardous Materials | Year: 2011

Copper hydroxide nitrate (Cu2(OH)3NO3) was synthesized solvothermally in anhydrous ethanol and characterized by XRD, FTIR, TG-DTA and SEM. The peroxide degradation of an azo dye (Direct Blue 15) on this material was evaluated by examining catalyst loading, initial pH, hydrogen peroxide dosage, initial dye concentration and temperature. The leaching of Cu from the copper hydroxide nitrate during the reaction was also measured. The copper hydroxide nitrate synthesized solvothermally, which was of a novel spherical morphology with complex secondary structures and contained high-dispersed Cu2O impurity, showed good performance for oxidation degradation of the azo dye, especially high catalytic activity, high utilization of hydrogen peroxide and a wide pH range, whereas the copper hydroxide nitrate synthesized by the direct reaction of copper nitrate and sodium hydroxide showed low catalytic activity. © 2011 Elsevier B.V.


Strunk T.,University of Western Australia | Strunk T.,King Edward Memorial Hospital | Inder T.,Washington University in St. Louis | Wang X.,Gothenburg University | And 6 more authors.
The Lancet Infectious Diseases | Year: 2014

Preterm birth and infectious diseases are the most common causes of neonatal and early childhood deaths worldwide. The rates of preterm birth have increased over recent decades and account for 11% of all births worldwide. Preterm infants are at significant risk of severe infection in early life and throughout childhood. Bacteraemia, inflammation, or both during the neonatal period in preterm infants is associated with adverse outcomes, including death, chronic lung disease, and neurodevelopmental impairment. Recent studies suggest that bacteraemia could trigger cerebral injury even without penetration of viable bacteria into the CNS. Here we review available evidence that supports the concept of a strong association between bacteraemia, inflammation, and cerebral injury in preterm infants, with an emphasis on the underlying biological mechanisms, clinical correlates, and translational opportunities. © 2014 Elsevier Ltd.


Li J.,Zhengzhou University | Wang Y.,Jiangnan University | Yu J.,Jiangnan University | Dong R.,Jiangnan University | Qiu H.,Zhengzhou University
Tumor Biology | Year: 2015

We recently found that HOTAIR (HOX antisense intergenic RNA) promotes development and induces radioresistance in cervical cancer. In the present study, we investigated the circulating HOTAIR expression and determined its relationships with the clinicopathological parameters in cervical cancer. The sera samples were obtained from 118 pathological diagnosed cervical cancer patients and 100 normal age-matched women. The expression of HOTAIR was measured by quantitative real time PCR. Patients’ information were collected and analyzed by the SPSS 17.0 software. Compared with normal control, the expression of HOTAIR was significantly upregulated in the sera of cervical cancer patients (P < 0.0001). In addition, elevated HOTAIR was associated with advanced tumor stages (P < 0.0001), adenocarcinoma (P < 0.0001), lymphatic vascular space invasion (P = 0.0065), and lymphatic node metastasis (P = 0.0259). In addition, our follow-up data showed that high HOTAIR was notably correlated with tumor recurrence (P = 0.013) and short overall survival (P = 0.009). Circulating HOTAIR was commonly upregulated and a potent prognostic marker in cervical cancer. © 2014, International Society of Oncology and BioMarkers (ISOBM).


Guo Y.,Zhengzhou University | Guo Y.,Massachusetts General Hospital | Xu F.,Xi'an University of Science and Technology | Xu F.,Xi'an Jiaotong University | And 5 more authors.
Cancer Treatment Reviews | Year: 2012

Interleukin-6 (IL-6) is a multifunctional cytokine which plays an important role in a wide range of biologic activities in different types of cell including tumor cells. IL-6 is involved in the host immune defense mechanism as well as the modulation of growth and differentiation in various malignancies. These effects are mediated by several signaling pathways, in particular the signal transducer and transcription activator 3 (Stat3). There exists abundant evidence demonstrating that deregulated overexpression of IL-6 was associated with tumor progression through inhibition of cancer cell apoptosis, stimulation of angiogenesis, and drug resistance. Clinical studies have revealed that increased serum IL-6 concentrations in patients are associated with advanced tumor stages of various cancers (e.g., multiple myeloma, non-small cell lung carcinoma, colorectal cancer, renal cell carcinoma, prostate cancer, breast cancer and ovarian cancer) and short survival in patients. Therefore, blocking IL-6 signaling is a potential therapeutic strategy for cancer (i.e., anti-IL-6 therapy) characterized by pathological IL-6 overproduction. Preliminary clinical evidence has shown that antibody targeted IL-6 therapy was well tolerated in cancer patients. In this review, we detail the progress of the current understanding of IL-6 signaling pathway in cancer as well as an antibody targeted IL-6 therapy for human cancer. © 2012 Elsevier Ltd.


Liu C.,Zhengzhou University | Liu C.,Rutgers University | Janowski P.A.,Rutgers University | Case D.A.,Rutgers University
Biochimica et Biophysica Acta - General Subjects | Year: 2015

Background: Molecular dynamics simulations can complement experimental measures of structure and dynamics of biomolecules. The quality of such simulations can be tested by comparisons to models refined against experimental crystallographic data. Methods: We report simulations of DNA and RNA duplexes in their crystalline environment. The calculations mimic the conditions for PDB entries 1D23 [d(CGATCGATCG)2] and 1RNA [(UUAUAUAUAUAUAA)2], and contain 8 unit cells, each with 4 copies of the Watson-Crick duplex; this yields in aggregate 64 μs of duplex sampling for DNA and 16 μs for RNA. Results: The duplex structures conform much more closely to the average structure seen in the crystal than do structures extracted from a solution simulation with the same force field. Sequence-dependent variations in helical parameters, and in groove widths, are largely maintained in the crystal structure, but are smoothed out in solution. However, the integrity of the crystal lattice is slowly degraded in both simulations, with the result that the interfaces between chains become heterogeneous. This problem is more severe for the DNA crystal, which has fewer inter-chain hydrogen bond contacts than does the RNA crystal. Conclusions: Crystal simulations using current force fields reproduce many features of observed crystal structures, but suffer from a gradual degradation of the integrity of the crystal lattice. General significance The results offer insights into force-field simulations that test their ability to preserve weak interactions between chains, which will be of importance also in non-crystalline applications that involve binding and recognition. This article is part of a Special Issue entitled Recent developments of molecular dynamics. © 2014 Elsevier B.V. All rights reserved.


Liu R.,Tianjin Medical University | Li J.,Zhengzhou University | Teng Z.,Kaifeng Peoples Hospital | Zhang Z.,Tianjin Medical University | Xu Y.,Tianjin Medical University
PLoS ONE | Year: 2013

MicroRNAs, non-coding 20-22 nucleotide single-stranded RNAs, result in translational repression or degradation and gene silencing of their target genes, and significantly contribute to the regulation of gene expression. In the current study, we report that miR-182 expression was significantly upregulated in prostate cancer tissues and four cell lines, compared to benign prostatic hyperplasia tissues and normal prostatic epithelial (RWPE-1) cells. Ectopic overexpression of miR-182 significantly promotes the proliferation, increases the invasion, promotes the G1/S cell cycle transition and reduces early apotosis of PC-3 cells, while suppression of miR-182 decreased the proliferation and invasion, inhibits the G1/S cell cycle transition and increase early apotosis of PC-3 cells. Additionally, we demonstrated that miR-182 could downregulate expression of NDRG1 by directly targeting the NDRG1 3′-untranslated region. In conclusion, our results suggest that miR-182 plays an important role in the proliferation of human prostate cancer cells by directly suppressing the tumor supressor gene NDRG1. We uncovered a new epigenetic regulation of NDRG1. © 2013 Liu et al.


« Wärtsilä dual-fuel main engines to power 15 barges operating mainly on LNG | Main | Audi testing autonomous driverless transport systems at Ingolstadt plant » Researchers at Zhengzhou University in China have optimized the process parameters for the direct production of hydrogen from raw corn stalks without substrate pretreatment by a mesophilic (growing in moderate temperatures) hydrogen-producing bacterium, Clostridium sartagoforme FZ11, that they had earlier isolated from cow dung compost. The highest yield of 96.2 mL/g of hydrogen was recorded under the optimal conditions of 6.21 g/L urea; 0.19 M phosphate-buffered saline (PBS); and 8.74 mL/L of nutrient solution. Meanwhile, approximately 45% of cellulose and 53% of hemicellulose were degraded in the raw corn stalk during H fermentation, implying that the strain FZ11 can directly convert cellulose and hemicellulose into bio-H without substrate pretreatment. A paper on their work appears in the ACS journal Energy & Fuels. While the production of bio-hydrogen from biomass via fermentation is of interest due to its cleanliness and renewability, the cellulosic feedstock has required pretreatment before fermentation. A variety of pretreatment methods havebeen tried to degrade the cellulosic substrates into soluble sugars for fermentation, including chemical, physical, and biological methods. All of these have issues, the researchers said, such as high cost or the generation of microbial growth inhibitors such as phenol compounds, organic acids, furfurals, and/or 5-hydroxymethyl-furfural. Generally, the pretreatment process for the cellulose hydrolysis step is a process of energy consumption and even has to use some corrosive chemicals (such as acid and alkali) or expensive cellulases as well as specialized equipment, which is recognized as the most expensive approach and rate-determining step in the overall H production process, and accounts for about 20% of the total costs. Therefore, the development of breakthrough approaches, including the integration of low-cost saccharification with fermentation, is crucial for bio-H production from cellulosic substrate, is challenging the scientific community, and will break a new path for utilization of cellulose wastes, having attracted more attention than ever. Among them, one of the strategies for achieving it is to isolate a new strain that can directly use cellulosic feedstock (such as raw corn stalk) to produce H without pretreatment. … In this work, the new strain Clostridium sp. FZ11, which was isolated from a bioreactor feeding raw corn stalk and acclimated compost by microcrystalline cellulose, was employed to produce H from untreated raw corn stalk. To screen the key factors influencing hydrogen production by Clostridium sp. FZ11 from raw corn stalk, the researchers used a Plackett−Burman (PB) design—an approach to optimum multifactorial experiments proposed by R.L. Plackett and J.P. Burman in 1946. On the basis of single-factor experimental results, the research team screened five independent variables—culture temperature, initial pH, urea, phosphate-buffered saline (PBS), and nutrient solution—and one dummy variable in 12 parallel runs. The significant independent variables (urea, PBS, and nutrient solution) and their mutual influences on H production were further explored by the Box−Behnken design (BBD)—experimental designs for response surface methodology, devised by George E. P. Box and Donald Behnken in 1960—and response surface analysis.


Jinhua Z.,Zhengzhou University | Ying C.,University of Manchester
Advanced Materials Research | Year: 2011

In this study a method to deposit a-Si:H-DLC film at room temperature has been explored by CVD. The interface structure of a-Si:H-DLC film and the compositions of DLC film were studied, the adhesion strength of DLC film deposited directly on metal substrates was very poor, there was an almost complete crack at interface between DLC film and metal substrates, the local shedding could also be observed on surface of DLC film. After inserting a-Si:H intermediate material into the interface, the adhesion strength of a-Si:H-DLC film was improved well, the a-Si:H intermediate layer with about 0.2μm thickness was formed, and was very impact. In addition the structures of DLC film mainly were graphite structure with SP2 bonding, and contain a certain amount of diamond structure with SP3 bonding. Load capacity of a-Si:H-DLC film deposited on the metal substrates was also evaluated, as the contact stress (Hertz stress) was less than 544MPa for the film with 1μm-thickness, the failure life was up to 100 million cycles or more by using "ball-on-disk" wear testing machine, therefore it could be used in practice. Changes in load had little effect on friction coefficient. © (2011) Trans Tech Publications, Switzerland.


Xie J.-J.,University of Valencia | Xie J.-J.,Zhengzhou University | Wilkin C.,University College London
Physical Review C - Nuclear Physics | Year: 2010

The total and differential cross sections for associated strangeness production in the pp→pK+K-p and pp→pK +π0Σ0 reactions have been studied in a unified approach using an effective Lagrangian model. It is assumed that both the K-p and π0Σ0 final states originate from the decay of the Λ(1405) that was formed in the production chain pp→p(N*(1535) →K+Λ(1405)). The available experimental data are well reproduced, especially the ratio of the two total cross sections, which is much less sensitive to the particular model of the entrance channel. The significant coupling of the N*(1535) to Λ(1405)K is further evidence for large ss components in the quark wave function of the N *(1535). © 2010 The American Physical Society.


Xie J.,University of Valencia | Xie J.,Zhengzhou University | Nieves J.,University of Valencia
Physical Review C - Nuclear Physics | Year: 2010

We investigate the Λ (1520) photoproduction in the γp → K+Λ (1520) reaction within the effective Lagrangian method near threshold. In addition to the "background" contributions from the contact, t-channel K-exchange, and s-channel nucleon pole terms, which were already considered in previous studies, the contribution from the nucleon resonance N*(2080) (spin-parity JP = 3/2-) is also considered. We show that the inclusion of the nucleon resonance N*(2080) leads to a fairly good description of the new LEPS differential cross-section data, and that these measurements can be used to determine some of the properties of this latter resonance. However, serious discrepancies appear when the predictions of the model are compared to the photon-beam asymmetry,which was also measured by the LEPS Collaboration. © 2010 The American Physical Society.


Wang C.,Texas State University | Hao X.-Q.,Zhengzhou University | Wang M.,Texas State University | Guo C.,University of Georgia | And 8 more authors.
Chemical Science | Year: 2014

Self-assembly of three-dimensional (3-D) architecture using terpyridine (tpy)-based building blocks is challenging and seldom addressed due the fixed geometry (around 180°) of tpy-M(ii)-tpy (M = Ru, Fe, Zn, and Cd) connectivity. Here we describe the self-assembly of 3-D giant metallo-supramolecular cubes using three-armed terpyridine ligands constructed on adamantane with molecular weight up to 18 k and edge length at ∼4.9 nm, which is significantly larger than the sizes of previous metallo-supramolecular cubes. Instead of using metal center as vertices in the commonly used synthetic strategy of 3-D molecular coordination ensembles, these cages [M 12L8] bear 8 ligands as vertices with 12 metal ions on the edges. With a suitable edge length, the giant cubes appear to be the sole product after self-assembly from a variety of possible architectures. The 3-D metallo-supramolecules were characterized and supported by NMR, DOSY, ESI-MS, travelling wave ion mobility-MS and AFM. This journal is © The Royal Society of Chemistry 2014.


Yao L.,Zhengzhou University | Qin J.,Zhengzhou University | Wang A.,Anhui University | Wang H.,University of Manchester
IET Control Theory and Applications | Year: 2013

The purpose of the fault detection and diagnosis of stochastic distribution control systems is to use the measured input and the system output probability density functions (PDFs) to obtain the fault information of the system. In this paper, the rational square-root B-spline model is used to represent the dynamics between the output PDF and the input. This is then followed by the novel design of a non-linear neural network observer-based fault diagnosis (FD) algorithm so as to diagnose the fault in the dynamic part of such systems. Convergency analysis is performed for the error dynamic system raised from the fault detection and diagnosis phase using the Lyapunov stability theorem. Finally, based on the FD information, a new faulttolerant control based on proportional integral tracking control scheme is designed to make the post-fault PDF still track the given distribution. A simulated example is given to illustrate the efficiency of the proposed algorithms. © 2013 The Institution of Engineering and Technology.


Gao N.,Zhengzhou University | Zou D.,Henan Medical College for Staff and Workers | Qiao H.-L.,Zhengzhou University
PLoS ONE | Year: 2013

Some of the components found in herbs may be inhibitors or inducers of cytochrome P450 enzymes, which may therefore result in undesired herb-drug interactions. As a component extracted from Radix Scutellariae, the direct effect of baicalin on cytochrome P450 has not been investigated sufficiently. In this study, we investigated concentration-dependent inhibitory effect of baicalin on the plasma protein binding and metabolism of chlorzoxazone (CZN), a model CYP2E1 probe substrate, in rats in vitro and in vivo. Animal experiment was a randomized, three-period crossover design. Significant changes in pharmacokinetic parameters of CZN such as Cmax, t1/2 and Vd were observed after treatment with baicalin in vivo (P<0.05). Cmax decreased by 25% and 33%, whereas t1/2 increased by 34% and 53%, Vd increased by 37% and 50% in 225 mg/kg and 450 mg/kg baicalin-treated rats, respectively. The AUC and CL of CZN were not affected (P>0.05). Correlation analysis showed that the changes in CZN concentrations and baicalin concentrations were in good correlation (r>0.99). In vitro experiments, baicalin decreased the formation of 6-OH-chlorzoxazone in a concentration-dependent manner and exhibited a competitive inhibition in rat liver microsomes, with a Ki value of 145.8 μM. The values of Cmax/Ki were 20 and 39 after treatment with baicalin (225 and 450 mg/kg), respectively. Protein binding experiments in vivo showed that the plasma free-fraction (fu) of CZN increased 2.6-fold immediately after baicalin treatment (450 mg/kg) and in vitro showed that baicalin (125-2500 mg/L) increased the unbound CZN from 1.63% to 3.58%. The results indicate that pharmacokinetic changes in CZN are induced by inhibitory effect of baicalin on the plasma protein binding of CZN and CYP2E1 activity. © 2013 Gao et al.


Chen F.-X.,Zhengzhou University | Zhao M.-R.,Henan Medical College for Staff and Workers | Liu C.-C.,Zhengzhou University | Peng F.-F.,South China University of Technology | Ren B.-Z.,Zhengzhou University
Journal of Chemical Thermodynamics | Year: 2012

Using a laser monitoring technique, the solubility of diosgenin in ethanol, 1-propanol, 1-butanol, isobutyl alcohol, tert-butanol, 1-pentanol, and iso-octyl alcohol was measured over the temperature range from (290.15 to 330.15) K at atmospheric pressure. Its corresponding (solid + liquid) equilibrium data will provide essential support for industrial design and further theoretical studies. From the experimental results, the solubility of diosgenin in ethanol, 1-propanol, 1-butanol, isobutyl alcohol, tert-butanol, 1-pentanol, and iso-octyl alcohol was found to increase with increasing temperature and decrease with the increase of the polarity of the alcohols solvents. The Apelblat equation, the ideal model and the λh equation were used to correlate the solubility values. The results showed that the three models mentioned above agreed well with the experimental data. © 2012 Elsevier Ltd. All rights reserved.


Chen F.-X.,Zhengzhou University | Zhao M.-R.,Henan Medical College for Staff and Workers | Ren B.-Z.,Zhengzhou University | Zhou C.-R.,Zhengzhou University | Peng F.-F.,Zhengzhou University
Journal of Chemical Thermodynamics | Year: 2012

The solubility of diosgenin in methanol, ethanol (95%), isopropanol, acetone, acetic ether, and propyl acetate were measured at temperatures from (295.15 to 330.15) K using the synthetic method by a laser monitoring observation technique at atmospheric pressure. Its corresponding (solid + liquid) equilibrium data will provide essential support for industrial design and further theoretical studies. The solubility data of diosgenin in isopropanol, acetone, ethanol (95%), and acetic ether were correlated with Apelblat equation, and the experimental data of diosgenin in methanol and propyl acetate were also correlated with the λh model. The calculated values were good in agreement with the experimental values. © 2011 Elsevier Ltd. All rights reserved.


Liu B.-C.,Xi'an Jiaotong University | Xie J.-J.,Zhengzhou University | Xie J.-J.,University of Valencia
Physical Review C - Nuclear Physics | Year: 2012

We report on a theoretical study of the K -p→ηΛ reaction near threshold by using an effective Lagrangian approach. The role of s-channel Λ(1670), t-channel K *, and u-channel proton pole diagrams are considered. We show that the total cross section data are well reproduced. However, only including the s-wave Λ(1670) state and the background contribution from t and u channels is not enough to describe the bowl structures in the angular distribution of the K -p→ηΛ reaction, which indicates that there should be higher partial waves contributing to this reaction in some energy region. Indeed, if we considered the contributions from a D 03 resonance, we could describe the bowl structures; however, a rather small width (∼2 MeV) of this resonance would be needed. © 2012 American Physical Society.


He X.,Shanghai Normal University | Lu H.,Zhengzhou University
Nanotechnology | Year: 2014

By depositing a graphene layer on the metallic film with subwavelength hole arrays, the tunable extraordinary transmission property based on the metal-dielectrics-graphene (MDG) structure has been investigated in the terahertz (THz) and near-infrared (NIR) regimes. The influences of operation frequency, composed materials, and the Fermi level of the graphene layer have been taken into account. The results show that by varying the Fermi level of the graphene layer, the transmission of the MDG structure can be tuned in a wide range and the modulation depth of the peak value of the transmission can reach more than 50%. But the tunable mechanisms in the THz and NIR regimes are quite different. In the infrared (THz) regime, the graphene behaves like the dielectric (metallic) layer; its dielectric constant decreases (increases) with the increase of Fermi level, resulting in the transmission increasing (decreasing). Compared with the metallic structure, the transmission of the semiconductor structure can also be modulated by using the doping or varying temperature; its peak position can also be changed in a much broader range. The results are very useful to understand the mechanism of the graphene plasmonic devices and to design novel filters, switchers, modulators, and sensors. © 2014 IOP Publishing Ltd.


Wang H.X.,Zhengzhou University | Wang H.X.,Zhengzhou University of Light Industry | Guan S.K.,Zhengzhou University | Wang X.,Zhengzhou University | And 2 more authors.
Acta Biomaterialia | Year: 2010

The key to manufacturing magnesium-based alloys that are suitable as biodegradable orthopaedic implants is how to adjust their degradation rates and mechanical integrity in the physiological environment. In this study, to solve this challenge, a soluble Ca-deficient hydroxyapatite (Ca-def HA) coating was deposited on an Mg-Zn-Ca alloy substrate by pulse eletrodeposition. This deposition can be demonstrated by X-ray diffractometry and energy dispersion spectroscopy analyses, and the Ca/P atomic ratio of as-deposited coating is about 1.33 (within the range from 1.33 to 1.65). By regulating the appropriate pulse amplitude and width, the Ca-def HA coating shows better adhesion to Mg-Zn-Ca alloy, whose lap shear strength is increased to 41.8 ± 2.7 MPa. Potentiodynamic polarization results in Kokubo's simulated body fluid (SBF) indicate that the corrosion potential of Mg alloy increases from -1645 to -1414 mV, while the corrosion current density decreases from 110 to 25 μA/cm 2, which illustrates that the Ca-def HA coating improves the substrate corrosion resistance significantly. Since orthopaedic implants generally serve under conditions of stress corrosion, the mechanical integrity of the Mg-Zn-Ca alloy was measured using the slow strain rate tensile (SSRT) testing technique in SBF. The SSRT results show that the ultimate tensile strength and time of fracture for the coated Mg-Zn-Ca alloy are higher than those of the uncoated one, which is beneficial in supporting fractured bone for a longer time. Thus Mg-Zn-Ca alloy coated with Ca-def HA is be a promising candidate for biodegradable orthopaedic implants, and is worthwhile to further investigate the in vivo degradation behavior. © 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.


Chen S.-C.,Chung Yuan Christian University | Li H.-M.,Zhengzhou University | Huang S.-T.,Chung Yuan Christian University | Wang Y.-C.,Chung Yuan Christian University
International Communications in Heat and Mass Transfer | Year: 2010

In-mold decoration (IMD) during injection molding is a relatively new injection molding technique and has been employed for plastic products to improve surface quality and achieving colorful surface design, etc. During IMD processing, the film is preformed as the shape of mold cavity and attached to one side of the mold wall (usually cavity surface), then molten polymer is filled into the cavity. Heat transfer toward the mold cavity side during molding IMD part is significantly retarded because the film is much less thermal conductive than metal mold. To investigate the effect of film on temperature field, polycarbonate (PC) was injection molded under various conditions including coolant temperature, melt temperature, film material and film thickness. Simulations were also conducted to evaluate the melt-film interface temperature and its influence from film initial temperature and film thermal properties. For PC film, it was found that the heat transfer retardation results in the mold temperature drop in cavity surface and the maximum temperature drop as compared to that of conventional injection molding without film may be as high as 17.7. °C. For PET film, this maximum mold temperature drop is about 13. °C. As PC film thickness increases, the retardation-induced mold temperature difference also increases. The initial film temperature (30. °C and 95. °C) may affect the melt-film interface temperature at the contact instant of melt and film by about 12. °C to 17. °C. When thermal conductivity of film increases from 0.1. W/(m-k) to 0.2. W/(m-k), melt-film interface temperature may vary by 22.9. °C. The simulated mold temperature field showed reasonable agreement with experimental results. © 2010.


Zhang O.,Zhengzhou University | Zhang O.,First Hospital Affiliated to Nanyang Medical College | Zhang J.,Zhengzhou University
International Immunopharmacology | Year: 2015

M1 and M2 macrophages are detectable in human atherosclerotic lesions, and M2 macrophages are present at locations distant from the lipid core in more stable zones of the plaque and appear to exert anti-inflammatory properties on M1 macrophages. Peroxisome proliferator-activated receptor (PPAR) γ promotes the differentiation of monocytes into anti-inflammatory M2 macrophages. Although both statins and PPARγ ligands have been reported to protect against the progression of atherosclerosis, no data are currently available regarding the implication of statins in the alternative differentiation of human monocytes. In the present study, we hypothesized that atorvastatin may exert novel effects to prime human monocytes toward an anti-inflammatory alternative M2 phenotype. To this aim, we first found that abundant M2 markers were expressed in human circulating monocytes after atorvastatin treatment. Moreover, atorvastatin was able to induce PPARγ expression and activation in human monocytes in vivo and in vitro, resulting in priming primary human monocytes differentiation into M2 macrophages with a more pronounced paracrine anti-inflammatory activity in M1 macrophages. Additional data with molecular approaches revealed that p38 mitogen-activated protein kinase (MAPK) but not extracellular signal-regulated kinase (ERK) 1/2 activation was involved in atorvastatin-mediated PPARγ activation and enhanced alternative M2 macrophage phenotype. Collectively, our data demonstrated that atorvastatin promotes human monocyte differentiation toward alternative M2 macrophages via p38 MAPK-dependent PPARγ activation. © 2015 Elsevier B.V.


Zhao J.,Zhengzhou University of Light Industry | Zhang F.,Zhengzhou University
Advances in Information Sciences and Service Sciences | Year: 2012

Feature selection is one of the important topics in text classification. However, most of existing feature selection methods are serial and inefficient to be applied to massive text data sets. In this case, a feature selection method based on parallel collaborative evolutionary genetic algorithm is presented. The presented method uses genetic algorithm to select feature subsets and takes advantage of parallel collaborative evolution to enhance time efficiency, so it can quickly acquire the feature subsets which are more representative. The experimental results show that: For accuracy and recall, the presented method is better than three classical methods: Information Gain, x 2 Statistics, Mutual Information; For the consumed time, the presented method with a CPU is inferior than the above mentioned three methods, but the presented method is superior after using the parallel strategy.


