Nebe T.,Speziallabor fur Hamatologie Onkologikum Frankfurt |
Ossendorf M.,Labor Limbach |
Stamminger G.,Zentrum fur Diagnostik GmbH |
Jansen H.,Fa. Sysmex |
Zerfass T.,Fraunhofer Institute for Integrated Circuits
LaboratoriumsMedizin | Year: 2012
Currently, automated microscopes are increasingly entering clinical and private labs, making necessary a critical review of their performance. Within two trials, the two most advanced systems were compared with a hematology analyzer, a manual whole blood differential and an immunophenotypic approach. The diverse handling of nuclear shadows leads to the largest differences, followed by different classification schemes for lymphocytes and judgement of red cells and platelets. The implementation of these instruments into hematological stepby- step diagnostic schemes will be discussed. Because of poor low count statistics, an automated hematology analyzer differential and an immunological differential were included for comparison.