Zhejiang Chinese Medical Hospital

Hangzhou, China

Zhejiang Chinese Medical Hospital

Hangzhou, China
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Hua J.,Second People Hospital of Xihu District | Hua J.,Zhejiang Chinese Medical University | Huang P.,Zhejiang Chinese Medical University | Zhu C.-M.,Zhejiang Chinese Medical University | And 2 more authors.
Journal of Ethnopharmacology | Year: 2012

Ethnopharmacological relevance: Modified Simiao Decoction (MSD), based on clinical experience, has been used for decades and famous for its efficiency in treating hyperuricemic and gouty diseases. Aim of the study: To investigate the effects of MSD on anti-hyperuricemic and nephroprotective effects are involved in potassium oxonate-induced hyperuricemic mice. Materials and methods: The effects of MSD were investigated in hyperuricemic mice induced by potassium oxonate. MSD were fed to hyperuricemic mice daily at a dose of 0.45, 0.90, 1.80 g/kg for 10 days, and allopurinol (5 mg/kg) was given as a positive control. Serum and urine levels of uric acid and creatinine, and fractional excretion of uric acid (FEUA) were determined by colorimetric method. Its nephroprotective effects were evaluated by determining a panel of oxidative stress markers after the intervention in hyperuricemic mice. Simultaneously, protein levels of urate transporter 1 (URAT1) and organic anion transporter 1 (OAT1) in the kidney were analyzed by Western blotting. Results: MSD could inhibit XOD activities in serum and liver, decrease levels of serum uric acid, serum creatinine and BUN, and increased levels of urine uric acid, urine creatinine, FEUA dose-dependently through down-regulation of URAT1 and up-regulation of OAT1 protein expressions in the renal tissue of hyperuricemic mice. It also effectively reversed oxonate-induced alterations on renal MDA levels and SOD activities in this model. Conclusion: MSD processes uricosuric and nephroprotective actions by regulating renal urate transporters and enhancing antioxidant enzymes activities to improve renal dysfunction in hyperuricemic mice. © 2012 Elsevier Ireland Ltd. All rights reserved.


Ding X.,Zhejiang Chinese Medical University | Yu Y.,Zhejiang Chinese Medical Hospital
Proceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012 | Year: 2012

In order to investigate systemic lupus erythematosus (SLE) possible disease biomarkers and disclose its pathogenesis, a rapid resolution liquid chromatography combined with quadrupole-time of flight mass spectrometry method (RRLC-Q-TOF/MS) was used to study the sera from 17 SLE patients and 15 healthy volunteers. Supervised pattern recognition methods combined with orthogonal signal correction partial least square-discriminate analysis (OSC-PLS-DA) were chosen to process the metabolic data. A nice distinction between SLE patients and healthy control group was observed. Further, ten ions, which had a significant contribution to classification, had been selected from metabolic profiles of SLE patients. The ten ions were identified and belong to seven metabolic biomarkers. It was shown that there were abnormal metabolisms of amino acids, phospholipids and porphyrin in SLE patients. It provided a scientific basis for the monitoring and diagnosis of SLE. © 2012 IEEE.


Yu Y.,Zhejiang Chinese Medical Hospital | Cao Y.,Zhejiang Chinese Medical Hospital | Chen Y.,Zhejiang Chinese Medical Hospital | Wen C.,Zhejiang Chinese Medical University | Xu Z.,CAS Dalian Institute of Chemical Physics
Chinese Journal of Chromatography (Se Pu) | Year: 2010

A rapid resolution liquid chromatography coupled with quadrupole-time of flight mass spectrometry method(RRLC-Q-TOF/MS) was used to analyze metabolic finger print of the plasma samples from systemic lupus erythematosus(SLE) patients. Supervised pattern recognition methods combined w ith orthogonal signal correction partial least square-discriminate analysis (OSC-PLS-DA) were used to process the metabolic data. A nice distinction between SLE patients and healthy co n trol group was observed. Further, tenions, which had as ignificant co ntribution to c las s ifica tion, had been selected from metabolic profiles of SLE patients. The ten ions were identified and belong to seven metabolic biomarkers. It was shown that there were abnormal metabolisms o f amino acids, phospholipids and porphyrin in SLE patients. It provided a scientific basis fo r the monitoring and diagnosis of SLE. These results w ill benefit the early intervention and treatment of SLE and the research of the mechanism of pathogenesis.


Xu L.,Zhejiang Chinese Medical Hospital
BMJ Case Reports | Year: 2011

The authors present the report of an ankylosing spondylitis combined with angioimmunoblastic T cell lymphoma after the anti-tumour necrosis factor treatment. Copyright 2011 BMJ Publishing Group. All rights reserved.


Xu L.,Zhejiang Chinese Medical Hospital
BMJ case reports | Year: 2011

The authors present the report of an ankylosing spondylitis combined with angioimmunoblastic T cell lymphoma after the anti-tumour necrosis factor treatment.


Yu Y.,Zhejiang Chinese Medical Hospital
Se pu = Chinese journal of chromatography / Zhongguo hua xue hui | Year: 2010

A rapid resolution liquid chromatography coupled with quadrupole-time of flight mass spectrometry method (RRLC-Q-TOF/MS) was used to analyze metabolic fingerprint of the plasma samples from systemic lupus erythematosus (SLE) patients. Supervised pattern recognition methods combined with orthogonal signal correction partial least square-discriminate analysis (OSC-PLS-DA) were used to process the metabolic data. A nice distinction between SLE patients and healthy control group was observed. Further, ten ions, which had a significant contribution to classification, had been selected from metabolic profiles of SLE patients. The ten ions were identified and belong to seven metabolic biomarkers. It was shown that there were abnormal metabolisms of amino acids, phospholipids and porphyrin in SLE patients. It provided a scientific basis for the monitoring and diagnosis of SLE. These results will benefit the early intervention and treatment of SLE and the research of the mechanism of pathogenesis.


PubMed | Zhejiang Chinese Medical Hospital
Type: Journal Article | Journal: Se pu = Chinese journal of chromatography | Year: 2010

A rapid resolution liquid chromatography coupled with quadrupole-time of flight mass spectrometry method (RRLC-Q-TOF/MS) was used to analyze metabolic fingerprint of the plasma samples from systemic lupus erythematosus (SLE) patients. Supervised pattern recognition methods combined with orthogonal signal correction partial least square-discriminate analysis (OSC-PLS-DA) were used to process the metabolic data. A nice distinction between SLE patients and healthy control group was observed. Further, ten ions, which had a significant contribution to classification, had been selected from metabolic profiles of SLE patients. The ten ions were identified and belong to seven metabolic biomarkers. It was shown that there were abnormal metabolisms of amino acids, phospholipids and porphyrin in SLE patients. It provided a scientific basis for the monitoring and diagnosis of SLE. These results will benefit the early intervention and treatment of SLE and the research of the mechanism of pathogenesis.


PubMed | Zhejiang Chinese Medical Hospital
Type: | Journal: BMJ case reports | Year: 2012

The authors present the report of an ankylosing spondylitis combined with angioimmunoblastic T cell lymphoma after the anti-tumour necrosis factor treatment.

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