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Kurek Eken M.,Zeynep Kamil Women And Childrens Health Training And Research Hospital And | Tuten A.,Zeynep Kamil Women And Childrens Health Training And Research Hospital | Ozkaya E.,Zeynep Kamil Women And Childrens Health Training And Research Hospital And | Dincer E.,Zeynep Kamil Women And Childrens Health Training And Research Hospital | And 3 more authors.
Journal of Maternal-Fetal and Neonatal Medicine | Year: 2016

Objective: To evaluate maternal and neonatal risk factors associated with the length of hospital stay in the neonatal intensive care unit (NICU). Material and method: This retrospective observational study was based on 3607 newborns who were admitted to the NICU of a tertiary teaching hospital from January 2012 through December 2014. Known obstetric risk factors associated with duration of hospitalization in NICUs were assessed including intrauterine growth restriction, maternal diabetes, oligohydramnios, chorioamnionitis, premeture rupture of membranes, preeclampsia, congenital malformations, neonatal sepsis, premature retinopathy, intracranial bleeding, necrotizing enterocolitis, meconium aspiration, maternal hypertension, fetal congenital cardiac malformations, congenital metabolic diseases, congenital hypothyroidism, pneumonia, pulmonary hypertension, bronchopulmonary dysplasia, pneumothorax and respiratory distress syndrome. Results: Gestational age (beta coefficient: −0.244, p<0.001) and birth weight (beta coefficient: −0.237, p<0.001) were significant confounders for duration of hospitalization in newborns. Conclusion: Gestational age and the birth weight were the most important confounders for duration of hospitalization. Neonate care in developing countries would further benefit from additional large population-based long-term studies with broad parameters. © 2016 Taylor & Francis. Source


Eken M.,Zeynep Kamil Women And Childrens Health Training And Research Hospital | Cnar M.,Zeynep Kamil Women And Childrens Health Training And Research Hospital | Senol T.,Zekai Tahir Maternity and Womens Health Training and Research Hospital | Ozkaya E.,Zeynep Kamil Women And Childrens Health Training And Research Hospital | Karateke A.,Zeynep Kamil Women And Childrens Health Training And Research Hospital
Turk Jinekoloji ve Obstetrik Dernegi Dergisi | Year: 2015

Objective: To present some features and incidence of cases of brachial plexus injury in deliveries at the Department of Obstetrics and Gynecology of Zeynep Kamil Maternity and Children’s Training and Research Hospital, from January 2010 through December 2014. Materials and Methods: In total, 38.896 deliveries in the Department of Obstetrics and Gynecology of Zeynep Kamil Maternity and Children’s Training and Research Hospital, from January 2010 through December 2014 were screened from a prospectively collected database. We recorded gravidity, parity, body mass index, maternal diabetes, labor induction, gestational age at delivery, operative deliveries, malpresentations, prolonged second stage of deliveries, shoulder dystocies, clavicle and humerus fructures, estimated fetal weight, biparietal diameter, abdominal circumference, femur length, fetal sex, route of delivery, maternal age, and fetal anomalies. Results: There were 28 (72/100.000) cases of brachial plexus injury among 38.896 deliveries. In the 6-year study period, there were 18.363 deliveries via c-section, whereas 20.533 were vaginal deliveries. Conclusion: Sonographic fetal weight estimation and clinical examination performed by experienced obstetricians, and active appropriate management of shoulder dystocias seemed to attenuate the incidence of brachial plexus injury in the at risk population in our tertiary referral center. © 2015, Turkish Society of Obstetrics and Gynecology. All rights reserved. Source


Senol T.,Zeynep Kamil Women And Childrens Health Training And Research Hospital | Polat M.,Zeynep Kamil Women And Childrens Health Training And Research Hospital | Ozkaya E.,Zeynep Kamil Women And Childrens Health Training And Research Hospital | Karateke A.,Zeynep Kamil Women And Childrens Health Training And Research Hospital
Asian Pacific Journal of Cancer Prevention | Year: 2015

