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Tang B.-C.,Zhejiang Casing Animal By Products Co. | Tong Y.-G.,Zhejiang Casing Animal By Products Co. | Pan W.-C.,Zhejiang Casing Animal By Products Co. | Yang Z.-Q.,Zhejiang Casing Animal By Products Co. | And 2 more authors.
Xiandai Huagong/Modern Chemical Industry | Year: 2015

To improve the enzymatic process of heparin sodium, a kind of innovative enzymatic technology of heparin sodium is presented. The combinative enzyme which combines 2709 alkaline protease with trypsin is adopted in enzymatic process. The optimum conditions in the enzymatic process are obtained through the single factor experiments and orthogonal experiments: 2:1 of 2709 alkaline protease and trypsin, 58℃ of reaction temperature, 0.79 mol/L of salinity, 9 of pH, 0.3 g/L of the amount of combinative enzyme and 2 hours of the reaction time. Compared to the original single enzymatic technology, the yield of crude heparin is improved by 6% and the quality of crude heparin is also improved. The new enzymatic technology of heparin sodium by combinative enzyme provides an important reference for practical workshop production. ©, 2015, China National Chemical Information Center. All right reserved.

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