Entity

Time filter

Source Type


Yu Y.,Zhejiang Chinese Medical Hospital
Se pu = Chinese journal of chromatography / Zhongguo hua xue hui | Year: 2010

A rapid resolution liquid chromatography coupled with quadrupole-time of flight mass spectrometry method (RRLC-Q-TOF/MS) was used to analyze metabolic fingerprint of the plasma samples from systemic lupus erythematosus (SLE) patients. Supervised pattern recognition methods combined with orthogonal signal correction partial least square-discriminate analysis (OSC-PLS-DA) were used to process the metabolic data. A nice distinction between SLE patients and healthy control group was observed. Further, ten ions, which had a significant contribution to classification, had been selected from metabolic profiles of SLE patients. The ten ions were identified and belong to seven metabolic biomarkers. It was shown that there were abnormal metabolisms of amino acids, phospholipids and porphyrin in SLE patients. It provided a scientific basis for the monitoring and diagnosis of SLE. These results will benefit the early intervention and treatment of SLE and the research of the mechanism of pathogenesis. Source


Ding X.,Zhejiang Chinese Medical University | Yu Y.,Zhejiang Chinese Medical Hospital
Proceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012 | Year: 2012

In order to investigate systemic lupus erythematosus (SLE) possible disease biomarkers and disclose its pathogenesis, a rapid resolution liquid chromatography combined with quadrupole-time of flight mass spectrometry method (RRLC-Q-TOF/MS) was used to study the sera from 17 SLE patients and 15 healthy volunteers. Supervised pattern recognition methods combined with orthogonal signal correction partial least square-discriminate analysis (OSC-PLS-DA) were chosen to process the metabolic data. A nice distinction between SLE patients and healthy control group was observed. Further, ten ions, which had a significant contribution to classification, had been selected from metabolic profiles of SLE patients. The ten ions were identified and belong to seven metabolic biomarkers. It was shown that there were abnormal metabolisms of amino acids, phospholipids and porphyrin in SLE patients. It provided a scientific basis for the monitoring and diagnosis of SLE. © 2012 IEEE. Source


Xu L.,Zhejiang Chinese Medical Hospital
BMJ case reports | Year: 2011

The authors present the report of an ankylosing spondylitis combined with angioimmunoblastic T cell lymphoma after the anti-tumour necrosis factor treatment. Source


Xu L.,Zhejiang Chinese Medical Hospital
BMJ Case Reports | Year: 2011

The authors present the report of an ankylosing spondylitis combined with angioimmunoblastic T cell lymphoma after the anti-tumour necrosis factor treatment. Copyright 2011 BMJ Publishing Group. All rights reserved. Source


Yu Y.,Zhejiang Chinese Medical Hospital | Cao Y.,Zhejiang Chinese Medical Hospital | Chen Y.,Zhejiang Chinese Medical Hospital | Wen C.,Zhejiang Chinese Medical University | Xu Z.,CAS Dalian Institute of Chemical Physics
Chinese Journal of Chromatography (Se Pu) | Year: 2010

A rapid resolution liquid chromatography coupled with quadrupole-time of flight mass spectrometry method(RRLC-Q-TOF/MS) was used to analyze metabolic finger print of the plasma samples from systemic lupus erythematosus(SLE) patients. Supervised pattern recognition methods combined w ith orthogonal signal correction partial least square-discriminate analysis (OSC-PLS-DA) were used to process the metabolic data. A nice distinction between SLE patients and healthy co n trol group was observed. Further, tenions, which had as ignificant co ntribution to c las s ifica tion, had been selected from metabolic profiles of SLE patients. The ten ions were identified and belong to seven metabolic biomarkers. It was shown that there were abnormal metabolisms o f amino acids, phospholipids and porphyrin in SLE patients. It provided a scientific basis fo r the monitoring and diagnosis of SLE. These results w ill benefit the early intervention and treatment of SLE and the research of the mechanism of pathogenesis. Source

Discover hidden collaborations