Zhejiang Supor Pharmaceuticals

China

Zhejiang Supor Pharmaceuticals

China
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Deng L.,Shaoxing University | Dong J.,Shaoxing University | Wang W.,Zhejiang Supor Pharmaceuticals
Mini-Reviews in Medicinal Chemistry | Year: 2013

Cantharidin (CTD), a natural toxin, can inhibit a variety of tumor cell lines, especially hepatocellular carcinoma cells. It is a strong inhibitor of protein phosphatase type 1 (PP1) and type 2A (PP2A). Because of the cytotoxicity, the clinical application of CDT is limited. Here, we review the structure-activity relationships of CDT analogues, including norcantharidin (NCTD), cantharimides and related derivatives of CTDs, which have more powerful antitumor activity but less cytotoxicity than CDT itself. Important advances in the design of the CTD-based inhibitors achieved recently are outlined here in order to establish principles for synthesis, screening, and the applications of promising anti-cancer drug candidates. In addition, efforts to ameliorate the intrinsic cytotoxicity through the use of drug carriers are also discussed. It is conceivable that rational design of the protein phosphatase inhibitors based on cantharidin analogues can be facilitated by studies of mechanism of the protein-inhibitor interactions and the related structural biology in the future. © 2013 Bentham Science Publishers.


Deng L.,Shaoxing University | Yong Z.,Shaoxing University | Tao W.,Zhejiang Supor Pharmaceuticals | Shen J.,Zhejiang Zhenyuan Pharmaceuticals | Wang W.,Zhejiang Supor Pharmaceuticals
Journal of Heterocyclic Chemistry | Year: 2011

Figure represented. Twenty novel norcantharidin derivatives, which were substituted by thiazole ring, were synthesized in a single step by the [3+2] 1,3-dipolar cycloaddition reaction with oxime or hydrazone in the presence of chloramine-T when compared with the conventional method. © 2011 HeteroCorporation.


Deng L.,Shaoxing University | Yong Z.,Shaoxing University | Tao W.,Zhejiang Supor Pharmaceuticals | Shen J.,Zhejiang Zhenyuan Pharmaceuticals | Wang W.,Zhejiang Supor Pharmaceuticals
Journal of Heterocyclic Chemistry | Year: 2011

We use one molecule of ethylene diamine as a connecting arm to combine two molecules of 5,6-dehydronorcantharidin. Then, ten novel norcantharidin derivatives were synthesized in a single step by the [3 + 2] 1,3-dipolar cycloaddition reaction with oxime or hydrazone in the presence of chloramine-T, which is simpler than the conventional method. © 2010 HeteroCorporation.


Deng L.P.,Shaoxing University | Deng L.P.,Johannes Gutenberg University Mainz | Dong J.,Shaoxing University | Cai H.,Shaoxing University | And 2 more authors.
Current Medicinal Chemistry | Year: 2013

This review summarizes the progress that has been made recently in the medicinal chemistry of cantharidin, a potent antitumor agent from traditional Chinese medicine. Thousands of analogs have been synthesized on the basis of cantharidin, a part of which shows excellent properties, in particular, norcantharidin and norcantharimide. Despite the enormous efforts made, the intriguing bioactivities, mechanism, indications, and their interplay are still ill-defined. This review provides our up-to-date understanding in connection with the therapeutic use, mechanism, structure-Activity relationship (SAR) and interesting properties of cantharidin analogs. Considerable development in the design of cantharidin analogs, in combination with mechanistic studies, has laid a foundation for transforming novel antitumor drugs into the clinic. © 2013 Bentham Science Publishers.


Hu C.,Shaoxing University | Li X.,Zhejiang University | Wang W.,Zhejiang Supor Pharmaceuticals | Zhang R.,Zhejiang University | Deng L.,Shaoxing University
Current Medicinal Chemistry | Year: 2014

It has been a long story of the development of anticancer metallopharmaceuticals since the identification of cisplatin. Advances in metallodrugs discovery during the past 40 years have made it an ever-growing area of research in medicinal inorganic chemistry. Meanwhile, the emerging of N-heterocyclic carbene (NHC) chemistry has stimulated the newly burgeoning interests in the biomedical applications of metal-NHC complexes. This review will detail what have been achieved hitherto in the research of metal-NHC complexes as potential anti-tumor agents coupled with gold, silver, copper, platinum and palladium. Their mechanism of action will also be discussed. All the results obtained indicate that this promising approach is worthy of more focuses and further studies. © 2014 Bentham Science Publishers.

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