Yao L.,Zhengzhou University | Yao L.,Nanjing University of Aeronautics and Astronautics | Qin J.,Zhengzhou University | Wang H.,University of Manchester | Jiang B.,Nanjing University of Aeronautics and Astronautics
Automatica | Year: 2012

New fault diagnosis (FD) and fault tolerant control (FTC) algorithms for non-Gaussian singular stochastic distribution control (SDC) systems are presented in this paper. Different from general SDC systems, in singular SDC systems, the relationship between the weights and the control input is expressed by a singular state space model, which increases the difficulty in the FD and FTC design. The proposed approach relies on an iterative learning observer (ILO) for fault estimation. The fault may be constant, fast-varying or slow-varying. Based on the estimated fault information, the fault tolerant controller can be designed to make the post-fault probability density function (PDF) still track the given distribution. Simulations are given to show the effectiveness of the proposed FD and FTC algorithms. © 2012 Elsevier Ltd. All rights reserved.


Xie J.-J.,University of Valencia | Xie J.-J.,Zhengzhou University | Martinez Torres A.,Kyoto University | Oset E.,University of Valencia
Physical Review C - Nuclear Physics | Year: 2011

We perform a calculation for the three-body NKÍK scattering amplitude by using the fixed-center approximation to the Faddeev equations, taking the interaction between N and KÍ, N and K, and KÍ and K from the chiral unitary approach. The resonant structures show up in the modulus squared of the three-body scattering amplitude and suggest that a NKÍK hadron state can be formed. Our results are in agreement with others obtained in previous theoretical works, which claim a new N* resonance around 1920 MeV with spin-parity JP=1/2+. The existence of these previous works allows us to test the accuracy of the fixed center approximation in the present problem and sets the grounds for possible application in similar problems, as an explorative tool to determine bound or quasibound three-hadron systems. © 2011 American Physical Society.


Cui H.-F.,Zhengzhou University | Zhang K.,Zhengzhou University | Zhang Y.-F.,Zhengzhou University | Sun Y.-L.,Zhengzhou University | And 3 more authors.
Biosensors and Bioelectronics | Year: 2013

Glucose oxidase (GOD) was adsorbed into a nanoporous TiO2 film layered on the surface of an iron phthalocyanine (FePc) vertically-aligned carbon nanotube (CNT) modified electrode. A Nafion film was then dropcast on the electrode's surface to improve operational and storage stabilities of the GOD-based electrode. Scanning electron microscopy (SEM) micrographs revealed the formation of FePc and nanoporous TiO2 nanoparticles along the sidewall and the tip of CNTs. Cyclic voltammograms of the GOD electrode in neutral PBS exhibited a pair of well-defined redox peaks, attesting the direct electron transfer of GOD (FAD/FADH2) with the underlying electrode. The potential of glucose electro-oxidation under nitrogen was ~+0.12V with an oxidation current density of 65.3μAcm-2 at +0.77V. Voltammetric and amperometric responses were virtually unaffected by oxygen, illustrating an efficient and fast direct electron transfer. The modification of the CNT surface with FePc resulted in a biosensor with remarkable detection sensitivity with an oxygen-independent bioelectrocatalysis. In deaerated PBS, the biosensor displayed average response time of 12s, linearity from 50μM to 4mM, and a detection limit of 30μM (S/N=3) for glucose. © 2013 Elsevier B.V.


Xie J.-J.,University of Valencia | Xie J.-J.,Zhengzhou University | Martinez Torres A.,Kyoto University | Oset E.,University of Valencia | Gonzalez P.,University of Valencia
Physical Review C - Nuclear Physics | Year: 2011

From a Faddeev calculation for the π-(Δρ)N5/2 -(1675) system we show the plausible existence of three dynamically generated I(JP)=3/2(5/2+) baryon states below 2.3 GeV, whereas only two resonances, Δ5/2 +(1905) (****) and Δ5/2 +(2000) (**), are cataloged in the Particle Data Book Review. Our results give theoretical support to data analyses extracting two distinctive resonances, Δ5/2 +(1740) and Δ5/2 +(2200), from which the mass of Δ5/2 +(2000)(**) is estimated. We propose that these two resonances should be cataloged instead of Δ5/2 +(2000). This proposal gets further support from the possible assignment of the other baryon states found in the approach in the I=1/2,3/2 with JP=1/2+,3/2+,5/2+ sectors to known baryonic resonances. In particular, Δ1/2 +(1750) (*) is naturally interpreted as a πN1/2 -(1650) bound state. © 2011 American Physical Society.


He L.,Zhengzhou University | He L.,Zhengzhou University of Light Industry | Zheng X.,Zhengzhou University | Xu Q.,Zhengzhou University
Journal of Physical Chemistry B | Year: 2010

We report herein a typical piezoelectric polymer, poly(vinylidene fluoride) (PVDF) to be successfully wrapped on single-walled carbon nanotubes (SWCNTs) using a simple supercritical carbon dioxide (SC CO2) antisolvent-induced polymer epitaxy method. Our study focused on the effect of different solvents on the morphology of PVDF wrapping on SWCNTs. Three organic solvents, dimethyl sulfoxide (DMSO), N,N-dimethylformamide (DMF), and N,N-dimethylacetamide (DMAc) were chosen for PVDF. When DMSO was used as solvent, the decorating degree of PVDF on the surface of SWCNTs increases significantly with the increase of SC CO2 pressure, and nanocrystals wrapping on SWCNTs can be observed at high pressure. FTIR and Raman spectra indicated that there exist interactions between SWCNTs and PVDF chains. Whats more, FTIR results also show that there exists a transformation from the β-phase to the α-phase of PVDF in DMSO with the assistance of SC CO2, which is similar to the action of elongation/shear flow field. It indicated that the α-phase is the predominant form occurring on the surface of SWCNTs after treatment with SC CO2. And the helical structure on SWCNTs observed from the TEM image reflected the alternate trans- and gauche-bond conformation of the α-form. When DMF or DMAc was used as the solvent, although nanocrystal wrapping and helical structure was not visible, the samples had more excellent dispersion than that in DMSO. Particularly, for DMF, a typical network structure was observed, which is similar to a spider web. Therefore, this work supplies a clue that the various morphologies of nanohybrid structure can be obtained just by changing the solvent during the treatment process of SC CO2, and accordingly, the tailored nanohybrid structure are promising and important for functional design as a basic component in microfabrication and other fields. © 2010 American Chemical Society.


Duan J.,Tianjin Institute of Urban Construction | Liu R.,Zhengzhou University | Chen T.,Henan Academy of science | Zhang B.,Zhengzhou University | Liu J.,Zhengzhou University
Desalination | Year: 2012

The magnetic composite of Fe 3O 4-halloysite nanotube (HNT) was prepared by chemical precipitation method. The prepared adsorbents were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), vibrating sample magnetometer (VSM), and multipoint Brunauer-Emmett-Teller (MBET). The results revealed that Fe 3O 4 particles with diameter of 3-5nm dispersed on the nanotube surface and formed a composite with halloysite. The Fe 3O 4-HNTs composite exhibited fine magnetic property (Ms=8.47emu/g) and could be easily separated from aqueous solution by the application of an external magnetic field. Adsorption results showed that Fe 3O 4-HNTs composite could maintain a high adsorption capacity for methyl violet (MV) when the pH, concentration of metal ion and temperature varied. Adsorption kinetics was best described by the pseudo-second-order model. Equilibrium data fitted well with the Langmuir isotherm. The used Fe 3O 4-HNTs could be regenerated by simple calcinations. The recovered adsorbents could be used again for MV removal and magnetic separation. Because of the excellent adsorption capacity at different conditions, reproducibility and separability, Fe 3O 4-HNTs composite is a promising candidate for removing cationic dye from waste water. © 2012 Elsevier B.V.


Hao Y.-B.,Xi'an Jiaotong University | Hao Y.-B.,Zhengzhou University | Yi S.-Y.,Zhengzhou University | Ruan J.,Tianjin Medical University | And 2 more authors.
Cancer Letters | Year: 2014

Chemotherapy is the mainstay of treatment in mid-advanced tumors. Considering their toxicity on hematopoietic cells, chemotherapeutics are often considered as immunosuppressive inducers. However, recently accumulating data indicate that some chemotherapeutic agents with specific administration schedules also display some positive immunological effect to contribute to tumor elimination. For instance, metronomic chemotherapy could promote tumor eradication not only by inhibiting tumor angiogenesis but also by selectively eliminating immunosuppressive cells and improving anti-tumor immune responses. In this review, we summarize what is currently known regarding metronomic chemotherapy-induced immunoregulation. Understanding of the molecular mechanisms of metronomic chemotherapy-induced immunoregulation may yield invaluable information for the optimal design of immunochemotherapies. © 2014 Elsevier Ireland Ltd. All rights reserved.


Chen X.,Zhengzhou University | Zhu C.,Zhengzhou University | Cui X.,Zhengzhou University | Cui X.,Huaqiao University | Wu Y.,Zhengzhou University
Chemical Communications | Year: 2013

An efficient and direct 2-acetoxylation of quinoline N-oxides via copper(i) catalyzed C-H bond activation has been developed. This transformation was achieved using TBHP as an oxidant in the cross-dehydrogenative coupling (CDC) reaction of quinoline N-oxides with aldehydes, and provided a practical pathway to 2-acyloxyl quinolines. © 2013 The Royal Society of Chemistry.


Cheng Z.,Zhengzhou University | Cheng Z.,Henan Polytechnic University | Ren J.,Zhengzhou University
Nonlinear Analysis: Real World Applications | Year: 2013

This paper is devoted to the existence of harmonic and subharmonic solutions for a damped Duffing equation. Our proofs are based on a twisting theorem due to W.Y. Ding. © 2012 Elsevier Ltd. All rights reserved.


Wu Z.,Zhengzhou University | Pi C.,Zhengzhou University | Cui X.,Zhengzhou University | Cui X.,Huaqiao University | And 2 more authors.
Advanced Synthesis and Catalysis | Year: 2013

An efficient and concise one-pot strategy for the direct alkylation of quinoline N-oxides via palladium-catalyzed dual C-H bonds activation has been developed. This methodology provides quinoline-containing heterocyclic molecules in moderate to excellent yields. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Wang Y.Q.,Zhengzhou University | Wang Y.Q.,Henan Polytechnic University | Ma S.,Zhengzhou University | Yang Q.Q.,Zhengzhou University | Li X.J.,Zhengzhou University
Applied Surface Science | Year: 2012

A series of silver/silicon nanoporous pillar arrays (Ag/Si-NPAs) were prepared by an immersion-plating method through controlling the immersing times and their surface-enhanced Raman scattering (SERS) behaviors to rhodamine 6G (R6G) were contrastively studied. With a concentration of 10 -15 M, the identification of R6G could be performed by all the samples, but the corresponding peak intensities varied largely. This phenomenon was attributed to the size difference of the deposited silver nanoparticles, and the optimal size range for obtaining the strongest SERS signal was determined to be ∼35-55 nm. Ag/Si-NPA might be an effective substrate for performing highly sensitive SERS detections. © 2012 Elsevier B.V. All rights reserved.


Zhang W.,Zhengzhou University | Zhang W.,University of Minnesota | Truhlar D.G.,University of Minnesota | Tang M.,Zhengzhou University
Journal of Chemical Theory and Computation | Year: 2013

One of the greatest challenges for the theoretical study of transition-metal-containing compounds is the treatment of intrinsically multiconfigurational atoms and molecules, which require a multireference (MR) treatment in wave function theory. The accuracy of density functional theory for such systems is still being explored. Here, we continue that exploration by presenting the predictions of 42 exchange-correlation (xc) functionals of 11 types [local spin density approximation (LSDA), generalized gradient approximation (GGA), nonseparable gradient approximation (NGA), global-hybrid GGA, meta-GGA, meta-NGA, global-hybrid meta-GGA, range-separated hybrid GGA, range-separated hybrid meta-GGA, range-separated hybrid meta-NGA, and DFT augmented with molecular mechanics damped dispersion (DFT-D)]. DFT-D is tested both for Grimme's DFT-D3(BJ) model with Becke-Johnson damping and for ωB97X-D, which has the empirical atom-atom dispersion parametrized by Chai and Head-Gordon. The Hartree-Fock (HF) method has also been included because it can be viewed as a functional with 100% HF exchange and no correlation. These methods are tested against a database including 70 first-transition-row (3d) transition-metal-containing molecules (19 single-reference molecules and 51 MR molecules), all of which have estimated experimental uncertainties equal to or less than 2.0 kcal/mol in the heat of formation. We analyze the accuracy in terms of the atomization energy per bond instead of the enthalpy of formation of the molecule because it allows us to test electronic energies without the possibility of cancellation of errors in electronic energies with errors in vibrational energies. All the density functional and HF wave functions have been optimized to a stable solution, in which the spatial symmetry is allowed to be broken to minimize the energy to a stable solution. We find that τ-HCTHhyb has the smallest mean unsigned error (MUE) in average bond energy, in particular 2.5 kcal/mol, for the full set of 70 molecules, and it also gives the smallest MUE for MR systems. For single-reference systems, MPW1B95 has the best performance, with an MUE of 1.6 kcal/mol. Among local functionals, which are the least expensive, the best performance (MUE = 3.4 kcal/mol) for the total database is achieved by OreLYP. It is observed that adding HF exchange does not guarantee better accuracy for GGAs or for the NGA, but inclusion of the kinetic energy densities can benefit the GGAs and NGA calculations. The metal hydrides and metal oxides are demonstrated to be the most difficult bond types to predict, and CrO3, FeH, CrO, VH, and MnS are found to be the most difficult molecules to predict. The middle transition metals (V, Cr, and Mn) lead to larger errors on average than either the early or late transition metals. © 2013 American Chemical Society.


Wang S.,Zhengzhou University | Zhang B.,Zhengzhou University | Hou Y.,Tianjin Polytechnic University | Du C.,Zhengzhou University | Wu Y.,Zhengzhou University
Journal of Materials Chemistry C | Year: 2013

A highly pure red luminescent heterobimetallic complex [EuZnL(tta) 2(μ-tfa)] (L = N,N′-bis(salicylidene)-2,3-propanediamine, tta = 2-thenoyltrifluoroacetonate, tfa = trifluoroacetate) was synthesized. The EL device with this complex exhibits an inspiring current efficiency of 3.7 cd A-1 at a brightness of 300 cd m-2 and gives a maximum Eu(iii)-based pure red emitting luminance of 1982.5 cd m-2 at 13.8 V. © The Royal Society of Chemistry 2013.


Huang M.,Zhengzhou University | Lv S.,Henan Provincial Institute of Food and Drug Control | Zhou C.,Zhengzhou University
Thermochimica Acta | Year: 2013

The non-isothermal decomposition kinetics of glycine was investigated using analyzer DTG-60. TG experiments were carried out under dynamic nitrogen atmosphere of 30 mL min-1 with heating rates of 10, 14, 18 and 22 K min-1. The kinetic parameters such as activation energy (E), exponential factor (A) and reaction order (n) were evaluated by Flynn-Wall-Ozawa, Doyle, Kissinger and Šatava-Šesták methods. The results show that the non-isothermal decomposition mechanism of glycine corresponds to nucleation and growth, following the Avrami-Erofeev equation with n = 1/3. Moreover, thermodynamic properties of the non-isothermal decomposition process such as the change in the values of enthalpy (ΔH), entropy (ΔS) and Gibbs free energy (ΔG) were calculated. © 2012 Elsevier B.V. All rights reserved.


Yi S.-Y.,Zhengzhou University | Hao Y.-B.,Zhengzhou University | Nan K.-J.,Xi'an Jiaotong University | Fan T.-L.,Zhengzhou University
Cancer Treatment Reviews | Year: 2013

Nowadays, cancer has been a frequent disease, and the first or second most common cause of death worldwide. Despite a better understanding of the biology of cancer cells, the therapy of most cancers has not significantly changed for the past four decades. It is because conventional chemotherapies and/or radiation therapies are usually designed to eradicate highly proliferative cells. Mounting evidence has implicated that cancer is a disease of stem cells. Cancer stem cells (CSC) are often relatively quiescent, and therefore may not be affected by therapies targeting rapidly dividing cells. Like normal stem cells (NSC) residing in a " stem cell niche" that maintains them in a stem-like state, CSC also require a special microenvironment to control their self-renewal and undifferentiated state. The " CSC niche" is likely to be the most crucial target in the treatment of cancer. In this article, we summarize the current knowledge regarding CSC and their niche microenvironments. Understanding of CSC's origin, molecular profile, and interaction with their microenvironments, this could be a paradigm shift in the treatment of cancer, away from targeting the blast cells and towards the targeting of the CSC, thus improving therapeutic outcome. © 2012 Elsevier Ltd.


Zhao L.,Colorado State University | Zhao L.,Zhengzhou University | Sullivan M.N.,Colorado State University | Chase M.,Colorado State University | And 2 more authors.
American Journal of Respiratory Cell and Molecular Biology | Year: 2014

Proliferation of airway smooth muscle cells (ASMCs) contributes to the remodeling and irreversible obstruction of airways during severe asthma, but the mechanisms underlying this disease process are poorly understood. Here we tested the hypothesis that Ca2+ influx through the vanilliod transient receptor potential channel (TRPV) 4 stimulates ASMC proliferation. We found that synthetic and endogenous TRPV4 agonists increase proliferation of primary ASMCs. Furthermore, we demonstrate that Ca2+ influx through individual TRPV4 channels produces Ca2+ microdomains in ASMCs, called "TRPV4 Ca2+ sparklets." We also show that TRPV4 channels colocalize with the Ca2+/calmodulin-dependent protein phosphatase calcineurin in ASMCs. Activated calcineurin dephosphorylates nuclear factor of activated T cells (NFAT) transcription factors cytosolic (c) to allow nuclear translocation and activation of synthetic transcriptional pathways. We show that ASMC proliferation in response to TRPV4 activity is associated with calcineurin-dependent nuclear translocation of the NFATc3 isoform tagged with green florescent protein. Our findings suggest that Ca2+ microdomains created by TRPV4 Ca2+ sparklets activate calcineurin to stimulate nuclear translocation of NFAT and ASMC proliferation. These findings further suggest that inhibition of TRPV4 could diminish asthma-induced airway remodeling. Copyright © 2014 by the American Thoracic Society.


Zhang H.,Zhengzhou University | Cui X.,Zhengzhou University | Cui X.,Huaqiao University | Yao X.,Zhengzhou University | And 3 more authors.
Organic Letters | Year: 2012

N,N-Dimethylaminomethyl ferrocenium could be generated in situ and served as a terminal oxidant for Pd-catalyzed directly dehydrogenative annulations of N,N-dimethylaminomethyl ferrocene and internal alkynes. This procedure utilized the redox activity of ferrocene and avoided adding an oxidant. A series of highly arylated naphthalenes functionalized by ferrocene were obtained in 53-81% yields. © 2012 American Chemical Society.


Dong X.-Y.,Zhengzhou University | Dong X.-Y.,Henan Polytechnic University | Wang R.,Zhengzhou University | Li J.-B.,Zhengzhou University | And 4 more authors.
Chemical Communications | Year: 2013

A new tetranuclear Cu4(μ3-OH)2-based metal-organic framework (MOF) with sulfonate-carboxylate ligands features large hydrophilic channels. This MOF exhibits proton conductivity over 10-3 S cm-1 at 85-100 °C and 98% relative humidity and colossal dielectric constant. © 2013 The Royal Society of Chemistry.


Chen X.,Zhengzhou University | Cui X.,Zhengzhou University | Cui X.,Huaqiao University | Yang F.,Zhengzhou University | Wu Y.,Zhengzhou University
Organic Letters | Year: 2015

An efficient cross-dehydrogenative coupling of quinoline N-oxides and 1,3-azoles has been developed under external oxidant and metal free conditions. The desired products were isolated in good to excellent yields for 26 examples. This methodology provides a practical pathway to biheteroaryls and features high practicality, high efficiency, and environmental friendliness. © 2015 American Chemical Society.


Li Y.,University of Minnesota | Li X.,Zhengzhou University | Dong Z.,University of Minnesota
Biochemistry | Year: 2014

In this work, we investigate the dynamic motions of fatty acid binding protein 4 (FABP4) in the absence and presence of a ligand by explicitly solvated all-atom molecular dynamics simulations. The dynamics of one ligand-free FABP4 and four ligand-bound FABP4s is compared via multiple 1.2 μs simulations. In our simulations, the protein interconverts between the open and closed states. Ligand-free FABP4 prefers the closed state, whereas ligand binding induces a conformational transition to the open state. Coupled with opening and closing of FABP4, the ligand adopts distinct binding modes, which are identified and compared with crystal structures. The concerted dynamics of protein and ligand suggests that there may exist multiple FABP4-ligand binding conformations. Thus, this work provides details about how ligand binding affects the conformational preference of FABP4 and how ligand binding is coupled with a conformational change of FABP4 at an atomic level. © 2014 American Chemical Society.


Liu B.-C.,Xi'an Jiaotong University | Liu B.-C.,Chinese Academy of Sciences | Xie J.-J.,Chinese Academy of Sciences | Xie J.-J.,Zhengzhou University
Physical Review C - Nuclear Physics | Year: 2012

Recently, we reported a theoretical study on the K -p→ηΛ reaction near threshold by using an effective Lagrangian approach. It was found that the description of angular distribution data measured by the Crystal Ball Collaboration needs a D 03 resonance with mass M=1668.5±0.5 MeV and total decay width Γ=1.5±0.5 MeV, which is not the conventional Λ(1690) or other Λ state listed in the Particle Data Group book. In the present work, we study the Λ polarization in the K -p→ηΛ reaction within the same framework. The results show that the existence of this narrow D 03 state is also compatible with current Λ polarization data and that the more accurate Λ polarization data at P K -=735 MeV can offer further evidence for the existence of this resonance. Furthermore, the role of the Λ(1690) resonance in this reaction is also discussed. © 2012 American Physical Society.


Wu Z.,Zhengzhou University | Song H.,Zhengzhou University | Cui X.,Zhengzhou University | Cui X.,Huaqiao University | And 3 more authors.
Organic Letters | Year: 2013

An efficient and concise one-pot protocol to synthesize sulfonylated quinoline N-oxides via copper-catalyzed C-H bond activation has been developed. Commercially available and less expensive aryl sulfonyl chlorides were used as the sulfonylation reagents. Various 2-aryl sulfonyl quinolines were obtained in up to 91% yields in chemo- and regioselective manners. © 2013 American Chemical Society.


Cheng G.,Huaqiao University | Zeng X.,Huaqiao University | Shen J.,Huaqiao University | Wang X.,Huaqiao University | And 2 more authors.
Angewandte Chemie - International Edition | Year: 2013

About specifics: A method for the regiospecific synthesis of the title compounds through an unprecedented Michael addition/deacylative diazo transfer/cyclization sequence has been established. The simple and practical method can be used for the modification of primary amines including chiral α-amines. The process involves the formation three covalent bonds and the cleavage of two covalent bonds (see scheme, Ts=4-toluenesulfonyl). © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Chen W.,Wuhan University | Chen W.,Zhengzhou University | Yang Y.,Wuhan University | Shao H.,Wuhan University
Journal of Power Sources | Year: 2011

New applications such as hybrid electric vehicles and power backup require rechargeable batteries to combine high energy density with high charge and discharge rate capability. In this study, the core-shell Ni(OH) 2@CoOOH composite is constructed via a simple cation-exchange route at moderate conditions. X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM) with energy dispersive X-ray (EDX), and inductively coupled plasma (ICP) are used to characterize the resulting Ni(OH)2@CoOOH composites. The Ni(OH)2@CoOOH electrode exhibits high power, higher capacity and longer life cycle when it is chosen as an positive electrode material for rechargeable alkaline MH-Ni battery. The enhanced electrochemical performance is attributed to the seamless combination of the CoOOH shell and the Ni(OH)2 core, avoiding the contact resistance between them at a large current density. It is believed that our methodology provides a simple and environment friendly route to a variety of core-shell materials with different composition and novel function. © 2010 Elsevier B.V.


Huang H.,Zhengzhou University | Li J.,Zhengzhou University | Lescop C.,CNRS Chemistry Institute of Rennes | Duan Z.,Zhengzhou University
Organic Letters | Year: 2011

Herein, a Pd-catalyzed reaction of simple and diverse bromothiophenes with alkynes via regioselective C-S bond activation is reported. This provides a new approach to prepare sulfur-based heterocycles and fulvenes. © 2011 American Chemical Society.


Xie X.-P.,Huazhong University of Science and Technology | Xie X.-P.,Henan Polytechnic University | Zhu X.-L.,Zhengzhou University | Wang Y.-C.,Northeastern University China
Signal Processing | Year: 2014

The problem of stability analysis of 2-D state-space digital filters described by Roesser model with parameter uncertainty is addressed in this paper. The underlying parameter uncertainty is modeled by a convex bounded (polytope type) uncertain domain. By applying both a new parameter-dependent Lyapunov function and a kind of matrix transformation technique, relaxed global asymptotic stability criteria of the 2-D state-space digital filters are proposed in terms of linear matrix inequalities (LMIs), which can be easily solved via standard numerical software. More importantly, the conservatism of the obtained global asymptotic stability criteria could be significantly reduced than existing ones. Finally, a numerical example is provided to illustrate the effectiveness of the proposed approach. © 2013 Elsevier B.V.


He D.,Wuhan University | Zhao W.,Dalian University of Technology | Wu S.,Zhengzhou University
International Journal of Network Security | Year: 2013

To guarantee secure communications in multi-server environment, Lee et al. proposed a dynamic ID-based remote user authentication scheme using smart card. They also demonstrated that their scheme could withstand various attacks. This paper reviews Lee et al.'s scheme and provides a security analysis on it. Our analysis shows that Lee et al. is vulnerable to the impersonation attack, the server spoofing attack, and the off-line password guessing attack.


Zhang W.,Zhengzhou University | Zhang W.,University of Minnesota | Truhlar D.G.,University of Minnesota | Tang M.,Zhengzhou University
Journal of Chemical Theory and Computation | Year: 2014

Vanadium dimer is a notoriously difficult case for Kohn-Sham (KS) density functional theory with currently available approximations to the exchange-correlation (xc) functionals, and many approximate xc functionals yield an exceedingly large error in the calculated bond energy. In this paper, we first test the bond energies estimated by 43 xc functionals and the Hartree-Fock (HF) method. The results further confirm the large errors and show that, with the experimental bond energy being 64.2 kcal/mol, the KS calculations give predictions all over the map with errors ranging from -61.5 to +60.5 kcal/mol, and the HF method performs much worse with an error of -124.4 kcal/mol! The reason for these very large errors is examined in this article by analyzing the atomic and molecular orbital energies calculated by various xc functionals. The results show that the errors in estimates of the bond energy of vanadium dimer can primarily be related to the calculated energy gap between the 4s and 3d z2 atomic orbitals of the vanadium atom and especially to the 3d z2 orbital energy. This interesting relation between the errors in the calculated bond energy and the magnitudes of the single-particle orbital energies provides a constructive alternative to the common but more sterile explanation that it is the static correlation energy due to multicenter left-right correlation that makes the vanadium dimer and many other transition metal compounds so difficult for Kohn-Sham calculations. One of the most important factors in determining the critical atomic orbital energy is the amount of nonlocal HF exchange that is included in the xc functional, but it is still difficult to explain why different local functionals (functionals with no HF exchange) yield quite different results. We conclude that improving calculations of orbital energies of atoms may provide a route to improving the accuracy of theoretical predictions of molecular bond energies for systems containing metal atoms. © 2014 American Chemical Society.


