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Merseburger T.,ZHAW | Pahl I.,ZHAW | Muller D.,ZHAW | Tanner M.,ZHAW
Advances in biochemical engineering/biotechnology | Year: 2014

: Quality management systems are, as a rule, tightly defined systems that conserve existing processes and therefore guarantee compliance with quality standards. But maintaining quality also includes introducing new enhanced production methods and making use of the latest findings of bioscience. The advances in biotechnology and single-use manufacturing methods for producing new drugs especially impose new challenges on quality management, as quality standards have not yet been set. New methods to ensure patient safety have to be established, as it is insufficient to rely only on current rules. A concept of qualification, validation, and manufacturing procedures based on risk management needs to be established and realized in pharmaceutical production. The chapter starts with an introduction to the regulatory background of the manufacture of medicinal products. It then continues with key methods of risk management. Hazards associated with the production of medicinal products with single-use equipment are described with a focus on bioreactors, storage containers, and connecting devices. The hazards are subsequently evaluated and criteria for risk evaluation are presented. This chapter concludes with aspects of industrial application of quality risk management.


Carella G.,TU Berlin | Edmonds A.,ZHAW | Dudouet F.,ZHAW | Corici M.,FOKUS | And 2 more authors.
2015 IEEE Conference on Network Function Virtualization and Software Defined Network, NFV-SDN 2015 | Year: 2015

This demonstration paper details the cloud based service enablement platform developed in the EU FP7 Mobile Cloud Networking project. This demonstration shows on a mobile core network can be instantiated on demand on top of a standard cloud infrastructure. © 2015 IEEE.


Rupf R.,ZHAW Zurich University of Applied Sciences | Wyttenbach M.,ZHAW Zurich University of Applied Sciences | Kochli D.,ZHAW Zurich University of Applied Sciences | Hediger M.,ZHAW | And 3 more authors.
Eco.mont | Year: 2011

Outdoor activities may have serious consequences for wildlife species that are sensitive to human disturbance. The pressure of outdoor activities on natural landscapes has increased dramatically in recent decades. However, we generally lack information on the spatial and temporal patterns of outdoor activities - a fact that makes it difficult to quantify the impact on wildlife and thus to implement and justify measures to constrain outdoor activities. In the winter seasons 2008/2009 and 2009/2010, we equipped 303 recreationists in the Val Müstair Biosphere Reserve, eastern Swiss Alps, with GPS loggers to record their spatial and temporal pattern of landscape use. We then analysed how the resulting pattern of spatial use overlapped with the habitat of capercaillie Tetrao urogallus, an endangered woodland grouse species that is highly sensitive to disturbance. For our study we used the official capercaillie core winter habitats observed by the game wardens of the Canton Grisons. The recorded 319 trips of 188 backcountry skiers and snowboarders and 231 trips of 115 snowshoers combined show an inhomogeneous use of subareas in the region. With one exception, the trips are located in the main valley and the adjoining southern and northern slopes and peaks. The trips of snowshoers result in a dispersed use pattern across the main valley, while the trips of the backcountry skiers and snowboarders are concentrated more on official and popular routes. Rarely did recreationists trespass official wildlife sanctuaries or cross capercaillie habitat patches. However, one official, very popular backcountry skiing route crosses one of the largest capercaillie habitats. Here the recorded trips show wide-ranging spatial use with many connectors to the main route. As a consequence, this capercaillie habitat patch is dissected into smaller undisturbed patches. GPS logging in combination with camera trap data provides detailed information on the spatio-temporal land-use pattern of outdoor activities. Based on these data, we identified a conflict of interest in the Val Müstair Biosphere Reserve that has to be resolved by management in a joint participatory process with the main stakeholders. Our methods and results could be transferred to other Alpine regions and be used for any land cover types. In this way we hope to contribute to mitigating conflicts between human outdoor activities and wildlife populations.


Gmuer A.,ETH Zurich | Nuessli Guth J.,ETH Zurich | Runte M.,ZHAW | Siegrist M.,ETH Zurich
Food Quality and Preference | Year: 2015

In recent years, new emotion and feeling lexicons developed in different languages and cultures have led to interesting insights into food- and odor-elicited emotions. However, most of the applied methods were not very systematic and used preexisting word lists as a starting point. None of the lexicons was generated from a linguistic perspective using comprehensive actual language use data. The aim of the present two studies was to explore the nature of the most appropriate terms used to describe food-related emotions with a systematic, linguistic-based method. In the first study, we applied a novel, three-step approach to the German language by collecting actively used emotion words. The collection and identification step resulted in 272 candidate terms that have an emotional connotation. In an online survey, 222 German-speaking participants rated the relevance of these candidate words in relation to food products. The positive-negative-neutral categorization in the second study was aimed to characterize the 272 candidate words and to test for the occurrence of a hedonic asymmetry. The application of the novel approach in Study 1 was useful to identify 49 terms. The result indicates that German-speaking consumers actively use differentiated and evaluative words to describe food-evoked emotions. Up to 70% of these expressions were positive, confirming the occurrence of a hedonic asymmetry by means of a linguistic-based approach. The nature of our identified expressions differed, however, from preexisting lists, which may be attributed to divergences in the applied approaches or suggested cultural aspects. Overall, the novel, systematic and linguistic-based approach, and the designed German emotion lexicon tailored to the consumers' active language use, are valuable tools to deepen our understanding of the role that emotions play in food consumption experiences. © 2014 Elsevier Ltd.


