Zhejiang NHU Company Ltd

Sanhe, China

Zhejiang NHU Company Ltd

Sanhe, China
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Chen K.,Zhejiang GongShang University | Xie H.,Zhejiang NHU Co. | Mao J.,Zhejiang NHU Co. | Jiang K.,Hangzhou Normal University
Journal of Catalysis | Year: 2016

N-Alkoxyphthalimides were studied to design new-type organocatalysts for aerobic oxidation that are capable of metal/initiator-freely forming both phthalimide N-oxyl radicals and alkyl radicals in situ via their light/heat-induced homolysis. Our results show that their >NO–C bond strengths and HOMO-LUMO gaps change greatly upon altering N-alkoxy groups, which greatly decrease when their N-alkoxy groups include steric fluorenyl, xanthenyloxy, or triphenylmethyl groups. The conventional substituents on the bilateral phenyl rings of N-benzyloxyphthalimide have negligible effects on their >NO–C bond strengths, but significantly tune their HOMO-LUMO gaps. The photochemical activity of N-benzyloxy-4-aminophthalimide and N-4-amino-benzyloxyphthalimide may be similar to that of known N-triphenylmethyloxyphthalimide and N-diphenylmethyloxyphthalimide. Both the thermal and photochemical stability of N-acetyloxyphthalimides are higher than those of N-alkoxyphthalimides, but their hydrolysis to form N-hydroxyphthalimide is more favorable. The present work allows a reasonable prediction of the catalytic performance of N-alkoxyphthalimides and provides a new perspective for the rational design of organocatalysts for industrial applications. © 2016 Elsevier Inc.


Patent
Zhejiang New Weipu Additive Co., Zhejiang University and ZHEJIANG NHU Co. | Date: 2014-06-03

Disclosed in the present invention is a method for preparing an oil-dispersible carotenoid preparation, comprising (by weight parts): mixing 100 parts of carotenoid microcapsule, 100-400 parts of vegetable oil and 0.1-1 part of oil-soluble antioxidant; and grinding the mixture in a colloid mill in a nitrogen atmosphere and at 10-30 C. to obtain a uniform oil-dispersible carotenoid preparation, wherein the preparation contains 2%-14% carotenoid with an average particle size of up to 0.1-1 m, and 100 parts of carotenoid microcapsule contains 10.5-35.8 parts carotenoid, 0.1-1 part of water-soluble antioxidant, and the remainder is a water-soluble colloid. The advantages of the present invention lie in that the oil-dispersible form has a high stability as the surface of the carotenoid particles is still protected with a dense water-soluble colloid, and that an oil-dispersible carotenoid preparation containing carotenoid with a content of up to 2%-14% and an average particle size of only 0.1-1 m can be prepared.


Patent
Zhejiang New Weipu Additive Co., Zhejiang University and Zhejiang Nhu Company Ltd | Date: 2016-05-18

Disclosed in the present invention is a method for preparing an oil-dispersible carotenoid preparation, comprising (by weight parts): mixing 100 parts of carotenoid microcapsule, 100-400 parts of vegetable oil and 0.1-1 part of oil-soluble antioxidant; and grinding the mixture in a colloid mill in a nitro - gen atmosphere and at 10-30C to obtain a uniform oil-dispersible carotenoid preparation, wherein the preparation contains 2%-14% carotenoid with an average particle size of up to 0.1-1m, and 100 parts of carotenoid microcapsule contains 10.5-35.8 parts carotenoid, 0.1-1 part of water-soluble antioxidant, and the remainder is a water-soluble colloid. The advantages of the present invention lie in that the oil-dispersible form has a high stability as the surface of the carotenoid particles is still protected with a dense water-soluble colloid, and that an oil-dispersible carotenoid preparation containing carotenoid with a content of up to 2%-14% and an average particle size of only 0.1-1 m can be prepared.


Patent
ZHEJIANG NHU Co., Zhejiang University and Shandong Nhu Amino Acids Co. | Date: 2013-01-06

The present invention discloses a clean method for preparing a D,L-methionine comprising the steps of: preparing a potassium cyanide solution using a crystallized mother solution containing potassium carbonate as an absorbing liquid to absorb hydrocyanic acid, then reacting the potassium cyanide solution with 3-methylthio propionaldehyde and an ammonium bicarbonate solution at 50-150 C. for 3-15 minutes so as to obtain a 5-(-methylthioethyl)glycolyurea solution, then bring the 5-(-methylthioethyl)glycolyurea solution to a temperature of 140-220 C. and subjecting to a saponification reaction for 2-5 minutes, after the completion of the saponification, reducing the temperature to 0-40 C., extracting with an organic solvent, neutralising the water phase with CO_(2 )and crystallizing, then filtering, washing, and drying to obtain an acceptable D,L-methionine product; bring the crystallized D,L-methionine mother solution from filtration to a temperature to 110-160 C. to remove CO_(2), which are all then circulated and used as a hydrocyanic acid-absorbing liquid. The process route of the present invention is a route suitable for a continuous and clean production, substantially without producing waste water and waste gas.


