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Hangzhou, China

Si C.-J.,Zhejiang Hospital
European Journal of Cancer Prevention | Year: 2016

Previous studies have attempted to assess the relation between different dietary patterns and the risk of endometrial cancer (EC); however, a consistent perspective has not been established to date. Therefore, we carried out this meta-analysis to evaluate the associations between dietary patterns and the risk of EC. The most common dietary patterns with high loadings of foods and/or nutrients were selected. A total of 27 studies fulfilled the inclusion criteria and were included in the present meta-analysis. There was evidence of a decreased risk of EC in the highest compared with the lowest categories of healthy dietary pattern [odds ratio (OR)=0.74; confidence interval (CI): 0.62–0.88; P=0.008]. An increased risk of EC was shown for the highest compared with the lowest category of a western-style dietary pattern (OR=1.37; CI: 1.15–1.64; P=0.0005). No significant association with the risk of EC was found in the highest compared with the lowest category of alcohol-drinking pattern (OR=0.98; CI: 0.73–1.30; P=0.87). The results of this meta-analysis indicate that some dietary patterns may be associated with the risk of EC. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.


Sun X.-D.,Zhejiang Provincial Peoples Hospital | Liu X.-E.,Zhejiang Hospital | Huang D.-S.,Zhejiang Provincial Peoples Hospital
Molecular Medicine Reports | Year: 2012

Curcumin is the major component of the spice turmeric, extracted from the rhizomes of the plant Curcuma longa. It exerts a number of therapeutic effects, including the inhibition of cancer cell proliferation. However, the anti-carcinogenic mechanism of curcumin has not been fully elucidated. Triple-negative breast cancer (TNBC), which lacks expression of the estrogen receptor (ER), progesterone receptor (PR) and epidermal growth factor receptor 2 (HER2/EGFR2), is an aggressive breast cancer phenotype with a poor prognosis. In this study, we investigated the effects of curcumin on triple-negative breast cancer cells and the possible molecular mechanisms. The MDA-MB-231 TNBC cells were treated with curcumin, the growth inhibition ratio of the cells was measured by MTT assay, apoptosis was detected by flow cytometry and the expression levels of extracellular regulated protein kinase (ERK1/2), pERK1/2, EGFR and pEGFR were detected by western blotting. After treatment with different concentrations of curcumin, the growth inhibition rates of the MDA-MB-231 breast cancer cells of the 30 μmol/ml curcumin-treated group were significantly different from those of the other groups. The level of apoptosis of the curcumin-treated group (26.34%) was significantly different from that of the control group (2.76%). The expression levels of pERK1/2 and pEGFR in the curcumin-treated group were significantly decreased compared with those of the control group. These results indicate that curcumin is able to inhibit the proliferation of TNBC cells. Inhibition of the EGFR signaling pathway is the likely underlying molecular mechanism.


Feng Y.-L.,Zhejiang Hospital
European Journal of Cancer Prevention | Year: 2016

The analysis of dietary patterns has recently drawn considerable attention as a method of investigating the association between the overall whole diet and the risk of colorectal cancer. However, the results have yielded conflicting findings. Here, we carried out a meta-analysis to identify the association between dietary patterns and the risk of colorectal cancer. A total of 40 studies fulfilled the inclusion criteria and were included in this meta-analysis. The highest category of ‘healthy’ dietary pattern compared with the lowest category was apparently associated with a decreased risk for colorectal cancer [odds ratio (OR)=0.75; confidence interval (CI): 0.68–0.83; P<0.00001]. An increased risk of colorectal cancer was shown for the highest compared with the lowest category of a ‘western-style’ dietary pattern (OR=1.40; CI: 1.26–1.56; P<0.00001). There was an increased risk of colorectal cancer in the highest compared with the lowest category of ‘alcohol-consumption’ pattern (OR=1.44; CI: 1.13–1.82; P=0.003). The results of this meta-analysis indicate that a ‘healthy’ dietary pattern may decrease the risk of colorectal cancer, whereas ‘western-style’ and ‘alcohol-consumption’ patterns may increase the risk of colorectal cancer. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.


Chen S.,Zhejiang University | Zhao Y.,University of Sydney | Zhang Y.,Zhejiang Hospital | Zhang D.,University of Canberra
PLoS ONE | Year: 2014

p Conclusion/Significance: Fucoidan exerts its anti-tumor function by modulating ER stress cascades. Contribution of ER stress to the fucoidan-induced cell apoptosis augments our understanding of the molecular mechanisms underlying its antitumour activity and provides evidence for the therapeutic application of fucoidan in cancer.


Zhan J.,Zhejiang University | Han Q.,Zhejiang Hospital | Wang K.,Chinese Academy of Sciences
Expert Opinion on Investigational Drugs | Year: 2013

Introduction: Small cell lung cancer (SCLC) is one of most aggressive cancers and only modest improvements have been achieved in overall survival over last 30 years. In recent years, antibody therapeutics has been actively studied and shown promise in treatment of SCLC. Areas covered: A comprehensive literature search through Medline and the registry database of clinical trials (ClinicalTrials.gov) was performed to collect all relevant preclinical and clinical data. The diverse antibody therapeutics which target against different antigens including VEGE-A, CEA, IGF-1R, CD56, EpCAM, CTLA-4, gangliosides GD2 and GD3, Lewis Y and tenascin-C are now under clinical investigation for therapeutic effects in SCLC. Expert opinion: During the last few decades, progresses have been made in antibody therapy for SCLC, however great challenges still remain. The major reasons are the complexity of SCLC and a lack of understanding of cancer immunology. The profound studies of signaling pathways involved in carcinogenesis, proliferation, metastasis and apoptosis in SCLC are crucial for the identification of new therapeutic targets and biomarkers. Moreover, a better understanding of the interplay between cancer and the immune system is a new direction for the design of more effective antibody therapeutics. © 2012 Informa UK, Ltd.

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