Gong Y.,Wuhan University | Gong Y.,Miami University Ohio | Zhou Q.,Miami University Ohio | Zhou Q.,Zhengzhou University
Geophysical Research Letters | Year: 2011

We report the analysis of the terdiurnal tide in the meridional wind from 90 to 350 km at a low latitude station. Our data is based on nine days of consecutive observation made by the Arecibo incoherent scatter radar during January 14-23, 2010. The terdiurnal tide is observed to be prominent at E-region heights in the first four days (Jan. 14-18) and at the F-region heights in the last five days (Jan. 18-23). The terdiurnal tide is among the two strongest tidal components in both regions. The vertical wavelength of the terdiurnal tide is about 100 km, and 950 km, for the altitude range of 128 to 142 km, and 180 to 320 km, respectively. The F-region terdiurnal tide amplitude is found to be well correlated with the background meridional wind in the lower F-region. Our analysis does not reveal any evidence that non-linear interaction between diurnal and semidiurnal tides is important for the F-region terdiurnal tide. Copyright 2011 by the American Geophysical Union.


He D.,Wuhan University | Wu S.,Zhengzhou University
Wireless Personal Communications | Year: 2013

Recently, Wang and Ma (Wireless Pers Commun, 2012. doi: 10.1007/s11277-011-0456-7) proposed a smart card based authentication scheme for multi-server environment. They also demonstrated that their scheme could overcome various attacks. In this paper, the security of Wang et al.'s scheme is evaluated. Our analysis shows their scheme is vulnerable to the server spoofing attack, the impersonation attack, the privileged insider attack and the off-line password guessing attack. © 2012 Springer Science+Business Media, LLC.


Lu D.,Zhengzhou University | Ma J.,Zhengzhou University | Guo M.,Chinese PLA General Hospital | Guo M.,Johns Hopkins University
Discovery Medicine | Year: 2014

Esophageal squamous cell carcinoma (ESCC) is one of the most malignant diseases and the five year survival rate remains less than 10%. RASSF10 is a newly identified member of the Ras-association family, but the regulation and the function of RASSF10 in ESCC remain unclear. Research methodologies such as methylation specific PCR (MSP), semi-quantitative RT-PCR, immunohistochemistry, Sodium bisulfite sequencing, and colony formation assay were utilized in this investigation. Loss of RASSF10 expression was found in KYSE150 cells and reduced expression was found in KYSE70 and KYSE180 cells. Expression of RASSF10 was found in KYSE140, KYSE450, KYSE510, TE1, TE3, and TE8 cell lines. Complete methylation was found in KYSE30 and KYSE150 cells, partial methylation was found in KYSE70, KYSE180, KYSE510, and TE1, and unmethylation was found in KYSE140, KYSE450, TE3, and TE8. Re-expression or increased expression was induced by 5-Aza-dC treatment. RASSF10 was methylated in 44.3% primary esophageal squamous cell carcinoma. RASSF10 inhibits cell proliferation and induces G2/M phase arrest in esophageal cancer cells. In conclusion: RASSF10 was frequently methylated in human esophageal squamous cell carcinoma and expression of RASSF10 was regulated by promoter region hypermethylation. RASSF10 may serve as a tumor suppressor of esophageal cancer. © Discovery Medicine.


Bai J.,Zhengzhou University | Cui X.,Zhengzhou University | Cui X.,Huaqiao University | Wang H.,Zhengzhou University | Wu Y.,Zhengzhou University
Chemical Communications | Year: 2014

An efficient protocol for copper-catalyzed reductive cross-coupling of aryl sulfonyl chlorides with H-phosphonates has been developed. The various S-aryl phosphorothioates were afforded in up to 86% yield for 20 examples. This protocol features high efficiency, wide functional group tolerance, commercially available aryl sulfonyl chlorides as starting materials and base-free conditions. This journal is © the Partner Organisations 2014.


Bihaqi S.W.,University of Rhode Island | Huang H.,Zhengzhou University | Wu J.,University of Rhode Island | Zawia N.H.,University of Rhode Island
Journal of Alzheimer's Disease | Year: 2011

The beginnings of late onset Alzheimer's disease (LOAD) are still unknown; however, the progressive and latent nature of neurodegeneration suggests that the triggering event occurs earlier in life. Aging primates exposed to lead (Pb) as infants exhibited an overexpression of the amyloid-β protein precursor (AβPP), amyloid-β (Aβ) and enhanced pathologic neurodegeneration. In this study, we measured the latent expression of a wide array of brain-specific genes and explored whether epigenetic pathways mediated such latent molecular and pathological changes. We analyzed the levels of proteins associated with DNA methylation, i.e., DNA methyltransferase 1 (Dnmt1), DNA methyltransferase3a (Dnmt3a), methyl-CpG binding protein-2 (MeCP2) and those involved in histone modifications (acetylated and methylated histones). We monitored the expression profiles of these intermediates across the lifespan and analyzed their levels in 23-year-old primate brains exposed to Pb as infants. Developmental Pb exposure altered the gene expression of the arrayed genes, which were predominately repressed, with fewer upregulated genes. The latent induction and repression of genes was accompanied by a significant decrease in the protein levels of Dnmts, MeCP2, and proteins involved in histone modifications. The attenuation of DNA methylation enzymes is consistent with hypomethylating effects, which promote upregulation of the genes, while the alterations in the histone modifiers are associated with the repression of genes. Hence, we deduce that early life exposure to Pb can reprogram gene expression resulting in both upregulation and down-regulation of genes through alternate epigenetic pathways contributing to an enhancement in neurodegeneration in old age. © 2011-IOS Press and the authors. All rights reserved.


Zhu C.,Zhengzhou University | Yi M.,Zhengzhou University | Wei D.,Zhengzhou University | Chen X.,Zhengzhou University | And 3 more authors.
Organic Letters | Year: 2014

A highly efficient and concise one-pot strategy for the direct amination of quinoline N-oxides via copper-catalyzed dehydrogenative C-N coupling has been developed. The desired products were obtained in good to excellent yields for 22 examples starting from the parent aliphatic amines. This methodology provides a practical pathway to 2-aminoquinolines and features a simple system, high efficiency, environmental friendliness, low reaction temperature, and ligand, additives, base, and external oxidant free conditions. © 2014 American Chemical Society.


Zhong W.,Zhengzhou University | Fan C.G.,Hefei University of Technology | Ji J.,Hefei University of Technology | Yang J.P.,Nanyang Fire Detachment
International Journal of Heat and Mass Transfer | Year: 2013

The influence of longitudinal wind on natural ventilation with vertical shaft in a road tunnel fire was investigated numerically by Large Eddy Simulation. The smoke flow characteristics of a road tunnel fire under the combined function of longitudinal wind and stack effect of shaft were analyzed. Results show that the stack effect, plug-holing and boundary layer separation are the dominating factors on the natural ventilation performance. Plug-holing occurs at small longitudinal velocity and causes the reduction of exhaust effect. At high longitudinal velocity, the driving force of smoke exhausting is weak and obvious boundary layer separation occurs, resulting in a poor exhaust capacity. There is a critical value of longitudinal wind velocity, in which a better smoke exhausting effect can be obtained. © 2012 Elsevier Ltd. All rights reserved.


Xu Z.,Zhengzhou University | Xu Z.,Henan Polytechnic University | Wang Q.,Henan Polytechnic University | Li H.,Zhengzhou University | And 4 more authors.
Chemical Communications | Year: 2012

[8+12]-metallamacrocycle-based 3D frameworks {[Cu4(pbt) 2(SO4)2(DMF)2(CH3OH)] ·7H2O·DMF}n (1) and [12]-macrocycle 3D {[Cu2(pbt)(SO4)(DMSO)(CH3OH) 2]·5H2O·CH3OH}n (2) have been obtained. Both complexes display antiferromagnetic couplings and high catalytic activity in the oxidative coupling reaction of 1-ethynylbenzene and oxazolidin-2-one. This journal is © 2012 The Royal Society of Chemistry.


Xu Z.,Zhengzhou University | Xu Z.,Henan Polytechnic University | Meng W.,Zhengzhou University | Li H.,Zhengzhou University | And 3 more authors.
Inorganic Chemistry | Year: 2014

A FeII-based metal-organic framework (MOF), {[Fe 2(pbt)2(H2O)2]·2H 2O}n, undergoes an irreversible dehydration, which triggers changes in the catalytic and magnetic properties of the MOF. These property changes are attributed to the high-spin to low-spin transition of 7.1% center FeII, which is demonstrated by 57Fe Mössbauer, X-ray photoelectron spectroscopy, and UV/vis absorption spectra. © 2014 American Chemical Society.


Pi C.,Zhengzhou University | Li Y.,Zhengzhou University | Cui X.,Zhengzhou University | Cui X.,Huaqiao University | And 3 more authors.
Chemical Science | Year: 2013

A novel strategy of dehydrogenative Heck reaction controlled by redox process of ferrocene has been developed. Commercially available chiral amino acid as ligand realized asymmetric dehydrogenative Heck reaction, leading to planar-chiral ferrocene derivatives with excellent enantioselectivity and in good to excellent yields (up to 99% ee and 98% yield). © 2013 The Royal Society of Chemistry.


Feng X.,Luoyang Normal University | Ma L.-F.,Luoyang Normal University | Liu L.,Zhengzhou University | Wang L.-Y.,Luoyang Normal University | And 3 more authors.
Crystal Growth and Design | Year: 2013

The combination of lanthanide and zinc nitrates reaction with a rigid 1-H-2-methyl-4,5-imidazole-dicarboxylic acid yields a new zinc complex of Zn(Hmimda)2·2H2O (1) and a family of heteronuclear polymers, namely, {[Ln2Zn2(μ3-Hmimda) 2 (μ3-mimda)2·4H2O] ·mH2O}n, Ln = Sm, m = 2 (2), Ln = Eu, m = 3 (3), Ln = Gd, m = 2 (4), Ln = Tb, m = 3 (5), Ln = Dy, m = 3 (6) (H3mimda = 1H-2-methyl-4,5-imidazole-dicarboxylic acid). Structural analysis shows that complexes 2-6 are isostructural and all crystallize in the monoclinic system, except for a slight disparity for 2. They have an extended nonporous structure constructed from tetraheteronuclear edifices with new framework topology, in which the Ln(III)-Zn square tetranuclear complexes act as the second building unit, which are further interconnected by the Hmimda to afford a two-dimensional corrugated layer. Both compounds 5 and 6 exhibit characteristic fluorescence in the visible region. The variable temperature magnetic investigations indicate that the magnetic interactions are mainly ascribed to depopulation of the Stark levels or possible antiferromagnetic couplings. The Dy(III)-Zn(II) compound exhibits possible ferromagnetic couplings and slow magnetic relaxation behavior of a single-molecule magnet nature. © 2013 American Chemical Society.


Yang Z.,Henan Normal University | Yang Z.,Henan Key Laboratory of Photovoltaic Materials | Wang Q.,Henan Normal University | Wei S.,Henan Normal University | And 2 more authors.
Journal of Physical Chemistry C | Year: 2010

The interaction of a water molecule with the (111) surfaces of stoichiometric and reduced ceria is investigated using first principle density functional theory with the inclusion of the on-site Coulomb interaction (DFT+U). It is found that on the stoichiometric ceria(111) surface, the water molecule is adsorbed spontaneously through single hydrogen bond configuration. In contrast, on the lightly reduced ceria(111), there exist both molecular adsorption (no-H-bond configuration) and dissociative adsorption (surface hydroxyl) modes. It is obvious that oxygen vacancies can enhance the interaction of water with the substrate. Phase diagrams for stoichiometric and reduced ceria(111) surfaces in equilibrium with water vapor in the complete range of experimentally accessible gas phase condition are calculated and discussed combining the DFT results and thermodynamics data using the ab initio atomistic thermodynamic method. We present a detailed analysis of the stability of the water-ceria system as a function of the ambient conditions, and focus on two important surface processes for water adsorption on the stoichiometric and on the lightly reduced surfaces, respectively. © 2010 American Chemical Society.


Cui J.,Zhengzhou University | Wang Z.Q.,Zhengzhou University | Xu B.L.,Center for Disease Control of Henan Province
Acta Tropica | Year: 2011

The endemic foci of human trichinellosis are mainly located in southwestern China. Seroepidemiological surveys of Trichinella spiralis infection in humans were carried out in 10 out of 34 Provinces/Autonomous Regions/Municipals (P/A/M) of China during 2004-2009. The overall seroprevalence was 3.19% (3198/100,282). The highest seroprevalences were mainly located in western China: 8.43% in Yunnan, 6.37% in Inner Mongolia and 5.35% in Sichuan. The seroprevalence of Trichinella infection in humans was related to the habit of eating meat and differed among nationalities. From 2004 to 2009, 15 outbreaks of human trichinellosis, consisting of 1387 cases and four deaths, were reported in the three southwestern-most P/A of China (nine outbreaks in Yunnan, two in Sichuan and four in Tibet), where ethnic groups routinely eat raw meat. Pork is the predominant source of outbreaks of human trichinellosis in China. Out of 15 outbreaks, 12 (85.71%) were caused by eating raw or undercooked pork, and 2 (13.33%) resulted from the consumption of raw wild boar, suggesting the significance of game meat as a source of infection for human trichinellosis. An outbreak of imported trichinellosis involving 49 cases in Yunnan during December 2006 from Laos is the first recorded outbreak of imported trichinellosis in China, but the source of that outbreak could not be identified. The mandatory inspection of pork should be further strengthened in southwestern China. © 2011.


Zhou Y.,Shangqiu Normal University | Dong H.,Zhengzhou University | Liu L.,Shangqiu Normal University | Li M.,Shangqiu Normal University | And 3 more authors.
Sensors and Actuators, B: Chemical | Year: 2014

A simple and rapid colorimetric sensor for Hg2+ in aqueous solution was developed based on the observation that the detection target, Hg2+, could inhibit the aggregation of gold nanoparticles (AuNPs) induced by 4-mercaptophenylboronic acid (MPBA). Without a potent competitor, MPBA can bind to the AuNPs via Au-S bonds and induces the aggregation of AuNPs by self-dehydration condensation of boronic acid groups, resulting in a visible color change of the AuNPs solution from red to blue. In the presence of Hg 2+, the thiol group of MPBA preferentially binds to Hg2+ and thus MPBA loses the ability to induce aggregation of AuNPs, which is mechanism behind the color change of the solution from blue to red. Our results showed that the absorbance ratio (A520/A690) was linear with the Hg2+ concentration in the range of 0.01-5 μM (R = 0.998). The detection limit of the colorimetric sensor was 8 nM (S/N = 3). The colorimetric changes of the sensor were extremely specific for Hg2+ and no obvious color change was observed when adding other competitive metal ions in parallel. Further promising results from Hg2+ detection in water samples indicated that our newly developed assay might open a new assay avenue for Hg2+ determination. © 2014 Elsevier B.V. All rights reserved.


Zhou Y.,Shangqiu Normal University | Dong H.,Zhengzhou University | Liu L.,Shangqiu Normal University | Liu J.,Shangqiu Normal University | And 2 more authors.
Biosensors and Bioelectronics | Year: 2014

A novel potentiometric approach was described for probing sialic acid (SA) using a poly(anilineboronic acid)/graphene modified glassy carbon (GC) electrode. The proposed electrode was prepared by electrodeposition of reduced graphene oxide (ERGO) at a GC electrode and then coated with a poly(anilineboronic acid) (PABA) film by electropolymerization of its monomer. Principle of SA detection at the PABA/ERGO/GC electrode was ascribed to a reversible and covalent boronic acid-diol binding which was sensitive to the electrochemical potential of the prepared sensor. The graphene layer introduced on the electrode surface was shown to dramatically improve the sensitivity of the sensor response. Under optimum conditions, the proposed sensor exhibited low detection limit of 0.8. μM with a wide linear range of 2. μM-1.38. mM, high stability, good regeneration, and remarkable selectivity. For the analysis of SA in human blood serum, the high accuracy and good recoveries revealed the great potential in the practical applications. © 2014 Elsevier B.V.


Chen X.-Y.,Zhengzhou University | He Q.-Y.,Zhengzhou University | Guo M.-Z.,Chinese PLA General Hospital
World Journal of Gastroenterology | Year: 2012

AIM: To explore epigenetic changes in the gene encoding X chromosome-linked inhibitor of apoptosis-associated factor 1 (XAF1) during esophageal carcinogenesis. METHODS: Methylation status of XAF1 was detected by methylation-specific polymerase chain reaction (MSP) in four esophageal cancer cell lines (KYSE30, KYSE70, BIC1 and partially methylated in TE3 cell lines), nine cases of normal mucosa, 72 cases of primary esophageal cancer and matched adjacent tissue. XAF1 expression was examined by semi-quantitative reverse transcriptional polymerase chain reaction and Western blotting before and after treatment with 5-azadeoxycytidine (5-aza-dc), a demethylating agent. To investigate the correlation of XAF1 expression and methylation status in primary esophageal cancer, immunohistochemistry for XAF1 expression was performed in 32 cases of esophageal cancer and matched adjacent tissue. The association of methylation status and clinicopathological data was analyzed by logistic regression. RESULTS: MSP results were as follows: loss of XAF1 expression was found in three of four esophageal cell lines with promoter region hypermethylation (completely methylated in KYSE30, KYSE70 and BIC1 cell lines and partially in TE3 cells); all nine cases of normal esophageal mucosa were unmethylated; and 54/72 (75.00%) samples from patients with esophageal cancer were methylated, and 25/72 (34.70%) matched adjacent tissues were methylated (75.00% vs 34.70%, χ 2 = 23.5840, P = 0.000). mRNA level of XAF1 measured with semi-quantitative reverse transcription polymerase chain reaction was detectable only in TE3 cells, and no expression was detected in KYSE30, KYSE70 or BIC1 cells. Protein expression was not observed in KYSE30 cells by Western blotting before treatment with 5-aza-dc. After treatment, mRNA level of XAF1 was detectable in KYSE30, KYSE70 and BIC1 cells. Protein expression was detected in KYSE30 after treatment with 5-aza-dc. Immunohistochemistry was performed on 32 cases of esophageal cancer and adjacent tissue, and demonstrated XAF1 in the nucleus and cytoplasm. XAF1 staining was found in 20/32 samples of adjacent normal tissue but was present in only 8/32 samples of esophageal cancer tissue χ 2= 9.143, P = 0.002). XAF1 expression was decreased in cancer samples compared with adjacent tissues. In 32 cases of esophageal cancer, 24/32 samples were methylated, and 8/32 esophageal cancer tissues were unmethylated. XAF1 staining was found in 6/8 samples of unmethylated esophageal cancer and 2/24 samples of methylated esophageal cancer tissue. XAF1 staining was inversely correlated with XAF1 promoter region methylation (Fisher's exact test, P = 0.004). Regarding methylation status and clinicopathological data, no significant differences were found in sex, age, tumor size, tumor stage, or metastasis with respect to methylation of XAF1 for the 72 tissue samples from patients with esophageal cancer. CONCLUSION: XAF1 is frequently methylated in esophageal cancer, and XAF1 expression is regulated by promoter region hypermethylation. © 2012 Baishideng. All rights reserved.


Liu Z.,Zhengzhou University | Gong R.,Brown University
American Journal of Kidney Diseases | Year: 2015

Preventing acute kidney injury (AKI) in high-risk patients following medical interventions is a paramount challenge for clinical practice. Recent data from animal experiments and clinical trials indicate that remote ischemic preconditioning, represented by limb ischemic preconditioning, confers a protective action on the kidney. Ischemic preconditioning is effective in reducing the risk for AKI following cardiovascular interventions and the use of iodinated radiocontrast media. Nevertheless, the underlying mechanisms for this protective effect are elusive. A protective signal is conveyed from the remote site undergoing ischemic preconditioning, such as the limb, to target organs, such as the kidney, by multiple potential communication pathways, which may involve humoral, neuronal, and systemic mechanisms. Diverse transmitting pathways trigger a variety of signaling cascades, including the reperfusion injury salvage kinase and survivor activating factor enhancement pathways, all of which converge on glycogen synthase kinase 3β (GSK3β). Inhibition of GSK3β subsequent to ischemic preconditioning reinforces the Nrf2-mediated antioxidant defense, diminishes the nuclear factor-κB-dependent proinflammatory response, and exerts prosurvival effects ensuing from the desensitized mitochondria permeability transition. Thus, therapeutic targeting of GSK3β by ischemic preconditioning or by pharmacologic preconditioning with existing US Food and Drug Administration-approved drugs having GSK3β-inhibitory activities might represent a pragmatic and cost-effective adjuvant strategy for kidney protection and prophylaxis against AKI. © 2015 National Kidney Foundation, Inc.


Yang G.,University of Puerto Rico at San Juan | Yang G.,Zhengzhou University | Baran P.,University of Puerto Rico at San Juan | Baran P.,Juniata College | And 2 more authors.
Crystal Growth and Design | Year: 2013

The interplay of argentophilic and dipolar (π-acid⋯base) interactions, on one hand, and the presence or absence of interstitial solvent molecules, on the other, determines the supramolecular organization of trinuclear silver-pyrazolato complexes in the solid state. The crystal structures of one gold and six silver metallacyclic complexes of the type [MI(μ-pz*)]3, where pz* are the substituted pyrazolato anions 3,5-Ph2-pz, 3-Me-5-Ph-pz, 4-Br-3,5-Ph 2-pz, 4-Br-3-tBu-pz and 3-(o-Cl-C6H 4)-pz and M = Ag and Au, are discussed in the context of their supramolecular organization. Two silver complexes, for which the π-acid character of their Ag3-faces is maximized by their peripheral electron-withdrawing substituents, show crystal packing dominated by short Ag3⋯Br contacts, the first structural manifestation of supramolecular structure via dipolar interactions involving the tunable π-acidity of the Ag3-face. © 2012 American Chemical Society.


Wei D.,Zhengzhou University | Wei D.,University of Kentucky | Fang L.,University of Kentucky | Tang M.,Zhengzhou University | Zhan C.-G.,University of Kentucky
Journal of Physical Chemistry B | Year: 2013

Proteasome is the major component of the crucial non-lysosomal protein degradation pathway in the cells, but the detailed reaction pathway is unclear. In this study, first-principles quantum mechanical/molecular mechanical free energy calculations have been performed to explore, for the first time, possible reaction pathways for proteasomal proteolysis/hydrolysis of a representative peptide, succinyl-leucyl-leucyl-valyl-tyrosyl-7-amino-4-methylcoumarin (Suc-LLVY-AMC). The computational results reveal that the most favorable reaction pathway consists of six steps. The first is a water-assisted proton transfer within proteasome, activating Thr1-Oγ. The second is a nucleophilic attack on the carbonyl carbon of a Tyr residue of substrate by the negatively charged Thr1-Oγ, followed by the dissociation of the amine AMC (third step). The fourth step is a nucleophilic attack on the carbonyl carbon of the Tyr residue of substrate by a water molecule, accompanied by a proton transfer from the water molecule to Thr1-Nz. Then, Suc-LLVY is dissociated (fifth step), and Thr1 is regenerated via a direct proton transfer from Thr1-Nz to Thr1-Oγ. According to the calculated energetic results, the overall reaction energy barrier of the proteasomal hydrolysis is associated with the transition state (TS3b) for the third step involving a water-assisted proton transfer. The determined most favorable reaction pathway and the rate-determining step have provided a reasonable interpretation of the reported experimental observations concerning the substituent and isotopic effects on the kinetics. The calculated overall free energy barrier of 18.2 kcal/mol is close to the experimentally derived activation free energy of ∼18.3-19.4 kcal/mol, suggesting that the computational results are reasonable. © 2013 American Chemical Society.


Yang K.,Beijing Institute of Technology | An J.,Beijing Institute of Technology | Bu X.,Beijing Institute of Technology | Sun G.,Zhengzhou University
IEEE Transactions on Vehicular Technology | Year: 2010

Determining the location of a source from its emissions has gained considerable interest over the past few years. In this paper, by utilizing the time difference of arrival (TDOA) of a signal received at spatially separated sensors, a novel algorithm for source location is proposed. The algorithm is based on the constrained total least-squares (CTLS) technique, and an iterative technique based on Newton's method is utilized to give a numerical solution. By using a perturbation analysis, the bias and covariance of the proposed CTLS algorithm are also derived. Simulation results show that the proposed CTLS algorithm gives sufficient accuracy with lower computational cost, and more importantly, it is more robust to large measurement noise than the compared algorithms. © 2006 IEEE.


Fu W.,Luoyang Normal University | Xu F.,Zhengzhou University | Fu Y.,Luoyang Normal University | Xu C.,Luoyang Normal University | And 2 more authors.
European Journal of Organic Chemistry | Year: 2014

A mild and efficient PhI(OAc)2-mediated trifluoromethylation reaction of N-arylacrylamides with TMSCF3 under metal-free conditions was developed. This method provides convenient access to a variety of useful CF3-containing oxindoles in moderate to good yields. © 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.


Lu Q.,Soochow University of China | Lu Q.,Tufts University | Zhu H.,Beijing Institute of Technology | Zhang C.,Soochow University of China | And 3 more authors.
Biomacromolecules | Year: 2012

Silkworms and spiders generate fibers that exhibit high strength and extensibility. The underlying mechanisms involved in processing silk proteins into fiber form remain incompletely understood, resulting in the failure to fully recapitulate the remarkable properties of native fibers in vitro from regenerated silk solutions. In the present study, the extensibility and high strength of regenerated silks were achieved by mimicking the natural spinning process. Conformational transitions inside micelles, followed by aggregation of micelles and their stabilization as they relate to the metastable structure of silk are described. Subsequently, the mechanisms to control the formation of nanofibrous structures were elucidated. The results clarify that the self-assembly of silk in aqueous solution is a thermodynamically driven process where kinetics also play a key role. Four key factors, molecular mobility, charge, hydrophilic interactions, and concentration underlie the process. Adjusting these factors can balance nanostructure and conformational composition, and be used to achieve silk-based materials with properties comparable to native fibers. These mechanisms suggest new directions to design silk-based multifunctional materials. © 2012 American Chemical Society.


Wei D.,Zhengzhou University | Wei D.,University of Kentucky | Lei B.,Northwest University, China | Lei B.,University of Kentucky | And 2 more authors.
Journal of the American Chemical Society | Year: 2012

First-principles quantum mechanical/molecular mechanical free energy calculations have been performed to provide the first detailed computational study on the possible mechanisms for reaction of proteasome with a representative peptide inhibitor, Epoxomicin (EPX). The calculated results reveal that the most favorable reaction pathway consists of five steps. The first is a proton transfer process, activating Thr1-O γ directly by Thr1-N z to form a zwitterionic intermediate. The next step is nucleophilic attack on the carbonyl carbon of EPX by the negatively charged Thr1-O γ atom, followed by a proton transfer from Thr1-N z to the carbonyl oxygen of EPX (third step). Then, Thr1-N z attacks on the carbon of the epoxide group of EPX, accompanied by the epoxide ring-opening (S N2 nucleophilic substitution) such that a zwitterionic morpholino ring is formed between residue Thr1 and EPX. Finally, the product of morpholino ring is generated via another proton transfer. Noteworthy, Thr1-O γ can be activated directly by Thr1-N z to form the zwitterionic intermediate (with a free energy barrier of only 9.9 kcal/mol), and water cannot assist the rate-determining step, which is remarkably different from the previous perception that a water molecule should mediate the activation process. The fourth reaction step has the highest free energy barrier (23.6 kcal/mol) which is reasonably close to the activation free energy (∼21-22 kcal/mol) derived from experimental kinetic data. The obtained novel mechanistic insights should be valuable for not only future rational design of more efficient proteasome inhibitors but also understanding the general reaction mechanism of proteasome with a peptide or protein. © 2012 American Chemical Society.


