Zhejiang Prov Key Laboratory Of Cardio Cerebr Vasc Detection Technology And Med Effectiveness Appraisal

Laboratory of, China

Zhejiang Prov Key Laboratory Of Cardio Cerebr Vasc Detection Technology And Med Effectiveness Appraisal

Laboratory of, China
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Zhang C.,Key Laboratory for Biomedical Engineering | Zhang C.,Zhejiang Prov Key Laboratory Of Cardio Cerebr Vasc Detection Technology And Med Effectiveness Appraisal | Gao C.,Key Laboratory for Biomedical Engineering | Chang M.-W.,Key Laboratory for Biomedical Engineering | And 3 more authors.
Applied Physics Letters | Year: 2016

Electrospinning (ES) enables simple production of fibers for broad applications (e.g., biomedical engineering, energy storage, and electronics). However, resulting structures are predominantly random; displaying significant disordered fiber entanglement, which inevitably gives rise to structural variations and reproducibility on the micron scale. Surface and structural features on this scale are critical for biomaterials, tissue engineering, and pharmaceutical sciences. In this letter, a modified ES technique using a rotating multi-nozzle emitter is developed and utilized to fabricate continuous micron-scaled polycaprolactone (PCL) ropes, providing control on fiber intercalation (twist) and structural order. Micron-scaled ropes comprising 312 twists per millimeter are generated, and rope diameter and pitch length are regulated using polymer concentration and process parameters. Electric field simulations confirm vector and distribution mechanisms, which influence fiber orientation and deposition during the process. The modified fabrication system provides much needed control on reproducibility and fiber entanglement which is crucial for electrospun biomedical materials. © 2016 Author(s).


Li H.,Zhejiang University | Li H.,Zhejiang Prov Key Laboratory Of Cardio Cerebr Vasc Detection Technology And Med Effectiveness Appraisal | Hao Y.,Zhejiang University | Zhang S.,Zhejiang University | And 4 more authors.
Behavioural Neurology | Year: 2017

Objective. Previous studies have demonstrated that target direction information presented by the dorsal premotor cortex (PMd) during movement planning could be incorporated into neural decoder for achieving better decoding performance. It is still unknown whether the neural decoder combined with only target direction could work in more complex tasks where obstacles impeded direct reaching paths. Methods. In this study, spike activities were collected from the PMd of two monkeys when performing a delayed obstacle-avoidance task. We examined how target direction and intended movement selection were encoded in neuron population activities of the PMd during movement planning. The decoding performances of movement trajectory were compared for three neural decoders with no prior knowledge, or only target direction, or both target direction and intended movement selection integrated into a mixture of trajectory model (MTM). Results. We found that not only target direction but also intended movement selection was presented in neural activities of the PMd during movement planning. It was further confirmed by quantitative analysis. Combined with prior knowledge, the trajectory decoder achieved the best performance among three decoders. Conclusion. Recruiting prior knowledge about target direction and intended movement selection extracted from the PMd could enhance the decoding performance of hand trajectory in indirect reaching movement. © 2017 Hongbao Li et al.


Wang J.-C.,Key Laboratory for Biomedical Engineering of Education Ministry of China | Wang J.-C.,Zhejiang Prov Key Laboratory Of Cardio Cerebr Vasc Detection Technology And Med Effectiveness Appraisal | Zheng H.,Hangzhou Dental Hospital | Chang M.-W.,Key Laboratory for Biomedical Engineering of Education Ministry of China | And 3 more authors.
Scientific Reports | Year: 2017