Patent
Zhejiang Nhu Special Materials Co., Zhejiang University, Shangyu Nhu Biological Chemical Co. and Zhejiang Nhu Company Ltd | Date: 2015-11-04

The present invention discloses a fiber-grade polyphenylene sulfide resin synthesis method, taking sodium bisulfide and p-dichlorobenzene as raw materials, N-methyl pyrrolidone as the solvent and C5-C6 fatty acid salt formed through dehydration to C5-C6 fatty acid and sodium hydroxide as the polymerization additive for synthesis through polymerization. White polyphenylene sulfide resin is obtained through acidification and washing of reaction slurry. In view of the fact that MFR is below 125 g/10min, weight-average molecular weight as measured by GPC is over 4.210^(4), and whiteness is over 90, it can satisfy requirements for fiber polyphenylene sulfide resin. C5-C6 fatty acid salt according to the method of the present invention has a higher solubility in NMP, which can better promote polymerization. It is to be fully diverted into the filtrate after filter prior to conversion into free fatty acid again through acidification with hydrochloric acid. C5-C6 fatty acid is available for azeotropy with water, which has a limited solubility in water. Therefore, it is applicable to recycle C5-C6 fatty acid from the filtrate through azeotropy with water, and thereby solve the problem with separation of additive and sodium chloride that are soluble in water.


Lu W.,Zhejiang University | Shi Y.,ZheJiang NHU Company | He S.,ZheJiang NHU Company | Fei Y.,ZheJiang NHU Company | And 2 more authors.
Biochemical Engineering Journal | Year: 2013

Coenzyme Q10 (CoQ10), as an essential electron carrier in the aerobic respiratory electron transfer system, has been proven to be an effective compound in health care and disease prevention. With the aim of improving the production of CoQ10, the biosynthetic pathway of CoQ10 was engineered in Rhodobacter sphaeroides by overexpressing 3-demethyl ubiquinone-9 3-methyltransferase (UbiG), which catalyzes the two steps of O-methylations of the quinonoid ring. For expressing the UbiG, a constitutive expression vector harboring tac promoter and ubiG gene was firstly developed. After cultivated in dark conditions, the transcriptional level of ubiG of the recombinant R. sphaeroides without inducer, which approached to that of with inducer, was about 133 times that of the wild type. The production was correspondingly improved up to 65.8mg/L compared to 47.6mg/L for the wild type. In addition, it was found that isopropyl-beta-d-thiogalactopyranoside (IPTG) had a negative effect on CoQ10 production when added to the medium, although it showed no significant influence on the growth rate of the microbes. © 2013 Elsevier B.V.


Patent
Zhejiang Nhu Company Ltd | Date: 2011-03-25

A method for continuously preparing stable-type vitamin A microcapsules is disclosed. The method comprises the following steps: adding vitamin A crystals and an antioxidant into a crystal melter continuously according to a certain ratio under the protection of nitrogen to prepare vitamin A melting oil containing the antioxidant; pumping the above melting oil into a high gravity rotary packed bed emulsifier with a liquid distributor by a pump, and pumping aqueous solution containing gellable modified starch into the above high gravity rotary packed bed emulsifier after deoxidation treatment to obtain vitamin A emulsion at the outlet of the high gravity rotary packed bed emulsifier; and atomizing and spraying the emulsion continuously in a cooled starch bed for granulating, and performing fluidization drying and gelation treatment in a fluidized bed by taking nitrogen as a drying medium to obtain the stable-type vitamin A microcapsules. Above method has the advantage of capability of continuous production, and has good embedding effect due to adopting the gellable modified starch, granulating and gelation treatment, thus the product has good storage stability.


Patent
Zhejiang University and Zhejiang Nhu Company Ltd | Date: 2010-03-18

A method of preparing nano-dispersed high-all-trans-carotenoid microcapsules is provided, comprising: preparing 10-20% carotenoid suspension by milling the high-all trans-carotenoid crystals with dichloromethane until the particle size thereof is in the range of 2-5 m, then supplying the suspension together with preheated dichloromethane of another pass into a dissolving tank to obtain a solution of 0.5-2%; delivering the solution together with ethanol or isopropanol into a crystallization device having high gravity rotating packed bed simultaneously and continuously, and then into a wiped-film evaporator for desolvation until the solid content is 10-20%, then a transparent alcohol dispersion of carotenoid is obtained; mashing the alcohol dispersion together with an aqueous solution containing an antioxidant and protective colloid and spray drying to obtain nano-dispersed high-all-trans-carotenoid microcapsules. As the crystals are nano-dispersed and the content of trans-isomer is more than 90%, the carotenoid microcapsules of present inventions exhibit high bioavailability.


Patent
Zhejiang Nhu Company Ltd and Zhejiang University | Date: 2015-07-15

The present invention discloses a clean method for preparing a D,L-methionine comprising the steps of: preparing a potassium cyanide solution using a crystallized mother solution containing potassium carbonate as an absorbing liquid to absorb hydrocyanic acid, then reacting the potassium cyanide solution with 3-methylthio propionaldehyde and an ammonium bicarbonate solution at 50-150C for 3-15 minutes so as to obtain a 5-(-methylthioethyl)glycolyurea solution, then bring the 5-(-methylthioethyl)glycolyurea solution to a temperature of 140-220C and subjecting to a saponification reaction for 2-5 minutes, after the completion of the saponification, reducing the temperature to 0-40C, extracting with an organic solvent, neutralising the water phase with CO_(2) and crystallizing, then filtering, washing, and drying to obtain an acceptable D,L-methionine product; bring the crystallized D,L-methionine mother solution from filtration to a temperature to 110-160C to remove CO_(2), which are all then circulated and used as a hydrocyanic acid-absorbing liquid. The process route of the present invention is a route suitable for a continuous and clean production, substantially without producing waste water and waste gas.


Nhu

Trademark
ZHEJIANG NHU COMPANY Ltd | Date: 2013-11-11

Sugar; non-medical nutrient capsules; mixed sweet rice porridge with mixed Chinese sweets; instant noodles; ice cream; condiments; essences for foodstuffs, except etheric essences and essential oils.

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