Wei D.,Zhengzhou University | Wei D.,University of Kentucky | Tang M.,Zhengzhou University | Zhan C.-G.,University of Kentucky
Organic and Biomolecular Chemistry | Year: 2015

In this study, molecular dynamics (MD) simulations and first-principles quantum mechanical/molecular mechanical free energy (QM/MM-FE) calculations have been performed to uncover the fundamental reaction pathway of proteasome with a representative inhibitor syringolin A (SylA). The calculated results reveal that the reaction process consists of three steps. The first step is a proton transfer process, activating Thr1-Oγ directly by Thr1-Nz to form a zwitterionic intermediate. The next step is a nucleophilic attack on the olefin carbon of SylA by the negatively charged Thr1-Oγ atom. The last step is a proton transfer from Thr1-Nz to another olefin carbon of SylA to complete the inhibition reaction process. The calculated free energy profile demonstrates that the second step should be the rate-determining step and has the highest free energy barrier of 24.6 kcal mol-1, which is reasonably close to the activation free energy (∼22.4-23.0 kcal mol-1) derived from the available experimental kinetic data. In addition, our computational results indicate that no water molecule can assist the rate-determining step, since the second step is not involved in a proton transfer process. The obtained mechanistic insights should be valuable for understanding the inhibition process of proteasome by SylA and structurally related inhibitors at a molecular level, and thus provide a solid mechanistic base and valuable clues for future rational design of novel, more potent inhibitors of proteasome. © The Royal Society of Chemistry.


Ma L.-F.,Luoyang Normal University | Li X.-Q.,Luoyang Normal University | Li X.-Q.,Zhengzhou University | Wang L.-Y.,Luoyang Normal University | Hou H.-W.,Zhengzhou University
CrystEngComm | Year: 2011

Four new NiII and CoII complexes, [Ni(5-Br-ip)(bip)(H2O)]n (1), [Ni(5-Br-ip)(bib)] n (2), [Co(5-Br-ip)(bip)]n (3) and [Co(5-Br-ip)(bip)] n (4) (5-Br-H2ip = 5-bromoisophthalic acid, bip = 1,3-bis(imidazol)propane, bib = 1,4-bis(imidazol)butane), have been synthesized and structurally characterized by elemental analysis, IR and single-crystal X-ray diffraction. Complex 1 features a 2D double layer extended by the intermolecular hydrogen bonds between 2D layers. Complex 2 shows a 2-fold interpenetrating 3D → 3D network based on the dinuclear Ni(ii) units. Complexes 3 and 4 can be regarded as supramolecular structural isomers. Isomer 3 possesses a 1D chain structure with binuclear Co units as subunits. Isomer 4 shows a 3D network and can be reduced to a 4-connected net with the (6 5.8) topology. The structural differences indicate that the backbone of the organic N-donor ligands and the nature of the metal ions play important roles in governing the structures of such metal-organic coordination architectures. Moreover, the magnetic properties of complexes 2 and 3 were also studied in 2-300 K. © The Royal Society of Chemistry 2011.


Han X.,Beijing Institute of Technology | Pan E.,Zhengzhou University
Mechanics of Materials | Year: 2012

In this article, we analyze the coupled elastic, electric and magnetic fields produced by an arbitrary three-dimensional dislocation loop in general anisotropic magneto-electro-elastic materials. We first extend the anisotropic elastic formulae of dislocations to the corresponding magneto-electro-elastic material system, including a general line-integration solution and the solution of a straight-line segment of dislocation. We then develop a new line-integral solution for the extended displacement field as well as the extended stress field. Furthermore, we derive analytical expressions for some useful parametric dislocation curves, such as the elliptic arc and straight line. Our solutions contain the piezoelectric, piezomagnetic, and purely anisotropic elastic solutions as special cases. As numerical examples, the fields produced by elliptic, hexagonal and cardioid shape dislocation loops in both piezoelectric crystals and magneto-electro-elastic materials are calculated. The efficiency and accuracy of different integral solutions of dislocation loops are compared and discussed. More important, the coupling magneto-electro-elastic effect is illustrated. It is shown that, due to the coupling among the elastic, electric and magnetic fields, an elastic dislocation, an electric potential discontinuity, or a magnetic potential discontinuity can induce all the elastic, electric and magnetic fields and that the coupling effect could be very strong near the dislocation loop line. © 2012 Elsevier Ltd.


Yu L.,Zhengzhou University | Zhang Y.,Zhengzhou University | Zhang Y.,University of New South Wales | Zhang H.,Zhengzhou University | Liu J.,Zhengzhou University
Desalination | Year: 2015

A positively charged nanomaterial was prepared adopting the graft polymerization of ionic liquid monomers on halloysite nanotubes (HNTs) via reverse atom transfer radical polymerization (RATRP). A novel and facile organic-inorganic hybrid molecular separation membrane was then fabricated by the incorporation of modified HNTs via phase inversion method. This hybrid membrane was investigated in terms of morphology structure, hydrophilicity, thermal, mechanical and electrical properties, and separation performances. The results revealed that the hybrid membranes represented thickened and loosened skin layer, enhanced surface hydrophilicity and water flux, as well as good thermal and mechanical properties. Most importantly, the hybrid membranes showed stabilized rejection for Reactive Black 5 (above 90%) and Reactive Red 49 (80%-90%), whereas the rejection for sorts of salts declined to below 10% indicating a potential molecular separation characteristic for dye desalination. © 2014 Elsevier B.V.


Xing L.,Zhengzhou University | Guo N.,Zhengzhou University | Zhang Y.,Zhengzhou University | Zhang Y.,University of New South Wales | And 2 more authors.
Separation and Purification Technology | Year: 2015

Silica spheres in nanoscale were prepared via sol-gel method and then sodium 4-styrene sulfonate was grafted onto the surfaces of SiO2 (PSS-SiO2) by surface-initiated atom transfer radical polymerization (SI-ATRP). Then, a negatively charged loose SiO2-PSS/polyethersulfone (PES) nanofiltration membrane with high flux was fabricated via phase inversion method. FT-IR and TEM results showed that SiO2 nanoparticles were synthesized and modified successfully. GPC results further proved the "living"/controlled behavior of SI-ATRP. The morphology, hydrophilicity of the membranes were investigated by SEM, static water contact angle and water ratio. The results revealed that the surface hydrophilicity and water permeability of hybrid membranes were greatly improved after adding SiO2-PSS and thus may enhance fouling resistance to a certain extent. The salt permeation and separation of dye/salt mixture of the hybrid membranes were significantly superior to the pure PES membrane, and the order of permeation for different salt solutions was NaCl > MgCl2 > MgSO4 > Na2SO4. When the content of SiO2-PSS was 3.0 wt%, the hybrid membrane showed optimal performance with IEC value of 0.07 mmol/g and pure water flux of 269.5 L m-2 h-1 and the rejections for all types of salts declined to under 11%. The above results indicated that SiO2-PSS incorporated into PES matrix played an important role in enhancing the performance of NF membranes, which may possess a significant impact on the application in dye purification and desalination. © 2015 Elsevier B.V. All rights reserved.


Yu B.,Zhengzhou University | Yu Z.,Southern Medical University | Qi P.-P.,Zhengzhou University | Yu D.-Q.,Zhengzhou University | Liu H.-M.,Zhengzhou University
European Journal of Medicinal Chemistry | Year: 2015

The identification of novel anticancer agents with high efficacy and low toxicity has always been an intriguing topic in medicinal chemistry. The unique structural features of spirooxindoles together with diverse biological activities have made them promising structures in new drug discovery. Among spirooxindoles, CFI-400945 holds its promise as the first potent PLK4 inhibitor, the fumarate of CFI-400945 has entered phase I clinical trials for the treatment of solid tumors. However, questions remain as to whether PLK4 is the only relevant therapeutic target for CFI-400945. To highlight this significant progress of CFI-400945 in last two years, this review centers on the identification from a focused kinase library, structural optimizations and strategies involved, structure-activity relationships, modes of action, target validation, chemical synthesis and, more importantly, the kinase selectivity between PLK4 and other targets. © 2015 Elsevier Masson SAS.


Dong C.Y.,Beijing Institute of Technology | Pan E.,University of Akron | Pan E.,Zhengzhou University
Engineering Analysis with Boundary Elements | Year: 2011

In this paper, a boundary element method (BEM) is proposed to analyze the stress field in nanoinhomogeneities with surface/interface effect. To consider this effect, the continuity conditions along the internal interfaces between the matrix and inhomogeneities are modeled by the well-known GurtinMurdoch constitutive relation. In the numerical analysis, the interface elastic moduli and the geometry of the nanoscale inhomogeneity are varied to show their influence on the induced stress field. The interaction between nanoscale inhomogeneities and the effect of different geometric shapes of inhomogeneities, including ellipse, triangle, and square are also investigated for different interface material parameters. It is shown that the elastic field can be greatly influenced by the interfacial energy and geometry of nanoscale inhomogeneities. The proposed BEM formulation is very general, including the complete GurtinMurdoch model and is further convenient for arbitrary shapes of inhomogeneity. © 2011 Elsevier Ltd. All rights reserved.


Zhao B.,Luoyang Normal University | Zhu W.,Zhengzhou University
Chinese Journal of Organic Chemistry | Year: 2014

The main focus of this review is on the supramolecular calixarene-tetrathiafulvalene chemistry. The general aspects of molecular design of calixarene-tetrathiafulvalene systems are reviewed on the attachment of tetrathiafulvalene unit(s) on the calixarene framework through the upper rims or lower rims, and the structually related thiacalixarene and calixpyrroles and so on. This survey is also presented from the view of supamolecular application of calixarene-tetrathiafulvalene systems in electrochemically molecular recognition, ion-mediated electron transfer, molecular assembly, molecular switches and devices etc. © 2014 Chinese Chemical Society & SIOC, CAS


Yan Z.,Zhengzhou University | Zhang Q.,Zhengzhou University | Li W.,Zhengzhou University | Wang J.,Henan Normal University
Journal of Chemical and Engineering Data | Year: 2010

The interactions of glycyl dipeptides (2-[(2-aminoacetyl)amino]acetic acid (commonly known as glycylglycine), 2-[(2-aminoacetyl)amino]-3-methylbutanoic acid (commonly known as glycyl-l-valine), and (2S)-2-[(2-aminoacetyl)amino]-4- methylpentanoic acid (commonly known as glycyl-l-leucine)) with sodium dodecyl sulfate (SDS) as a function of temperature in aqueous solution have been investigated by a combination of density, conductivity, and fluorescence methods. The standard partial molar volume (V2,φo), standard partial molar volumes of transfer for dipeptide from water to aqueous SDS solutions (ΔtVo), partial molar expansibility (Eφo), and Heplers constant have been calculated from density data. Electrical conductivity was used to estimate the critical micellar concentration (cmc) and the thermodynamic parameters of micellization of SDS in aqueous peptide solutions. The change of micropolarity produced by the interaction was monitored by the measurement of emission intensity ratio between the first and the third bands (I1/I3) of pyrene fluorescence. The obtained data have been discussed in light of various interactions operating in the ternary system of peptide, water, and SDS. © 2010 American Chemical Society.


Xia C.,Henan Normal University | Xue B.,Henan Normal University | Wang T.,Henan Normal University | Peng Y.,Henan Normal University | Jia Y.,Zhengzhou University
Applied Physics Letters | Year: 2015

The electronic characteristics of arsenene-graphene van der Waals (vdW) heterostructures are studied by using first-principles methods. The results show that a linear Dirac-like dispersion relation around the Fermi level can be quite well preserved in the vdW heterostructures. Moreover, the p-type Schottky barrier (0.18 eV) to n-type Schottky barrier (0.31 eV) transition occurs when the interlayer distance increases from 2.8 to 4.5 Å, which indicates that the Schottky barrier can be tuned effectively by the interlayer distance in the vdW heterostructures. © 2015 AIP Publishing LLC.


Zhang G.P.,Renmin University of China | Zhang G.P.,Iowa State University | Qin Z.J.,Zhengzhou University
Physics Letters, Section A: General, Atomic and Solid State Physics | Year: 2010

The transport property of zigzag graphene nanoribbon (ZGNR) connected by two normal metal contacts is investigated by Landauer-Buttiker formula combined with transfer matrix method. In addition to even-odd parity, we found that the conductivity is completely determined by the width-to-length ratio. For certain wide ZGNR with even number carbon atoms in the width direction, the conductivity dependence on the length changes from linearly to inversely, when the length approaches the thermodynamic limit, as the transport property is quite different for different aspect of ZGNR. © 2010 Elsevier B.V.


Yu J.,Zhengzhou University | Sun R.,PLA Fourth Military Medical University | Zhao Z.,Chinese PLA General Hospital | Wang Y.,PLA Fourth Military Medical University
International Journal of Biological Macromolecules | Year: 2014

In the present study, the anticancer activity of Auricularia polytricha polysaccharides (APPs) towards A549 human lung cancer cells and its underlying mechanisms were investigated. APPs significantly inhibited the proliferation and DNA synthesis of A549 cells in a concentration-dependent manner. The compound also induced apoptosis in A549 cells by arresting cell cycle progression at the G0/G1 phase. Western blotting assay demonstrated that APPs significantly increased the expression of cyclin-dependent kinase (CDK) inhibitors p53 and p21, whereas the expression of cyclin A, cyclin D, and CDK2 were decreased by treatment with APPs. This apoptotic induction in APPs-treated A549 cells was also associated with the release of cytochrome c from mitochondria to cytosol, which in turn resulted in the activation of caspase-9 and -3, and the cleavage of poly (ADP-ribose) polymerase (PARP). Furthermore, the inhibitory effect of APPs on the growth in BALB/c-nu nude mice bearing A549 cells was also proven. These findings suggested that APPs might be a useful chemotherapeutic agent for lung cancer. © 2014 Elsevier B.V.


Bajaj A.,The Wright Center for Graduate Medical Education | Rathor P.,Zhengzhou University | Sehgal V.,The Common Wealth Medical College | Shetty A.,The Common Wealth Medical College
Heart and Lung: Journal of Acute and Critical Care | Year: 2015

The objective our meta-analysis is to update the evidence on the efficacy of noninvasive ventilation (NIV) compared with conventional oxygen therapy after planned extubation. We did a systematic literature review of database, including Pubmed, EMBASE, and Cochrane. We included randomized controlled trials comparing NIV with conventional oxygen therapy after planned extubation in medical intensive care unit (ICU) in our analysis. The results of our meta-analysis is consistent with the results of previous reviews and show that NIV decreased reintubation rate significantly as compared to conventional oxygen therapy in chronic obstructive pulmonary disease (COPD) and patients at high risk for extubation failure; COPD (RR, 0.33; 95% CI, 0.16-0.69; I2 = 0), high risk (RR, 0.47; 95% CI, 0.32-0.70; I2 = 0). However, in a mixed medical ICU population, there was no statistical difference of reintubation rate between the two groups (RR, 0.66; 95% CI, 0.25-1.73; I2 = 68%). Our study suggests that use of NIV after planned extubation significantly decreases the reintubation rate in COPD patients and patients at high risk for extubation failure, confirming the findings of previous reviews. There is no difference in the reintubation rate between the two groups in the mixed medical ICU population. © 2015 Elsevier Inc..


Zhang G.P.,Renmin University of China | Zhang G.P.,Iowa State University | Qin Z.J.,Zhengzhou University
Chemical Physics Letters | Year: 2011

Our investigation of the transport properties in graphene nanoribbon's (GNR) between quantum wire contact and decoupled chains contact confirms general predictions for the transport through GNR for specific geometries. We found that electron-hole (e-h) symmetry depends sensitively on the contact and interface. For quantum wire contacts, the breaking of e-h symmetry occurs in armchair GNR due to odd-numbered ring at the interface, and at Dirac point the maximal transmission corresponds to the momentum ky=2π33a (a = 0.142 ). The spatial density of states of armchair GNR is shown. Furthermore, the conductance at Dirac point is independent of contacts with dense modes. © 2011 Elsevier Inc. All rights reserved.


Wei D.,Zhengzhou University | Wei D.,University of Kentucky | Huang X.,University of Kentucky | Liu J.,University of Kentucky | And 2 more authors.
Biochemistry | Year: 2013

Possible reaction pathways for papain-catalyzed hydrolysis of N-acetyl-Phe-Gly 4-nitroanilide (APGNA) have been studied by performing pseudobond first-principles quantum mechanical/molecular mechanical-free energy (QM/MM-FE) calculations. The whole hydrolysis process includes two stages: acylation and deacylation. For the acylation stage of the catalytic reaction, we have explored three possible paths (A, B, and C) and the corresponding free energy profiles along the reaction coordinates. It has been demonstrated that the most favorable reaction path in this stage is path B consisting of two reaction steps: the first step is a proton transfer to form a zwitterionic form (i.e., Cys-S-/His-H+ ion-pair), and the second step is the nucleophilic attack on the carboxyl carbon of the substrate accompanied by the dissociation of 4-nitroanilide. The deacylation stage includes the nucleophilic attack of a water molecule on the carboxyl carbon of the substrate and dissociation between the carboxyl carbon of the substrate and the sulfhydryl sulfur of Cys25 side chain. The free energy barriers calculated for the acylation and deacylation stages are 20.0 and 10.7 kcal/mol, respectively. Thus, the acylation is rate-limiting. The overall free energy barrier calculated for papain-catalyzed hydrolysis of APGNA is 20.0 kcal/mol, which is reasonably close to the experimentally derived activation free energy of 17.9 kcal/mol. © 2013 American Chemical Society.


Ding S.-Z.,Zhengzhou University | Ding S.-Z.,University of Kentucky | Zheng P.-Y.,Zhengzhou University
Gut Pathogens | Year: 2012

Helicobacter pylori infection is the major cause of gastric cancer, which remains an important health care challenge. Recent investigation in gastric stem cell or progenitor cell biology has uncovered valuable information in understanding the gastric gland renewal and maintenance of homeostasis, they also provide clues for further defining the mechanisms by which gastric cancer may originate and progress. Lgr5, Villin-promoter, TFF2-mRNA and Mist have recently been identified as gastric stem/progenitor cell markers; their identification enriched our understanding on the gastric stem cell pathobiology during chronic inflammation and metaplasia. In addition, advance in gastric cancer stem cell markers such as CD44, CD90, CD133, Musashi-1 reveal novel information on tumor cell behavior and disease progression implicated for therapeutics. However, two critical questions remain to be of considerable challenges for future exploration; one is how H. pylori or chronic inflammation affects gastric stem cell or their progenitors, which give rise to mucus-, acid-, pepsinogen-, and hormone-secreting cell lineages. Another one is how bacterial infection or inflammation induces oncogenic transformation and propagates into tumors. Focus on the interactions of H. pylori with gastric stem/progenitor cells and their microenvironment will be instrumental to decipher the initiation and origin of gastric cancer. Future studies in these areas will be critical to uncover molecular mechanisms of chronic inflammation-mediated oncogenic transformation and provide options for cancer prevention and intervention. We review recent progress and discuss future research directions in these important research fields. © 2012 Ding and Zheng; licensee BioMed Central Ltd.


Guo Q.,Zhengzhou University | Xu C.,Luoyang Normal University | Zhao B.,Zhengzhou University | Jia Y.,Zhengzhou University | And 2 more authors.
Crystal Growth and Design | Year: 2012

Five interesting interpenetrating networks, namely, [Co(p-bdc)(beb) 0.5] n (1), {[Co(p-bdc)(bmb)] ·H 2O} n (2), {[Co(p-bdc)(bmp)] ·H 2O} n (3), {[Zn(p-bdc)(bmp)] ·H 2O} n (4), and [Zn 2(p-bdc) 2(bmp)(H 2O) 2] n (5) [p-H 2bdc = 1,4-benzenedicarboxylic acid, beb = 1,4-bis(2-ethylbenzimidazol-1-ylmethyl)benzene, bmb = 1,4-bis(2- methylbenzimidazol-1-ylmethyl)benzene, and bmp = 1,5-bis(2-methylbenzimidazol) pentane], have been synthesized by employing mixed ligands of various benzimidazole-based ligands with p-H 2bdc. Complex 1 possesses a 2-fold interpenetrating 3D framework with (4 12·6 3)-pcu topology. Complex 2 exhibits a 3-fold interpenetrating 3D network with 6 6-dia topology, and complex 3 displays a 4-fold interpenetrating 3D diamond network containing Co/bmp left- and right-handed helical chains. Obviously, with the reducing of the steric hindrance of the N-donor ligand, complexes 1-3 show interpenetrating networks from 2-fold to 3-fold and 4-fold. Complex 4 is isostructural to 3 and also forms a 4-connected 3D framework with a diamond topology. Complex 5 features a 3D framework generated by 2D → 3D interpenetration and exhibits (8 2· 10) 2 topology. Our study shows that the steric hindrance changing of ligands can tune the final interpenetrating networks directly. © 2012 American Chemical Society.


Wang X.,Zhengzhou University | Wang X.,University of Delaware
Journal of Applied Mechanics, Transactions ASME | Year: 2010

We investigate the problem of an N-phase elliptical inhomogeneity in plane elasticity. The elliptical inhomogeneity is bonded to the unbounded matrix through the intermediate (N-2) interphases, and the matrix is subjected to remote uniform stresses. We observe that the stress field inside the elliptical inhomogeneity is still uniform when the following two conditions are satisfied: (i) The formed interfaces are (N-1) confocal ellipses, and (ii) the interphases and the matrix possess the same shear modulus but different Poisson's ratios. In Appendixes A and B, we also discuss an arbitrary number of interacting arbitrary shaped inhomogeneities embedded in an infinite matrix, and an N-phase inhomogeneity with (N-1) interfaces of arbitrary shape. Here all the phases comprising the composite possess the same shear modulus but different Poisson's ratios. The results in the main body and in Appendixes A and B are further extended in Appendix C to finite plane strain deformations of compressible hyperelastic harmonic materials. © 2010 by ASME.


Zhu J.,Zhengzhou University | Zhang Y.,Zhengzhou University | Zhang Y.,University of New South Wales | Tian M.,Zhengzhou University | Liu J.,Zhengzhou University
ACS Sustainable Chemistry and Engineering | Year: 2015

A facile and novel method for the fabrication of mixed matrix membranes (MMMs) has been developed, i.e., in situ synthesis of quaternized polyethylenimine (QPEI) soft nanoparticles (SNPs) followed by quaternization with bromoethane in poly(ether sulfone) (PES) casting solution. The resulting composite membranes were constructed via phase inversion method. The influences of SNPs on the morphology and performance of the hybrid membranes were systematically investigated by scanning electron microscopy, dynamic water contact angle, antifouling measurement, etc. The composite membranes exhibited a thin top layer and porous finger-like structure, which were greatly affected by in situ synthesized SNPs. Contact angle and water uptake measurements indicated that the hydrophilicity of hybrid membranes markedly improved in contrast with that of unfilled membrane. Meanwhile, the water flux of the membranes significantly enhanced due to the incorporation of SNPs. The ion-exchange capacity (IEC) value could achieve as high as 0.72 mmol g-1 with an initial PEI content of 1.5 wt %. The salts rejection of MMMs followed the order: MgCl2 > MgSO4 > Na2SO4 > NaCl, confirming that the hybrid membranes were positively charged. Meanwhile, the fouling parameters demonstrated that the composite membranes exhibited a preferable antifouling property. The newly developed membranes demonstrated an impressive prospect for the dye purification due to the high rejection of reactive dyes with a high permeation flux, as well as low multivalent ions retention. The possible separation mechanism of dyes and salts for composite membranes influenced by synthesized SNPs was also proposed in this study. © 2015 American Chemical Society.


Zhao Y.,Zhengzhou University | Zhao Y.,Luoyang Normal University | Deng D.-S.,Luoyang Normal University | Ma L.-F.,Luoyang Normal University | And 3 more authors.
Chemical Communications | Year: 2013

Assembly of 5-nitro-1,2,3-benzenetricarboxylic acid (H3nbta) with CuII in the presence of 1,3-bis(1,2,4-triazol-1-yl)propane (1,3-btp) leads to a new metal-organic framework, [Cu(Hnbta)(1,3-btp)] ·2H2O (A1), which is shown to be an efficient and recyclable heterogeneous catalyst for enamination of β-ketoesters with excellent product yields and selectivity. © 2013 The Royal Society of Chemistry.


Xu X.,Zhengzhou University | Hou J.,University of Reading
Mechanics of Time-Dependent Materials | Year: 2011

Creep and stress relaxation are inherent mechanical behaviors of viscoelastic materials. It is considered that both are different performances of one identical physical phenomenon. The relationship between the decay stress and time during stress relaxation has been derived from the power law equation of the steady-state creep. The model was used to analyse the stress relaxation curves of various different viscoelastic materials (such as pure polycrystalline ice, polymers, foods, bones, metal, animal tissues, etc.). The calculated results using the theoretical model agree with the experimental data very well. Here we show that the new mathematical formula is not only simple but its parameters have the clear physical meanings. It is suitable to materials with a very broad scope and has a strong predictive ability. © 2010 Springer Science+Business Media, B. V.


Guo X.-B.,Zhengzhou University | Guan S.,Zhengzhou University | Fan Y.,Tianjin Huanhu Hospital | Song L.-J.,Zhengzhou University
American Journal of Neuroradiology | Year: 2012

BACKGROUND AND PURPOSE: Cerebral venous thrombosis is a rare entity that can be difficult to manage. Most patients with cerebral sinus thrombosis recover after treatment with heparin, but a subgroup of severe cerebral venous sinus thrombosis has a poor prognosis. Those patients may benefit from intrasinus thrombolysis. The purpose of this research was to carry out a retrospective analysis of patients with severe cerebral venous sinus thrombosis, and to study the safety and efficacy of intrasinus thrombolysis in patients with cerebral venous sinus thrombosis unresponsive to conventional heparin therapy. MATERIALS AND METHODS: Thirty-seven patients with cerebral venous sinus thrombosis who received intrasinus thrombolysis during a 3-year period (January 2007 to December 2009) were included in this study. Urokinase was infused into the sinus via a microcatheter. Data regarding demographic, clinical, and radiologic features were collected. Follow-up data were obtained at 6 months. MRV was repeated to assess the recanalization of the venous sinus. RESULTS: Twenty-seven patients (73%) had good outcome and 7 patients (19%) who were independent for activities of daily life had only mild deficits. One patient survived with severe neurologic deficits and 2 patients died. Complete recanalization of the superior sagittal sinus was seen in 35 patients (97%). At a follow-up of 6 months, 34 patients (92%) were either asymptomatic or had only minor subjective symptoms. CONCLUSIONS: Intrasinus thrombolysis is safe and effective in patients with severe cerebral venous sinus thrombosis. However, the subgroup of patients that is likely to benefit the most from this procedure is not clear from our data. Large randomized controlled trials are required to further clarify this issue.