The design, preparation and application of three-dimensional (3D) printed structures have gained appreciable interest in recent times, particularly for drug dosage development. In this study, the electrohydrodynamic (EHD) printing technique was developed to fabricate aligned-fiber antibiotic (tetracycline hydrochloride, TE-HCL) patches using polycaprolactone (PCL), polyvinyl pyrrolidone (PVP) and their composite system (PVP-PCL). Drug loaded 3D patches possessed perfectly aligned fibers giving rise to fibrous strut orientation, variable inter-strut pore size and controlled film width (via layering). The effect of operating parameters on fiber deposition and alignment were explored, and the impact of the film structure, composition and drug loading was evaluated. FTIR demonstrated successful TE-HCL encapsulation in aligned fibers. Patches prepared using PVP and TE-HCL displayed enhanced hydrophobicity. Tensile tests exhibited changes to mechanical properties arising from additive effects. Release of antibiotic from PCL-PVP dosage forms was shown over 5 days and was slower compared to pure PCL or PVP. The printed patch void size also influenced antibiotic release behavior. The EHDA printing technique provides an exciting opportunity to tailor dosage forms in a single-step with minimal excipients and operations. These developments are crucial to meet demands where dosage forms cannot be manufactured rapidly or when a personalized approach is required. © 2017 The Author(s).


Zhou H.,Zhejiang University | Han Y.,Zhejiang University | Zhao M.,Zhejiang University | Tristan L.J.C.,National University of Singapore | And 2 more authors.
Processing of 2014 International Conference on Multisensor Fusion and Information Integration for Intelligent Systems, MFI 2014 | Year: 2014

The current state of development regarding rat-robots suffers from its dependency on reward-based directional control. To overcome this challenge, we proposed a Ventral Posteromedial(VPM) thalamic nucleus electrical stimulation based turning control method in this paper. With appropriate electrical stimulation parameters, the rat-robots showed ipsilateral turning behavior with controllable turning angle. This new head direction control method allowed the rat-robots to finish complex navigation tasks right after they recovered from surgery without any training process. Although the mechanism of this turning control method is still unclear, this new method possesses good prospects of application in the animal-robot field. © 2014 IEEE.


Wang L.,Zhejiang University | Wang L.,Zhejiang Prov Key Laboratory Of Cardio Cerebr Vasc Detection Technology And Med Effectiveness Appraisal | Chen H.,Zhejiang University | Chen H.,Zhejiang Prov Key Laboratory Of Cardio Cerebr Vasc Detection Technology And Med Effectiveness Appraisal | And 2 more authors.
Proceedings - 2014 IEEE Workshop on Electronics, Computer and Applications, IWECA 2014 | Year: 2014

In order to achieve the simultaneous monitoring of multiple physiological signals and finish the real-time storage and transmission of data, this paper presents a multi-parameter physiological signal monitoring system based on Cortex-M3. The system uses high-capacity SD card for data storage and USB for data transmission, which achieves synchronous storage and display. In addition, it reduces the operating frequency to achieve the goal of low power consumption.The experimental results show that the system is characterized by high-capacity, low-power and high accuracy, which meets the user's requirements for physiological signal monitoring. © 2014 IEEE.


Zhao D.,Zhejiang University | Zhao D.,Zhejiang Prov Key Laboratory Of Cardio Cerebr Vasc Detection Technology And Med Effectiveness Appraisal | Zhao D.,University College London | Li J.-S.,Zhejiang University | And 4 more authors.
Materials Science and Engineering C | Year: 2016

Ganoderma lucidum spores (GLSs), popular functional food in preventive medicine, are susceptible to oxidative and acidic degradation during processing, storage and oral administration, resulting in the loss of sensory and nutritional qualities. The main objective of the study was to encapsulate the GLS in order to fully preserve the bioactivity of the ingredients as well as providing controlled and targeted delivery. Electrospraying was applied to prepare GLS-Alginate (GLS/A) micro beads in the current study. The size of GLS/A beads can be tailored by varying the applied voltage and drying processes. pH responsive release profiles of GLS/A beads were revealed from in vitro study in a simulated gastrointestinal environment: no release of GLS encapsulated beads in the simulated gastric fluid (pH of 1.8) was observed; while a rapid, size dependent release was found in the simulated intestinal solution (pH of 7.5). The release from smaller beads (e.g. 600 μm) was 1.5 times faster than that of larger beads (e.g. 2000 μm). In addition, the GLS release from freeze dried beads was almost 3 times faster than those of air and vacuum dried beads in the first 90 min. The present results illustrate the potential to protect GLS by encapsulation using electrospraying to achieve the controlled release of GLS ingredients. This will pave the way to develop effective GLS products with desirable bioactive components for healthcare applications. © 2016 Elsevier B.V. All rights reserved.


