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Wu Y.,Zhejiang University of Science and Technology | Wu Y.,Zhejiang Provincial Key Laboratory for Chemical and Bio Processing Technology of Farm Produces | Zou L.,Hangzhou Academy of Agricultural science | Mao J.,Zhejiang University of Science and Technology | And 5 more authors.
Carbohydrate Polymers | Year: 2014

Sulforaphane (SF) has received much attention because of its anticarcinogenic, antioxidant and anti-inflammatory properties, but it is quite unstable. Microencapsulation is one way to improve its stability. The aim of this work was to produce microcapsules containing sulforaphane using a spray drying technique. The effects of different wall materials, inlet air temperature and core to wall ratio on the SF stability, encapsulation efficiency, encapsulation yield, moisture content and SF content were determined. The results indicated that optimal encapsulation conditions for SF were: maltodextrin for the wall material, 170 C for the inlet air temperature and 1:20 for the core/wall ratio. Characterization study showed that the microcapsules had a regular spherical shape. The stability of SF in spray dried microcapsules was greatly enhanced compared with that of free SF. © 2013 Elsevier Ltd. All rights reserved.


Wu Y.,Zhejiang University of Science and Technology | Wu Y.,Zhejiang Provincial Key Laboratory for Chemical and Bio Processing Technology of Farm Produces | Mao J.,Zhejiang University of Science and Technology | Mao J.,Zhejiang Provincial Key Laboratory for Chemical and Bio Processing Technology of Farm Produces | And 4 more authors.
Food Chemistry | Year: 2014

The objective of this study was to investigate the thermal degradation kinetics of sulforaphane (SF) in broccoli extract at selected temperatures (60, 75, 82 and 100 C) and pH values (2.2, 3.0, 4.0, 5.0 and 6.0). The results indicated that SF is unstable at high temperatures, but is more heat-stable when present in acidic food products. The degradation rate constants of SF in broccoli extract were lower than those obtained in purified SF. The thermal degradation of SF followed first-order reaction kinetics, and the rate constant increased with increase of temperature and pH values. The rate constant vs temperature relationships, which yield linear Arrhenius plots, were described by a simpler exponential equation, and a mathematical model was developed, using the steady-state kinetic parameters obtained to predict the retentions of SF at various pH values, heating times and temperatures. © 2014 Elsevier Ltd. All rights reserved.


Yanli C.,Zhejiang University | Caixia W.,Zhejiang University | Jianwei M.,Zhejiang University of Science and Technology | Jianwei M.,Zhejiang Provincial Key Laboratory For Chemical And Bio Processing Technology Of Farm Produces | Yongping Y.,Zhejiang University
Journal of Chemical Technology and Biotechnology | Year: 2010

BACKGROUND: Because of its high demand for use in pharmaceutical products, cosmetics, soil remediation technologies, etc., randomly methylated β-cyclodextrin (RM-β-CD) is one of the most important cyclodextrin (CD) derivatives. The aim of this present work is to use a green and commercially available approach to obtain RM-β-CD. Compared with othermethylated CDs, RM-β-CDwith an asymmetric molecular structure has higherwater solubility. When the degree of substitution (DS) is about 1.8, the solubility tends to increase with increasing temperature and is suitable for pharmaceutical applications. RESULTS: RM-β-CD was synthesized using a green approach with ideal DS equal to 1.79. The one step process of β-cyclodextrin methylation by CH3Cl instead of (CH 3)2SO4 at mild temperature (80°C) and pressure (1.60MPa) with a good yield (78%), is convenient and environmentally friendly. The mixture of RM-β-CD obtained contained five compounds with various DS, from which the main compound with a DS equal to 1.8 was separated by column chromatography. The compounds were carefully characterized by infra-red, NMR andmass spectrometry. CONCLUSIONS: The one-step process to RM-β-CDs with CH3Cl is more economical, more efficient and less noxious than the usual method using (CH3)2SO4. Moreover, this approach avoids some poisonous residual materials and meets the demand for protecting the environment. © 2009 Society of Chemical Industry.


Cui Y.,Zhejiang University | Xu M.,Zhejiang University | Mao J.,Zhejiang University of Science and Technology | Mao J.,Zhejiang Provincial Key Laboratory For Chemical And Bio Processing Technology Of Farm Produces | And 3 more authors.
European Journal of Medicinal Chemistry | Year: 2012

A series of berbamine glycosides was designed, synthesized and evaluated as a new class of antitumor agents. An efficient glycosylation route was developed for berbamide derivatives. The newly synthesized glycosides were evaluated for their cytotoxic activity in vitro against a human leukemia cell line K562, a human lung adenocarcinoma cell line A549 and mouse lymphocytic leukemia cells L1210. In contrast to berbamine most of its glycosides manifested potent cytotoxic activities. The acetyl glycosyl berbamine 5a, 5d caused distinct improvement against K562, A549 and L1210. It is suggested that the acetyl d-glucose residue has affinity to these cancer cells. © 2012 Elsevier Masson SAS. All rights reserved.


