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PubMed | Zhejiang Provincial Tongde Hospital, Huzhou Third Peoples Hospital and Zhejiang University
Type: Journal Article | Journal: Shanghai archives of psychiatry | Year: 2015

It remains unclear whether or not a positive family history of affective disorders predicts the effectiveness of antidepressant treatment of depression.Assess the relationship of a family history of affective disorders to the efficacy of duloxetine in the treatment of depressive disorder.Seventy-seven patients with depressive disorder (as defined by the 10th edition of the International Classification of Diseases, ICD-10) were enrolled in the study and treated with standard doses of duloxetine for 12 weeks. Among these patients 37 had a family history of affective disorder in first-degree relatives and 40 did not. The Hamilton Depression rating scale (HAMD-17), Hamilton Anxiety rating scale (HAMA), Side Effects Rating Scale (SERS), Snaith-Hamilton Pleasure Scale (SHAPS), and Beck Depression Inventory (BDI) were assessed at baseline and at the end of the 2(nd), 4(th), 6(th), 8(th), and 12(th) week after enrollment. Repeated measures analysis of variance and logistic regression were used to analyze the association between a family history of affective disorders and the efficacy of duloxetine.Patients with a positive family history of affective disorders had an earlier age of onset, a longer duration of illness, a higher level of psychic anxiety, and more prominent anhedonia. Repeated measures analysis of variance showed a significant improvement in the severity of depression over the 12 weeks but no differences in the magnitude or speed of improvement between the two groups. Treatment was considered effective (i.e., drop in baseline HAMD-17 total score of 50%) in 75.7% of those with a family history of affective disorders and in 77.5% of those without a family history (X(2)=0.04, p=0.850).Family history of affective disorders is not associated with the effectiveness of duloxetine in the acute treatment of depressive disorder.


Mo F.,Zhejiang University | Chi C.,Zhejiang University | Guo M.,Chinese Research Academy of Environmental Sciences | Chu X.,Zhejiang Provincial TongDe Hospital | And 3 more authors.
Journal of Hazardous Materials | Year: 2014

Concentrations and risk of monoaromatic hydrocarbons (MAHC), formaldehyde (HCHO), and polycyclic aromatic hydrocarbons (PAHs) in two moxibustion rooms were determined. The mean concentrations of MAHC, HCHO and PAHs were 535.2μg/m3, 157.9μg/m3 and 12.86μg/m3, respectively, with notable health risks, indicating relatively serious pollution in indoor air due to the use of burning moxa. The indoor emissions of target pollutants from burning moxa in test chamber were also investigated. Toluene, benzene and xylene appeared to be dominant MAHCs, and naphthalene (NA) the dominant PAH, which were consistent with the pollution levels of the detected moxibustion rooms. The emission characteristics of smoky moxa and mild moxa were much in common and relatively close to that of tobacco; while that of smoke-free moxa showed a distinction. Though pollutants emission patterns varied within the three types of moxa, all of them had apparently higher emission intensities than other typical indoor sources, including tobacco. The results of this study can offer some references during the selection of moxa sticks and application of moxibustion. © 2014 Elsevier B.V.


Yang S.-W.,Zhejiang University | Yang S.-W.,Key Laboratory of Biotherapy of Zhejiang Province | Wang W.,Zhejiang Provincial Tongde Hospital | Xie X.-Y.,Zhejiang University | And 3 more authors.
American Journal of Chinese Medicine | Year: 2011

Pancreatic cancer is a devastating disease characterized by low sensitivity to conventional chemotherapeutic treatment that has a poor prognosis. Therefore, novel effective chemotherapeutic regimens need to be developed. In this study, we analyzed the combined cytotoxic effect of triptolide and hydroxycamptothecin (HCPT) on pancreatic cancer cell line PANC-1 by using 3-(4.5-dimethylthiazol-2-yl)-5-(3-carboxy-methoxyphenyl)-2-(4-sulfophenyl) -2H-tetrazolium, inner salt (MTS) and fluorescence- activated cell sorting (FACS) assays. Our results showed that the sensitivity of a combined therapy using triptolide and HCPT was higher than that of triptolide or HCPT alone and that activation of caspase-9/caspase-3 and inhibition of nuclear factor-kappaB (NF-κB) signaling pathway may contribute to the synergistic cytotoxic effect of this combination therapy. Therefore, our observations provided evidence supporting the clinical applications of the combination chemotherapy using triptolide and HCPT for treating pancreatic cancer. © 2011 World Scientific Publishing Company & Institute for Advanced Research in Asian Science and Medicine.