Yang X.-J.,Zhengzhou University | Yang X.-J.,China University of Mining and Technology | Baleanu D.,Cankaya University | Baleanu D.,King Abdulaziz University | Baleanu D.,Romanian Space Science Institute
Thermal Science | Year: 2013

This paper points out a novel local fractional variational iteration method for processing the local fractional heat conduction equation arising in fractal heat transfer.


Peng J.,Zhengzhou University | Wang J.,Zhengzhou University | Wang Y.,Hunan University
Nonlinear Dynamics | Year: 2011

Abstract A novel robust hybrid tracking control for robotic system is proposed. This hybrid control scheme combines computed torque control (CTC) with neural network, variable structure control (VSC) and nonlinear H8 control methods. It is assumed that the nominal system of robotic system is completely known, which is controlled by using CTC method. Neural network is designed to approximate parameter uncertainties, VSC is used to eliminate the effect of approximation error, and H8 control is employed to achieve a desired robust tracking performance. Based on Lyapunov stability theorem, it can be guaranteed that all signals in closed loop are bounded and a specified H8 tracking performance is achieved by employing the proposed robust hybrid control. The validity of the control scheme is shown by computer simulation of a two-link robotic manipulator. © Springer Science+Business Media B.V. 2010.


Wu C.,Zhengzhou University | Li C.,Hunan University | Du L.,Zhengzhou University | Cao Y.,Hunan University
Dianli Xitong Zidonghua/Automation of Electric Power Systems | Year: 2010

Electric vehicle has received more and more extensive attention, which is one of the major development directions of motor vehicles using new energy sources. The construction of charging infrastructure is an important prerequisite for the advancement of electric vehicles. Different from substation planning and gas station planning, the planning of electric vehicle charging infrastructure has its own distinct characteristics. The development stages of electric vehicle charging infrastructure is proposed, which can be divided into 3 stages, the demonstration stage, public promotional stage and commercial utilization stage. And the characteristics of each stage are studied. The optimization model of charge mode choices is also proposed, and the charging demand of each changing methods can be forecasted based on this model. The principle, process and model of planning for charging infrastructure are proposed, together with the interval-distance ratio, charge capacity redundancy and charging power redundancy. Case studies are given to show that the proposed planning method is adaptive. © 2010 State Grid Electric Power Research Institute Press.


Chao C.,Zhengzhou University | Liu J.,Zhengzhou University | Wang J.,Zhengzhou University | Zhang Y.,Zhengzhou University | And 3 more authors.
ACS Applied Materials and Interfaces | Year: 2013

Halloysite nanotubes (HNTs) have been proposed as a potential support to immobilize enzymes. Improving enzyme loading on HNTs is critical to their practical applications. Herein, we reported a simple method on the preparation of high-enzyme-loading support by modification with dopamine on the surface of HNTs. The modified HNTs were characterized by transmission electron microscopy, Fourier transform infrared spectroscopy, and X-ray photoelectron spectroscopy analyses. The results showed that dopamine could self-polymerize to adhere to the surface of HNTs and form a thin active coating. While the prepared hybrid nanotubes were used to immobilize enzyme of laccase, they exhibited high loading ability of 168.8 mg/g support, which was greatly higher than that on the pristine HNTs (11.6 mg/g support). The immobilized laccase could retain more than 90% initial activity after 30 days of storage and the free laccase only 32%. The immobilized laccase could also maintain more than 90% initial activity after five repeated uses. In addition, the immobilized laccase exhibited a rapid degradation rate and high degradation efficiency for removal of phenol compounds. These advantages indicated that the new hybrid material can be used as a low-cost and effective support to immobilize enzymes. © 2013 American Chemical Society.


Tan T.,Beijing University of Chemical Technology | Lu J.,Beijing University of Chemical Technology | Lu J.,Zhengzhou University | Nie K.,Beijing University of Chemical Technology | And 2 more authors.
Biotechnology Advances | Year: 2010

Fatty acid alkyl esters, also called biodiesel, are environmentally friendly and show great potential as an alternative liquid fuel. Biodiesel is produced by transesterification of oils or fats with chemical catalysts or lipase. Immobilized lipase as the biocatalyst draws high attention because that process is "greener". This article reviews the current status of biodiesel production with immobilized lipase, including various lipases, immobilization methods, various feedstocks, lipase inactivation caused by short chain alcohols and large scale industrialization. Adsorption is still the most widely employed method for lipase immobilization. There are two kinds of lipase used most frequently especially for large scale industrialization. One is Candida antartica lipase immobilized on acrylic resin, and the other is Candida sp. 99-125 lipase immobilized on inexpensive textile membranes. However, to further reduce the cost of biodiesel production, new immobilization techniques with higher activity and stability still need to be explored. © 2010 Elsevier Inc.


Zhang J.,Zhengzhou University | Zhao Y.,China Institute of Water Resources and Hydropower Research | Ding Z.,Tianjin Zhongshui Science and Technology Consulting Co.
Water Resources Management | Year: 2014

Rainfall and grain yield are two closely related random variables to be worthy of studying. The meteorological yield explains the influences of weather changes on grain yield. Based on the data series from 1980 to 2006 in Jinghuiqu irrigation district of Shaanxi Province in China, the meteorological yield is achieved from grain yield. Then, the empirical mode decomposition method is applied to analyze fluctuating periods and local features of rainfall and meteorological yield. Meanwhile, the copula method is introduced into describe the joint probability distribution of rainfall and meteorological yield. The studied results show that rainfall and meteorological yield exist vary fluctuation periods with multi-time scales, including 2 to 4 years of short period level, 4 to 6 (or 7) years of middle period level and 19 (or 10 to 11) years of long period level. Using the frank copula method, the bivariate distribution and return period of rainfall and meteorological yield was successfully developed to reveal the encounter risk of their different magnitudes. Finally, similarly with rainfall and meteorological yield, the complex changes and fluctuation periods are also proven to be existed in their joint probability. © 2014 Springer Science+Business Media Dordrecht.


Wang H.,Chinese Academy of science | Wang H.,Zhengzhou University | Yan H.,Chinese Academy of science | Liu Z.,Chinese Academy of science
Geochimica et Cosmochimica Acta | Year: 2014

Water samples and modern endogenic (thermogene) travertine calcite deposited on plexiglass substrates in travertine pools and a ramp stream were collected along the Huanglong Ravine, Sichuan, SW China at regular ~10day intervals from early May to early November in 2010, including both wet and dry conditions. Temporal and spatial variations in the δ13C and δ18O values of the modern travertine were examined to understand their potential for paleoclimatic and paleoenvironmental interpretations. It was found that δ13C and δ18O of travertine formed in the ramp stream were low in the warm rainy season and high in the cold dry season. Their positive correlation was mainly due to dilution and rainfall seasonal effects on δ13C and δ18O values, respectively, i.e., low δ13C values were caused by dilution by overland flow with depleted δ13C values and reduced CO2-degassing in the warm rainy season while low δ18O values of travertine were because of low δ18O values of water induced by seasonal variation in oxygen isotopic ratios of rainwater. Meanwhile, kinetic effect on oxygen isotopic fractionation during ramp travertine deposition existed and reduced this positive correlation. In contrast, the δ13C and δ18O values of the pool travertines displayed a converse behavior which was caused mainly by the temperature effect. Low δ18O values and high δ13C values in the warm rainy season were correlated chiefly with the higher water temperatures. Therefore, the δ13C and δ18O values of the travertine may be used for paleo-rainfall or paleotemperature reconstruction respectively. This study demonstrates that endogenic travertine, like epigenic (meteogene) tufa, may be a suitable candidate for high-resolution paleoclimatic and paleoenvironmental reconstructions. However, since travertines deposited under differing hydrodynamic conditions (e.g., pools with still water contrasted to fast flow streams) have different climatic responses, it is necessary to check the depositional facies of fossil travertine samples before they can be used for palaeoclimate (temperature and/or rainfall) reconstruction. © 2013 Elsevier Ltd.


Yu H.,Zhengzhou University | Zhang X.,China Nuclear Power Engineering Co. | Zhang Y.,Zhengzhou University | Liu J.,Zhengzhou University | Zhang H.,Zhengzhou University
Desalination | Year: 2013

SiO2@N-Halamine/polyethersulfone (PES) ultrafiltration membranes were prepared by phase inversion method. The morphology, hydrophilicity, permeation performance, porosity, antifouling and antibacterial properties of the membrane were investigated. FT-IR spectra, TEM and XPS spectra results showed that SiO2 nanoparticles were prepared and modified successfully. SEM images indicated that the cross-section morphology of membrane was influenced by the introduction of SiO2@N-Halamine. The surface hydrophilicity of membranes was significantly improved after adding SiO2@N-Halamine. The filtration results indicated that the permeation properties of the hybrid membranes were significantly superior to the pure PES membrane. The water flux of the hybrid membranes increased with the additional amount of SiO2@N-Halamine increased, when the SiO2@N-Halamine content was 5%, the water flux of the membranes reached the maximum at 384.4L·m-2·h-1. Moreover, the hybrid membranes showed good antifouling and antibacterial properties, which might expand the usage of PES in water treatment and also could make some potential contributions to membrane antifouling. © 2013 Elsevier B.V.


Wang F.,Henan Institute of Engineering | Wang F.,Zhengzhou University | Wu Y.,Henan Institute of Engineering | Lu K.,Henan Institute of Engineering | Ye B.,Zhengzhou University
Electrochimica Acta | Year: 2013

A simple but highly sensitive and selective electrochemical sensor for the determination of serotonin (5-HT) was presented. Pretreated glassy carbon electrode (GCE) as enhancer of electron transfer and C-undecylcalix[4] resorcinarene film as molecular receptor are integrated in the electrochemical sensor system. The electrochemical behavior of 5-HT at the modified electrode had been investigated in pH 7.0 phosphate buffers solutions by cyclic voltammetry, square wave voltammetry and chronocoulometry. Compared with bare GCE, the proposed integrated sensor showed improved analytical performance characteristics in catalytic oxidation of 5-HT. Under the selective conditions, the modified electrode showed a linear voltammetric response for the 5-HT within a concentration range of 1.0 × 10-7 to 1.0 × 10 -5 mol L-1, and a value of 3.0 × 10-8 mol L-1 was calculated for the detection limit. Besides, due to the difference of potentials, the modified electrode exhibited an excellent immunity from dopamine, epinephrine, ascorbic acid and folic acid interference. © 2012 Elsevier Ltd.


Zhao Y.-X.,Swedish Medical Center | Zhao Y.-X.,Zhengzhou University | Shaw A.,Swedish Medical Center | Zeng X.,Swedish Medical Center | And 3 more authors.
ACS Nano | Year: 2012

In the assembly of DNA nanostructures, the specificity of Watson-Crick base pairing is used to control matter at the nanoscale. Using this technology for drug delivery is a promising route toward the magic bullet concept, as it would allow the realization of complex assemblies that co-localize drugs, targeting ligands and other functionalities in one nanostructure. Anthracyclines' mechanism of action in cancer therapy is to intercalate DNA, and since DNA nanotechnology allows for such a high degree of customization, we hypothesized that this would allow us to tune the DNA nanostructures for optimal delivery of the anthracycline doxorubicin (Dox) to human breast cancer cells. We have tested two DNA origami nanostructures on three different breast cancer cell lines (MDA-MB-231, MDA-MB-468, and MCF-7). The different nanostructures were designed to exhibit varying degrees of global twist, leading to different amounts of relaxation in the DNA double-helix structure. By tuning the nanostructure design we are able to (i) tune the encapsulation efficiency and the release rate of the drug and (ii) increase the cytotoxicity and lower the intracellular elimination rate when compared to free Dox. Enhanced apoptosis induced by the delivery system in breast cancer cells was investigated using flow cytometry. The findings indicate that DNA origami nanostructures represent an efficient delivery system for Dox, resulting in high degrees of internalization and increased induction of programmed cell death in breast cancer cells. In addition, by designing the structures to exhibit different degrees of twist, we are able to rationally control and tailor the drug release kinetics. © 2012 American Chemical Society.


Zhang J.,Zhengzhou University | Critchley L.A.H.,Chinese University of Hong Kong
Anesthesiology | Year: 2016

Background: Hypotension is a common side effect of general anesthesia induction, and when severe, it is related to adverse outcomes. Ultrasonography of inferior vena cava (IVC) is a reliable indicator of intravascular volume status. This study investigated whether preoperative ultrasound IVC measurements could predict hypotension after induction of anesthesia. Methods: One hundred four adult patients, conforming to American Society of Anesthesiologists physical status I to III, scheduled for elective surgery after general anesthesia were recruited. Maximum IVC diameter (dIVCmax) and collapsibility index (CI) were measured preoperatively. Before induction, mean blood pressure (MBP) was recorded. After induction, MBP was recorded for 10 min after intubation. Hypotension was defined as greater than 30% decrease in MBP from baseline or MBP less than 60 mmHg. Receiver operating characteristic curve analysis with gray zone approach and regression analyses were used. Results: IVC scanning was unsuccessful in 13.5% of patients. Data from 90 patients were analyzed. After induction, 42 patients developed hypotension. Areas (95% confidence interval) under the curves were 0.90 (0.82 to 0.95) for CI and 0.76 (0.66 to 0.84) for dIVCmax. The optimal cutoff values were 43% for CI and 1.8 cm for dIVCmax. The gray zone for CI was 38 to 43% and included 12% of patients and that for dIVCmax was 1.5 to 2.1 cm and included 59% of patients. After adjusting for other factors, it was found that CI was an independent predictor of hypotension with the odds ratio of 1.17 (1.09 to 1.26). CI was also positively associated with a percentage decrease in MBP (regression coefficient = 0.27). Conclusions: Preoperative ultrasound IVC CI measurement was a reliable predictor of hypotension after induction of general anesthesia, wherein CI greater than 43% was the threshold. © 2015, the American Society of Anesthesiologists, Inc. Wolters Kluwer Health, Inc.


Cao L.-H.,Zhengzhou University | Xu Q.-Q.,Zhengzhou University | Zang S.-Q.,Zhengzhou University | Hou H.-W.,Zhengzhou University | And 2 more authors.
Crystal Growth and Design | Year: 2013

Hydrothermal assembly of ZnII ion, a tripodal ligand with both flexible imidazole and rigid carboxylate groups [HL = 3,5-bis(imidazol-1- ylmethyl)benzoic acid hydrochloride], and rigid bidentate linker 5-iodoisophthalic acid (5-iipa) yields a novel three-dimensional (3D) self-penetrating metal-organic framework [Zn2(L)2(5-iipa)] n (1). Complex 1 exhibits a (62·8)(6 3·8·102) topology that is unprecedented with the rare (10,3)-d (or utp) subnets. In addition, photoluminescence was also performed on 1. © 2013 American Chemical Society.


Li Y.,CAS Fujian Institute of Research on the Structure of Matter | Li Y.,Zhengzhou University | Ju Z.,CAS Fujian Institute of Research on the Structure of Matter | Wu B.,Zhengzhou University | Yuan D.,CAS Fujian Institute of Research on the Structure of Matter
Crystal Growth and Design | Year: 2013

A 2-fold interpenetrated microporous MOF [Ni2(C 2O4)(L)2]n·6nH2O (HL = 4,2′:4″,2′-terpyridine-4′-carboxylic acid) (1) was synthesized and structurally characterized. 1 has obvious 1D channels along the crystallographic a and c axes with a pore size of 5.7 to 6.9 Å. Topological analysis shows that the framework of 1 can be interpreted as a (3,4)-connected net with point symbol (63)(65·8). 1 exhibits high water and thermal stability, which is demonstrated by TGA, PXRD, and VT-PXRD. Additionally, the high temperature structure of 1′ (433 K) undoubtedly demonstrates the stability of the framework. More importantly, 1 shows high selectivities for CO2 over N2, H2, and CH4 at low pressure and 273 K. © 2013 American Chemical Society.


Li W.,Zhengzhou University | Li S.,Zhongyuan University of Technology
International Journal of Systems Science | Year: 2015

We study the online batch scheduling of equal-length jobs on two identical batch machines. Each batch machine can process up to b jobs simultaneously as a batch (where b is called the capacity of the machines). The goal is to determine a schedule that maximises the (weighted) number of early jobs. For the non-preemptive model, we first present an upper bound that depends on the machine capacity b, and then we provide a greedy online algorithm with a competitive ratio of 1/(b + 1). For the preemption-restart model with b = ∞, we first show that no online algorithm has a competitive ratio greater than 0.595, and then we design an online algorithm with a competitive ratio of. © 2013 Taylor and Francis.


Zang S.-Q.,Zhengzhou University | Fan Y.-J.,Zhengzhou University | Li J.-B.,Zhengzhou University | Hou H.-W.,Zhengzhou University | And 2 more authors.
Crystal Growth and Design | Year: 2011

A series of seven divalent coordination polymers based on 5-iodo-isophthalic acid (5-iipa) and ancillary nitrogen ligands (phen = 1,10-phenanthroline, bpe = 1,2-bis(4-pyridyl)ethene, p-bix = 1,4-bis(imidazol-1-ylmethyl)-benzene, m-bix = 1,3-bis(imidazol-1-ylmethyl)- benzene), namely, [Zn2(5-iipa)2(phen)2(H 2O)]n (1), [Zn(5-iipa)(bpe)1.5]n (2), [Cd2(5-iipa)2(phen)2]n (3), [Mn2(5-iipa)2(phen)2]n (4), [Mn 4(5-iipa)4(bpe)4·5H2O] n (5), [Co(5-iipa)(p-bix)]n (6), and [Co(5-iipa)(m-bix)] n (7), have been synthesized. The structure of compound 1 exhibits a double zigzag metal-organic chain, and such chains are further united together to generate a three-dimensional (3D) supramolecular structure through interchain I...π interactions. Compound 2 features interesting 3-fold parallel interpenetrated two-dimensional (2D) → 3D network motifs which are stabilized by interlayer I...π, π ...π, and C-H...π interactions. In isomorphous compounds 3 and 4, the 5-iipa2- ligand acts as a μ3-bridge to connect metal atoms to form a 2D metal-organic layer, and such layers are united together to yield a 3D supramolecular structure through interlayer I...π and C-H...π interactions. In the structures of 5 and 7, the rare 2-fold interpenetrating 3D supramolecular architectures based on I...I interactions or O...I halogen bonding are found, respectively. In compound 6, 3-fold interpenetrated 2D → 3D network motifs based on covalent bonding are expanded to a rare 3D supramolecular structure based on O...I halogen bonding. The above results demonstrate a useful guideline in the crystal engineering of supramolecular architectures in coordination network assembly under the influence of halogen bonding as well as related I...I and I...π interactions. Their thermal analysis, X-ray diffraction, UV-vis absorption spectra, and photoluminescent properties have been investigated as well. © 2011 American Chemical Society.


Zhang X.,Central Hospital of Zhengzhou | Wang H.,Zhengzhou University | Wang J.,Zhengzhou University
Wspolczesna Onkologia | Year: 2013

Aim of the study: To study high mobility group protein B1 (HMGB1) and nuclear transcription factor p65 (NF-?B p65) ex - pression in non-small cell lung cancer and its significance. Material and methods: 106 hospitalized patients with non-small cell lung cancer after thoracic surgery were enrolled; HMGB1 and p65 protein expression was detected by the immunohistochemical method. Semiquantitative expression of HMGB1 and NF-?B p65 was analyzed using Image Pro Plus (IPP) software and statistical analysis. Results: The rate of HMGB1 positive expression in the non-small cell lung cancer protein B1 family was significantly higher than normal tissues (P < 0.05); p65 protein expression in the non-small cell lung carcinoma group was significantly higher than that of normal tissues (P < 0.05). HMGB1 and NF-?B p65 protein expression was significantly higher compared with the non-metastatic group (P < 0.01). HMGB1 and NF-?B p65 protein expression showed a positive correlation (P < 0.05). Conclusions: HMGB1 and NF-?B p65 ex - pression may be related to non-small cell lung cancer metastasis.


Zhao H.,South China University of Technology | Cui Z.,Fujian University of Technology | Wang X.,Zhengzhou University | Turng L.-S.,University of Wisconsin - Madison | Peng X.,South China University of Technology
Composites Part B: Engineering | Year: 2013

The morphology, microstructure, tensile properties, and dynamic mechanical properties of solid and microcellular poly(lactic acid) (PLA)/ polyhydroxybutyrate-valerate (PHBV) blends, as well as PLA/PHBV/clay nanocomposites, together with the thermal and rheological properties of solid PLA/PHBV blends and PLA/PHBV/clay nanocomposites, were investigated. Conventional and microcellular injection-molding processes were used to produce solid and microcellular specimens in the form of ASTM tensile test bars. Nitrogen in the supercritical state was used as the physical blowing agent in the microcellular injection molding experiments. In terms of rheology, the PLA/PHBV blends exhibited a Newtonian fluid behavior, and their nanocomposite counterparts showed a strong shear-thinning behavior, over the full frequency range. An obvious pseudo-solid-like behavior over a wide range of frequencies in the PLA/PHBV/clay nanocomposites suggested a strong interaction between the PLA/PHBV blend and the nanoclay that restricted the relaxation of the polymer chains. PLA/PHBV/clay nanocomposites possess a higher modulus and greater melt strength than PLA/PHBV blends. The addition of nanoclay also decreased the average cell size and increased the cell density of microcellular PLA/PHBV specimens. As a crystalline nucleating agent, nanoclay significantly improved the crystallinity of PHBV in the blend, thus leading to a relatively high modulus for both solid and microcellular specimens. However, the addition of nanoclay had less of an effect on the tensile strength and strain-at-break. © 2013 Elsevier Ltd.


Zhou S.-L.,Xinxiang Medical University | Zhou S.-L.,Zhengzhou University | Wang L.-D.,Xinxiang Medical University | Wang L.-D.,Zhengzhou University
World Journal of Gastroenterology | Year: 2010

Esophageal carcinogenesis is a multi-stage process, involving a variety of changes in gene expression and physiological structure change. MicroRNAs (miRNAs) are a class of small non-coding endogenous RNA molecules. Recent innovation in miRNAs profiling technology have shed new light on the pathology of esophageal carcinoma (EC), and also heralded great potential for exploring novel biomarkers for both EC diagnosis and treatment. Frequent dysregulation of miRNA in malignancy highlights the study of molecular factors upstream of gene expression following the extensive investigation on elucidating the important role of miRNA in carcinogen-esis. We herein present a thorough review of the role of miRNAs in EC, addressing miRNA functions, their putative role as oncogenes or tumor suppressors and their potential target genes. The recent progresses in discovering the quantifiable circulating cancer-associated miRNAs indicate the potential clinical use of miRNAs as novel minimally invasive biomarkers for EC and other cancers. We also discuss the potential role of miRNAs in detection, screening and surveillance of EC as miRNAs can be a potential target in personalized treatment of EC. © 2010 Baishideng.


Dong X.-Y.,Zhengzhou University | Li B.,Zhengzhou University | Ma B.-B.,Nanjing University | Li S.-J.,Zhengzhou University | And 7 more authors.
Journal of the American Chemical Society | Year: 2013

A polar homochiral 3D MOF [{Co2(L)(bpe)(H2O)} ·5H2O]n constructed with cobalt(II) and a new ligand N-(1,3-dicarboxy-5-benzyl)-carboxymethylglycine (H4L) accommodates ordered helical water streams in its helical grooves. It provides the first example of switchable ferroelectric and optical behavior through two-step reversible single-crystal to single-crystal transformation (SCSC) upon desorption/adsorption of water spirals and coordinated water molecules, respectively. © 2013 American Chemical Society.


Liang J.J.,Zhengzhou University | Qu B.Y.,Zhongyuan University of Technology
Proceedings of the 2013 IEEE Symposium on Swarm Intelligence, SIS 2013 - 2013 IEEE Symposium Series on Computational Intelligence, SSCI 2013 | Year: 2013

Portfolio optimization problems involve selection of different assets to invest so that the investor is able to maximize the overall return and minimize the overall risk. The complexity of an asset allocation problem increases with the increasing number of assets available for investing. When the number of assets/stocks increase to several hundred, it is difficult for classical method to optimize (construct a good portfolio). In this paper, the Multi-objective Dynamic Multi-Swarm Particle Swarm Optimizer is employed to solve a portfolio optimization problem with 500 assets (stocks). The results obtained by the proposed method are compared several other optimization methods. The experimental results show that this approach is efficient and confirms its potential to solve the large scale portfolio optimization problem. © 2013 IEEE.


Zhang J.,Zhengzhou University | Ho K.-Y.,Raffles Hospital | Wang Y.,Zhengzhou University
British Journal of Anaesthesia | Year: 2011

Multimodal treatment of postoperative pain using adjuncts such as gabapentin is becoming more common. Pregabalin has anti-hyperalgesic properties similar to gabapentin. In this systematic review, we evaluated randomized, controlled trials (RCTs) for the analgesic efficacy and opioid-sparing effect of pregabalin in acute postoperative pain. A systematic search of Medline (1966-2010), the Cochrane Central Register of Controlled Trials (CENTRAL), and Google Scholar was performed. We identified 11 valid RCTs that used pregabalin for acute postoperative pain. Postoperative pain intensity was not reduced by pregabalin. Cumulative opioid consumption at 24 h was significantly decreased with pregabalin. At pregabalin doses of ≥300 mg, there was a reduction of 8.8 mg [weighted mean difference (WMD)]. At pregabalin doses <300 mg, cumulative opioid consumption was even lower (WMD, -13.4 mg). Pregabalin reduced opioid-related adverse effects such as vomiting [risk ratio (RR) 0.73; 95% confidence interval (CI) 0.56-0.95]. However, the risk of visual disturbance was greater (RR 3.29; 95% CI 1.95-5.57). Perioperative pregabalin administration reduced opioid consumption and opioid-related adverse effects after surgery. © The Author [2010]. Published by Oxford University Press on behalf of the British Journal of Anaesthesia. All rights reserved.


Wei W.,Zhengzhou University | Mi L.,Zhongyuan University of Technology | Mi L.,Xuchang University | Gao Y.,Zhengzhou University | And 3 more authors.
Chemistry of Materials | Year: 2014

A novel method to adjust the composition of a material while maintaining its morphology was described in this study. Nickel sulfide, the material investigated in this work, was found to be useful as a high surface area electrode material for supercapacitor applications. First, a nest-like Ni 3S2@NiS composite electrode with 1D nanorod as structural unit was synthesized by simultaneously using Ni foam as template and Ni as a source through a one-step in situ growth method. Co and Se ions, which respectively acted as beneficial cation and anion, were successfully introduced into the nest-like Ni3S2@NiS material, resulting in the formation of Ni3S2@Co9S8 and NiS@NiSe2 composite electrodes with structures similar to those of the parent materials. The material structure was virtually retained and single-crystal-to-single-crystal transformation was achieved in the process. Introducing the cation and anion into the same type of material while maintaining topology could be important for the field of material synthesis and preparation of supercapacitor electrodes. Moreover, the electrochemical properties of these three materials were studied by cyclic voltammetry measurements and galvanostatic charge-discharge tests. The results indicated that the rate performance was improved significantly by ion exchange. In particular, the derived electrode with Se still showed superior oxidation and reduction ability at high scan rate of 10000 mV s-1. In addition, the second charge-discharge specific capacity also increased from 516 F g -1 to 925 F g-1 and 1412 F g-1 at the current density of 0.5 A g-1 and by Co and Se exchange, respectively. This work contributes to the knowledge on electrode materials for supercapacitors and can provide good reference for the fabrication of desired materials. © 2014 American Chemical Society.


