Zhejiang Hospital of Zhejiang Province

Hangzhou, China

Zhejiang Hospital of Zhejiang Province

Hangzhou, China
SEARCH FILTERS
Time filter
Source Type

Yang S.-J.,Zhuji Peoples Hospital Of Zhejiang Province | Shao G.-F.,Zhuji Peoples Hospital Of Zhejiang Province | Chen J.-L.,Zhuji Peoples Hospital Of Zhejiang Province | Gong J.,Zhejiang Hospital of Zhejiang Province
Cellular and Molecular Neurobiology | Year: 2017

Hemorrhagic stroke is a devastating clinical event with no effective medical treatment. Neuroinflammation, which follows a hemorrhagic stroke, is an important element that involves both acute brain injury and subsequent brain rehabilitation. Therefore, delineating the key inflammatory mediators and deciphering their pathophysiological roles in hemorrhagic strokes is of great importance in the development of novel therapeutic targets for this disease. The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is a multi-protein complex that is localized within the cytoplasm. This NOD-like receptor orchestrates innate immune responses to pathogenic organisms and cell stress through the activation of caspase-1 and the maturation of the proinflammatory cytokines such as interleukin-1β (IL-1β) and IL-18. Mounting evidence has demonstrated that when the NLRP3 inflammasome is activated, it exerts harmful effects on brain tissue after a hemorrhagic stroke. This review article summarizes the current knowledge regarding the role and the underlying mechanisms of the NLRP3 inflammasome in the pathophysiological processes of hemorrhagic strokes. A better understanding of the function and regulation of the NLRP3 inflammasome in hemorrhagic strokes will provide clues for devising novel therapeutic strategies to fight this disease. © 2017 Springer Science+Business Media, LLC

Loading Zhejiang Hospital of Zhejiang Province collaborators
Loading Zhejiang Hospital of Zhejiang Province collaborators