PubMed | Lishui Central Hospital, Zhejiang Provincial Tongde Hospital and Zhejiang Academy of Traditional Chinese Medicine
Type: Journal Article | Journal: Molecules (Basel, Switzerland) | Year: 2016

Sanguis draconis, a resin known to improve blood circulation, relieve pain, stimulate tissue regeneration, and heal wounds, is widely used in clinical practice. In this study, we prepared an ethanol extract of sanguis draconis (EESD) containing 75.08 mg/g of dracorhodin. The experiment was carried out on 20 rats that were divided into two groups, a control group (


Zhang Y.,Zhejiang Provincial Tongde Hospital | Feng B.,Zhejiang Provincial Tongde Hospital | Xie J.-P.,Jiaxing Municipal Kangci Hospital | Xu F.-Z.,Zhejiang Provincial Tongde Hospital | Chen J.,Zhejiang Provincial Tongde Hospital
Journal of Traditional Chinese Medicine | Year: 2011

Objective: To study the curative effect of acupoint stimulation on the earthquake-caused post-traumatic stress disorder (PTSD). Methods: The 91 PTSD patients in Wenchuan hit by a strong earthquake were randomly divided into a control group of 24 cases treated by the cognitive-behavior therapy, and a treatment group of 67 cases treated by both cognitive-behavior therapy and acupoint stimulation. The scores were evaluated according to Chinese version of the incident effect scale revised (IES-R) and the self-compiled questionnaire for the major post-traumatic psychological condition, and the curative effect was compared between the two groups. Results: The total scores of IES-R, the scores of all factors and the total scores of the questionnaire in the two groups after treatment were much lower than those before treatment (P<0.01). The comparison of reduction in the factor scores between the two groups showed that the curative effect in the treatment group was better that of in the control group. Conclusion: The acupoint stimulation is effective for the PTSD patients, with better results than that of cognitive-behavior therapy used alone.


Ren Y.L.,Zhejiang Provincial Tongde Hospital
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology | Year: 2011

This study was aimed to explore the effect of homoharringtonine in combination with AG490 on JAK2-STAT5 associated signal pathway in HEL cells, and analyze its mechanism so as to provide theoretical basis for therapy of chronic myeloproliferative neoplasma by new program. The cell survival rates were tested by MTT, apoptosis was tested by flow cytometry after HEL cells were treated by 20 ng/ml HHT, 100 μmol/L AG490 and 20 ng/ml HHT in combination with 100 μmol/L AG490, while the signal proteins such as P-JAK2, P-STAT5 and BCL-xL activated by abnormal activated JAK2 were tested by Western blot. The results showed that both HHT and AG490 could inhabit the HEL cell proliferation after being treated for 24 hours, and Annexin V-PI double staining confirmed early apoptosis while HHT effect was more obvious, Western blot showed that the expressions of P-JAK2 and P-STAT5 were down-regulated, while the total protein levels of JAK2 and STAT5 were stable. It is concluded that HHT combined with AG490 can obviously inhibit the proliferation and induce early apoptosis of HEL cells, and there is synergistic effect between the two drugs. HHT possibly acts as a broad-spectrum PTK inhibitor and synergistically with AG490 inhibits the phosphorylation of signal proteins caused by JAK2V617F, thus down-regulating the transcription of STAT5.


Qian J.G.,Zhejiang Provincial Tongde Hospital | Wang X.J.,Zhejiang Provincial Tongde Hospital
Journal of Plastic, Reconstructive and Aesthetic Surgery | Year: 2010

Patients with osmidrosis are particularly concerned with malodour elimination after surgery. Open excision of the subcutaneous apocrine glands through a small incision seems to be the most logical and effective method available for osmidrosis. However, literature on long-term results and complications after such surgery based on large case series are rare. From January 2005 to May 2008, 256 consecutive patients with axillary osmidrosis were treated with our subcutaneous glands excision technique, of which 206 could be followed up from 3 to 40 (mean 18.1) months. Patients ranged in age from 14 to 52 (mean 23.4) years and the female to male ratio was 131:75. Among the 206 cases, 183 cases had family histories of the disease and 16 were accompanied with axillary hyperhidrosis. Postoperatively, as high as 97% of the patients achieved good results in terms of malodour elimination during the follow-up period. All patients reported reduction in axillary sweating; among them 16 patients complicated with axillary hyperhidrosis reported a significant reduction. Axillary hair growth was much reduced in most (95%) patients, and four female patients complicated with axillary hirsutism were extremely satisfied with axillary hair reduction. Early postoperative complications included haematoma (0.7%), seroma (1.2%), folding of skin flap (0.7%), pressure blister (3.6%), contact dermatitis (1%), superficial epidermis necrosis (37%), small granuloma (0.5%), wound infection (0.7%) and wound dehiscence (5.1%). Late complications included comedones (1.2%), milia (0.5%), sebaceous cyst (or with abscess) (0.7%), hypertrophic scar (1%), temporary skin pigmentation (0.5%), temporary mild lactation (0.5%) and temporary sweating outside the axillae (1%). In general, 196 patients (95%) were totally satisfied with the procedure and nine (4.4%) patients partially satisfied, with only one (0.5%) regretful. The procedure has a very high success rate with minor complications. It should become the preferred procedure for the surgical treatment of axillary osmidrosis. © 2009 British Association of Plastic, Reconstructive and Aesthetic Surgeons.