Huang L.,Chinese University of Hong Kong | Mo L.,South China Normal University | Li Y.,Zhengzhou University
Journal of Experimental Psychology: Human Perception and Performance | Year: 2012

A large part of the empirical research in the field of visual attention has focused on various concrete paradigms. However, as yet, there has been no clear demonstration of whether or not these paradigms are indeed measuring the same underlying construct. We collected a very large data set (nearly 1.3 million trials) to address this question. We tested 257 participants on nine paradigms: conjunction search, configuration search, counting, tracking, feature access, spatial pattern, response selection, visual short-term memory, and change blindness. A fairly general attention factor was identified. Some of the participants were also tested on eight other paradigms. This general attention factor was found to be correlated with intelligence, visual marking, task switching, mental rotation, and Stroop task. On the other hand, a few paradigms that are very important in the attention literature (attentional capture, consonance-driven orienting, and inhibition of return) were found to be dissociated from this general attention factor. © 2012 American Psychological Association.


Li H.-Y.,Zhengzhou University | Wei Y.-L.,Zhengzhou University | Dong X.-Y.,Zhengzhou University | Zang S.-Q.,Zhengzhou University | And 2 more authors.
Chemistry of Materials | Year: 2015

Tunable inorganic nodes and modifiable organic linkers enable designable functionality to come to fruition in new-type porous hybrid materials, namely metal-organic frameworks (MOFs). By using viologen-functionalized m-benzenedicarboxylate as an organic linker, a terbium-organic framework embedded with asymmetric viologen species has been constructed. The reversible photochromism from bright yellow to dark green is implemented due to the favorable spatial stack of the electron donor and acceptor. The photochromic component of the organic linkers can modulate the luminescence of the tetranuclear terbium cluster under irradiation of UV light, which is defined as photoluminescence switching behavior. The different protonation levels of uncoordinated N atoms with varying pH enable the MOF as a potential fluorescent pH sensor. Thus, multiphotofunctionality, viz. photoluminescence, photochromism as well as the derivate fluorescent response to irradiation and pH have been combined in the Tb-MOF, which is the first example in the viologen-based photochromic hybrid materials. © 2015 American Chemical Society.


Li X.,Zhengzhou University | Zhang W.,Zhongyuan University of Technology
Proceedings - 6th International Conference on Internet Computing for Science and Engineering, ICICSE 2012 | Year: 2012

With more and more attention on the software quality, the test case reuse has become a focus in current research. By integrating knowledge management and software reuse theory, several design guidelines for reusable test cases are identified according to the characteristics of software components. A reusable test case knowledge management model is proposed to support the knowledge reuse based on the ontology representation of reusable test cases in this paper. With the ontology and knowledge management model, test engineers can retrieve and reuse test cases flexibly. © 2012 IEEE.


Chen C.,CAS Dalian Institute of Chemical Physics | Xu J.,CAS Dalian Institute of Chemical Physics | Zhang Q.,CAS Dalian Institute of Chemical Physics | Ma Y.,Missouri University of Science and Technology | And 2 more authors.
Chemical Communications | Year: 2011

A new type of superhydrophobic material, FP-Co-SiO2 was prepared with organic groups immobilized on the surface of the SiO2-based nanocomposite. This material showed much higher catalytic activity for selective oxidation of hydrocarbons than an equivalent hydrophilic catalyst. © 2011 The Royal Society of Chemistry.


Zhai J.,Zhengzhou University | Liu C.-X.,Zhengzhou Peoples Hospital | Tian Z.-R.,Zhengzhou Peoples Hospital | Jiang Q.-H.,Zhengzhou Peoples Hospital | Sun Y.-P.,Zhengzhou University
Biology of Reproduction | Year: 2012

The objective was to explore the effects of metformin on the expression of endometrial glucose transporter 4 (GLUT4) and analyze the related factors of GLUT4 in patients with polycystic ovary syndrome (PCOS). This study included 20 obese patients with PCOS (PCOS group) and 20 obese patients who had infertility caused by oviducal or pelvic factors but had no PCOS (control group). Follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol-2 (E2), testosterone (T), fasting serum glucose (FSG), fasting insulin serum (FINS), homeostasis model assessment-insulin resistance (HOMA-IR), and endometrial GLUT4 expression were determined in the two groups. In PCOS group, patients were given 500 mg of metformin three times per day for 3 mo, and then the parameters above were determined again and compared with that before metformin treatment. The parameters above also were compared between PCOS and control groups. The correlation of GLUT4 with its related factors was analyzed. The levels of T, FINS, and HOMA-IR were higher in PCOS group than in the control group (P<0.01). The levels of protein and mRNA of endometrial GLUT4 were lower in the PCOS group than in the control group (P<0.001). The expression of protein and mRNA of endometrial GLUT4 increased after metformin treatment (P<0.001). HOMA-IR was negatively correlated with GLUT4 expression (P=0.027). In patients with PCOS, the levels of protein and mRNA of endometrial GLUT4 were lower compared with that in non-PCOS women, and HOMA-IR was strongly associated with endometrial GLUT4 expression. Metformin may up-regulate endometrial GLUT4 expression to improve endometrial IR. © 2012 by the Society for the Study of Reproduction, Inc.


Zheng J.-L.,Zhengzhou University | Zheng J.-L.,Zheng Zhou HengXing Science and Technology Co. | Kong Y.-P.,Zheng Zhou HengXing Science and Technology Co.
Energy Conversion and Management | Year: 2010

The research presented here is focused primarily on spray combustion of pure fast pyrolysis bio-oil from rice husk. A combustion systems is developed to attain a possibility of firing of the bio-oil in a routine way. The start-up and shut down combustion procedures is established. The bio-oil is properly pretreated and spray combustion properties of pure fast pyrolysis bio-oil are studied. After 40 min combustion become steady and the temperature in the center of the combustion chamber is above 1400 °C. The CO concentration decreases with ER, and below a certain ER, the CO level exponentially increases. The measured NOx concentrations slightly increase at higher ER. Low values of SOx emissions are measured, and as expected these values are very low (<30 ppm). The O2 concentration increases with ER. Bio-oil has the potential to replace diesel and gas for on-site power generation and heating, to be a fuel source for large-scale combustion systems such as furnaces, boilers and gas turbines. © 2009 Elsevier Ltd. All rights reserved.


Dong X.-P.,Zhengzhou University | Xie F.-Z.,Henan Province Water Resources No. 2 Engineering Bureau
Yantu Gongcheng Xuebao/Chinese Journal of Geotechnical Engineering | Year: 2013

To explore the nonlinear behavior and the crush history of the segment joint (without packing materials and with bolts) for the segmented tunnel lining under high load level, a simplified analysis model for the segment joint is introduced. The stress distribution and rotation angle of the joint are deduced at different stages of linear rotation, tension-induced opening and compression-induced yielding. In terms of the bending moment-rotation angle curve and the limit bending moment, the results of the analytic solution of the segment joint are verified through the full-scale tests. It is demonstrated that the nonlinear behaviors of segment joint are captured exactly by the model formula, and the analytical solution can be utilized to trace the initiation and development of opening and crush of the segment joint.


Zhu Y.,Zhengzhou University | Wang J.,Zhengzhou University | Qu B.,Zhongyuan University of Technology
International Journal of Electrical Power and Energy Systems | Year: 2014

Due to the increasing deterioration of environmental problem, multi-objective Economic Emission Dispatch (EED) problem has become one of the active research areas in recent years. Meanwhile, the renewable energy such as wind energy is an important approach to reduce pollution emissions, as well as the dependence on fossil fuels. In this paper, a newly developed optimization technique, called Multi-Objective Evolutionary Algorithm based on Decomposition (MOEA/D), has been applied to optimize the cost and emission of wind-thermal power system. MOEA/D provides a simple but efficient framework which decomposes a Multi-objective Optimization Problem (MOP) into a number of scalar optimization subproblems and optimizes them simultaneously. The stochastic nature of wind power is modeled by Weibull probability distribution function and the uncertainty of wind power is considered as system constraints with stochastic variables. To validate the effectiveness of the MOEA/D method, it is first applied to solve the traditional EED problem of standard IEEE 30-bus 6-generator system as the benchmark. Then, the effect of wind power penetration on cost and emission is analyzed by MOEA/D in a 6-generator system and a 40-generator system with wind farms based on the proposed EED model. A comparative analysis with other similar optimization methods reveals that the MOEA/D method is able to generate better performance in terms of both solution quality and computational efficiency. © 2014 Elsevier B.V. All rights reserved.


Zhou Y.,Zhengzhou University | Li Z.-X.,Zhengzhou University | Zang S.-Q.,Zhengzhou University | Zhu Y.-Y.,Zhengzhou University | And 6 more authors.
Organic Letters | Year: 2012

A C 3-symmetric Schiff-base example of the new simple, low cost, highly water soluble, and sensitive turn-on fluorescent Zn 2+ chemosensor is described. The sensor was successfully applied to the detection of intracellular Zn 2+. Moreover, the sensor could also serve as a potential recyclable component in sensing materials. Notably, the color change is so obvious that all of the recycling process can be seen clearly by the naked eye. © 2012 American Chemical Society.


Li B.,Zhengzhou University | Zang S.-Q.,Zhengzhou University | Ji C.,Zhengzhou University | Hou H.-W.,Zhengzhou University | And 2 more authors.
Crystal Growth and Design | Year: 2012

The reactions of 1,1′-biphenyl-2,2′,6,6′-tetracarboxylic acid (H 4bptc), N-containing auxiliary ligand, with different silver(I) salts under hydrothermal or solvent evaporation conditions yielded five unusual complexes with distinct structural features: {[Ag 4(bptc)(bpy) 4(H 2O)]•(H 2O) 12} n (1), {[Ag 1.5(bptc) 0.5(bpy) 1.5]•(NH 4) 0.5•(H 2O) 3} n (2), {[Ag 2(H 2bptc)(bpy) 2]•(H 2O) 2} n (3), {[Ag 2(H 2bptc)(bpy) 2]•(HClO 4)} n (4), and {[Ag(H 2bptc) 0.5(bpe)]•(H 2O) 2} n (5) (bpy = 4,4′-bipyridine, bpe = 1,2-bis(4-pyridyl)ethene). Complexes 1-3 and 5 exhibit two-dimensional (2D) layer, and such layers are further united together to generate three-dimensional supramolecular structure through hydrogen bonding and π••• π interactions, respectively. In complexes 1 and 2, butterfly shaped 16-membered water ring and infinite water tape are obtained, respectively. Both compounds 4 and 5 are 2-fold interpenetrated 3D frameworks. Complex 4 shows channels along the c axis that are occupied by the perchloric acid molecules. Different from robust 4, the 3D supramolecular architecture of 5 is based on the formation of hydrogen bonding between (H 2O) 4 cluster and the adjacent layers. In addition, the thermogravimetric analysis, powder X-ray diffraction (XRD), and photoluminescent behavior of the complexes have also been investigated. © 2012 American Chemical Society.


Zang S.-Q.,Zhengzhou University | Dong M.-M.,Zhengzhou University | Fan Y.-J.,Zhengzhou University | Hou H.-W.,Zhengzhou University | And 2 more authors.
Crystal Growth and Design | Year: 2012

A series of four novel cobaltic coordination polymers based on 5-iodo-isophthalic acid (5-iipa) and 1,1′-(1,4-butanediyl)bis(imidazole) (bbi), namely, [Co(5-iipa)(bbi)•3(H 2O)] n (1), [Co 2(5-iipa) 2(bbi) 2•3(C 2H 6O 2)] n (2), [Co(5-iipa)(bbi)•DMF] n (3) (DMF = N,N′-dimethylformamide), and [Co 2(5-iipa) 2(bbi) 2•2DMAc] n (4) (DMAc = N,N′-dimethylacetamide) have been solvothermally synthesized by using various solvents. Their thermal analysis, XRD and UV-vis absorption spectra have been investigated as well. Structural analyses exhibit that they all form 2D covalent structures based on the intersection of Co-5-iipa and Co-bbi chains, and adjacent layers are parallel and united together to yield a 3D supramolecular structure through interlayer I•••I, I•••π, or C-H•••O interactions, respectively. More interestingly, channels are detected in the architectures, which are mainly occupied by the guest solvent molecules. Compound 1 features a rare 3-fold interpenetrating 3D supramolecular architecture, while compound 2 exhibits an interesting 3-fold parallel interpenetrated two-dimensional (2D) → three-dimensional (3D) network motifs based on I•••I interactions. The adjacent 2D parallel layers in compound 3 deviate from each other with the shift of 3.89 Å along the b or -b axis. Compound 4 shows a double layer structure in which the bbi-Co waving-like ribbon is running along the c-axis. Results demonstrate that both halogen-related interaction and solvent effect play important roles in the assembly of the supramolecular metal-organic networks. © 2012 American Chemical Society.


Wang D.,Zhengzhou University | Wang H.,China Shipbuilding Industry Corporation | Liu L.,Peoples Bank of China
Swarm and Evolutionary Computation | Year: 2016

Effective environment exploration in unknown environment is precondition of constructing the environment map and carrying out other tasks for multi-robot system. Due to its excellent performance, particle swarm optimization (PSO) has been widely used in multi-robot exploration field. To deal with its drawback - easily trapped in local optima, Darwinian PSO (DPSO) optimization is proposed by Tillett et al. [1] with the natural selection function and first used in real world robot exploration by Couceiro et al. [2], forming the robotic DPSO (RDPSO). To increase the algorithm performance and control its convergence rate, fractional calculus is used to replace inertia component in RDPSO for its "memory" ability and forming the fractional order RDPSO (FORDPSO). This paper presents a formal analysis of RDPSO and studies the influence of the coefficients on FORDPSO algorithm. To satisfy the requirement of dynamically changing robots' behaviors during the exploration, fuzzy inferring system is designed to achieve better control coefficients. Experiment results obtained in two complex simulated environments illustrate that biological and sociological inspiration is effective to meet the challenges of multi-robot system application in unknown environment exploration, and the exploration effect of the fuzzy adaptive FORDPSO is better than that of the fixed coefficient FORDPSO. Furthermore, the performance of FORDPSO with different neighborhood topologies are studied and compared with other six PSO variations. All the results demonstrate the effect of the FORDPSO on the multi-robot environment exploration. © 2015 Elsevier B.V. All rights reserved.


Chen Y.,Peoples Hospital of Zhengzhou | Chen Y.,Henan Institute of Science and Technology | Huang L.,First Affiliated Hospital of Xinxiang Medical Colleague | Yu J.,Zhengzhou University
Journal of Dermatology | Year: 2012

Elevated heparanase and matrix metalloproteinase (MMP)-9, frequently found in human cancer, is a major cause of degradation of the extracellular matrix (ECM) and basement membrane (BM), thus facilitating tumor cell migration and invasion. Although a lot of work has been done, the role of heparanase and MMP-9 has not been delineated in skin cancer progression. The purpose of this study was to do such an exploration. To investigate the role of heparanase and MMP-9 in cutaneous malignant melanoma (CMM) development, we performed immunohistochemical analysis to detect the alternation of these two factors in paraffin-embedded biopsy specimens of normal skin, junctional nevi and CMM. It is interesting to note that the expression profile of heparanase and MMP-9 was similar. Contrary to negative staining in normal skin, overexpression of heparanase and cytoplasmic MMP-9 was observed in as many as 70% of CMM, whereas only 10% of the junctional nevi exhibited faint staining (P = 0.0005, P = 0.0000). Considering the lymph node (LN) metastasis, the expression of the two factors is significantly higher in LN-positive lesions than that in LN-negative lesions (P = 0.0295, P = 0.0013). Meanwhile, there was positive correlation between the expression of MMP-9 and heparanase (r = 0.689, P = 0.003). The first expression of MMP-9 and heparanase occurs at benign lesions. However, the significantly increased expression in advanced CMM stages, particularly in LN-positive metastasis lesions, might synergistically contribute to degradation of ECM and BM, therefore promoting carcinogenesis and metastasis. © 2011 Japanese Dermatological Association.


Liu J.,Zhengzhou University | Yuan E.,Zhengzhou University | Lee L.,Central Hospital of Zhengzhou
Clinica Chimica Acta | Year: 2012

Background: Human gestation is a period that requires particular considerations. During this period, the blood of parturient women is in a hypercoagulable state. Therefore, reference ranges based on healthy men or nonpregnant women are not optimal for informing clinical decisions during pregnancy. There are few reports of gestational age-specific reference intervals; therefore, it is essential to explore such reference ranges. Methods: Four analytes, including prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT) and fibrinogen (Fib), were assayed on an ACL TOP automatic coagulation analyser using plasma samples from 1130 pregnant women. Outliers were excluded from each group. Results: The reference ranges for PT, TT, APTT, and Fib at ≤ 12 weeks' gestation were 8.87-12.23, 11.84-18.00, 27.58-41.87, 2.00-4.23, respectively. At 13-20. weeks' gestation the ranges were 8.37-13.20, 12.00-17.56, 26.26-40.85, 2.35-4.90, respectively. At 21-27. weeks' gestation the ranges were 8.37-12.79, 11.94-17.33, 25.04-40.61, 2.38-5.19, respectively. At 28-35. weeks' gestation the ranges were 8.10-11.90, 12.27-17.56, 23.90-43.34, 2.35-4.90, respectively. At 36-42. weeks' gestation the ranges were 8.50-11.05, 10.08-16.60, 25.59-42.53, 2.48-5.06, respectively. Conclusion: The above-established gestational age-specific reference intervals may assist clinicians in making accurate clinical decisions and can be adopted in other laboratories after further validation. © 2011 Elsevier B.V.


Sun X.-L.,Zhengzhou University | Song W.-C.,Zhengzhou University | Zang S.-Q.,Zhengzhou University | Du C.-X.,Zhengzhou University | And 3 more authors.
Chemical Communications | Year: 2012

The hierarchical assembly of a homochiral triple concentric helical system in a novel 3D metal-organic framework with SHG activity has been observed. The result also provides a better understanding of host-guest chemistry and the process of water transport in biological systems. © 2012 The Royal Society of Chemistry.


Cheng K.,Cedars Sinai Heart Institute | Cheng K.,Moore Research | Cheng K.,University of North Carolina at Chapel Hill | Shen D.,Zhengzhou University | And 6 more authors.
Nature Communications | Year: 2015

Stem cell transplantation is a promising strategy for therapeutic cardiac regeneration, but current therapies are limited by inefficient interaction between potentially beneficial cells (either exogenously transplanted or endogenously recruited) and the injured tissue. Here we apply targeted nanomedicine to achieve in vivo cell-mediated tissue repair, imaging and localized enrichment without cellular transplantation. Iron nanoparticles are conjugated with two types of antibodies (one against antigens on therapeutic cells and the other directed at injured cells) to produce magnetic bifunctional cell engager (MagBICE). The antibodies link the therapeutic cells to the injured cells, whereas the iron core of MagBICE enables physical enrichment and imaging. We treat acute myocardial infarction by targeting exogenous bone marrow-derived stem cells (expressing CD45) or endogenous CD34-positive cells to injured cardiomyocytes (expressing myosin light chain. Targeting can be further enhanced by magnetic attraction, leading to augmented functional benefits. MagBICE represents a generalizable platform technology for regenerative medicine. © 2014 Macmillan Publishers Limited. All rights reserved.


Cai Y.,Japan International Research Center for Agricultural science | Pang H.,Zhengzhou University | Kitahara M.,RIKEN | Ohkuma M.,RIKEN
International Journal of Systematic and Evolutionary Microbiology | Year: 2012

Two strains of lactic acid bacteria, designated SU 18T and SU 83, were isolated from silage prepared with Sudan grass [Sorghum sudanense (Piper) Stapf.]. The isolates were Gram-stainpositive, catalase-negative, facultatively anaerobic rods that did not produce gas from glucose. The isolates exhibited ≤93.5% DNA-DNA relatedness to each other and shared the same phenotypic characteristics, which indicated that they belonged to a single species. The DNA G+C content was 58.5-59.2 mol%. On the basis of 16S rRNA gene sequence analysis, the isolates were placed in the genus Lactobacillus. Their closest phylogenetic neighbours were Lactobacillus manihotivorans JCM 12514T and Lactobacillus camelliae JCM 13995T (95.9 and 96.8% 16S rRNA gene sequence similarity, respectively, with strain SU 18T). Ribotyping revealed that strain SU 18T was well separated from L. manihotivorans JCM 12514T and L. camelliae JCM 13995T. Strain SU 18T exhibited ≤23.7% DNA-DNA relatedness with its closest phylogenetic neighbours. The isolates represent a novel species in the genus Lactobacillus, for which the name Lactobacillus nasuensis sp. nov. is proposed. The type strain is SU 18T (=JCM 17158T =CGMCC 1.10801T). The description of the genus Lactobacillus is also amended. © 2012 IUMS.


Ren B.,Henan Institute of Engineering | Shen Z.,Zhengzhou University | Liu Z.,Zhengzhou University
Journal of Alloys and Compounds | Year: 2013

The paper investigates the structure and properties of AlCrMnMoNiZr nitride films prepared by reactive direct current sputtering at various N 2-to-Ar flow ratios (RN). The films deposited at low RN show amorphous phase, micro-voids and clusters structure, and hence have low hardness and modulus. As RN increases, the films present face-centered cubic structure (FCC) with (1 1 1) preferred orientation, small crystalline sizes, dense structure, smooth surface, and consequently have higher hardness and modulus. When RN = 1.0, the nitride film has peak hardness and modulus of 11.9 GPa and 202 GPa, and the highest value of H/E and H3/E2. Compared with the metallic film its tribological properties are relatively worse. This can be ascribed to the difference in film thickness. According to the observations of the typical surface morphologies, the dominant wear mechanism of the AlCrMnMoNiZr nitride films is adhesive wear. © 2013 Elsevier B.V. All rights reserved.


Li J.,Zhengzhou University | Miao D.,Zhengzhou University | Yang R.,Zhengzhou University | Qu L.,Zhengzhou University | And 2 more authors.
Electrochimica Acta | Year: 2014

Poly(sodium 4-styrenesulfonate) (PSS) intercalated graphene (PSS-GN) was prepared via in situ reduction of exfoliated graphite oxides in the presence of PSS, and then mixed with CTAB to form a stable PSS-GN-CTAB nanocomposite through electrostatic self-assembly. The prepared composites were characterized by Fourier transform infrared spectrometry (FT-IR), ultraviolet and visible spectrometry (UV-vis) and X-ray diffraction (XRD). A novel 2,4-dichlorophenol (2,4-DCP) electrochemical sensor was fabricated based on a PSS-GN-CTAB modified glassy carbon electrode. It was found that the composite of PSS-GN-CTAB exhibited excellent electrocatalytic activity towards the oxidation of 2,4-DCP. Linear sweep voltammetry (LSV) was used for the quantitative determination of 2,4-DCP. Under the optimum conditions, the peak current of 2,4-DCP was proportional to its concentration at the range of 1.0 × 10-8 to 2.0 × 10-6 mol L-1 with a detection limit 2.0 × 10-9 mol L-1. The newly developed method was successfully applied for the determination of 2,4-DCP in the waste water with good recoveries. The proposed electrode system represents a new platform for designing excellent electrochemical sensors with water-dispersed graphene. © 2014 Elsevier Ltd.


Fan C.Z.,Zhengzhou University | Liang E.J.,Zhengzhou University | Huang J.P.,Fudan University
Journal of Physics D: Applied Physics | Year: 2011

We theoretically investigate the properties of optical propagation in one-dimensional soft photonic crystals based on ferrofluids using the transfer matrix method. The proposed structure is composed of an alternating ferrofluid layer and a dielectric layer. Ferrofluids are composed of suspended ferromagnetic nanoparticles coated with silver, which has a frequency-dependent dielectric function. Core-shell nanocomposites incorporating an optical signature with magnetic response are particularly useful. The calculated results of dispersion relation show that tunable band gaps can be realized by varying the local magnetic field factor α, the shell thickness parameter t, or the filling fraction ν of the ferrofluid layer. An additional band gap appears in the lower frequency region due to the absorption. These band gaps blue shift when the external magnetic field is enhanced, and red shift when either t or ν is increased. We also extend our analysis to the variation of band width. To meet the requirements of optical devices, such a tunable structure can be used to design optical filters, modulators and waveguides. © 2011 IOP Publishing Ltd.


Chen C.,CAS Dalian Institute of Chemical Physics | Shi S.,CAS Dalian Institute of Chemical Physics | Wang M.,CAS Dalian Institute of Chemical Physics | Ma H.,CAS Dalian Institute of Chemical Physics | And 2 more authors.
Journal of Materials Chemistry A | Year: 2014

A surface organic modification strategy is utilized to design and prepare a series of superhydrophobic SiO2-based nanocomposites with cobalt ions in the bulk phase and different organic groups on the surface. Physical properties such as BET surface area, surface hydrophilicity/hydrophobicity, and water adsorption amount changed significantly with the introduction of organic groups of various chain lengths, which was confirmed by TEM, SEM, FTIR, 29Si-NMR, N2 adsorption-desorption, sessile water contact angle, and TG-DTA measurements. Surface hydrophilicity/hydrophobicity altered from hydrophilic to superhydrophobic with an increase in carbon chain length, which showed an obvious effect on the catalytic performance in selective oxidation of hydrocarbons such as ethylbenzene. Superhydrophobicity was guaranteed for high catalytic activity, and the carbon chain length of the organic group was also an important factor. Superhydrophobic Pr-Co-SiO 2 that contained the propyl group was the most efficient catalyst, and the conversion of ethylbenzene reached 70.4% with O2 as an oxidant under solvent-free conditions at 393 K for 7 h, which is nearly nine times that of the hydrophilic Co-SiO2 without surface organic modification. This journal is © the Partner Organisations 2014.


He L.,Henan University of Technology | Zhang K.,Henan University of Technology | Wang C.,Henan University of Technology | Wang C.,Zhengzhou University | And 2 more authors.
Journal of Chromatography A | Year: 2011

An ionic liquid dispersive liquid-liquid microextraction high-performance liquid chromatography (IL-DLLME-HPLC) method for effective enrichment and determination of nitrite ion in water and biological samples was developed. The method was based on the reaction of nitrite ion with p-nitroaniline in the presence of diphenylamine in acid media and IL-DLLME of azo product. The optimization of reaction and extraction conditions, such as kind and concentration of acid, reaction time, volume of reaction solvent, temperature, kind of extraction and dispersive solvent, volume of extraction and dispersive solvent, addition of salt, extraction and centrifugal time were studied. Under the optimal conditions, 1-octyl-3-methylimidazolium bis[(trifluoromethyl)sulfonyl]imide IL-DLLME procedure provided high enrichment factor of 430 and good extraction recovery of 91.7% for nitrite ion. The linearity was observed in the range of 0.4-500.0μgL-1 with good correlation coefficient (r2=0.9996). The relative standard deviations (RSDs) for five replicate measurements varied between 1.5% and 4.8%. The limit of detection of the method (S/N=3) was 0.05μgL-1. The interference effect of some anions and cations was also tested. The developed method allowed achieving an excellent enrichment factor, yielding a lower LOD in comparison with other methods. Moreover, the proposed method was able to analyze nitrite ion in water and biological samples with satisfactory recovery ranged from 96.5% to 107.3%. © 2011 Elsevier B.V.