Barbera-Guillem R.,Institute Biomecanica Of Valencia | Poveda-Puente R.,Institute Biomecanica Of Valencia | Neumann S.,ZHAW | Becker H.,ZHAW | And 3 more authors.
Studies in Health Technology and Informatics | Year: 2015

In user-centred design and marketing, personas are fictional characters created to represent the different user types that might use a site, brand, or product in a similar way [1]. As in other projects, the main application and use value of the persona approach in WeTakeCare project has been to depict and thus make 'vivid' the characters and the milieus created and selected. It has helped to better understand and communicate the differences among the potential users. It has also helped to understand the heterogeneity and diversity of the users' lives and to focus on how to meet their actual needs [2]. © 2015 The authors and IOS Press. All rights reserved.


Papafotiou A.,Intera Inc. | Senger R.,Intera Inc. | Keller L.,ZHAW | Marschall P.,National Cooperative for the Disposal of Radioactive Waste
International Workshop on Geomechanics and Energy: The Ground as Energy Source and Storage | Year: 2013

The candidate host rocks for a deep geological repository in Switzerland are analyzed in terms of correlations between petrophysical and geomechanical properties such as clay content, porosity, permeability and effective stress. The analysis leads to a workflow for estimating formation hydraulic properties for the different host rocks and at different depths based on geophysical log data. Consequently, common empirical relationships for permeability are tested for their ability to predict matrix permeability of the candidate formations. The coupled hydro-mechanical observations are additionally verified with micro-structural investigations of the pore space using nanotomography. The derived physical properties are finally compared to analyses of packer tests, evaluating the predictive ability of the proposed approach for the different host rock formations, and conclusively ranking them according to the predictability of the barrier function of the host rock.


Schulze C.,ZHAW | Schulze C.,Karolinska Institutet | Kottorp A.,ZHAW | Kottorp A.,Karolinska Institutet | And 3 more authors.
Physical and Occupational Therapy in Pediatrics | Year: 2015

Activities of daily living (ADL) of children are widely assessed with the Pediatric Evaluation Disability Inventory (PEDI). This study examined test-retest and inter-rater reliability of the German PEDI (PEDI-G). During the adaptation of the PEDI nine items were added. In total, 117 parents of 53 children without and 64 children with a diagnosed physical disability from Austria, Germany, and Switzerland participated. Reliability was examined by intraclass correlation coefficient (ICC), standard error of measurement (SEM) and smallest detectable difference (SDD) for the Functional Skill Scale with and without added items and the Caregiver Assistance Scale. Cohen's Kappa was used to calculate the reliability of the Modification Scale. All ICC's for test-retest and inter-rater reliability were above 0.75, indicating good to very good reliability. The SDD varied from 0.83-5.58 across PEDI domains and scales. For the Modification Scale, Cohen's weighted kappa varied from 0.25 to 1.00 indicating sufficient reliability for some but not all items. Our findings indicate that the Functional Skill Scale and the Caregiver Assistance Scale of the PEDI-G are reliable scales that can be used to evaluate ADLs of children with and without physical disability. © 2015 Informa Healthcare USA, Inc.


PubMed | ZHAW, University of Konstanz and Empa - Swiss Federal Laboratories for Materials Science and Technology
Type: Journal Article | Journal: Archives of toxicology | Year: 2016

Halogen-free organophosphorus flame retardants are considered as replacements for the phased-out class of polybrominated diphenyl ethers (PBDEs). However, toxicological information on new flame retardants is still limited. Based on their excellent flame retardation potential, we have selected three novel 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) derivatives and assessed their toxicological profile using a battery of in vitro test systems in order to provide toxicological information before their large-scale production and use. PBDE-99, applied as a reference compound, exhibited distinct neuro-selective cytotoxicity at concentrations 10M. 6-(2-((6-oxido-6H-dibenzo[c,e][1,2]oxaphosphinin-6-yl)amino)ethoxy)-6H-dibenzo[c,e][1,2]oxaphosphinine 6-oxide (ETA-DOPO) and 6,6-(ethane-1,2-diylbis(oxy))bis(6H-dibenzo[c,e][1,2]oxaphosphinine-6-oxide) (EG-DOPO) displayed adverse effects at concentrations >10M in test systems reflecting the properties of human central and peripheral nervous system neurons, as well as in a set of non-neuronal cell types. DOPO and its derivative 6,6-(ethane-1,2-diylbis(azanediyl))bis(6H-dibenzo[c,e][1,2]oxaphosphinine-6-oxide) (EDA-DOPO) were neither neurotoxic, nor did they exhibit an influence on neural crest cell migration, or on the integrity of human skin equivalents. The two compounds furthermore displayed no inflammatory activation potential, nor did they affect algae growth or daphnia viability at concentrations 400M. Based on the superior flame retardation properties, biophysical features suited for use in polyurethane foams, and low cytotoxicity of EDA-DOPO, our results suggest that it is a candidate for the replacement of currently applied flame retardants.


