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Hangzhou, China

Zhejiang Chinese Medical University (ZJNU; simplified Chinese: 浙江中医药大学; traditional Chinese: 浙江中醫藥大學; pinyin: Zhèjiāng yīyào dàxué is a comprehensive public university based in Hangzhou city, capital of Zhejiang province, China. Wikipedia.


Hu X.,Zhejiang University | Hu X.,Zhejiang Chinese Medical University | Ji J.,Zhejiang University
Biomacromolecules | Year: 2011

A convenient and simple route to multifunctional surface coatings via the alternating covalent layer-by-layer (LBL) assembly of pnitrophenyloxycarbonyl group-terminated hyperbranched polyether (HBPO-NO 2) and polyethylenimine (PEI) is described. The in situ chemical reaction between HBPO-NO 2 and PEI onto aminolyzed substrates was rapid and mild. Results from ellipsometry measurements, contact angle measurements, and ATR-FTIR spectra confirmed the successful LBL assembly of the building blocks, and the surface reactivity of the multilayer films with HBPO-NO 2 as the outmost layer was demonstrated by the immobilization of an amine-functionalized fluorophore. Furthermore, a biomimetic surface was achieved by surface functionalization of the multilayer films with extracellular matrix protein collagen to promote the adhesion and growth of cells. The studies on the drug loading and in vitro release behaviors of the multilayer films demonstrated their application potentials in local delivery of hydrophilic and hydrophobic therapeutic agents. © 2011 American Chemical Society. Source


Zhang L.,Zhejiang Chinese Medical University
BMC complementary and alternative medicine | Year: 2014

Allicin, a primary ingredient of garlic, has been proposed to possess cardioprotective properties, which are commonly mediated by improved endothelial function. To investigate the effect and mechanism of allicin on the apoptosis of human umbilical vein endothelial cells (HUVECs), we used Propidium iodide (PI) staining and Annexin V/ PI staining assays to establish a model of oxidative stress apoptosis induced by H2O2. MTT, RT-PCR and western-blot assays were used to detect the effects and mechanism of allicin on the model. PI staining, Annexin V/ PI staining assays and morphological assessment suggest that the cell death induced by 0.5 mM H2O2 is primarily apoptotic. Conversely, allicin reverses the effect of H2O2 on cell death, suggesting a role in protecting HUVECs from apoptosis. We demonstrated that H2O2 activates PARP cleavage, reduces pro-Caspase-3 levels and activates Bax expression; however, allicin inhibits each of these apoptotic signaling indicators. Allicin also reduces the levels of malondialdehyde and increases the levels of superoxide dismutase, nitric oxide release and endothelial nitric oxide synthase mRNA, but has no significant effect on inducible nitric oxide synthase mRNA levels. These results demonstrate that allicin has powerful effects in protecting HUVECs from apoptosis and suggest that protection occurs via a mechanism involving the protection from H2O2-mediated oxidative stress. Source


Chu L.,Zhejiang Chinese Medical University
Zhonghua nei ke za zhi [Chinese journal of internal medicine] | Year: 2012

To study the epidemiologic features of functional bowel disorders (FBD) among medical students and science and engineering students in Zhejiang province, China, and to explore the relationship between psychological factors and FBD. This study was a survey of random sampling based on the Rome III Diagnostic Questionnaire (Rome III-DQ) conducted from November 2010 to March 2011. The survey was carried out among medical students and science and engineering students respectively in two universities in Zhejiang province. Symptom Check List 90 (SCL-90) was used for psychological analysis. Among 1870 participants, 1033 were diagnosed as FBD based on Rome III criteria, with an overall incidence of 55.24%. The majority cases were unspecified functional bowel disorder, with an incidence of 26.58% (497/1870), others were functional constipation 16.95% (317/1870), irritable bowel syndrome 6.90% (129/1870), functional bloating 4.12% (77/1870) and functional diarrhea 0.70% (13/1870). The prevalence varied in different genders, majors and grades. In the multivariate analysis, women had a higher risk of any FBD than men [68.33% (617/903) vs 43.02% (416/967)] except for functional diarrhea; and medical students had a higher risk of any FBD than science and engineering students [68.53% (734/1071) vs 37.42% (299/799)]. Generally higher grade undergraduates had relatively higher risks than lower grade students, especially in medical students. Among the participants with FBD, 44.05% (455/1033) had other functional gastrointestinal disorders. In those overlapped parts, 9.00% (93/1033) had belching disorders, and 8.23% (85/1033) had functional dyspepsia. Students with FBD got higher scores in SCL-90 than healthy students. This study revealed a high rate of FBD among college students in Zhejiang province. The prevalence varied in different majors, and female higher than male. Psychological factors also had close relationships with FBD. Source


Chao G.-Q.,Zhejiang University | Zhang S.,Zhejiang Chinese Medical University
World Journal of Gastroenterology | Year: 2014

To evaluate the efficacy of acupuncture for treatment of irritable bowel syndrome (IBS) through metaanalysis of randomized controlled trials. Methods: We searched MEDLIINE, PubMed, Scopus, Web of Science, and Cochrane Central Register of Controlled Trials from 1966 to February 2013 for doubleblind, placebo-controlled trials investigating the efficacy of acupuncture in the management of IBS. Studies were screened for inclusion based on randomization, controls, and measurable outcomes reported. We used the modified Jadad score for assessing the quality of the articles. STATA 11.0 and Revman 5.0 were used for meta-analysis. Publication bias was assessed by Begg's and Egger's tests. Results: Six randomized, placebo-controlled clinical trials met the criteria and were included in the metaanalysis. The modified Jadad score of the articles was > 3, and five articles were of high quality. We analyzed the heterogeneity and found that these studies did not cause heterogeneity in our meta-analysis. Begg's test showed P = 0.707 and Egger's test showed P = 0.334. There was no publication bias in our meta-analysis (Begg's test, P = 0.707; Egger's test, P = 0.334). From the forest plot, the diamond was on the right side of the vertical line and did not intersect with the line. The pooled relative risk for clinical improvement with acupuncture was 1.75 (95%CI: 1.24-2.46, P = 0.001). Using the two different systems of STATA 11.0 and Revman 5.0, we confirmed the significant efficacy of acupuncture for treating IBS. Conclusion: Acupuncture exhibits clinically and statistically significant control of IBS symptoms. © 2014 Baishideng Publishing Group Co., Limited. All rights reserved. Source


Zhou Y.,Zhejiang Chinese Medical University
PLoS ONE | Year: 2014

Design: Using a constructivist grounded theory method, 46 in-depth interviews were conducted with 28 China-educated nurses in two major cities in Australia.Background and Purpose: Transnational nurse migration is a growing phenomenon. This study explored the experiences of China-educated nurses working in Australia.Results: The core category emerged was "reconciling different realities". Three phases of reconciling were conceptualised: realising, struggling, and reflecting. Realising refers to an awareness of the discrepancies between different realities. Struggling reflects the dilemma of the "middle position" and how being situated as "the other" is experienced. Reflecting is the process of making sense of the experience and rationalising the gains and losses associated with immigration.Conclusions: This study produced a theoretical understanding of the experience of China-educated nurses working in Australia. The findings not only inform Chinese nurses who wish to migrate but contribute to the implementation of more effective support services for immigrant nurses. © 2014 PLOS ONE. Source

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