Wu J.,Zhejiang University | Wu J.,Zhejiang Prov Key Laboratory Of Cardio Cerebr Vasc Detection Technology And Med Effectiveness Appraisal | Wu J.,Key Laboratory for Biomedical Engineering | Xu Y.,Zhejiang University | And 7 more authors.
Computational and Mathematical Methods in Medicine | Year: 2015

Quantitative analysis of the dynamic behavior about membrane-bound secretory vesicles has proven to be important in biological research. This paper proposes a novel approach to automatically identify the elusive fusion events between VAMP2-pHluorin labeled GLUT4 storage vesicles (GSVs) and the plasma membrane. The differentiation is implemented to detect the initiation of fusion events by modified forward subtraction of consecutive frames in the TIRFM image sequence. Spatially connected pixels in difference images brighter than a specified adaptive threshold are grouped into a distinct fusion spot. The vesicles are located at the intensity-weighted centroid of their fusion spots. To reveal the true in vivo nature of a fusion event, 2D Gaussian fitting for the fusion spot is used to derive the intensity-weighted centroid and the spot size during the fusion process. The fusion event and its termination can be determined according to the change of spot size. The method is evaluated on real experiment data with ground truth annotated by expert cell biologists. The evaluation results show that it can achieve relatively high accuracy comparing favorably to the manual analysis, yet at a small fraction of time. © 2015 Jian Wu et al.


Gao Y.,Zhejiang University | Gao Y.,Zhejiang Prov Key Laboratory Of Cardio Cerebr Vasc Detection Technology And Med Effectiveness Appraisal | Chang M.-W.,Zhejiang University | Chang M.-W.,Zhejiang Prov Key Laboratory Of Cardio Cerebr Vasc Detection Technology And Med Effectiveness Appraisal | And 2 more authors.
RSC Advances | Year: 2016

Several magnetic-polymer particle systems have been developed in recent times to facilitate improved targeting, localization and controlled delivery of active compounds. The main focus for such systems has centered on solid or core-shelled (non-porous) particles incorporating drug and magnetic features into individual polymeric carriers. In this study porous particles hosting drug (indomethacin) and magnetic Fe3O4 nanoparticles (NPs) were prepared, using a single needle one-step electrospraying technique via a non-solvent collection method. The resulting particles were characterized using scanning electron microscopy, energy dispersive spectra analysis, infrared spectroscopy, X-ray diffraction and Brunauer-Emmett-Teller specific area measurements. Analysis confirmed the incorporation of Fe3O4 NPs within the microspheres (∼20 μm in diameter), which could be further modified and tuned for porosity, magnetic response and thus release of incorporated active compounds. In vitro drug release for both porous and solid (non-porous) particle systems demonstrated high drug encapsulation efficiencies, ranging from ∼75% to 98%. Furthermore, the one-step synthesis process also suggested that the drug incorporated exists in an amorphous state, which is highly beneficial for drug absorption. Releases studies indicate a short drug burst period followed by a prolonged phase of dissolutive release. Based on mathematical fitting to both Higuchi and Korsmeyer-Peppas model, a release mechanism based on Fickian diffusion was confirmed. Through external alternating magnetic fields (AMF, 40 kHz), the drug release rate from magnetic-responsive microspheres was enhanced, facilitating drug release over the established Fickian process. This work demonstrates a versatile and efficient method for the development of drug-magnetic porous microparticles via a one-step electrospraying technique that enables controlled drug targeting, localization and tunable release. © The Royal Society of Chemistry 2016.

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