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Medicine, China

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Zhu H.Z.,Zhejiang universityZhejiang | Wu Z.,Shanxi University of Finance and Economics
Applied Mechanics and Materials | Year: 2014

With the development of global economic "integration" and "regionalization", it promoted the pace of changes of information technology and the market environment. The current companies attach great importance to the long-term business development strategic and coupled with resource constraints and increased competition, especially under the IT technical support environment. The companies begin to think about selecting ERP supply chain management, encouraging themselves to raise the whole level of integrated management and maximize expand business scope and finally improve the economic efficiency of the enterprises. © (2014) Trans Tech Publications, Switzerland.


Jian L.,The Second Affiliated Hospital of Zhengzhou UniversityHenan | Jian D.,Zhejiang UniversityZhejiang | Chen Q.,Zhejiang UniversityZhejiang | Zhang L.,Zhejiang UniversityZhejiang
Journal of Atherosclerosis and Thrombosis | Year: 2016

Long noncoding RNAs (lncRNAs) were a group of non-protein-coding RNAs >200 nucleotides and participated in biological processes and pathophysiological conditions in vivo or in vitro. Recently, more and more lncRNAs interfering with the progress of atherosclerosis were identified and characterized in the atherogenic cells such as vascular smooth muscle cells (VSMCs), endothelial cells (ECs), and monocytes/macrophages showing that lncRNAs play an important role in the occurrence of atherosclerosis. In this review, we summarized and highlighted the lncRNAs that play a role in the process of atherosclerosis. This study may provide helpful insights regarding further study of lncRNAs associated with atherosclerosis. © 2016, Journal of Atherosclerosis and Thrombosis. All rights reserved.


Li X.,Zhejiang UniversityZhejiang | Zhang H.,State Key Laboratory of Shield Machine and Boring Technology | Xue Y.,Zhejiang UniversityZhejiang | Shao C.,Zhejiang UniversityZhejiang
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2015

The most important part of the excavation for slurry shield machine is keeping the earth pressure and slurry circulation system pressure in balance. In this paper, an excavating face pressure balance principle for direct type slurry shield machine is analyzed and the pressure balance dynamic model is introduced. Then, a controller is designed based on predictive function control method. Finally, the controller initialization method is proposed to deal with the problem of controller switching from manual to automatic mode. Simulation results show the improved performance of proposed method. © Springer International Publishing Switzerland 2015.


Liang H.,Zhejiang University | Xu Z.,Zhejiang University | Zheng Z.,Hengdian Hospital of Zhejiang ProvinceZhejiang | Lou H.,Zhejiang UniversityZhejiang | Yue W.,Tianjin Huanhu Hospital
Orphanet Journal of Rare Diseases | Year: 2015

Background: Reversible cerebral vasoconstriction syndrome (RCVS) is an infrequent disease characterized by severe headaches with or without focal neurological deficits or seizures and a reversible vasoconstriction of cerebral arteries. The Orpha number for RCVS is ORPHA284388. However, RCVS triggered by blood transfusion is rare. Here we provided the clinical, neuroimaging and outcome data of patients diagnosed with RCVS resulting from red blood cells transfusion. Methods: We retrospectively identified 7 patients presenting with RCVS after red blood cells transfusion from January 2010 to May 2014. The information on clinical features, neuroimaging and outcome were collected and analyzed. Results: All 7 patients were Chinese women, with a mean age of 42 years (38-46). All the patients had severe anemia (Hb level<6 g/dl) caused by primary menorrhagia due to uterine myoma (n=5) or end-stage renal disease (n=2) and severe anemia persisted for a average period of 4 months (2-6). Each patient received packed red blood cells transfusion (average: 1580 ml) over a period of 2-5 days. Blood transfusion increased the hemoglobin level by at least 4.5 g/dL from baseline. The neurological symptoms appeared a mean of 6.3 days (2-13) after the last blood transfusion. Headache was the most frequent symptom and seizure, transient or persistent neurological disorders were observed. Neuroimaging showed cortical subarachnoid hemorrhage (n=2), focal intracerebral hemorrhage (n=2), localized brain edema (n=3), cerebral infarction (n=1), and posterior reversible encephalopathy syndrome (n=2). Cerebral vasoconstrictions were demonstrated by magnetic resonance angiography or cerebral angiography. Arterial constriction reversed in all patients within 1 to 3 months of follow-up after disease onset and no relapse was observed up to a mean of 17.1±4.8 months of follow-up. Conclusions: RCVS is a rare complication as a result of blood transfusion in patients with chronic severe anemia and should be considered in patients who show severe headache or neurologic deficits after transfusion. © 2015 Liang et al.; licensee BioMed Central.


PubMed | Zhejiang UniversityZhejiang, Sir Run Run Shaw Hospital Hangzhou and Zhejiang University
Type: Journal Article | Journal: American journal of translational research | Year: 2017

The study was designed to investigate the oxidative stress levels of endothelial progenitor cells (EPCs) in stable coronary artery disease (CAD) and to explore the underlying mechanisms of NADPH oxidase activation and subsequent EPCs dysfunction.EPCs were isolated from patients with stable CAD (n=50) and matched healthy volunteers (n=50). NADPH oxidase activation was detected by measuring the expression of each subunit using western blotting and qPCR analyses and the membrane translocation of p47Oxidative stress level was increased and the in vivo angiogenesis capacity was impaired in EPCs obtained from CAD subjects with the activation of NADPH oxidase. P47NADPH oxidase activation via p47


Waygood E.O.D.,Laval University | Sun Y.,Zhejiang UniversityZhejiang | Letarte L.,Laval University
International Journal of Environmental Research and Public Health | Year: 2015

