Zhejiang Apeloa Medical Technology Co.

Dongyang, China

Zhejiang Apeloa Medical Technology Co.

Dongyang, China
SEARCH FILTERS
Time filter
Source Type

Ao J.,Zhejiang University | Gao H.,Zhejiang Apeloa Medical Technology Co. | Tang X.,Zhejiang Apeloa Medical Technology Co. | Zhou L.,Zhejiang University | Zhang G.,Zhejiang University
Journal of Chinese Pharmaceutical Sciences | Year: 2015

Of all reported polymorphs of clopidogrel hydrogen sulfate, Form I is difficult to produce and store owing to its poor thermostability. It is reported that Form I can spontaneously transform into Form II at high temperature and humidity. In this study, high purity Form I of clopidogrel hydrogen sulfate with good thermodynamic stability was prepared by a centrifugationassisted recrystallization technology. The resultant product was characterized by powder Xray diffraction (PXRD), differential scanning calorimetry (DSC) and scanning electron microscope (SEM). The results showed that the crystallinity and crystallite size of the Form I prepared by the centrifugationassisted recrystallization method were larger than those obtained by conventional antisolvent recrystallization methods. Longterm thermostability testing demonstrated that the improved product can keep stable crystal structure even at high temperature and humidity. © 2015 Journal of Chinese Pharmaceutical Sciences, School of Pharmaceutical Sciences, Peking University.


Zhou M.,Zhejiang Sci-Tech University | Ao J.,Zhejiang Sci-Tech University | Liu S.,Zhejiang Sci-Tech University | Wu C.,Zhejiang Apeloa Medical Technology Co | And 3 more authors.
Pharmaceutical Development and Technology | Year: 2017

Only one crystal form of metoprolol succinate (Form I) was reported during previous researches and production. In this study, a new polymorph of metoprolol succinate (here named as Form II) was discovered and investigated by X-ray diffraction, thermoanalysis and infrared spectroscopy. The results show its crystal structure and thermal properties are significantly different with Form I. Compared with Form I, Form II exhibits specific diffraction pattern, lower melting temperature and weaker hydrogen bond effect. The thermostability testing suggests Form II is a metastable crystal form and will gradually transform into Form I undergoing treatment of high temperature and humidity. Metastable crystal form generally has better dissolubility than its corresponding stable form. Subsequent measurement also verified that Form II can dissolve in the water more quickly than Form I. © 2016 Informa UK Limited, trading as Taylor & Francis Group.


Wang L.-S.,CAS Chengdu Institute of Organic Chemistry | Wang L.-S.,University of Chinese Academy of Sciences | Chen H.-C.,CAS Chengdu Institute of Organic Chemistry | Zhang L.-F.,CAS Chengdu Institute of Organic Chemistry | And 3 more authors.
Journal of Polymer Research | Year: 2011

A biodegradable and thermoplastic elastomer-poly(L-lactide-co-ε- caprolactone) (PLLCA) - was reinforced with 5, 10, 20, and 30 wt% of CaCO 3whiskers. We assessed the influence of the CaCO3whisker content on the mechanical and thermal properties of the PLLCA/CaCO 3whisker composites. Scanning electron microscopy (SEM) revealed that the CaCO3whiskers were uniformly distributed in the composite matrices. The results of differential scanning calorimetry (DSC) and dynamic mechanical analysis (DMA) showed that the glass transition temperatures (Tg) of the composites increased slightly with increasing CaCO3whisker content. At low CaCO3whisker contents, the tensile strengths of the composites increased sharply with increasing CaCO3content, the Young's moduli also increased, and the elongation at break values gradually decreased. Thermogravimetric analysis (TGA) showed that the CaCO 3whiskers can promote the thermal degradation of PLLCA. Shape memory test results indicated that an appropriate amount of CaCO3whiskers can improve the shape memory properties of PLLCA. © Springer Science+Business Media B.V. 2010.


Wang L.-S.,CAS Chengdu Institute of Organic Chemistry | Wang L.-S.,University of Chinese Academy of Sciences | Chen H.-C.,CAS Chengdu Institute of Organic Chemistry | Xiong Z.-C.,CAS Chengdu Institute of Organic Chemistry | And 2 more authors.
Macromolecular Materials and Engineering | Year: 2010

In this paper, a new, completely biodegradable shapememory elastomer comprising PLLCA reinforced by in situ PGA fibrillation is described. The effects of PGA content, screw speed and draw ratio on the average diameter of PGA Acknowledgements: This project was financially supported by Bureau of Life Sciences and Biotechnology of the Chinese Academy of Sciences, and the Science and Technology Department of Zhejiang Province, China (2008C11126). © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Wang L.-S.,CAS Chengdu Institute of Organic Chemistry | Wang L.-S.,Chinese Academy of Sciences | Chen H.-C.,CAS Chengdu Institute of Organic Chemistry | Xiong Z.-C.,CAS Chengdu Institute of Organic Chemistry | And 2 more authors.
Materials Letters | Year: 2010

