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Kirmizibekmez H.,Zeynep Kamil Obstetrics and Children Education and Research Hospital | Mutlu R.G.Y.,Zeynep Kamil Obstetrics and Children Education and Research Hospital | Urganci N.D.,Sisli Etfal Education and Research Hospital | Oner A.,Academic Hospital
JCRPE Journal of Clinical Research in Pediatric Endocrinology | Year: 2015

Autoimmune polyglandular syndrome type 2 is defined as the occurrence of Addison's disease concomitantly with autoimmune thyroid disease and/ or type 1 diabetes mellitus. An 11-year-old boy with Hashimoto's disease, Addison's disease, celiac disease and Langerhans islet cell autoimmunity is described in this case report. Treatment of an endocrine disease may also trigger the onset of another endocrine disease. This case report underlines the importance of early recognition and treatment of critical endocrine diseases as well as the necessity to investigate pediatric patients with autoimmune diseases for coexisting conditions. Furthermore, the role of psychological stress as an inducer of autoimmunity was also discussed. © Journal of Clinical Research in Pediatric Endocrinology. Source


Krmzbekmez H.,Zeynep Kamil Obstetrics and Children Education and Research Hospital | Mutlu R.G.Y.,Zeynep Kamil Obstetrics and Children Education and Research Hospital | Dursun F.,Umraniye Education and Research Hospital | Gunay M.,Zeynep Kamil Obstetrics and Children Education and Research Hospital
JCRPE Journal of Clinical Research in Pediatric Endocrinology | Year: 2014

Hashitoxicosis is generally differentiated from Graves’ hyperthyroidism by its shorter course and absence of ophthalmopathy. In this case report, we describe an adolescent girl who presented with significant clinical findings of hyperthyroidism, a diffuse goiter with homogenously increased uptake in scintigraphy, and with ocular findings of ophthalmopathy. The thyroid stimulating hormone receptor antibody test was positive, and the family history revealed thyroid-associated ophthalmopathy. Clinical findings supported the diagnosis of Hashimoto’s disease (HD) in the follow-up period. Radioactive iodine uptake investigation was found to be a reliable method for differential diagnosis. Attention was drawn to the rarity of pediatric cases of HD who present with ophthalmopathy. © Journal of Clinical Research in Pediatric Endocrinology. Source


Klrmlzlbekmez H.,Zeynep Kamil Obstetrics and Children Education and Research Hospital | Yesiltepe Mutlu R.G.,Zeynep Kamil Obstetrics and Children Education and Research Hospital | Dursun F.,Umraniye Education and Research Hospital | Isguven S.P.,Sakarya University
Journal of Pediatric Endocrinology and Metabolism | Year: 2015

Tamoxifen, a selective estrogen receptor modulator, has been used in the treatment of peripheral precoccious puberty. A 5-year and 3-month-old girl, diagnosed with McCune-Albright syndrome, came in with abnormal hair growth approximately 2 months after the initiation of tamoxifen. The pattern of terminal hair on the skin following the administration of the drug and the exclusion of other causes suggested tamoxifen-induced hirsutism. © 2015 by De Gruyter. Source

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