PubMed | ZHAW
Type: | Journal: Advances in biochemical engineering/biotechnology | Year: 2013

: Quality management systems are, as a rule, tightly defined systems that conserve existing processes and therefore guarantee compliance with quality standards. But maintaining quality also includes introducing new enhanced production methods and making use of the latest findings of bioscience. The advances in biotechnology and single-use manufacturing methods for producing new drugs especially impose new challenges on quality management, as quality standards have not yet been set. New methods to ensure patient safety have to be established, as it is insufficient to rely only on current rules. A concept of qualification, validation, and manufacturing procedures based on risk management needs to be established and realized in pharmaceutical production. The chapter starts with an introduction to the regulatory background of the manufacture of medicinal products. It then continues with key methods of risk management. Hazards associated with the production of medicinal products with single-use equipment are described with a focus on bioreactors, storage containers, and connecting devices. The hazards are subsequently evaluated and criteria for risk evaluation are presented. This chapter concludes with aspects of industrial application of quality risk management.


News Article | December 10, 2015
Site: phys.org

California-based automaker Faraday Future's choice of Nevada over three other states is contingent on state lawmakers' approval of tax incentives that haven't been publicly described. The company's announcement, in a letter to Nevada legislators that was obtained by The Associated Press, also came with the revelation that it's backed by a Chinese billionaire investor who styles himself after Apple's late Steve Jobs. "We plan to revolutionize the automobile industry by creating an integrated, intelligent mobility system that protects the earth and improves the living environment of mankind," wrote Jia Yueting (ZHAW' YOO'-weh-ting), who's the founder and CEO of the holding company LeTV. Faraday has offered few details on its product so far, but has said it hopes to bring a vehicle to market as early as 2017 and plans to unveil a concept car in January ahead of the Consumer Electronics Show in Las Vegas. Company spokeswoman Stacy Morris added that Faraday will share its manufacturing plans very soon. Republican Gov. Brian Sandoval and his top economic development officer are scheduled to attend a news conference in Las Vegas on Thursday that's expected to include a formal announcement of a tentative agreement to bring the plant to North Las Vegas. Tax breaks to seal the deal would need authorization from Nevada lawmakers, who approved a $1.3 billion incentive package in a special session last year to secure electric carmaker Tesla Motors' massive battery factory outside of Reno. One automotive industry analyst noted Wednesday that Faraday was starting behind Tesla and traditional auto makers that are already developing technology to provide vehicle Internet access and over-the-air updates to electronic controls. "I'm not saying they can't succeed, but they're not going to be first," said Stephanie Brinley, senior analyst with IHS Automotive in Southfield, Michigan. Economics Professor Edward Leamer, director of the Anderson Forecast at the University of California, Los Angeles, said an upstart company might find it hard to sell enough vehicles to break even. "It could be tough going," he said. "That whole electric vehicle marketplace is tough, with oil prices low." The startup of about 500 employees has poached executive talent from electric carmaker Tesla and also draws its name from a luminary scientist—Michael Faraday—whose discoveries in the early 1800s laid the groundwork for the modern electric motor. Nevada topped finalists California, Georgia and Louisiana in the race to land the 2.5 million square foot plant. It's expected to sit on 600 acres in North Las Vegas's Apex Industrial Park and bring 4,500 jobs to Nevada. Mayor John Lee called the site choice "a transformational opportunity" for his city of about 220,000 residents. North Las Vegas boomed as the nation's fastest-growing city in the early 2000s and nearly busted when the recession hit and pushed it close to insolvency. It also comes as Nevada, the state hardest-hit by the housing crisis, attempts to diversify its casino-heavy economy by attracting high-tech companies. In addition to clearing the way for Tesla, state officials have awarded hundreds of millions of dollars in incentives to encourage data centers to build and expand in the state. "I'm excited about the opportunity and I hope it works out," said Republican Assembly Majority Leader Paul Anderson, who will need to rally support for the deal among lawmakers, some of whom have publicly expressed skepticism. "I look forward to working with people across the board to see if we can get these jobs created." The Faraday Future news came a day after another Southern California company working on a futuristic transportation project, Hyperloop Technologies, announced plans to expand to the same industrial park. The firm, which is trying to develop a system that would propel passengers and cargo through nearly airless tubes at the speed of sound, said it will build a test track and conduct early-phase testing at the park. Hyperloop officials, who haven't decided on a location for a larger, second-phase test track, said they chose Nevada because the state was able to move quickly to approve the project. Faraday Future is another foray by a China-based firm into the US transportation market. A proposed high-speed train from Southern California to Las Vegas and an electric bus company are other examples, as a massive country that has grown at breakneck speed begins to export its expertise in moving people around. Explore further: Nevada offers Tesla up to $1.3B for battery plant

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