Hangzhou, China

Zhejiang Chinese Medical University (ZJNU; simplified Chinese: 浙江中医药大学; traditional Chinese: 浙江中醫藥大學; pinyin: Zhèjiāng yīyào dàxué is a comprehensive public university based in Hangzhou city, capital of Zhejiang province, China. Wikipedia.


Time filter

Source Type

Li Z.,Zhejiang Chinese Medical University
Current protein & peptide science | Year: 2017

BACKGROUND: Regardless of the achievable of chiral switch, most of the chiral nature agrochemical is still sold as racemate or enantiomer-enriched pesticides. Herbicides, accounted for a large proportion in pesticide market, are of great concern due to the frequent occurrence in environment and the structure selective phyto-biochemical impact on plants.METHODS: We give a systematic search on the literature database and included approximately 50 papers which were related to the review. We do careful categories for the chiral herbicides according to their structure and listed out the acute phytotoxicity endpoints. The potential mechanism for the enantioselective toxicity was concluded into 5 main points.RESULTS: The enantiomer-specific toxicity on plant growth and flowers are limited on phenoxyalkanoic acid herbicide, aryloxyphenoxypropanoic acid, imidazolinone herbicide, and acetamide pesticide. Data available on the potential mechanism explanation of enantioselective phytotoxicity has been concerned on the genetic transcription, oxidative stress, and photosynthesis disruption, etc. A comparison between the two enantiomers' enantioselective effects identified an organ-specific and species-specific phenomenon for several herbicides. Moreover, a more herbicidal activity enantiomer is also displayed the more toxicity than its antipode.CONCLUSION: The review elucidated a paucity of information on the enantioselective effect research on various types of plants at the different life stages. It appealed us to conduct a more holistic approach to balance the benefit between herbicidal activity and phytotoxicity when try to develop an enantio-pure herbicide.


News Article | November 7, 2016
Site: www.eurekalert.org

Scientists at Duke Health and Zhejiang Chinese Medical University have developed a strategy to stop the uncontrollable itch caused by urushiol, the oily sap common to poison ivy, poison sumac, poison oak and even mango trees. The team found that by blocking an immune system protein in the skin with an antibody, they could halt the processes that tell the brain the skin is itchy. The research was done in mice and is described in the Nov. 7 Proceedings of the National Academy of Sciences. They hope their model could lead to potential treatments for people who are allergic to poison ivy -- an estimated 80 percent of the population. For most people, contact with poisonous plants is painful but not life-threatening. Still, there are significant health care costs associated with more than 10 million people in the U.S. affected each year, said senior author Sven-Eric Jordt, Ph.D., associate professor of anesthesiology at Duke. "Poison ivy rash is the most common allergic reaction in the U.S., and studies have shown that higher levels of carbon dioxide in the atmosphere are creating a proliferation of poison ivy throughout the U.S. -- even in places where it wasn't growing before," Jordt said. "When you consider doctor visits, the costs of the drugs that are prescribed and the lost time at work or at school, the societal costs are quite large." Some symptoms of the fiery, blistering rash can be alleviated with antihistamines and steroids. But in recent years, scientists have determined that the most severe itching doesn't go away with antihistamines, because it arises from a different source, Jordt said. Jordt and collaborators determined the itch is triggered by interleukin 33 (IL-33), a protein in the skin involved in immune response. All people have IL-33 in their skin, but the protein is elevated in people who have eczema and psoriasis, Jordt said. The protein is known for inducing inflammation, but these new experiments show the protein also acts directly on the nerve fibers in the skin, exciting them and telling the brain that the skin is severely itchy. The researchers used an antibody to block IL-33 and found that it not only reduced inflammation, but also cut down scratching in mice with poison ivy rashes. An antibody that counteracts human IL-33 is currently being evaluated in humans through a Phase 1 clinical trial to determine its safety and potential side effects. In an additional approach tested in the mouse experiments, the researchers also found they could also alleviate itch by blocking a receptor for IL-33, called ST2. "There could be translational significance here," Jordt said. "So our next step will be to look at human skin to see if we see the same activity and the same pathways. We will also look at anti-inflammatory drugs that are already approved to see if they have the potential to alleviate itch." In addition to Jordt, study authors include Boyi Liu; Yan Tai; Satyanarayana Achanta; Melanie M. Kaelberer; Ana I. Caceres; Xiaomei Shao; and Jianqiao Fang. The research was supported by the Duke Anesthesiology DREAM Innovation Grant (2015-DIG LIU), Zhejiang Chinese Medical University Start-Up Funding (722223A08301/ 001/004), the National Natural Science Foundation of China (81603676) and three National Institutes of Health -- the National Center for Advancing Translational Sciences (UL1 TR001117), the National Institute of Environmental Health Sciences (R01 ES015056, U01 ES015674) and the National Institute of Arthritis and Musculoskeletal and Skin Disease (R21 AR070554). The authors declare no conflicts of interest.


