Time filter

Source Type

Wang C.-L.,Zhejiang Province Tumor Hospital | Jiang J.-W.,Zhejiang Province Tumor Hospital | Hou G.-L.,Zhejiang Province Tumor Hospital
Chinese Traditional and Herbal Drugs | Year: 2016

Objective: To establish an HPLC fingerprint method of Jizhi Syrup and determine the contents of its main components. Methods: The Waters XTerra RP-18 (250 mm × 4.6 mm, 5 μm) column was used with a mobile phase of 0.8% acetic acid (containning 0.2% triethylamine) and acetonitrile gradient elution, the flow rate was 1.0 mL/min, the column temperature was 35℃, and the detection wavelength was 280 nm. The Similarity Evaluation System for Chromatographic Fingerprint of TCM (2012 edition) was used to establish the fingerprint spectra and analyze the similarity degree. The common peaks were identified by reference compounds and negative controls, and the content was detected. Results: The fingerprint chromatography included 17 mutual peaks. Peak 2 and peak 8 were from Houttuyniae Herba, peak 4 and peak 10 were from Fagopyri Dibotryis Rhizoma, peaks 7, 12, and 15 were from Ilicis Chinensis Folium, peaks 1 and 13 were from Ephedrae Herba, peaks 16 and 17 were from Aurantii Fructus, and peaks 3 and 6 were from Houttuyniae Herba, Fagopyri Dibotryis Rhizoma, and Ilicis Chinensis Folium. The similarity among the batches was more than 0.98. Based on the retention time of master compounds, six components [protocatechuic acid (peak 3), protocatechualdehyde (peak 6), ferulic acid (peak 7), chlorogenic acid (peak 10), ephedrine hydrochloride (peak 13), and naringin (peak 16)] were identified and quantified. The contents of protocatechuic acid, protocatechualdehyde, ferulic acid, chlorogenic acid, ephedrine hydrochloride, and naringin in 10 batches of Jizhi Syrup were 3.122 1-3.270 0, 5.108 6-5.224 9, 8.893 2-9.120 8, 6.792 1-6.931 0, 2.154 4-2.236 2, and 4.125 8-4.183 3 mg/mL, respectively. Conclusion: The established method has high sensitivity, fast, precise and specificity, and can be used for the quality control of Jizhi Syrup. © 2016, Editorial Office of Chinese Traditional and Herbal Drugs. All right reserved.


Zhang H.-T.,Jiangwan Hospital | Gao X.-Y.,Fudan University | Xu Q.-S.,Jiangwan Hospital | Chen Y.-T.,Zhejiang Province Tumor Hospital | And 2 more authors.
OncoTargets and Therapy | Year: 2016

Objective: To evaluate the characteristics of enhancement of focal nodular hyperplasia (FNH) of the liver by analyzing the dynamic contrast-enhanced multislice computed tomography (MSCT) features and correlating them with pathological findings. Patients and methods: Nine males and 16 females with pathologically confirmed FNH and complete preoperative contrast-enhanced MSCT data were recruited for this study. The imaging features of FNH on the pre- and postcontrast MSCT were analyzed by two experienced radiologists by consensus. Results: Pathology showed central scars and abnormal blood vessels in 17 and 21 of 25 lesions, respectively, while MSCT with multiphase enhancement showed central scars in eight of the 17 lesions (47.1%) and abnormal arteries or draining veins in 13 of the 21 lesions (61.9%). Furthermore, abnormal draining veins in five lesions were found to be diagnostic, which is another important finding. Conclusion: Multiphase scanning can provide the panorama of FNH lesions and reveal their enhancement patterns and pathological characteristics. Abnormal blood vessels within or around the lesion are demonstrated more often than central scar, and both should be observed for FNH diagnosis. © 2016 Zhang et al.


PubMed | Fudan University, Jiangwan Hospital and Zhejiang Province Tumor Hospital
Type: | Journal: OncoTargets and therapy | Year: 2016

To evaluate the characteristics of enhancement of focal nodular hyperplasia (FNH) of the liver by analyzing the dynamic contrast-enhanced multislice computed tomography (MSCT) features and correlating them with pathological findings.Nine males and 16 females with pathologically confirmed FNH and complete preoperative contrast-enhanced MSCT data were recruited for this study. The imaging features of FNH on the pre- and postcontrast MSCT were analyzed by two experienced radiologists by consensus.Pathology showed central scars and abnormal blood vessels in 17 and 21 of 25 lesions, respectively, while MSCT with multiphase enhancement showed central scars in eight of the 17 lesions (47.1%) and abnormal arteries or draining veins in 13 of the 21 lesions (61.9%). Furthermore, abnormal draining veins in five lesions were found to be diagnostic, which is another important finding.Multiphase scanning can provide the panorama of FNH lesions and reveal their enhancement patterns and pathological characteristics. Abnormal blood vessels within or around the lesion are demonstrated more often than central scar, and both should be observed for FNH diagnosis.


Wan Y.-T.,Armed Police Corps Hospital of Jiangxi Province | Hong Y.,Armed Police Corps Hospital of Jiangxi Province | Lu K.,Zhejiang Province Tumor Hospital | Wang J.-S.,Jiangxi University of Traditional Chinese Medicine | And 4 more authors.
Chinese Journal of New Drugs | Year: 2012

Objective: To explore the general pattern and characteristics of adverse drug reactions/events (ADR/ADE) induced by Honghua injection so as to establish safety assessment and the secondary development of Honghua injection, as well as to provide reference for clinical rational drug use. Methods: Honghua injection-induced ADR/ADEs reported in domestic medical journals during 2000-2010 were collected from CNKI, VIP and Wanfang Database with the keyword 'Honghua injection'. The relationship between the ADR/ADE and the dose, symptoms, route of administration, administration methods and solvent was analyzed. Results: The main type of Honghua injection-induced ADR/ADEs was allergic reaction, such as anaphylactic shock, systemic hypersensitivity reactions and skin rash, laryngeal edema, drug heat, and chest tightness. These reactions were attenuated after treatment. No death was reported. Conclusion: Clinical physicians and pharmaceutists should pay attention to Honghua injection-induced ADR/ADE and rational drug use. The use of Honghua injection should be under strict monitoring at the first 30 min, and the ADR/ADE should be observed and managed timely to reduce the occurrence of serious reactions.

Loading Zhejiang Province Tumor Hospital collaborators
Loading Zhejiang Province Tumor Hospital collaborators