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Huina L.,Zhengzhou University | Huina L.,The Zhengzhou Central Hospital | Huirong S.,Zhengzhou University | Hailing Z.,Zhengzhou University | And 3 more authors.
African Journal of Microbiology Research | Year: 2011

The aim of the present study was to examine effect of DLC-1 gene transfect OVCAR-3 cells in vivo on tumour growth in nude mice. Results showed that tumor development rate in OVCAR-3/DLC-1 group, OVCAR-3/pEGFP-C3 group and OVCAR-3 group were 87, 87 and 100%, respectively. After 40 days, tumour cells were not detected in peripheral blood of mice in every group. Low expression of P-FAK, P- P130 cas and P-JNK proteins was detected in group OVCAR-3/DLC-1, while high expression was found in group OVCAR-3/pEGFP-C3 and OVCAR-3. the brightness of the bands of P130cas mRNA, FAK mRNA and JNK mRNA in group OVCAR-3/DLC-1 became weaker, while the brightness of the bands become stronger in group OVCAR-3/pEGFP-C3 and group OVCAR-3. DLC-1, as a anti-tumor related target gene, possesses a promising future. © 2011 Academic Journals.

HuiNa L.,Zhengzhou University | HuiNa L.,The Zhengzhou Central Hospital | HuiRong S.,Zhengzhou University | HaiLing Z.,Zhengzhou University | And 3 more authors.
International Journal of Physical Sciences | Year: 2011

We investigated expression of DLC1 and p-FAK proteins in epithelial ovarian cancer using immunohistochemistry method. Results showed that low expression of DLC-1 gene and high expression of p-FAK gene might have a correlation with occurrence, metastasis and infiltration of epithelial ovarian cancer. They might play together an important role in occurrence and development of epithelial ovarian cancer. ©2011 Academic Journals.

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