Active travel can contribute to physical activity achieved over a day. Previous studies have examined active travel associated with trips in various western countries, but few studies have examined this question for the Asian context. Japan has high levels of cycling, walking and public transport, similar to The Netherlands. Most studies have focused either on children or on adults separately, however, having children in a household will change the travel needs and wants of that household. Thus, here a household lifecycle stage approach is applied. Further, unlike many previous studies, the active travel related to public transport is included. Lastly, further to examining whether the built environment has an influence on the accumulation of active travel minutes, a binary logistic regression examines the built environment’s influence on the World Health Organization’s recommendations of physical activity. The findings suggest that there is a clear distinction between the urbanized centers and the surrounding towns and unurbanized areas. Further, active travel related to public transport trips is larger than pure walking trips. Females and children are more likely to achieve the WHO recommendations. Finally, car ownership is a strong negative influence. © 2015 by the authors; licensee MDPI, Basel, Switzerland.


Liu K.,New York University | Sun Z.,Zhejiang UniversityZhejiang | Wei T.,Zhejiang UniversityZhejiang
Clinical Medicine Insights: Cardiology | Year: 2015

Although most patients with Takotsubo cardiomyopathy (TTC) have benign clinical course and prognosis, TTC can induce acute heart failure and hemodynamic instability. TTC mimics the clinical features of acute anterior wall myocardial infarction (AMI). Bedside clinicians often have a diagnostic dilemma when cardiac catheterization and angiography are either contraindicated or can cause potential adverse consequences. Misdiagnosing TTC as AMI will lead to initiation of harmful pharmacological or device-based treatment, which worsens hemodynamic compromise. Therefore, under-standing and interpreting the unique pathophysiological and hemodynamic features of TTC in a better manner becomes crucial to guide effective clinical management of acute heart failure/cardiogenic shock during TTC. We review recent advances in echocardiographic diagnosis of TTC and its role in guid-ing bedside management of acute heart failure and cardiogenic shock, with specific focus on the interpretation of discrepant, but reciprocally dependent, left and right ventricular hemodynamics during acute stages of TTC. © the authors, publisher and licensee Libertas Academica Limited.


Zhang H.,Zhejiang UniversityZhejiang | Pei Y.,Zhejiang UniversityZhejiang
International Journal of Environmental Research and Public Health | Year: 2016

Quantitative prediction of construction noise is crucial to evaluate construction plans to help make decisions to address noise levels. Considering limitations of existing methods for measuring or predicting the construction noise and particularly the equivalent continuous noise level over a period of time, this paper presents a discrete-event simulation method for predicting the construction noise in terms of equivalent continuous level. The noise-calculating models regarding synchronization, propagation and equivalent continuous level are presented. The simulation framework for modeling the noise-affected factors and calculating the equivalent continuous noise by incorporating the noise-calculating models into simulation strategy is proposed. An application study is presented to demonstrate and justify the proposed simulation method in predicting the equivalent continuous noise during construction. The study contributes to provision of a simulation methodology to quantitatively predict the equivalent continuous noise of construction by considering the relevant uncertainties, dynamics and interactions. © 2016 by the authors; licensee MDPI, Basel, Switzerland.


Luo J.,Zhejiang UniversityZhejiang | Mao Y.,Zhejiang UniversityZhejiang | Cai S.,Zhejiang UniversityZhejiang | Shen X.,Zhejiang UniversityZhejiang | And 2 more authors.
OncoTargets and Therapy | Year: 2014

Recently, iatrogenic foreign-body granuloma has been increasingly reported. The asymptomatic presentation and confusing appearance of granuloma can lead to misdiagnosis of a secondary malignancy, especially for a patient with a corresponding past medical history. Sometimes, surgical treatment is unavoidable, and the diagnosis relies upon the pathologic result. Herein, we report an unusual case of a 43-year-old man who underwent a nephrectomy for renal cell carcinoma (clear cell type) 5 years ago. A secondary granuloma was identified behind the inferior vena cava in the retroperitoneum 6 months after the surgery, but the radiologists had failed to identify it throughout the 4 years of routine examination. Later on, the lesion was identified by positron emission tomography, which classified it as a highly 1 8F-fuorodeoxyglucose-avid lesion. Considering no visible foreign-bodies identified on images, the lesion was arguably diagnosed as a lymph node metastasis of renal cancer. Finally, it was confirmed as a foreign-body granuloma encasing surgical suture and adipose tissue by the pathological analysis. © 2014 Luo et al.


Liang D.,Hokkaido University | Kaneko S.,Hokkaido University | Hashimoto M.,Chukyo University | Iwata K.,Japan National Institute of Advanced Industrial Science and Technology | Zhao X.,Zhejiang UniversityZhejiang
Pattern Recognition | Year: 2015

An illumination-invariant background model for detecting objects in dynamic scenes is proposed. It is robust in the cases of sudden illumination fluctuation as well as burst motion. Unlike the previous works, it uses the co-occurrence differential increments of multiple pixel pairs to distinguish objects from a non-stationary background. We use a two-stage training framework to model the background. First, joint histograms of co-occurrence probability are employed to screen supporting pixels with high normalized correlation coefficient values; then, K-means clustering-based spatial sampling optimizes the spatial distribution of the supporting pixels; finally the background model maintains a sensitive criterion with few parameters to detect foreground elements. Experiments using several challenging datasets (PETS-2001, AIST-INDOOR, Wallflower and a real surveillance application) prove the robust and competitive performance of object detection in various indoor and outdoor environments. © 2014 Elsevier Ltd. All rights reserved.

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