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Xu H.-J.,Hefei University of Technology | Xu H.-J.,Hefei University | Zheng F.-Y.,Hefei University of Technology | Liang Y.-F.,Hefei University of Technology | And 4 more authors.
Tetrahedron Letters | Year: 2010

CuCl-catalyzed N-arylation of alkyl amines and N-heterocycles with substituted aryl iodides and bromides can be carried out in 40% nBu4N+OH- aqueous solution without any ligands. Crown Copyright © 2009. Source


Umemoto T.,Zhejiang Jiuzhou Pharmaceutical Co.
Journal of Fluorine Chemistry | Year: 2015

There was lack of fluorination reagents around 1978 when the author started his fluorine research. This account presents the author's ideas and development of many reagents which include (perfluoroalkyl)phenyliodonium triflates (FITS reagent) and sulfates (FIS), (1,1-dihydroperfluoroalkyl)phenyliodonium triflates (FMITS), N-trifluoromethyl-N-nitroso-benzene- and -trifluoromethane-sulfonamide (TNS-B and -Tf), N-fluoropyridinium salt series (F-Plus™), N-fluoropyridinium-2-sulfonate series, N,N′-difluoro-2,2′-bipyridinium salt series (MEC-31, SynFluor™), N,N′-difluoro-1,4-diazoniabicyclo[2.2.2]octane salts, S-, Se-, and Te-(trifluoromethyl)dibenzo-thio-, -seleno-, and -tellurophenium salts and their 3-sulfonate series, O-(trifluoromethyl)dibenzofuranium salts and their precursors, 4-tert-butyl-2,6-dimethylphenylsulfur trifluoride (FLUOLEAD™), and arylsulfur chlorotetrafluorides. These reagents have made new areas and significant advancement in fluorine chemistry. The incidental fruits are also described, which include discoveries of new cyclic carbene reactions of N-fluoropyridinium salts and the first practical industrial method for production of arylsulfur pentafluorides. Application of N-fluoropyridinium salts to electronic materials is briefly mentioned. © 2014 Elsevier B.V. All rights reserved. Source


Patent
Zhejiang Jiuzhou Pharmaceutical Co. | Date: 2011-11-16

Disclosed is a preparation method of -imatinib mesylate. The reaction temperature of the method is low and the yield of the crystal is improved. Furthermore, the method is applicable to the industrial production.


Patent
Zhejiang Jiuzhou Pharmaceutical Co. | Date: 2012-06-29

A new compound is provided, which is used for preparing lacosamide. A novel method for preparing lacosamide is also provided. During the reaction, iodomethane and silver oxide that are cost expensive are not used, nor a Pd-c catalyst is used, so the production cost is low, the raw materials and accessory materials are cheap and easily available, and the process is simple, so that industrial production is easy to realize; and moreover, the yield is high, and good economic efficiency can be achieved.


Patent
Zhejiang Jiuzhou Pharmaceutical Co. | Date: 2012-07-27

The present invention relates to a spirobenzylamine-phosphine, preparation method therefor and use thereof. The compound has a structure represented by formula (I), wherein n=0 to 3; R

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