Lu B.,Zhejiang Chinese Medical University | Li M.,Zhejiang Chinese Medical University
World Journal of Gastroenterology | Year: 2014

Helicobacter pylori (H. pylori) infection is a major risk factor for gastric cancer (GC) development, which is one of the most challenging malignant diseases worldwide with limited treatments. In the multistep pathogenesis of GC, H. pylori infection slowly induces chronic active gastritis, which progresses through the premalignant stages of atrophic gastritis, intestinal metaplasia, and dysplasia, and then finally to GC. Although eradication of H. pylori is a reasonable approach for the prevention of GC, there have been some contradictory reports, with only some long-term follow-up data showing efficacy of this approach. The inconsistencies are likely due to the insufficient number of participants, relatively short follow-up periods, poor quality of study designs, and the degree and extent of preneoplastic changes at the time of H. pylori eradication. This review analyzes recent high-quality studies to resolve the discrepancies regarding the eradication of H. pylori for GC prevention. The relationship between H. pylori eradication and GC/ precancerous lesions/metachronous GC is examined, and the cost-effectiveness of this strategy in the prevention of GC is assessed. Although it is assumed that eradication of H. pylori has the potential to prevent GC, the feasibility and appropriate timing of this strategy for cancer prevention remain to be determined. As a result, additional well-designed trials with longer followup periods are needed to clarify this issue. © 2014 Baishideng Publishing Group Inc. All rights reserved.


Chu L.,Zhejiang Chinese Medical University
Zhonghua nei ke za zhi [Chinese journal of internal medicine] | Year: 2012

To study the epidemiologic features of functional bowel disorders (FBD) among medical students and science and engineering students in Zhejiang province, China, and to explore the relationship between psychological factors and FBD. This study was a survey of random sampling based on the Rome III Diagnostic Questionnaire (Rome III-DQ) conducted from November 2010 to March 2011. The survey was carried out among medical students and science and engineering students respectively in two universities in Zhejiang province. Symptom Check List 90 (SCL-90) was used for psychological analysis. Among 1870 participants, 1033 were diagnosed as FBD based on Rome III criteria, with an overall incidence of 55.24%. The majority cases were unspecified functional bowel disorder, with an incidence of 26.58% (497/1870), others were functional constipation 16.95% (317/1870), irritable bowel syndrome 6.90% (129/1870), functional bloating 4.12% (77/1870) and functional diarrhea 0.70% (13/1870). The prevalence varied in different genders, majors and grades. In the multivariate analysis, women had a higher risk of any FBD than men [68.33% (617/903) vs 43.02% (416/967)] except for functional diarrhea; and medical students had a higher risk of any FBD than science and engineering students [68.53% (734/1071) vs 37.42% (299/799)]. Generally higher grade undergraduates had relatively higher risks than lower grade students, especially in medical students. Among the participants with FBD, 44.05% (455/1033) had other functional gastrointestinal disorders. In those overlapped parts, 9.00% (93/1033) had belching disorders, and 8.23% (85/1033) had functional dyspepsia. Students with FBD got higher scores in SCL-90 than healthy students. This study revealed a high rate of FBD among college students in Zhejiang province. The prevalence varied in different majors, and female higher than male. Psychological factors also had close relationships with FBD.