Cui Y.,Zhejiang University | Lai T.,Zhejiang University of Science and Technology | Mao J.,Zhejiang University of Science and Technology | Mao J.,Zhejiang Provincial Key Laboratory for Chemical and Bio Processing Technology of Farm Produces | Yu Y.,Zhejiang University
2010 International Conference on Advances in Energy Engineering, ICAEE 2010 | Year: 2010

Catalytic copyrolysis of biomass/polypropylene( pp) mixture was performed in airfree atmospheres. The gases were analyzed with GC. The optimum condition for C3-C4 gases production was temperature 410 °C, the biomass/pp (in mass) mixtures ratio 1:1. At 410°C, the copyrolysis leaded to the production of more than 30% (in mass) of gases. It should be noted that for the composition of C1-C2 hydrocarbons close to 30% (in all gaseous hydrocarbons), the composition of C3-C4 hydrocarbons 67% (in all gaseous hydrocarbons), and the distillable liquids fraction represents close 30% in mass of the final products. © 2010 IEEE.


Wu Y.F.,Zhejiang University of Science and Technology | Wu Y.F.,Zhejiang Provincial Key Laboratory For Chemical And Bio Processing Technology Of Farm Produces | Mao J.W.,Zhejiang University of Science and Technology | Mao J.W.,Zhejiang Provincial Key Laboratory For Chemical And Bio Processing Technology Of Farm Produces | And 4 more authors.
Advanced Materials Research | Year: 2011

The extraction of total flavonoids from Perilla, using ultrasonic-assisted method, was investigated in this work. Various extraction conditions, such as ethanol concentraction (V/V), volume-weight ratio between the extraction solution and the weight of Perilla (V/W), the extraction time (t), pH, temperature (T), agent concentration (c) have been investigated for their influences. With the help of orthogonal analysis, the optimum extraction conditions have been identified, an extraction rate of 0.97% could be achieved at an ethanol concentration of 60%, an extraction temperature of 50 °C, a volume-weight ratio of 30:1, an ultrasonication time of 50 min. Then 8 samples were screened under this optimal extraction condition, the extraction rate could be 1.71% when use the Perilla leave (production in Linan, Zhenjiang province) as raw material. © (2011) Trans Tech Publications.


Cui Y.,Zhejiang University | Xu M.,Zhejiang University | Yao W.,Jiangnan University | Mao J.,Zhejiang Provincial Key Laboratory For Chemical And Bio Processing Technology Of Farm Produces
Carbohydrate Research | Year: 2015

We herein report an efficient synthesis of β-glycosyl 1-ester in room-temperature ionic liquids (RTILs) promoted via silver salt and quaternary ammonium salt (PTC) with good or excellent yields. All products were isolated exclusively as the β-anomers. Four different RTILs, eight metal salts and four quaternary ammonium salts were screened in the glycosylation reaction. The synergistic effect of C6mim·OTf, Ag2O and tetrabutylammonium iodine gave the best results. Their promotion to the system was integral. Thorough study provided insight into the catalytic activity of ionic liquid structure, metal salts and quaternary ammonium salt to these reactions. It is worth mentioning that the yield of aliphatic compound 2,3,4,6-tetra-O-acetyl-β-d-galactopyranosyl butyrate (3l) was highly improved when using C6mim·OTf as solvent compared with the normal volatile solvents under the same catalysts. This green approach has been proved to be practical and compatible with a wide range from aliphatic to aromatic substrates. © 2015 Elsevier Ltd. All rights reserved.


Cui Y.,Zhejiang University | Xu S.,Zhejiang University | Mao J.,Zhejiang Provincial Key Laboratory For Chemical And Bio Processing Technology Of Farm Produces
Journal of Inclusion Phenomena and Macrocyclic Chemistry | Year: 2015

A mild one-pot synthesis of hexias (6-O-acryl) cyclodextrin derivatives from per-O-benzyl-cyclodextrin was described. It was at room temperature that a regioselective conversion from benyl groups on the primary rim of cyclodextrin to the corresponding acryl groups was achieved with BF3·Me2O as catalyst and acrylic anhydride or acrylic chloride as acylating agent. The reaction was successfully applied in 6-O-acryl regioselective introduction from benzyl 2,3,4,6-tetra-O-benzyl-β-mannopyranoside as well. The products obtained can be valuable precursors for the thiol-ene click reaction or other further modification of carbohydrates. © 2015 Springer Science+Business Media.


Cui Y.,Zhejiang University | Cheng Z.,Zhejiang University | Mao J.,Zhejiang Provincial Key Laboratory For Chemical And Bio Processing Technology Of Farm Produces | Yu Y.,Zhejiang University
Tetrahedron Letters | Year: 2013

A convenient methodology has been developed for the regioselective removal of primary trimethylsilyl group (TMS) of various per-O-TMS-protected carbohydrates by inexpensive ammonium acetate. After acetylation and trichloroacetimidation of 6-hydroxyl sugar 1b, other TMS groups of 1d and 1c were inert to ammonium acetate in the same conditions, and this approach was also successfully applied in TMS-protected sphingosine. © 2013 Elsevier Ltd. All rights reserved.

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