Calgary, Canada

Zephyr Sleep Technologies

zephyrsleep.com/
Calgary, Canada

Time filter

Source Type

Remmers J.,University of Calgary | Remmers J.,Zephyr Sleep Technologies | Charkhandeh S.,Snore Center | Charkhandeh S.,Zephyr Sleep Technologies | And 7 more authors.
Sleep | Year: 2013

Study Objectives: The present study addresses the need for a validated tool that prospectively identifes favorable candidates for oral appliance therapy in treatment of obstructive sleep apnea. The objective of the study was to evaluate the ability of a mandibular titration study, performed with a remotely controlled mandibular positioner (RCMP), to predict treatment outcome with a mandibular repositioning appliance (MRA) and to predict an effective target protrusive position (ETPP). Design: A prospective, blinded, outcome study. Setting: Standard clinical care with tests performed in the polysomnographic laboratory. Participants: Consecutive patients (n = 67) recruited from a sleep center or a dental practice using broad inclusion criteria (age 21-80 years; AHI > 10/h; BMI > 40 kg/m2). Interventions: Therapeutic outcome with a mandibular protruding oral appliance was predicted following a mandibular protrusive titration study in the polysomnographic laboratory using a remotely controlled positioner and prospectively established predictive rules. An ETPP was also prospectively determined for participants predicted to be therapeutically successful with MRA therapy. All participants were blindly treated with a MRA, at either the predicted ETPP or a sham position, and therapeutic outcome was compared against prediction. Measurements and Results: At the fnal protrusive position, standard predictive parameters (sensitivity, specifcity, positive and negative predictive values) showed statistically signifcant predictive accuracy (P < 0.05) in the range of 83% to 94%. The predicted ETPP provided an effcacious protrusive position in 87% of participants predicted to be therapeutically successful with MRA therapy (P < 0.05). Conclusions: Using prospectively established rules for interpreting the polysomnographic data, the mandibular titration study predicted mandibular repositioning appliance therapeutic outcome with signifcant accuracy, particularly with regard to accurately predicting therapeutic success. As well, among the participants predicted to be therapeutically successful with mandibular repositioning appliance therapy, the effective target protrusive position provided effcacious mandibular protrusion in the majority.


Zephyr Sleep Technologies | Entity website

Copyright 2012-2014 Zephyr Sleep Technologies, Inc


PubMed | University of Alberta and Zephyr Sleep Technologies
Type: Journal Article | Journal: Computer methods in biomechanics and biomedical engineering | Year: 2016

Quantifying the contribution of passive mechanical deformation in the human pharynx to upper airway collapse is fundamental to understanding the competing biomechanical processes that maintain airway patency. This study uses finite element analysis to examine deformation in the passive human pharynx using an intricate 3D anatomical model based on computed tomography scan images. Linear elastic properties are assigned to bone, cartilage, ligament, tendon, and membrane structures based on a survey of values reported in the literature. Velopharyngeal and oropharyngeal cross-sectional area versus airway pressure slopes are determined as functions of Youngs moduli of muscle and adipose tissue. In vivo pharyngeal mechanics for small deformations near atmospheric pressure are matched by altering Youngs moduli of muscle and adipose tissue. The results indicate that Youngs moduli ranging from 0.33 to 14 kPa for muscle and adipose tissue matched the in vivo range of area versus pressure slopes. The developed anatomical model and determined Youngs moduli range are expected to be useful as a starting point for more complex simulations of human upper airway collapse and obstructive sleep apnea therapy.


The present study addresses the need for a validated tool that prospectively identifies favorable candidates for oral appliance therapy in treatment of obstructive sleep apnea. The objective of the study was to evaluate the ability of a mandibular titration study, performed with a remotely controlled mandibular positioner (RCMP), to predict treatment outcome with a mandibular repositioning appliance (MRA) and to predict an effective target protrusive position (ETPP).A prospective, blinded, outcome study.Standard clinical care with tests performed in the polysomnographic laboratory.Consecutive patients (n = 67) recruited from a sleep center or a dental practice using broad inclusion criteria (age 21-80 years; AHI > 10/h; BMI < 40 kg/m(2)).Therapeutic outcome with a mandibular protruding oral appliance was predicted following a mandibular protrusive titration study in the polysomnographic laboratory using a remotely controlled positioner and prospectively established predictive rules. An ETPP was also prospectively determined for participants predicted to be therapeutically successful with MRA therapy. All participants were blindly treated with a MRA, at either the predicted ETPP or a sham position, and therapeutic outcome was compared against prediction.At the final protrusive position, standard predictive parameters (sensitivity, specificity, positive and negative predictive values) showed statistically significant predictive accuracy (P < 0.05) in the range of 83% to 94%. The predicted ETPP provided an efficacious protrusive position in 87% of participants predicted to be therapeutically successful with MRA therapy (P < 0.05).Using prospectively established rules for interpreting the polysomnographic data, the mandibular titration study predicted mandibular repositioning appliance therapeutic outcome with significant accuracy, particularly with regard to accurately predicting therapeutic success. As well, among the participants predicted to be therapeutically successful with mandibular repositioning appliance therapy, the effective target protrusive position provided efficacious mandibular protrusion in the majority.


Zephyr Sleep Technologies | Entity website

Patient referrals from a MATRx-Equipped lab are qualified and will be successful with OAT


Zephyr Sleep Technologies | Entity website

Contacts Location Zephyr Sleep Technologies, Inc. 610A 70th Ave ...


Zephyr Sleep Technologies | Entity website

Since co-founding Zephyr Sleep Technologies in 2010, Paul has been on a mission to revolutionize the sleep health market. As CEO of Zephyr, Paul leverages his entrepreneurial background, experience with emerging technology and practical understanding of the sleep medical business to drive Zephyr to success ...


Zephyr Sleep Technologies | Entity website

As a leader in the development of sleep technology, Zephyr works with sleep labs, technicians, physicians, dentists & other leading edge sleep researchers. Zephyrs technology undergoes rigorous testing and validation prior to being released ...


Zephyr Sleep Technologies | Entity website

Test More Patients with MATRx Complete your Business Case Estimate to learn how MATRx can help to increase your Sleep Labs occupancy rates. Diversify your testing capability by reaching a new segment of patients for in-lab testing: those who are intolerant to CPAP or prefer alternate therapy, and those who reject CPAP or the diagnostic study up-front

Loading Zephyr Sleep Technologies collaborators
Loading Zephyr Sleep Technologies collaborators