Chao G.-Q.,Zhejiang University | Zhang S.,Zhejiang Chinese Medical University
World Journal of Gastroenterology | Year: 2014

To evaluate the efficacy of acupuncture for treatment of irritable bowel syndrome (IBS) through metaanalysis of randomized controlled trials. Methods: We searched MEDLIINE, PubMed, Scopus, Web of Science, and Cochrane Central Register of Controlled Trials from 1966 to February 2013 for doubleblind, placebo-controlled trials investigating the efficacy of acupuncture in the management of IBS. Studies were screened for inclusion based on randomization, controls, and measurable outcomes reported. We used the modified Jadad score for assessing the quality of the articles. STATA 11.0 and Revman 5.0 were used for meta-analysis. Publication bias was assessed by Begg's and Egger's tests. Results: Six randomized, placebo-controlled clinical trials met the criteria and were included in the metaanalysis. The modified Jadad score of the articles was > 3, and five articles were of high quality. We analyzed the heterogeneity and found that these studies did not cause heterogeneity in our meta-analysis. Begg's test showed P = 0.707 and Egger's test showed P = 0.334. There was no publication bias in our meta-analysis (Begg's test, P = 0.707; Egger's test, P = 0.334). From the forest plot, the diamond was on the right side of the vertical line and did not intersect with the line. The pooled relative risk for clinical improvement with acupuncture was 1.75 (95%CI: 1.24-2.46, P = 0.001). Using the two different systems of STATA 11.0 and Revman 5.0, we confirmed the significant efficacy of acupuncture for treating IBS. Conclusion: Acupuncture exhibits clinically and statistically significant control of IBS symptoms. © 2014 Baishideng Publishing Group Co., Limited. All rights reserved.


Li Z.,Shanxi University | Yang P.,Shanxi University | Li Z.,Zhejiang Chinese Medical University
Biochimica et Biophysica Acta - Reviews on Cancer | Year: 2014

Tumor cells undergo metabolic rewiring from oxidative phosphorylation towards aerobic glycolysis to maintain the increased anabolic requirements for cell proliferation. It is widely accepted that specific expression of the M2 type pyruvate kinase (PKM2) in tumor cells contributes to this aerobic glycolysis phenotype. To date, researchers have uncovered myriad forms of functional regulation for PKM2, which confers a growth advantage on the tumor cells to enable them to adapt to various microenvironmental signals. Here the richness of our understanding on the modulations and functions of PKM2 in tumor progression is reviewed, and some new insights into the paradoxical expression and functional differences of PKM2 in distinct cancer types are offered. © 2014 Elsevier B.V.


Zhou Y.,Zhejiang Chinese Medical University
PLoS ONE | Year: 2014

Design: Using a constructivist grounded theory method, 46 in-depth interviews were conducted with 28 China-educated nurses in two major cities in Australia.Background and Purpose: Transnational nurse migration is a growing phenomenon. This study explored the experiences of China-educated nurses working in Australia.Results: The core category emerged was "reconciling different realities". Three phases of reconciling were conceptualised: realising, struggling, and reflecting. Realising refers to an awareness of the discrepancies between different realities. Struggling reflects the dilemma of the "middle position" and how being situated as "the other" is experienced. Reflecting is the process of making sense of the experience and rationalising the gains and losses associated with immigration.Conclusions: This study produced a theoretical understanding of the experience of China-educated nurses working in Australia. The findings not only inform Chinese nurses who wish to migrate but contribute to the implementation of more effective support services for immigrant nurses. © 2014 PLOS ONE.