Considering the mechanical properties and shape-memory properties, we developed a novel biodegradable compound shape-memory-polymer blend composed of poly (l-lactide-co-ε-caprolactone) (PLLCA) and poly (l-lactide-co-glycolide) (PLLGA). In comparison with most reported shape-memory blends, our blend showed outstanding shape-memory properties at higher stationary-phase concentrations (more than 50% w/w). The results of scanning electron microscopy (SEM) demonstrated the immiscibility between PLLCA and PLLGA. The tensile test results revealed that blends with different PLLGA concentrations showed different mechanical properties. The results of the shape-memory tests suggested that the blends showed improved recovery and fixing performances with an increase in the PLLGA content, especially at PLLGA concentrations greater than 50 wt.%. © 2009 Elsevier B.V. All rights reserved.


Liuyun J.,CAS Chengdu Institute of Organic Chemistry | Chengdong X.,CAS Chengdu Institute of Organic Chemistry | Dongliang C.,CAS Chengdu Institute of Organic Chemistry | Lixin J.,CAS Chengdu Institute of Organic Chemistry | And 2 more authors.
Applied Surface Science | Year: 2012

Three different surface modification methods for nano-hydroxyapatite (n-HA) of stearic acid, grafted with l-lactide, combining stearic acid and surface-grafting l-lactic were adopted, respectively. The surface modification reaction and the effect of different methods were evaluated by Fourier transformation infrared (FTIR), X-ray photoelectron spectra (XPS), thermal gravimetric analysis (TGA), transmission electron microscopy (TEM). The results showed that n-HA surfaces were all successful modified, and the modification method of combining stearic acid and surface-grafting l-lactic had the greatest grafting amount and the best dispersion among the three modification methods. Then, the n-HA with three different surface modification and unmodified n-HA were introduced into PLGA, respectively, and a serials of n-HA/PLGA composites with 3% n-HA amount in weight were prepared by solution mixing, and the properties of n-HA/PLGA composites were also investigated by electromechanical universal tester and scanning electron microscope(SEM), comparing with PLGA. The results showed that the n-HA/PLGA composite with the n-HA surface modified by combining stearic acid and surface-grafting l-lactic had the highest bending strength and the best dispersion and interfacial adhesion among the three different modification methods, suggesting the surface modification of combining stearic acid and surface-grafting l-lactic was the most ideal method in this study, which has a great deal of enhancement of bending strength than PLGA, and it would be potential to be used in the field of bone fracture internal fixation in future. Crown Copyright © 2012 Published by Elsevier B.V. All rights reserved.


Li C.,Zhejiang University of Technology | Liu Y.,Zhejiang University of Technology | Zhang Y.,Zhejiang Apeloa Medical Technology Co. | Zhang X.,Zhejiang University of Technology
Journal of Chemical Research | Year: 2011

A convergent and efficient synthesis of anticoagulant rivaroxaban was developed using the cycloaddition of commercially available (R)-epichlorohydrin with 4-(morpholin-3-one)phenyl isocyanate catalysed by MgI2 etherate as the key step, in 22% overall yield.


Weng C.,China Jiliang University | Zhang H.,Hangzhou Cancer Hospital | Xiong X.,China Jiliang University | Lu X.,China Jiliang University | And 2 more authors.
Asian Journal of Chemistry | Year: 2014

The present short review about a great deal of researches have been dedicated to the development of the reaction (catalyzing the ring opening of epoxide with amines for the corresponding amino-alcohols) in recent years.


Liu J.,China Jiliang University | Zhu F.-M.,Zhejiang Apeloa Tospo Pharmaceutical Co. | Chu Y.-B.,Zhejiang Apeloa Medical Technology Co. | Huang L.-H.,China Jiliang University | Zhou Y.-F.,China Jiliang University
Tetrahedron Asymmetry | Year: 2015

Optically active isatin-derived N,O-aminals were obtained through the catalytic asymmetric addition of various alcohols to isatin-derived N-Boc ketimines. Using 2′-phenyl cinchonidine thiourea as the catalyst, adducts were obtained in 96% yield and with up to 92% ee. © 2015 Elsevier Ltd. All rights reserved.


Jiang H.,China Jiliang University | Hu J.,China Jiliang University | Xu X.,Zhejiang Apeloa Medical Technology Co. | Zhou Y.,China Jiliang University | Zhou Y.,Zhejiang Apeloa Medical Technology Co.
Asian Journal of Chemistry | Year: 2015

Nitriles undergo reduction to primary amines under optimized conditions at 50 °C using 0.25 equiv of copper chloride and 3.0 equiv of potassium borohydride in 80 % isopropanol. The aromatic and aralkyl nitriles could be effectively reduced in yield ranging from 60 to 90 %.

Loading Zhejiang Apeloa Medical Technology Co. collaborators
Loading Zhejiang Apeloa Medical Technology Co. collaborators