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Zhu X.,Zhejiang Cancer Research Institute | Du L.,Zhejiang Provincial Cancer Center | Feng J.,Zhejiang Cancer Research Institute | Ling Y.,Zhejiang Cancer Research Institute | Xu S.,Zhejiang Cancer Research Institute
Clinical Laboratory | Year: 2014

Background: This study was designed to examine the serum levels of six cytokines (IFN-γ, TNF-α, IL-2, IL-4, IL-5, and IL-10) in treated and untreated breast cancer patients and assess their clinical significance. The correlation of the Th1/Th2 type cytokine levels and the clinicopathologic variables was further evaluated. Methods: Cytometric Bead Array (CBA) was used to examine the levels of Th1 cytokines (TNF-α, IFN-γ, and IL-2) and Th2 cytokines (IL-4, IL-5, and IL-10) in serum of 36 untreated and 73 treated breast cancer patients and 51 healthy females as control. Results: In the untreated group, the levels of IFN-γ, IL-4 and IL-5 were significantly higher than in control group (p < 0.05). IFN-<, IL-2, IL-5, and IL-10 levels were higher in treated group than in untreated group (p < 0.05); IFN-γ/IL-4 ratio of the treated group was higher than the untreated group (p < 0.05). Meanwhile, the cytokine levels were significantly different in different pTNM stages and lymph node involvement groups. Survival analysis revealed that the IFN-γ/IL-4 ratio, pTNM stage, and lymph node involvement affected the survival of breast cancer patients. The pTNM stage was an independent significant prognostic factor. Conclusions: Breast cancer patients presented a Th1/Th2 imbalance and immune function disorder, which correlated with pTNM stage and lymph node involvement. Higher IFN-γ/IL-4 ratio predicted a favorable outcome in breast cancer patients.

Du L.-B.,Zhejiang Provincial Cancer Center | Li H.-Z.,Zhejiang Provincial Cancer Center | Wang X.-H.,Zhejiang Provincial Cancer Center | Zhu C.,Zhejiang Provincial Cancer Center | And 8 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2014

Objective: The Zhejiang Provincial Cancer Prevention and Control Office collected cancer registration data during 2000 to 2009 from 6 cancer registries in Zhejiang province of China in order to analyze the cancer incidence. Methods: Descriptive analysis included cancer incidence stratified by sex, age and cancer site group. The proportions and cumulative rates of 10 common cancers in different groups were also calculated. Chinese population census in 1982 and Segi's population were used for calculating age-standardized incidence rates. The log-linear model was used for fitting to calculate the incidence trends. Results: The 6 cancer registries in Zhejiang province in China covered a total of 60,087,888 person-years during 2000 to 2009 (males 30,445,904, females 29,641,984). The total number of new cancer cases were 163,104 (males 92,982, females 70,122). The morphology verified cases accounted for 69.7%, and the new cases verified only by information from death certification accounted for 1.23%. The crude incidence rate in Zhejiang cancer registration areas was 271.5/105 during 2000 to 2009 (male 305.41/105, female 236.58/105), age-standardized incidence rates by Chinese standard population (ASIRC) and by world standard population (ASIRW) were 147.1/105 and 188.2/105, the cumulative incidence rate (aged from 0 to 74) being 21.7%. The crude incidence rate was 209.6/105 in 2000, and it increased to 320.20/105 in 2009 (52.8%), with an annual percent change (APC) of 4.51% (95% confidence interval, 3.25%-5.79%). Age-specific incidence rate of 80-84 age group was achieved at the highest point of the incidence curve. Overall with different age groups, the cancer incidences differed, the incidence of liver cancer being highest in 15-44 age group in males; the incidence of breast cancer was the highest in 15-64 age group in females; the incidences of lung cancer were the highest in both males and females over the age of 65 years. Conclusions: Lung cancer, digestive system malignancies and breast cancer are the most common cancers in Zhejiang province in China requiring an especial focus. The incidences of thyroid cancer, prostate cancer, cervical cancer and lymphoma have increased rapidly. Prevention and control measures should be implemented for these cancers.

Li H.,Zhejiang Provincial Cancer Center | Wang Y.,Zhejiang Provincial Cancer Center | Zhu C.,Zhejiang Provincial Cancer Center | Wang X.,Zhejiang Provincial Cancer Center | Du L.,Zhejiang Provincial Cancer Center
Journal of Cancer Research and Therapeutics | Year: 2015

Background: Laryngeal cancer is the one of the most prevalent cancer of the upper respiratory tract. Aiming to get a better understanding of the epidemiological characteristics and trends of laryngeal cancer in Zhejiang cancer registry in China during 2000-2011, we used the standardized quality control and statistical methods to analyze the incidence and mortality that were vital for making decision about laryngeal cancer prevention and control. Materials and Methods: Comparably high-quality data from eight population-based cancer registries in Zhejiang from 2000 to 2011 were qualified for analysis. The pooled data were stratified by area, sex, and age group. All incidence and mortality rates were age-standardized to the 2000 Chinese standard population and Segi's population, which were expressed per 100,000 populations. Average annual percent changes (AAPCs) and 95% confidence intervals of laryngeal cancer incidence and mortality were calculated for the temporal trends. The logarithmic trend line was also drawn to reflect the time trends of incidence and mortality. Results: During the 12 years, the 8 cancer registries covered a total of 81,758,277 person-year population (65,500,842 in urban and 16,257,435 in rural areas) including 41,315,911 person-year males and 40,442,366 person-year females. The age-standardized incidence rates were 1.10/105 by Chinese population and 1.12/105 by world population, respectively. The incidence of laryngeal cancer was relatively low in subjects under 44 years old. Then, it increased sharply after 45 years old and finally reached the peak in subjects of 75-79 years old. The age-standardized mortality rates of the Chinese population and world population were 0.28/105 and 0.35/105, respectively. The mortality of laryngeal cancer was at a low level in subjects under 49 years old. The rate dramatically increased in subjects over 50 years old, and then peaked in the age group of 80-84 years. The crude incidence of laryngeal cancer in Zhejiang cancer registration areas in 2000 was approximately 1.39/105, and it reached 1.78/105 in 2011, with the AAPC of 2.47%; the temporal trend line indicates that the incidence remained steady during the 12 years. The crude mortality of laryngeal cancer in Zhejiang registration areas in 2000 was about 0.30/105 and increased to 0.66/105, with the AAPC of 4.24% which showed no statistical significance; the temporal trend line indicates that mortality was going up to a certain extent, but not evident. Conclusions: Laryngeal cancer significantly influenced the quality of life for the patients. The comprehensive measures should be carried out to prevent the upward trend of laryngeal cancer.

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