He M.,Zhejiang Chinese Medical University
Chinese journal of traumatology = Zhonghua chuang shang za zhi / Chinese Medical Association | Year: 2013

To study the influence and mechanism of acute ethanol intoxication (AEI) on rat neuronal apoptosis after severe traumatic brain injury (TBI). Ninety-six Sprague-Dawley rats were randomly divided into four groups: normal control, AEI-only, TBI-only and TBI+AEI (n equal to 24 for each). Severe TBI model was developed according to Feeney's method. Rats in TBI+AEI group were firstly subjected to AEI, and then suffered head trauma. In each group, animals were sacrificed at 6 h, 24 h, 72 h, and 168 h after TBI. The level of neuronal apoptosis and the expression of Bcl-2 protein were determined by TUNEL assay and immunohistochemical method, respectively. Apoptotic cells mainly distributed in the cortex and white matter around the damaged area. Neuronal apoptosis significantly increased at 6 h after trauma and peaked at 72 h. Both the level of neuronal apoptosis and expression of Bcl-2 protein in TBI-only group and TBI+AEI group were higher than those in control group (P less than 0.05). Compared with TBI-only group, the two indexes were much higher in TBI+AEI group at all time points (P less than 0.05). Our findings suggest that AEI can increase neuronal apoptosis after severe TBI.


An arsenic compound solution, and an albumin nanoparticle and a lyophilized preparation prepared using same and entrapping an arsenic compound. The arsenic compound solution is prepared using the following method: adding As_(2)O_(3 )powder in sterile deionized water to obtain a suspension, 6 to 25 mg of As_(2)O_(3 )powder being added in every mL of sterile deionized water; dripping an NaOH solution to the obtained suspension until the powder is fully dissolved and adjusting the pH of the solution to 7.5 to 9, and making the concentration of the obtained arsenic compound solution be 5 to 20 mg/mL in terms of the added As_(2)O_(3). The albumin nanoparticle is prepared by mixing an albumin solution and the arsenic solution and the arsenic solution with the mass ratio of the added As_(2)O_(3 )in arsenic compound solution to the albumin ranging from 1:5 to 1:20 and using a method of solvent removing and physical curing.


News Article | November 8, 2016
Site: www.sciencedaily.com

Scientists at Duke Health and Zhejiang Chinese Medical University have developed a strategy to stop the uncontrollable itch caused by urushiol, the oily sap common to poison ivy, poison sumac, poison oak and even mango trees. The team found that by blocking an immune system protein in the skin with an antibody, they could halt the processes that tell the brain the skin is itchy. The research was done in mice and is described in the Nov. 7 Proceedings of the National Academy of Sciences. They hope their model could lead to potential treatments for people who are allergic to poison ivy -- an estimated 80 percent of the population. For most people, contact with poisonous plants is painful but not life-threatening. Still, there are significant health care costs associated with more than 10 million people in the U.S. affected each year, said senior author Sven-Eric Jordt, Ph.D., associate professor of anesthesiology at Duke. "Poison ivy rash is the most common allergic reaction in the U.S., and studies have shown that higher levels of carbon dioxide in the atmosphere are creating a proliferation of poison ivy throughout the U.S. -- even in places where it wasn't growing before," Jordt said. "When you consider doctor visits, the costs of the drugs that are prescribed and the lost time at work or at school, the societal costs are quite large." Some symptoms of the fiery, blistering rash can be alleviated with antihistamines and steroids. But in recent years, scientists have determined that the most severe itching doesn't go away with antihistamines, because it arises from a different source, Jordt said. Jordt and collaborators determined the itch is triggered by interleukin 33 (IL-33), a protein in the skin involved in immune response. All people have IL-33 in their skin, but the protein is elevated in people who have eczema and psoriasis, Jordt said. The protein is known for inducing inflammation, but these new experiments show the protein also acts directly on the nerve fibers in the skin, exciting them and telling the brain that the skin is severely itchy. The researchers used an antibody to block IL-33 and found that it not only reduced inflammation, but also cut down scratching in mice with poison ivy rashes. An antibody that counteracts human IL-33 is currently being evaluated in humans through a Phase 1 clinical trial to determine its safety and potential side effects. In an additional approach tested in the mouse experiments, the researchers also found they could also alleviate itch by blocking a receptor for IL-33, called ST2. "There could be translational significance here," Jordt said. "So our next step will be to look at human skin to see if we see the same activity and the same pathways. We will also look at anti-inflammatory drugs that are already approved to see if they have the potential to alleviate itch."

Loading Zhejiang Chinese Medical University collaborators
Loading Zhejiang Chinese Medical University collaborators