Xu B.,CAS Dalian Institute of Chemical Physics | Zhou L.,Zhengzhou University | Wang F.,CAS Dalian Institute of Chemical Physics | Qin H.,CAS Dalian Institute of Chemical Physics | And 2 more authors.
Chemical Communications | Year: 2012

Hierarchical Ti-aluminophosphate-5 molecular sieves templated by glucose have been synthesized and applied as a potential adsorbent for the first time to selectively capture phosphopeptides from complex peptide mixtures prior to MALDI-TOF MS analysis. © 2012 The Royal Society of Chemistry.


Lan Y.-B.,Suzhou University | Zhao H.,Suzhou University | Liu Z.-M.,Zhengzhou University | Liu G.-G.,Zhengzhou University | And 2 more authors.
Organic Letters | Year: 2011

The combination of a cinchona-based chiral primary amine and a BINOL-phosphoric acid has been demonstrated as a powerful and synergistic catalyst system for the double Michael addition of isatylidene malononitriles with α,β-unsaturated ketones, to provide the novel chiral spiro [cyclohexane-1,3′-indoline]-2′,3-diones in high yields (88-99%) with excellent diastereo- and enantioselectivities (94:6-99:1 dr's, 95-99% ee's). © 2011 American Chemical Society.


Cui Z.,Zhengzhou University | Fisher J.A.,University of Toronto | Duffin J.,University of Toronto
Respiratory Physiology and Neurobiology | Year: 2012

We investigated the interaction between the central and peripheral chemoreflexes in humans using a temporal separation technique in three tests. In two tests hyperventilation was used to reduce central PCO2. In these tests the difference in the responses to the same step increases in PCO2 to 45mmHg at normoxic and hypoxic O 2 tensions provided a measure of the response to isocapnic hypoxia at a low central PCO2. In a third test the response to a hypoxic step during sustained isocapnia at 45mmHg provided a measure of the response to isocapnic hypoxia at a high central PCO2. The responses to isocapnic hypoxia at high and low central PCO2 were not significantly different, confirming the conclusion of previous studies that central and peripheral chemoreflex signals interact additively. This finding contrasts with those from recent animal experiments and emphasizes the need for caution when using animal experiments to make conclusions about the physiology of the respiratory chemoreflexes in humans. © 2011 Elsevier B.V.


Zeng H.-J.,Zhengzhou University | Yang R.,Zhengzhou University | Wang Q.-W.,Zhengzhou University | Li J.-J.,Zhengzhou University | And 2 more authors.
Food Chemistry | Year: 2011

In this paper, based upon the phenomenon that melamine can obviously enhance the CL signal of the luminol-H2O2 system in basic medium, a simple, rapid and sensitive flow injection chemiluminescence (FI-CL) method for the determination of melamine has been developed. Under the optimum conditions, the linear range for the determination of melamine was 0.2-80 μg mL-1 with a detection limit of 0.12 μg mL-1 calculated as proposed by IUPAC and a relative standard deviation of 3.26% for 11 solutions of 10 μg mL-1 melamine on the same day. The proposed method was satisfactorily applied to determine melamine in milk-based products and satisfactory results were obtained without interferences from the sample matrix. Moreover, one assay produce takes only 25 s and the minimum sampling rate is about 120 samples h-1, which indicated that the FI-CL method was suitable for high throughput and real-time melamine analysis.


Lu P.-X.,Henan University of Technology | Qu L.-B.,Zhengzhou University | Cheng Q.-H.,Zhengzhou University
Journal of Alloys and Compounds | Year: 2013

To enhance the Seebeck coefficient and reduce the thermal conductivity while maintaining a satisfied electrical conductivity, a disordered structure was introduced into the La0.3Ce0.37Fe3CoSb 12 crystalline by adding a low-melting-point lead telluride (PbTe). The results suggest that the disordered structure created by the melted PbTe at 870 K can be partly preserved into the La0.3Ce0.37Fe 3CoSb12 materials at room temperature. With the existence of the disordered structure the Seebeck coefficient at 773 K is increased from 143 μV K-1 to 265 μV K-1, while the thermal conductivity is reduced from 2.12 W m-1 K-1 to 1.60 W m-1 K-1, nevertheless the electrical conductivity is dropped from 78,000 Ω-1 m-1 to 23,500 Ω-1 m-1. A figure of merit of 0.95 at 773 K is observed for the material containing 40% PbTe. © 2012 Elsevier B.V. All rights reserved.


Guo P.,CAS Beijing National Laboratory for Molecular | Chen P.,CAS Beijing National Laboratory for Molecular | Chen P.,Zhengzhou University | Liu M.,CAS Beijing National Laboratory for Molecular
ACS Applied Materials and Interfaces | Year: 2013

Surfactant-assisted self-assembly (SAS) has received much attention for supramolecular nanoassemblies, due to its simplicity and easiness in realizing a controllable assembly. However, in most of the existing SAS protocols, the employed surfactants work only as a regulator for a controllable assembly but not as active species for function improvement. In this paper, we report that a porphyrin, zinc 5,10,15,20-tetra(4-pyridyl)-21H,23H-porphine (ZnTPyP), could be assembled to form one-dimensional (1D) supramolecular nanostructures via a SAS method, wherein graphene oxide (GO) plays a fascinating role of sheetlike surfactant. We show that, when a chloroform or tetrahydrofuran solution of ZnTPyP is injected into an aqueous dispersion of GO, 1D supramolecular nanoassemblies of ZnTPyP with well-defined internal structures could be easily formulated in a controllable manner. Our experimental facts disclose that the complexation of ZnTPyP with the two-dimensional GO nanosheets plays an important role in this new type of SAS. More interestingly, compared with the 1D ZnTPyP nanoassemblies formulated via a conventional SAS, wherein cetyltrimethylammonium bromide is used as surfactant, those constructed via our GO-assisted SAS display distinctly enhanced photocatalytic activity for the photodegradation of rhodamine B under visible-light irradiation. Our new findings suggest that GO could work not only as an emergent sheetlike surfactant for SAS in terms of supramolecular nanoassembly but also as functional components during the performance of the assembled nanostructures. © 2013 American Chemical Society.


Zhang H.,Zhengzhou University | Hou L.,Zhengzhou University | Jiao X.,Zhengzhou University | Ji Y.,Zhengzhou University | And 3 more authors.
Biomaterials | Year: 2015

Artesunate (AS) is an iron-dependent drug, which has been used extensively as anti-malarial drugs worldwide with no obvious side effects. Recently, studies have shown that AS also possess profound cytotoxicity against tumor cells. However, simultaneous delivery of hydrophobic AS and Fe2+ into tumor cells remains a major challenge. Herein, we report a new kind of active-targeting preparations which could not only specially target to tumor cells but also synchronously transfer AS and irons into tumor tissue. In this study, hyaluronic acid (HA) was grafted onto fullerene to get a water-soluble biomaterial (HA-C60) with excellent biocompatibility, and then combined with transferrin (Tf) to obtain a multi-functional drug delivery system (HA-C60-Tf) with significant tumor-targeting efficacy and powerful photodynamic therapy capacity. Finally, AS was adsorbed on HA-C60-Tf with a high loading efficacy of 162.4% (weight ratio of AS: HA-C60-Tf). Compared with free AS, remarkably enhanced antitumor efficacy of AS-loaded HA-C60-Tf nanoparticles was realized both in a cultured MCF-7 cells invitro and in a tumor-bearing murine model invivo, due to increased intracellular accumulation of AS in tumor and activated mechanism by co-delivery of Tf and AS analogs. Furthermore, with laser irradiation invivo, the relative tumor volume (V/V0) of HA-C60-Tf/AS declined by half, from 1.72±0.12 to 0.84±0.07, suggesting a new way with multi-mechanism for tumor treatment was developed. © 2014 Elsevier Ltd.


Hennig A.K.,University of Washington | Peng G.-H.,University of Washington | Peng G.-H.,Zhengzhou University | Chen S.,University of Washington
PLoS ONE | Year: 2013

Rod and cone photoreceptor neurons in the mammalian retina possess specialized cellular architecture and functional features for converting light to a neuronal signal. Establishing and maintaining these characteristics requires appropriate expression of a specific set of genes, which is tightly regulated by a network of photoreceptor transcription factors centered on the cone-rod homeobox protein CRX. CRX recruits transcription coactivators p300 and CBP to acetylate promoter-bound histones and activate transcription of target genes. To further elucidate the role of these two coactivators, we conditionally knocked out Ep300 and/or CrebBP in differentiating rods or cones, using opsin-driven Cre recombinase. Knockout of either factor alone exerted minimal effects, but loss of both factors severely disrupted target cell morphology and function: the unique nuclear chromatin organization seen in mouse rods was reversed, accompanied by redistribution of nuclear territories associated with repressive and active histone marks. Transcription of many genes including CRX targets was severely impaired, correlating with reduced histone H3/H4 acetylation (the products of p300/CBP) on target gene promoters. Interestingly, the presence of a single wild-type allele of either coactivator prevented many of these defects, with Ep300 more effective than Cbp. These results suggest that p300 and CBP play essential roles in maintaining photoreceptor-specific structure, function and gene expression. © 2013 Hennig et al.


Zhao H.,Zhengzhou University | Lan Y.-B.,Zhengzhou University | Liu Z.-M.,Soochow University of China | Wang Y.,Soochow University of China | And 2 more authors.
European Journal of Organic Chemistry | Year: 2012

Heterocyclic spirooxindoles that bear a multisubstitutedheterocyclic motif and quaternary stereocenter at the 3-position are prevalent in a large number of spirooxindole alkaloids, which are pharmaceutically relevant compounds with remarkable biological activities. In this paper, we report an efficient method for the construction of enantiomerically enriched spiro[2H-pyran-3,4′- indoline] derivatives by a systematic Michael/reduction/cyclization sequence. The initial Michael addition of isatylidenemalononitriles with ketones was catalyzed by a cinchona-based chiral primary amine and L-camphorsulfonic acid and furnished multifunctional, optically active Michael adducts in high yields (81-99 %) with excellent enantioselectivities (95 to >99 % ee). Subsequently, the Michael adducts were converted into spiro[2H-pyran-3,4′-indoline] derivatives in 52-93 % yields with 1.5:1 to 20:1 diastereomeric ratio and 90-99 % ee by utilizing NaBH 4 as a cascade reduction/cyclization reagent. An efficient method for the construction of spiro[2H-pyran-3,4′-indoline] derivatives through a systematic Michael/reduction/cyclization sequence is reported. The Michael addition of isatylidenemalononitriles with ketones was catalyzed by chiral primary amine I and L-camphorsulfonic acid (A9). Subsequently, the Michael adducts were converted into spiro[2H-pyran-3,4′- indoline] derivatives. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Ou X.,CAS Beijing National Laboratory for Molecular | Chen P.,CAS Beijing National Laboratory for Molecular | Chen P.,Zhengzhou University | Jiang L.,CAS Beijing National Laboratory for Molecular | And 4 more authors.
Advanced Functional Materials | Year: 2014

Graphene-based ultrathin films with tunable performances, controlled thickness, and high stability are crucial for their uses. The currently existing protocols, however, could hardly simultaneously meet these requirements. Using amino-substituted π-conjugated compounds, including 1,4-diaminobenzene (DABNH2), benzidine (BZDNH2), and 5,10,15,20-tetrakis (4-aminophenyl)-21H,23H- porphine (TPPNH2), as cross-linkages, a new protocol through which graphene oxide (GO) nanosheets can be anchored on solid supports with a high stability and controlled thickness via a layer-by-layer method is presented. A thermal annealing leads to the reduction of the films, and the qualities of the samples can be inherited by the as-produced reduced GO films (RGO). When RGO films are integrated as source/drain electrodes in OFETs, tunable performances can be realized. The devices based on the BZDNH2-crosslinked RGO electrodes exhibit similar electrical behaviors as those based on the non-π-conjugated compound crosslinked electrodes, while improved performances can be gained when those crosslinked by DABNH2 are used. The performances can be further improved when RGO films crosslinked by TPPNH2 are employed. This work likely paves a new avenue for graphene-based films of tunable performances, controlled thickness, and high stability. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Li G.,Zhengzhou University | Wang Y.,CAS Beijing National Laboratory for Molecular | Mao L.,CAS Beijing National Laboratory for Molecular
RSC Advances | Year: 2014

As one of the most promising and efficient approaches for remediating the deterioration of natural environments, semiconductor-based photocatalysis has received considerable attention. To date, numerous efforts have been focused to explore novel materials for highly efficient photocatalysis under visible light or sunlight irradiation. Among them, Ag-based compounds are emerging to be a promising candidate because of their excellent visible light-responsive photoelectrochemical properties. This review summarizes the recent progress in the design and fabrication of Ag-compound-based semiconductor photocatalysts and their applications in the photocatalytic decomposition of organic molecules. Initially, the mechanisms of the related photocatalytic reactions will be discussed, and then we will highlight some of the recent progresses in Ag-based micro- or nano-structured material fabrication that exhibit enhanced photocatalytic performance. These novel and highly efficient photocatalysts mainly include Ag2O, Ag2S, AgX (X = Cl, Br, I), Ag2CO3 and Ag3PO4. We expect that the present tutorial review will provide insights in the direction of the future visible-light photocatalyst design. This journal is © the Partner Organisations 2014.


Xia C.,Zhengzhou University | Xia C.,University of Texas at Arlington | Jia Y.,Zhengzhou University | Tao M.,Arizona State University | Zhang Q.,University of Texas at Arlington
Physics Letters, Section A: General, Atomic and Solid State Physics | Year: 2013

Based on the density functional theory, the band structure and optical absorption of the isovalent sulfur-doped hematite α-Fe2O 3 are studied systematically. The results show that the band gap of α-Fe2O3 - xSx decreases monotonically with increasing the sulfur concentration, resulting in an obvious increase of the optical absorption edge in the visible range. Most intriguingly, unlike the pure α-Fe2O3 material, the α-Fe 2O3-xSx with x≈0.17 (S concentration of ∼5.6%) exhibits a direct band gap of an ideal value (∼1.45 eV), together with high optical absorption (∼105 cm-1) and lower carriers effective masses. These results indicate that α-Fe 2O3 - xSx, with a proper concentration of sulfur, may serve as a promising candidate for low-cost solar-cell materials. © 2013 Elsevier B.V.


Yang X.,Zhengzhou University | Wang J.,Henan University
Physics Letters, Section A: General, Atomic and Solid State Physics | Year: 2010

The Lax pair of a lattice equation is given by a discrete spectral problem and the negative Kaup-Newell spectral problem. Based on the Lax nonlinearization technique, they are transformed into a symplectic map and a Hamiltonian system, which are integrable in the Liouville sense and are straightened out in the Jacobi coordinates. An algebraic-geometric solution of the lattice equation is obtained by the Riemann-Jacobi inversion. Explicit solutions of the associated lattice hierarchy are given. © 2010 Elsevier B.V. All rights reserved.


Wang D.-S.,Beijing Information Science and Technology University | Zeng X.,Zhengzhou University | Ma Y.-Q.,Beijing Information Science and Technology University
Physics Letters, Section A: General, Atomic and Solid State Physics | Year: 2012

The exact vortex soliton solutions of the quasi-two-dimensional cubic-quintic Gross-Pitaevskii equation with spatially inhomogeneous nonlinearities are constructed by similarity transformation. It is demonstrated that spatially inhomogeneous cubic-quintic nonlinearity can support exact vortex solitons in which there are two quantum numbers S and m. The radius structures and density distributions of these vortex solitons are studied, and it is shown that the number of ring structure of the vortex solitons increases by one with increasing the radial quantum number m by one. © 2012 Elsevier B.V.


He J.-H.,Soochow University of China | Kong H.-Y.,Soochow University of China | Chen R.-X.,Soochow University of China | Hu M.-S.,Zhengzhou University | Chen Q.-L.,Zhengzhou University
Carbohydrate Polymers | Year: 2014

This paper points out that the so called enhanced variational iteration method (Colantoni & Boubaker, 2014) for a nonlinear equation arising in electrospinning and vibration-electrospinning process is the standard variational iteration method. An effective algorithm using the variational iteration algorithm-II is suggested for Bratu-like equation arising in electrospinning. A suitable choice of initial guess results in a relatively accurate solution by one or few iteration. © 2014 Elsevier Ltd.


Wang Y.,Nanjing University | Xia H.,Wannan Medical College | Xia H.,Jinan University | Zhuang Z.,Soochow University of China | And 3 more authors.
Cell Death and Disease | Year: 2014

The involvement of Axl kinase in non-small cell lung cancer's (NSCLC) acquired resistance to tyrosine kinase inhibitors (TKIs) gefitinib or erlotinib has been identified recently, but the mechanism by which Axl contributes to TKI resistance is largely unknown. MicroRNAs (miRNAs) repress gene expression and their critical role in tumorigenesis has been implicated. To investigate the role of miRNAs in the Axl-mediated acquired gefitinib resistance, we examined the Axl-mediated miRNA changes in gefitinib-resistant lung cancers. A panel of Axl kinase-altered miRNAs was identified. In this study, we validate and report that miR-374a and miR-548b modulated by Axl have essential roles in cell cycle arrest, gefitinib-induced apoptosis, epithelial-to-mesenchymal transition, migration and tumorigenesis of gefitinib-resistant lung cancer cells in vitro and in vivo by targeting Wnt5a and CCNB1 genes, respectively. Of clinical significance, high expression of Axl and miR-374a and low expression of miR-548b are associated with poor disease-free survival postoperatively. These findings indicate that the modulation of specific miRNAs may provide a therapeutic target to treat or reverse gefitinib resistance in NSCLC with high expression of Axl in the future. © 2014 Macmillan Publishers Limited.


Luo P.,Zhengzhou University | Luo P.,Tongji University | Zhao Y.,Zhengzhou University | Zhang B.,Zhengzhou University | And 3 more authors.
Water Research | Year: 2010

Halloysite nanotubes (HNTs), a low-cost available clay mineral, were tested for the ability to remove cationic dye, Neutral Red (NR), from aqueous solution. Natural HNTs used as adsorbent in this work were initially characterized by XRD, FT-IR, TEM and BET. The effect of adsorbent dose, initial pH, temperature, initial concentration and contact time were investigated. Adsorption increased with increase in adsorbent dose, initial pH, temperature and initial concentration. The equilibrium data were well described by both the Langmuir and Freundlich isotherm models. The maximum adsorption capacity was 54.85, 59.24 and 65.45 mg/g at 298, 308 and 318 K, respectively. Batch kinetic experiments showed that the adsorption followed pseudo-second-order kinetic model with correlation coefficients greater than 0.999. Thermodynamic parameters of ΔG0, ΔH0 and ΔS0 indicated the adsorption process was spontaneous and endothermic. The results above confirmed that HNTs had the potential to be utilized as low-cost and relatively effective adsorbent for cationic dyes removal. © 2009 Elsevier Ltd. All rights reserved.


Zhu M.,CAS Beijing National Laboratory for Molecular | Chen P.,CAS Beijing National Laboratory for Molecular | Chen P.,Zhengzhou University | Liu M.,CAS Beijing National Laboratory for Molecular
Langmuir | Year: 2013

We report herein that Ag/AgCl-based plasmonic photocatalysts with controlled size and shape could be easily formulated by a one-pot approach via a precipitation reaction between AgNO3 or Ag(NH3) 2NO3 and NaCl. It is found that near-spherical and cube-like Ag/AgCl nanoarchitectures of 500 nm could be fabricated at lower and higher temperature, respectively. Fascinatingly, when graphene oxide (GO) nanosheets are introduced into the synthesis medium, the size of the formulated near-spherical and cube-like nanostructures, Ag/AgCl/GO, could be 2.5 and 5 times reduced to ca. 200 and 100 nm, respectively, when AgNO3 and Ag(NH3)2NO3 are employed as the silver source. The series of our Ag/AgCl-based nanostructures could be used as visible-light-driven plasmonic photocatalysts for the photodegradation of methyl orange pollutants, wherein the cube-like Ag/AgCl/GO nanoarchitectures of 100 nm display the highest catalytic activity. It is disclosed that the synergistic effect of size, shape, and GO nanosheets plays an important role for their boosted photocatalytic performances. The investigation reveals that GO nanosheets work not only as a capping agent for a controllable fabrication of Ag/AgCl nanostructures, but also as catalyst promoter during the photocatalytic performances, leading to an enhanced catalytic activity. Our unique GO-assisted method likely paves a facile avenue and initiates new opportunities for the exploration of GO-hybridized high-performance catalysts. © 2013 American Chemical Society.


The current study intended to examine the signal transduction pathway of N1-(quinolin-2-ylmethyl) butane-1, 4-diamine (QMA) in antiplatelet aggregation. Rats were divided randomly into five groups: control group; QMA-treated groups (0.3, 1, and 3 mg/kg); and r-Hirudin-treated group (0.3 mg/kg). Sample groups intravenously injected the corresponding agents once a day for 5 days; control group took 0.9% NaCl in the same way. Ten minutes after the last injection, blood samples were obtained from the rat abdominal aorta. Aggregation ex vivo was tested after irritating platelets by 1.5 U/ml thrombin for 5 min with a platelet aggregometer. Malondialdehyde production, activity of superoxide dismutase and nitric oxide production were determined by the microplate reader. Measurement of [Ca2+]i was performed using a fluorescence spectrophotometer. Thromboxane A2, cyclic adenosine monophosphate and cyclic guanosine monophosphate levels, vasodilator-stimulated phosphoprotein, and mitogen-activated protein kinase phosphorylation were measured with ELISA kits. Phospholipase C γ2 and protein kinase C were observed by immunoblotting study. QMA inhibited thrombin-induced platelet aggregation ex vivo. QMA significantly elevated superoxide dismutase activity, levels of cyclic adenosine monophosphate, cyclic guanosine monophosphate, nitric oxide, and subsequently promoted vasodilator-stimulated phosphoprotein phosphorylation. Meanwhile, QMA suppressed phospholipase C γ2, protein kinase C and mitogenactivated protein kinase phosphorylation, as well as malondialdehyde, thromboxane A2 formation and [Ca2+]i mobilization. QMA has a strong antiplatelet potential via its multitarget mechanism. Copyright © 2014 Lippincott Williams & Wilkins.


Zhang Q.,Zhengzhou University | Cui X.,Zhengzhou University | Zhang L.,CAS Beijing National Laboratory for Molecular | Luo S.,CAS Beijing National Laboratory for Molecular | And 2 more authors.
Angewandte Chemie - International Edition | Year: 2015

Presented herein is a redox tuning strategy for asymmetric aminocatalysis with a designed chiral ferrocenophane. Under redox control, the ferrocenophane catalyst efficiently catalyzes the asymmetric aldol reaction at room temperature with excellent yield and good stereoselectivity. Moreover, the redox-active ferrocene moiety also served as phase-tag to facilitate catalyst recovery and reuse. The catalyst can be reused for five cycles without much loss of activity. Ferrocenium of the oxidized ferrocenophane was proposed to serve as Lewis acidic site, thus accounting for the stereo control. Stay tuned: A redox tuning strategy has been developed for asymmetric aminocatalysis using a chiral ferrocenophane. Under redox control, the catalyst catalyzes the asymmetric aldol reaction at room temperature with excellent yield and good stereoselectivity. Moreover, the catalyst is recyclable. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Zhao H.,Henan University | Yang J.,Zhengzhou University | Fan T.,Zhengzhou University | Li S.,Zhengzhou University | Ren X.,Henan University
Tumor Biology | Year: 2012

Emerging evidence indicates that RhoE as novel member of the Rho GTPases family plays an essential role in carcinogenesis and tumor progression of human various tumors, but the functional significance of RhoE in human esophageal squamous cell carcinoma (ESCC) is still unclear. In the current study, RhoE expression in ESCC tissues and cells was examined, and the biological functions of RhoE in ESCC cells were determined. The results revealed that RhoE expression at mRNA and protein levels was significantly downregulated in ESCC tissues and cell lines (P < 0.05). RhoE expression was tightly associated with differentiation degree, clinical staging, and lymph node metastasis of the patients with ESCC (P < 0.05), but no significant correlations were found between RhoE expression and gender or age of the patients with ESCC (P > 0.05). Additionally, we found that downregulation of RhoE expression in ESCC cells promoted cell proliferation, cell cycle progression, as well as cell invasion in vitro, and inhibited cell apoptosis. Conversely, upregulation of RhoE expression in ESCC cells inhibited cell proliferation, arrested cell cycle at G0/G1 phase, reduced cell invasion, and promoted cell apoptosis. Furthermore, the downregulation of RhoE expression significantly reduced PTEN level and enhanced pAkt level; however, elevation of RhoE expression markedly increased PTEN level and decreased pAkt level. Stepwise investigations demonstrated that overexpression of RhoE in ESCC cells increased the expressions of p27 and bax proteins but decreased the expressions of cyclin D1 and bcl-2 proteins. These data demonstrate that RhoE may play a driving role in the development and progression of ESCC, and targeting the RhoE may be an effective and feasible approach for treatment of ESCC. © 2012 International Society of Oncology and BioMarkers (ISOBM).


Ok C.Y.,University of Houston | Li L.,University of Houston | Li L.,Zhengzhou University | Young K.H.,University of Houston
Experimental and Molecular Medicine | Year: 2015

Epstein-Barr virus (EBV) is a ubiquitous herpesvirus, affecting >90% of the adult population. EBV targets B-lymphocytes and achieves latent infection in a circular episomal form. Different latency patterns are recognized based on latent gene expression pattern. Latent membrane protein-1 (LMP-1) mimics CD40 and, when self-aggregated, provides a proliferation signal via activating the nuclear factor-kappa B, Janus kinase/signal transducer and activator of transcription, phosphoinositide 3-kinase/Akt (PI3K/Akt) and mitogen-activated protein kinase pathways to promote cellular proliferation. LMP-1 also induces BCL-2 to escape from apoptosis and gives a signal for cell cycle progression by enhancing cyclin-dependent kinase 2 and phosphorylation of retinoblastoma (Rb) protein and by inhibiting p16 and p27. LMP-2A blocks the surface immunoglobulin-mediated lytic cycle reactivation. It also activates the Ras/PI3K/Akt pathway and induces Bcl-xL expression to promote B-cell survival. Recent studies have shown that ebv-microRNAs can provide extra signals for cellular proliferation, cell cycle progression and anti-apoptosis. EBV is well known for association with various types of B-lymphocyte, T-lymphocyte, epithelial cell and mesenchymal cell neoplasms. B-cell lymphoproliferative disorders encompass a broad spectrum of diseases, from benign to malignant. Here we review our current understanding of EBV-induced lymphomagenesis and focus on biology, diagnosis and management of EBV-associated B-cell lymphoproliferative disorders. © 2015 KSBMB. All rights reserved 2092-6413/15.