Jiang K.,Zhejiang University | Jiang K.,Zhejiang Provincial Tongde Hospital | He B.,309 Hospital of PLA | Lai L.,Zhejiang University | And 4 more authors.
International Journal of Molecular Medicine | Year: 2012

The high proliferative rate of tumor cells leads to metabolic needs distinct from those of their normal counterparts. An embryonic- and tumor-specific isoform of the enzyme pyruvate kinase M2 (PKM2) is overexpressed in cancer cells to increase the use of glycolytic intermediates for macromolecular biosynthesis and tumor growth. We report that Cyclosporin A (CsA) can regulate the expression and activity of PKM2 in breast cancer cell lines MCF-7, MDA-MB-435 and MDA-MB-231. PKM2 was found to be highly expressed in the three breast cancer cell lines compared to normal primary breast cells. Treatment with CsA inhibited the viability of breast cancer cells in a time- and dose-dependent manner. CsA significantly downregulated the expression of PKM2 in breast cancer cells and decreased adenosine triphosphate (ATP) synthesis, which induced cancer cells to undergo necrosis. Furthermore, the growth suppression effect of CsA was impaired in MCF-7 cells when they were transfected with the PKM2 overexpression plasmid, suggesting that CsA was an effective inhibitor of PKM2-dependent proliferation of breast cancer cells. These results may provide new insights into the mechanism of CsA in cancer therapy.


Zheng X.,Zhejiang University | Meng J.-B.,Zhejiang Provincial Tongde Hospital | Fang Q.,Zhejiang University
Acupuncture in Medicine | Year: 2012

Objective: Electroacupuncture, a modern variation on a traditional Chinese treatment, might be useful for sedation and analgesia. This study aims to investigate whether electroacupuncture can modify the dose of midazolam monitored by the bispectral index (BIS) in critically ill patients with mechanical ventilation. Methods: Orotracheally intubated patients undergoing mechanical ventilation were randomly assigned into three groups (groups A, B and C). All patients were given an intravenous infusion of midazolam. Patients in group A received no additional treatment. Patients in group B were given acupuncture without electrical stimulation at acupuncture points GV24 and EX-HN3 (Yintang) for 6 h simultaneously, and patients in group C were given electroacupuncture to the same points as in group B. Results: Maintaining the BIS between 60 and 80, the hourly mean one dose of midazolam within the first 6 h after sedation in group C was 0.05 (±0.02 mg/kg per hour), which was significantly lower than both group A (0.08±0.03 mg/kg per hour, p <0.001) and group B (0.07±0.01 mg/kg per hour, p <0.021). The doses in groups A and B showed no significant difference. Between-group comparison analysis of hepatic and renal function and severe adverse reactions all showed no significant difference between the three groups. Conclusions: Electroacupuncture appears to reduce markedly the dose of sedative drug required in critically ill patients with mechanical ventilation monitored by BIS, without any obvious severe adverse action, and larger studies to confirm the effect are justified.


Zhang B.,Zhejiang Provincial Tongde Hospital
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban | Year: 2010

To observe the effects of Gutuo Qingfu Decoction (GQD) via gastro-enteric perfusion on blood level of bacterial 16S rRNA gene in severe multi-traumatic (SMT) patients at early stage. Sixty SMT patients were assigned to two groups, the 33 in the treated group and the 27 in the control group. They were treated with the same conventional treatment, but different in the gastro-enteric infusion with GOD for the former and saline for the latter. Blood 16SrRNA gene, body temperature, leukocyte count, C-reactive protein (CRP), and blood bacterial culture positive rate on the 3, 6, 9 post-trauma days were detected, and incidences of infective complication and mortality were observed. Body temperature on day 9 in the treated group was significantly lower than in the control group (37.6 +/- 0.12 degrees C vs 38.1 +/- 0.15 degrees C, P < 0.05); so did the CRP level on day 6 (52.4 +/- 6.3 mg/L vs 104.3 +/- 20.1 mg/L, P < 0.05) and day 9 (42.9 + 7.5 mg/L vs 92.5 +/- 17.1 mg/L, P < 0.05), as well as the positive rates of blood 16SrRNA gene on day 6 and 9 (33.3% vs 59.3% and 30.3% vs 77.8%, P < 0.05 and P < 0.01, respectively). However, the positive rates of blood culture were insignificantly different between the two groups ( P > 0.05). Besides, incidence of infective complication in the treated group was significantly lower than in the control group (30.3% vs 59.3%, P < 0.05). Early stage gastrointestinal administration of GQD is likely to have benefits for the improvement of intestinal mucosa barrier and reduction of enteric bacterial translocation in SMT patients, and it may also reduce the incidence of infective complication in these patients.

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