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Liu W.,Zhengzhou Children s Hospital | Zhou C.-C.,Zhengzhou Children s Hospital | Tian L.,Zhengzhou Children s Hospital | Mao Y.-N.,Zhengzhou Children s Hospital | Zou X.-F.,Zhengzhou Children s Hospital
Journal of Leukemia and Lymphoma | Year: 2012

Objective To improve the diagnosis rate and decrease misdiagnosis through analyzing the clinical and experimental features of neuroblastoma (NB) in children. Methods The clinical and experimental features associated with the misdiagnosis factors of 22 NB cases were analyzed retrospectively. Results Of the 22 cases, leg pain in 15 cases (68.18 %), fever in 19 cases (86.36 %), anemia in 20 cases (90.90 %), abdominal pain and bloating in 15 cases (68.18 %), exophthalmoses and bruises eyes in 4 cases (18.18 %) and easily perspire in 20 cases (90.90 %). Abdomen was the most common primary site founding in 16 cases (accounting for 72.72 %), followed by mediastinum founding in 4 cases (accounting for 18.18 %), other sites were 2 cases (9.09 %). Laboratory results showed that anemia was the most common cause in 20 cases (90.90 %), oligoleukocythemia in 2 cases (9.09 %) and less in thrombocytopenia about 3 cases (13.63 %). Elevated values were recorded in 77.77 % of patients for vanillylmandelic acid (VMA), 86.36 % for ferritin (Fer), 90.90 % for lactate dehydrogenase (LDH), and in 100.00 % for neuron specific enolase (NSE). 20 cases were found metastasis when diagnosed, which accounted for 90.90 % 16 cases (72.72 %) were found tumour cells which determined in bone marrow and 20 cases (90.90 %) were positive for CD56-FITC/CD81-PE/ CD45-Percp by flow cytometry (FCM). 12 (54.54 %) of 22 NB cases were misdiagnosed for rheumatoid diseases (4 cases), dyspepsia (4 cases), leukemia (3 cases) and thrambocytopenia (1 case). In 22 cases, 20 cases (90.90 %) were positive for CT scan, 16 cases (72.72 %) were positive for abdominal B ultrasonography, and 14 cases (63.63 %) were positive for radionuclide bone scan. Conclusion B ultrasonography and CT scan will contribute to find the primary focus of NB at early stage. VMA, bone marrow smear, biopsy and FCM detection could reduce misdiagnose rate. Source

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