Zhan Y.,Zhengzhou University | Li H.,Hainan Medical College | Chen Y.,Zhengzhou University
Journal of Hazardous Materials | Year: 2010

Copper hydroxyphosphate was synthesized hydrothermally and characterized by XRD and SEM. The peroxide degradation of azo dye on this material was evaluated by examining initial pH, catalyst loading, H2O2 dosage, initial dye concentration and temperature. Although copper hydroxyphosphate is a low surface area material without micropores or mesopores, it shows considerable activity for oxidative degradation of azo dyes under near-neutral pH conditions. A catalyst with such simple and clear structure may be a suitable model material for research on the mechanism of generating hydroxyl radicals and heir destruction of organic molecules. © 2010 Elsevier B.V.


Zhang J.,Zhengzhou University | Wang K.,Zhengzhou University | Xu Q.,Zhengzhou University | Zhou Y.,CAS Changchun Institute of Applied Chemistry | And 2 more authors.
ACS Nano | Year: 2015

To well address the problems of large volume change and dissolution of Fe3O4 nanomaterials during Li+ intercalation/extraction, herein we demonstrate a one-step in situ nanospace-confined pyrolysis strategy for robust yolk-shell nanospindles with very sufficient internal void space (VSIVS) for high-rate and long-term lithium ion batteries (LIBs), in which an Fe3O4@Fe3C core@shell nanoparticle is well confined in the compartment of a hollow carbon nanospindle. This particular structure can not only introduce VSIVS to accommodate volume change of Fe3O4 but also afford a dual shell of Fe3C and carbon to restrict Fe3O4 dissolution, thus providing dual roles for greatly improving the capacity retention. As a consequence, Fe3O4@Fe3C-C yolk-shell nanospindles deliver a high reversible capacity of 1128.3 mAh g-1 at even 500 mA g-1, excellent high rate capacity (604.8 mAh g-1 at 2000 mA g-1), and prolonged cycling life (maintaining 1120.2 mAh g-1 at 500 mA g-1 for 100 cycles) for LIBs, which are much better than those of Fe3O4@C core@shell nanospindles and Fe3O4 nanoparticles. The present Fe3O4@Fe3C-C yolk-shell nanospindles are the most efficient Fe3O4-based anode materials ever reported for LIBs. © 2015 American Chemical Society.


Aim: To evaluate the diagnostic value of anti-mutated citrullinated vimentin antibodies (anti-MCV), anti-cyclic citrullinated peptides antibodies (anti-CCP), anti-glucose-6-phosphate isomerase antibodies (anti-GPI) and anti-keratin antibodies (AKA) and rheumatoid factor (RF) in rheumatoid arthritis (RA). Methods: The five auto-antibodies were detected in serum samples of 56 patients with RA, 21 patients with systemic lupus erythematosus (SLE), 11 with ankylosing spondylitis (AS), six with Sjögren's syndrome (SS), four with connective tissue disease (CTD) and 20 healthy controls. Anti-MCV, anti-CCP and anti-GPI were detected by enzyme-linked immunosorbent assays (ELISA), AKA was determined by indirect immunofluorescence and RF was determined by rate nephelometry. Results: In RA, anti-MCV and anti-GPI had the highest sensitivity (78.6% and 75.0%, respectively), anti-CCP and AKA had the highest specificity (97.6%). Anti-GPI had the lowest specificity (64.3%), and AKA had the lowest sensitivity (48.2%). When two antibodies were detected together, the sensitivity of anti-MCV/anti-CCP/RF were highest (92.9%) with a lower specificity (73.8%). The combination of anti-MCV/anti-CCP had a slightly decreased sensitivity (89.3%) and the same specificity (73.8%). Conclusions: The combination RF/anti-MCV/anti-CCP or anti-MCV/anti-CCP are usefully serologic tests for the diagnosis of RA in Chinese patients. © 2013 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.


Meng Z.,Zhengzhou University | Yu X.-H.,Soochow University of China | Chen J.,Zhengzhou University | Li L.,Zhengzhou University | Li S.,Soochow University of China
Acta Pharmacologica Sinica | Year: 2014

Aim:To investigate the effects of curcumin (Cur) on cardiac fibrosis in spontaneously hypertensive rats (SHRs) and the mechanisms underlying the anti-fibrotic effect of Cur in rat cardiac fibroblasts (CFs) in vitro.Methods:SHRs were orally treated with Cur (100 mg·kg-1 ·d-1) or Cur (100 mg·kg-1 ·d-1) plus the PPAR-γ antagonist GW9662 (1 mg·kg-1 ·d-1) for 12 weeks. Cultured CFs were treated with angiotensin II (Ang II, 0.1 μmol/L) in vitro. The expression of relevant proteins and mRNAs was analyzed using Western blotting and real-time PCR, respectively. The expression and activity of peroxisome proliferator-activated receptor-γ (PPAR-γ) were detected using Western blotting and a DNA-binding assay, respectively.Results:Treatment of SHRs with Cur significantly decreased systolic blood pressure, blood Ang II concentration, heart weight/body weight ratio and left ventricle weight/body weight ratio, with concurrently decreased expression of connective tissue growth factor (CTGF), plasminogen activator inhibitor (PAI)-1, collagen III (Col III) and fibronectin (FN), and increased expression and activity of PPAR-γ in the left ventricle. Co-treatment with GW9662 partially abrogated the anti-fibrotic effects of Cur in SHRs. Pretreatment of CFs with Cur (5, 10, 20 μmol/L) dose-dependently inhibited Ang II-induced expression of CTGF, PAI-1, Col III and FN, and increased the expression and binding activity of PPAR-γ. Pretreatment with GW9662 partially reversed anti-fibrotic effects of Cur in vitro. Furthermore, pretreatment of CFs with Cur inhibited Ang II-induced expression of transforming growth factor-β1 (TGF-β1) and phosphorylation of Smad2/3, which were reversed by GW9662.Conclusion:Cur attenuates cardiac fibrosis in SHRs and inhibits Ang II-induced production of CTGF, PAI-1 and ECM in CFs in vitro. The crosstalk between PPAR-γ and TGF-β1/Smad2/3 signaling is involved in the anti-fibrotic and anti-proliferative effects of Cur. © 2014 CPS and SIMM.


Ou X.,CAS Beijing National Laboratory for Molecular | Jiang L.,CAS Beijing National Laboratory for Molecular | Chen P.,CAS Beijing National Laboratory for Molecular | Chen P.,Zhengzhou University | And 5 more authors.
Advanced Functional Materials | Year: 2013

Highly stable graphene oxide (GO)-based multilayered ultrathin films can be covalently immobilized on solid supports through a covalent-based method. It is demonstrated that when (3-aminopropyl) trimethoxysilane (APTMS), which works as a covalent cross-linking agent, and GO nanosheets are assembled in an layer-by-layer (LBL) manner, GO nanosheets can be covalently grafted on the solid substrate successfully to produce uniform multilayered (APTMS/GO)N films over large-area surfaces. Compared with conventional noncovalent LBL films constructed by electrostatic interactions, those assembled using this covalent-based method display much higher stability and reproducibility. Upon thermal annealing-induced reduction of the covalent (APTMS/GO)N films, the obtained reduced GO (RGO) films, (APTMS/RGO)N, preserve their basic structural characteristics. It is also shown that the as-prepared covalent (APTMS/RGO)N multilayer films can be used as highly stable source/drain electrodes in organic field-effect transistors (OFETs). When the number of bilayers of the (APTMS/RGO)N film exceeds 2 (ca. 2.7 nm), the OFETs based on (APTMS/RGO)N electrodes display much better electrical performance than devices based on 40 nm Au electrodes. The covalent protocol proposed may open up new opportunities for the construction of graphene-based ultrathin films with excellent stability and reproducibility, which are desired for practical applications that require withstanding of multistep post-production processes. Highly stable graphene-based multilayers films are covalently immobilized on solid supports. Compared with those formulated through a noncovalent-based method, the as-constructed covalent-based multilayered films display much higher stability and reproducibility, suggesting a bright future for practical applications that require withstanding of multistep post-production processes. The application of the covalent graphene-based films as source/drain electrodes in organic field-effect transistors is investigated. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Wang W.-Y.,Tongji University | Pei L.-J.,Zhengzhou University
Acta Mechanica Sinica/Lixue Xuebao | Year: 2011

Since the ratio-dependent theory reflects the fact that predators must share and compete for food, it is suitable for describing the relationship between predators and their preys and has recently become a very important theory put forward by biologists. In order to investigate the dynamical relationship between predators and their preys, a so-called Michaelis-Menten ratio-dependent predator-prey model is studied in this paper with gestation time delays of predators and preys taken into consideration. The stability of the positive equilibrium is investigated by the Nyquist criteria, and the existence of the local Hopf bifurcation is analyzed by employing the theory of Hopf bifurcation. By means of the center manifold and the normal form theories, explicit formulae are derived to determine the stability, direction and other properties of bifurcating periodic solutions. The above theoretical results are validated by numerical simulations with the help of dynamical software WinPP. The results show that if both the gestation delays are small enough, their sizes will keep stable in the long run, but if the gestation delays of predators are big enough, their sizes will periodically fluctuate in the long term. In order to reveal the effects of time delays on the ratio-dependent predator-prey model, a ratio-dependent predator-prey model without time delays is considered. By Hurwitz criteria, the local stability of positive equilibrium of this model is investigated. The conditions under which the positive equilibrium is locally asymptotically stable are obtained. By comparing the results with those of the model with time delays, it shows that the dynamical behaviors of ratio-dependent predator-prey model with time delays are more complicated. Under the same conditions, namely, with the same parameters, the stability of positive equilibrium of ratio-dependent predator-prey model would change due to the introduction of gestation time delays for predators and preys. Moreover, with the variation of time delays, the positive equilibrium of the ratio-dependent predator-prey model subjects to Hopf bifurcation. © 2011 The Chinese Society of Theoretical and Applied Mechanics; Institute of Mechanics, Chinese Academy of Sciences and Springer-Verlag GmbH.


Liu J.-B.,Nanjing University | Yue J.-Y.,Zhengzhou University
Journal of International Medical Research | Year: 2014

Objective: To study the apoptosis-inducing effect of the Chinese medicine oridonin in the human oesophageal squamous cell carcinoma cell line EC9706, in vitro. Methods: The effect of oridonin on cell proliferation was studied using the colorimetric 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Effects on the cell cycle and apoptosis were studied by flow cytometry; effects on intracellular Ca2+ concentration were studied by measuring the fluorescence intensity of a fluorescent Ca2+ probe by laser scanning confocal microscopy. Results: The EC9706 cell-proliferation rate decreased with time and oridonin concentration (10-40 μmol/l). The number of cells in G0 and G1 phases increased significantly following exposure to oridonin for 48 and 72 h respectively, and oridonin was shown to be most effective at inducing apoptosis in EC9706 cells at 40 μmol/l. Compared with the control group, all concentrations of oridonin tested (10-40 μmol/l) significantly increased the Ca2+ fluorescence intensity of EC9706 cells. Conclusions: Oridonin was shown to inhibit proliferation and induce apoptosis in the human oesophageal squamous cell carcinoma cell line EC9706, in vitro. These data provide preliminary experimental evidence for the anticancer effects of oridonin, which is as a traditional Chinese medicine used to treat various cancers, including oesophageal squamous cell carcinoma. Further studies are required to elucidate the mode of action. © The Author(s) 2014.


Li S.,Zhengzhou University | Ng C.T.,Hong Kong Polytechnic University | Yuan J.,Zhengzhou University
International Journal of Production Economics | Year: 2011

We consider a single-machine scheduling problem involving both the due date assignment and job scheduling under a group technology environment. The jobs (orders) of customers are classified into groups according to their production similarities in advance. To achieve production efficiency and save time/money resource, all jobs of the same group are required to be processed contiguously on the machine. A sequence-independent setup time precedes the processing of each group. The due dates are assignable according to one of the following three due date assignment methods: FML-CON, FML-SLK and DIF, where FML-CON means that all jobs within the same group are assigned a common due date, FML-SLK means that all jobs within the same group are assigned an equal flow allowance, and DIF means that each job can be assigned a different due date with no restrictions. The goal is to determine an optimal combination of the due date assignment strategy and job schedule so as to minimize an objective function that includes earliness, tardiness, due date assignment and flow time costs. An O(nlogn) time unified optimization algorithm is provided for all of the above three due date assignment methods. © 2010 Elsevier B.V. All rights reserved.


Ng C.T.,Hong Kong Polytechnic University | Lu L.,Hong Kong Polytechnic University | Lu L.,Zhengzhou University
Journal of Scheduling | Year: 2012

In this paper, we consider the on-line integrated production and outbound distribution scheduling problem to minimize the maximum delivery completion time. All jobs arrive over time, and each job and its processing time become known at its arrival time. The jobs are first processed on a single machine and then delivered by a vehicle to a single customer. The vehicle can deliver at most c jobs to the customer at a time. When preemption is allowed and c > 2, we can provide an on-line algorithm with the best competitive ratio 2 √5+1/2≈ 1.618. When preemption is not allowed, we provide an on-line algorithm which has the best competitive ratio √5+1/2≈ 1.618 for the case c = 1 and has an asymptotic competitive ratio √5+1/2≈1.618 for the case c > 2. © Springer Science+Business Media, LLC 2011.


Yang B.,Zhengzhou University | Yang B.,Beijing Jiaotong University | Huang H.,Beijing Jiaotong University
Knowledge and Information Systems | Year: 2010

Frequent itemset mining over data streams becomes a hot topic in data mining and knowledge discovery in recent years, and has been applied to different areas. However, the setting of a minimum support threshold needs some domain knowledge. It will bring a lot of difficulties or much burden to users if the support threshold is not set reasonably. It is interesting for users to find top-K frequent itemsets over data streams. In this paper, a dynamical incremental approximate algorithm TOPSIL-Miner is presented to mine top-K significant itemsets in landmark windows. A new data structure, TOPSIL-Tree, is designed to store the potential significant itemsets and other data structures of maximum support list, ordered item list, TOPSET and minimum support list are devised to maintain information about mining results. Moreover, three optimal strategies are exploited to reduce time and space cost of the algorithm: (1) pruning trivial nodes in the current data stream, (2) promoting mining support threshold during mining process adaptively and heuristically, and (3) promoting pruning threshold dynamically. The accuracy of the algorithm is also analyzed. Extensive experiments are performed to evaluate the good effectiveness and the high efficiency and precision of the algorithm. © 2009 Springer-Verlag London Limited.


Qu B.Y.,Zhengzhou University | Qu B.Y.,Nanyang Technological University | Liang J.J.,Zhengzhou University | Suganthan P.N.,Nanyang Technological University
Information Sciences | Year: 2012

Multimodal optimization is still one of the most challenging tasks for evolutionary computation. In recent years, many evolutionary multi-modal optimization algorithms have been developed. All these algorithms must tackle two issues in order to successfully solve a multi-modal problem: how to identify multiple global/local optima and how to maintain the identified optima till the end of the search. For most of the multi-modal optimization algorithms, the fine-local search capabilities are not effective. If the required accuracy is high, these algorithms fail to find the desired optima even after converging near them. To overcome this problem, this paper integrates a novel local search technique with some existing PSO based multimodal optimization algorithms to enhance their local search ability. The algorithms are tested on 14 commonly used multi-modal optimization problems and the experimental results suggest that the proposed technique not only increases the probability of finding both global and local optima but also reduces the average number of function evaluations. © 2012 Elsevier Inc. All rights reserved.


Ding L.,Kyoto University | Ding L.,Zhengzhou University | Chung L.W.,Kyoto University | Morokuma K.,Kyoto University
Journal of Chemical Theory and Computation | Year: 2014

The detailed DFT investigation clears the working mechanism of the irreversible photoisomerization of trans-[Ru(tpy)(pynp)(OH2)] 2+ (TA) and cis-[Ru(tpy)(pynp)(OH2)]2+ (CA) complexes. Both TA and CA complexes present two types of low lying triplet states, one resulting from a triplet metal-ligand charge-transfer (T MLCT) and the other from a triplet metal-centered d-d transition (TMC). The vertical excitation of the singlet ground state of the complexes leads to a singlet excited state, which undergoes ultrafast decay to the corresponding TMLCT. For TA, this TMLCT transforms with a low barrier to a TMC state. The dissociative nature of the TMC state leads to easy water removal to produce a five-coordinate intermediate that can isomerize via rotation of a pynp ligand and proceed towards the CA product. For CA, however, during this excitation and intersystem crossing process, an excited-state proton transfer (ESPT) occurs and the resultant TMLCT is very much stabilized with a very strong Ru(II)-OH bond; the high barrier from this TMLCT blocks conversion to a T MC state and thus prevents isomerization from the cis to the trans isomer. This high barrier also prevents the possibility of the isomerization process from TA to CA solely on the adiabatic triplet pathway. Instead, crossing points (XMC-CB, XMC-CA) near the minimum of the triplet metal-centered state of the cis isomer provide nonadiabatic decay channels to the ground-state S0 - CA, which completes the photoisomerization pathway from TA to CA. © 2014 American Chemical Society.


Bian X.Y.,Shanghai University of Electric Power | Tse C.T.,Hong Kong Polytechnic University | Zhang J.F.,Hong Kong Polytechnic University | Wang K.W.,Zhengzhou University
International Journal of Electrical Power and Energy Systems | Year: 2011

This paper presents an application of probabilistic theory to the coordinated design of power system stabilizers (PSSs) and FACTS controllers, taking static VAr system (SVC) as an example. The aim is to enhance the damping of multi electro-mechanical modes in a multimachine system over a large and pre-specified set of operating conditions. In this work, conventional eigenvalue analysis is extended to the probabilistic environment in which the statistical nature of eigenvalues corresponding to different operating conditions is described by their expectations and variances. Probabilistic sensitivity indices (PSIs) are used for robust damping controller site selection and for optimization objective functions. A probabilistic eigenvalue-based objective function is employed for coordinated design of PSS and SVC controller parameters. The effectiveness of the proposed controllers is demonstrated on an 8-machine system. © 2010 Elsevier Ltd. All rights reserved.


Yu R.,Georgia Institute of Technology | Dong L.,Georgia Institute of Technology | Dong L.,Zhengzhou University | Pan C.,Georgia Institute of Technology | And 7 more authors.
Advanced Materials | Year: 2012

The transport properties of GaN nanobelts (NBs) are tuned using a piezotronic effect when a compressive/tensile strain is applied on the GaN NB. This is mainly due to a change in Schottky barrier height (SBH). A theoretical model is proposed to explain the observed phenomenon. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Zhu X.,Zhengzhou University | Wang Y.,Nanyang Technological University
IEEE International Conference on Control and Automation, ICCA | Year: 2011

This paper studies the stability problem of a class of linear switched systems with time-varying delay in the sense of Hurwitz convex combination. By designing a parameter-dependent switching law and using a reciprocally convex combination technique to deal with delay terms, a new stability criterion is established in terms of linear matrix inequalities (LMIs), which is dependent on the parameters of Hurwitz convex combination. The advantage of the new criterion lies in its less conservatism and simplicity. Numerical examples are given to illustrate the effectiveness and the less conservatism of the proposed method. © 2011 IEEE.


Zhu G.,Nanjing Medical University | Lou W.,Zhengzhou University
Head and Neck | Year: 2014

Background Because of ease of harvest and low immunogenicity, xenogeneic acellular nerve graft (XANG) may be an alternative to autologous nerve to repair facial nerve defects. Methods Facial nerve defects of Wistar rats were repaired by XANG, and nerve gap regeneration was investigated by electrophysiological test, horseradish peroxidase (HRP) retrograde tracing and histomorphometric analysis, as compared to autograft. Results Twenty weeks after the grafting, electrophysiology showed that whisker pad muscles responded to the electrical stimuli given at the site proximal to the transplantation in 2 groups. Some HRP-labeled facial motorneurons were located on the facial nucleus of the operated side, and an abundance of myelinated axons were found at the middle of the grafts and obvious motor endplates in the target muscles in 2 groups, although they were inferior to the contralateral side in numbers. Conclusion XANG represents an alternative approach for the reconstruction of peripheral facial nerve defects. © 2013 Wiley Periodicals, Inc.


Zhang Q.,CAS Shanghai Institute of Organic Chemistry | Sun J.,CAS Shanghai Institute of Organic Chemistry | Zhu Y.,CAS Shanghai Institute of Organic Chemistry | Zhang F.,Zhengzhou University | Yu B.,CAS Shanghai Institute of Organic Chemistry
Angewandte Chemie - International Edition | Year: 2011

Persuaded with gold: The title reaction in the presence of [Ph 3PAuNTf2] (Tf=trifluoromethanesulfonyl) led conveniently to the corresponding nucleosides with excellent regioselectivity (see scheme). Even purine derivatives underwent this transformation owing to the mild conditions, which enabled the use of protecting groups that would not usually be compatible with N-glycosylation conditions. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Liu Y.,Zhengzhou University | Liu Y.,The First Peoples Hospital of Shangqiu | Song L.,Zhengzhou University
International Journal of Clinical and Experimental Pathology | Year: 2015

Neuroblastoma inflicts mostly on children, and the pathogenesis remains elusive. Clinical diagnosis and therapeutic approaches are still on the incipient stage, so further understanding of the molecular and cellular mechanisms of the disease is necessary. Inflammation has been commonly regarded as a hallmark in tumorigenesis and development, and we identified a new inflammatory factor, HMGB1, is considerably increased in neuroblastoma. Our study shows that HMGB1 induces autophagy in Schwann cells through activation of TLR4, and knockdown of TLR4 obviates the HMGB1-induced autophagy. The HMGB1-induced autophagy is through classical pathway, as deficiency of Beclin 1 deprived autophagy in Schwann cells. Coculture of neuroblastoma with Schwann cells pretreated with HMGB1 promoted the proliferation of neuroblastoma cells, and if Beclin 1 is knocked down in Schwann cells, no promotion effects is observed. Taken together, our study demonstrates that HMGB1-induced autophagy in Schwann cells contributes to neuroblastoma cell proliferation, thus providing a potential therapeutic approach on neuroblastoma development.


Pan Q.-K.,Liaocheng University | Suganthan P.N.,Nanyang Technological University | Liang J.J.,Zhengzhou University | Tasgetiren M.F.,Yaşar University
Expert Systems with Applications | Year: 2011

In this paper, a local-best harmony search (HS) algorithm with dynamic sub-harmony memories (HM), namely DLHS algorithm, is proposed to minimize the total weighted earliness and tardiness penalties for a lot-streaming flow shop scheduling problem with equal-size sub-lots. First of all, to make the HS algorithm suitable for solving the problem considered, a rank-of-value (ROV) rule is applied to convert the continuous harmony vectors to discrete job sequences, and a net benefit of movement (NBM) heuristic is utilized to yield the optimal sub-lot allocations for the obtained job sequences. Secondly, an efficient initialization scheme based on the NEH variants is presented to construct an initial HM with certain quality and diversity. Thirdly, during the evolution process, the HM is dynamically divided into many small-sized sub-HMs which evolve independently so as to balance the fast convergence and large diversity. Fourthly, a new improvisation scheme is developed to well inherit good structures from the local-best harmony vector in the sub-HM. Meanwhile, a chaotic sequence to produce decision variables for harmony vectors and a mutation scheme are utilized to enhance the diversity of the HM. In addition, a simple but effective local search approach is presented and embedded in the DLHS algorithm to enhance the local searching ability. Computational experiments and comparisons show that the proposed DLHS algorithm generates better or competitive results than the existing hybrid genetic algorithm (HGA) and hybrid discrete particle swarm optimization (HDPSO) for the lot-streaming flow shop scheduling problem with total weighted earliness and tardiness criterion. © 2010 Elsevier Ltd. All rights reserved.


Li S.F.,University College London | Li S.F.,Zhengzhou University | Guo Z.X.,University College London
Journal of Physical Chemistry C | Year: 2010

From first-principles simulations, we identify that CO2 is strongly activated and chemically adsorbed via both the carbon and the oxygen atoms and can totally dissociate on the Ti (0001) surface, under appropriate conditions, in contrast to relatively weak interactions of CO2 with other transition metals reported previously. This strong activation is due to the relatively small work function or electronegativity of Ti. We postulate that a structure with a smaller work function provides greater activation for CO2. The findings point to new directions for the design of efficient Ti-based alloy catalysts for CO2 capture and conversion. © 2010 American Chemical Society.


Zhang H.-L.,Central Hospital of Zhumadian City | Zhang Y.-J.,Zhengzhou University
Tumor Biology | Year: 2013

Tumor necrosis factor alpha (TNF-α) is a multifunctional cytokine which plays an important role in the human immune response against various pathogens, and there may be a relationship between TNF-α 308 G/A polymorphism and cervical cancer risk. We performed a meta-analysis to get a systemic assessment of the association between TNF-α 308 G/A polymorphism and cervical cancer risk. Electronic searches of PubMed, Embase, and Web of Science were performed for all publications on the association between TNF-α 308 G/A polymorphism and cervical cancer risk through October 26, 2012. The pooled odds ratios (ORs) with their 95 % confidence interval (95 % CIs) were calculated to assess the association. Fifteen studies with a total of 3,743 cervical cancer cases and 4,096 controls were finally included into the meta-analysis. Overall, TNF-α 308 G/A polymorphism was significantly associated with increased risk of cervical cancer under three main genetic comparison models (A vs. G, OR 1.20, 95 % CI 1.02-1.42, P = 0.03; AA vs. GG, OR 1.31, 95 % CI 1.00-1.72, P = 0.048; AA vs. GG/GA, OR 1.30, 95 % CI 1.00-1.71, P = 0.05). Subgroup analysis by ethnicity further showed that there was a significant association between TNF-α 308 G/A polymorphism and increased risk of cervical cancer in Asians (AA vs. GG, OR 1.83, 95 % CI 1.05-3.20, P = 0.034; AA vs. GG/GA, OR 1.84, 95 % CI 1.05-3.22, P = 0.032). The meta-analysis suggests that TNF-α 308 G/A polymorphism is associated with increased risk of cervical cancer, and TNF-α 308 G/A mutant allele A is a risk factor of cervical cancer. © 2013 International Society of Oncology and BioMarkers (ISOBM).


Zhu X.-L.,Zhengzhou University | Zhu X.-L.,Huazhong University of Science and Technology | Chen B.,Qingdao University | Yue D.,Huazhong University of Science and Technology | Wang Y.,Nanyang Technological University
IEEE Transactions on Fuzzy Systems | Year: 2012

In this paper, we investigate the problem of stabilization for sampled-data fuzzy systems under variable sampling. A novel Lyapunov-Krasovskii functional (LKF) is defined to capture the characteristic of sampled-data systems, and an improved input delay approach is proposed. By the use of an appropriate enlargement scheme, new stability and stabilization criteria are obtained in terms of linear matrix inequalities (LMIs). Compared with the existing results, the newly obtained ones contain less conservatism. Some illustrative examples are given to show the effectiveness of the proposed method and the significant improvement on the existing results. © 2012 IEEE.


Qu B.Y.,Nanyang Technological University | Qu B.Y.,Zhengzhou University | Suganthan P.N.,Nanyang Technological University | Liang J.J.,Zhengzhou University
IEEE Transactions on Evolutionary Computation | Year: 2012

In this paper, a neighb