Aims: To analyse the predictors of recurrence, disease free survival and overall survival in cases with endometrial cancer. Materials and Methods: A total of 152 women diagnosed with endometrial cancer were screened using a prospectively collected database including age, smoking history, menopausal status, body mass index, CA125, systemic disorders, tumor histology, tumor grade, lymphovascular space invasion, tumor diameter, cervical involvement, myometrial invasion, adnexal metastases, positive cytology, serosal involvement, other pelvic metastases, type of surgery, fertility sparing approach to assess their ability to predict recurrence, disease free survival and overall survival. Results: In ROC analyses tumor diameter was a significant predictor of recurrence (AUC:0.771, P<0.001). The optimal cut off value was 3.75 with 82% sensitivity and 63% specificity. In correlation analyses tumor grade (r=0.267, p=0.001), tumor diameter (r=0.297, p<0.001) and the serosal involvement (r=0.464, p<0.001) were found to significantly correlate with the recurrence. In Cox regression analyses when some different combinations of variables included in the model which are found to be significantly associated with the presence of recurrence, tumor diameter was found to be a significant confounder for disease free survival (OR=1.2(95 CI,1.016-1.394, P=0.031). On Cox regression for overall survival only serosal involvement was found to be a significant predictor (OR=20.8 (95 % CI 2.4-179.2, P=0.006). In univariate analysis of tumor diameter > 3.75 cm and the recurrence, there was 14 (21.9 %) cases with recurrence in group with high tumor diameter where as only 3 (3.4 %) cases group with smaller tumor size (Odds ratio:7.9 (95 %CI 2.2-28.9, p<0.001). Conclusions: Although most of the significantly correlated variables are part of the FIGO staging, tumor diameter was also found to be predictor for recurrence with higher values than generally accepted. Source


Polat M.,Zeynep Kamil Women And Childrens Health Training And Research Hospital | Senol T.,Zeynep Kamil Women And Childrens Health Training And Research Hospital | Ozkaya E.,Zeynep Kamil Women And Childrens Health Training And Research Hospital | Ogurlu Pakay G.,Zeynep Kamil Women And Childrens Health Training And Research Hospital | And 4 more authors.
Clinical and Translational Oncology | Year: 2015

Objective: The aim of this study was to assess the predictive value of neutrophil/lymphocyte and platelet/lymphocyte ratios for borderline, malignant ovarian tumors, and borderline cases with microinvasion. Methods: Totally 275 women with sonographically detected ovarian tumor were enrolled for this study. All subjects underwent gynecological surgery via endoscopic or conventional approach and ovarian masses were all evaluated histopathologically by the same pathologist. All study population was divided into three groups as group with borderline tumors, benign tumors, or malignant tumors according to the histopathological diagnosis. Just before surgical intervention, a blood sample was obtained from each participant to analyze CA125 level, neutrophil, platelet, and lymphocyte count. Results: Neutrophil/lymphocyte ratio (AUC = 0.604, P = 0.02) was a significant predictor for malignant cases. Optimal cutoff value for the neutrophil/lymphocyte ratio was found to be 2.47 with 63.4 % sensitivity and 63.5 % specificity for malignancy prediction. Odds ratio of high neutrophil/lymphocyte ratio for malignancy risk was 2.5 (95 % CI 1.3–4.8, P = 0.004). Platelet/lymphocyte ratio (AUC = 0.621, P = 0.007) was a significant predictor for malignant cases. Platelet/lymphocyte ratio (AUC = 0.568, P = 0.05) was also predictive for cases without a benign mass. Optimal cutoff value for the platelet/lymphocyte ratio was found to be 144.3 with 54 % sensitivity and 59 % specificity for malignancy prediction. Odds ratio of high platelet/lymphocyte ratio for malignancy risk was 2.1 (95 % CI 1.1–3.8, P = 0.02). Conclusion: Neutrophil/lymphocyte and platelet/lymphocyte ratios are predictors for malignant ovarian tumors but not borderline tumors even in case of microinvasion. © 2015 Federación de Sociedades Españolas de Oncología (FESEO) Source

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