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Tunc T.,Gulhane Military Medical Academy | Karaoglu A.,Gulhane Military Medical Academy | Demirkaya E.,Gulhane Military Medical Academy | Kul M.,Etlik Zubeyde Hanim Maternity Hospital | And 3 more authors.
Pediatrics International | Year: 2010

Background: The perinatal morbidity risk is higher in operative deliveries than normal vaginal deliveries. 'Tau protein' is a cytoskeletal component that is predominantly expressed in axons of neurons. The aim of this study was to investigate whether delivery type, particularly the forceps application, had any effect on cord blood tau levels. Methods: Ninety babies born in the Division of Maternal-Fetal Medicine of Ankara Etlik Maternity and Women's Health Teaching Hospital, Ankara, Turkey were involved in the study. The babies were divided into three groups according to delivery type: Group 1: normal vaginal delivery (NVD); Group 2: caesarean section; Group 3: forceps application. Cord blood samples were drawn from umbilical veins of the babies soon after the birth. Results: The cord blood tau protein levels in the caesarean section group (79 pg/mL [45-223]) were found to be significantly lower than those of NVD (135 pg/mL [44-627]) and forceps (175 pg/mL [17-418]) groups (P= 0.001 and P < 0.001, respectively). Conclusion: We have shown that forceps applications uncomplicated with perinatal asphyxia did not affect the cord blood tau protein level significantly. Tau levels in caesarean section group were significantly lower than the other two groups. Caesarean section in this manner might be considered especially in conditions of risk of perinatal asphyxia to avoid hypoxia. © 2010 Japan Pediatric Society. Source

Demirel G.,Zekai Tahir Burak Maternity | Oguz S.S.,Zekai Tahir Burak Maternity | Erdeve O.,Zekai Tahir Burak Maternity | Dilmen U.,Zekai Tahir Burak Maternity | Dilmen U.,Yildirim Beyazit University
Renal Failure | Year: 2012

Ergotamine, an ergot alkaloid, used for the treatment and prevention of migraine attacks, is considered as a teratogenic drug and, therefore, should be avoided in pregnancy. Here, we report a newborn infant with unilateral renal agenesis, urethral atresia, and pulmonary hypoplasia associated with the use of ergotamine for the treatment of migraine attacks at early pregnancy. Genitourinary anomalies in association with ergotamine usage were rarely reported and this was the third case of renal agenesia in association with ergotamine usage in literature. We suggest that ergotamine teratogenicity may be dose dependent and should be avoided in pregnancy for the possibility of genitourinary anomalies. Copyright © Informa Healthcare USA, Inc. Source

Celik I.H.,Zekai Tahir Burak Maternity | Demirel G.,Zekai Tahir Burak Maternity | Sukhachev D.,LabTech Ltd | Erdeve O.,Zekai Tahir Burak Maternity | And 2 more authors.
International Journal of Laboratory Hematology | Year: 2013

Introduction: Neonatal sepsis remains an important clinical syndrome despite advances in neonatology. Current hematology analyzers can determine cell volume (V), conductivity for internal composition of cell (C) and light scatter for cytoplasmic granularity and nuclear structure (S), and standard deviations which are effective in the diagnosis of sepsis. Statistical models can be used to strengthen the diagnosis. Effective modeling of molecular activity (EMMA) uses combinatorial algorithm of the selection parameters for regression equation based on modified stepwise procedure. It allows obtaining different regression models with different combinations of parameters. Methods: We investigated these parameters in screening of neonatal sepsis. We used LH780 hematological analyzer (Beckman Coulter, Fullerton, CA, USA). We combined these parameters with interleukin-6 (IL-6) and C-reactive protein (CRP) and developed models by EMMA. Results: A total of 304 newborns, 76 proven sepsis, 130 clinical sepsis and 98 controls, were enrolled in the study. Mean neutrophil volume (MNV) and volume distribution width (VDW) were higher in both proven and clinical sepsis groups. We developed three models using MNV, VDW, IL-6, and CRP. These models gave more sensitivity and specificity than the usage of each marker alone. Conclusions: We suggest to use the combination of MNV and VDW with markers such as CRP and IL-6, and use diagnostic models created by EMMA. © 2012 Blackwell Publishing Ltd. Source

Guzoglu N.,Zekai Tahir Burak Maternity | Sari F.N.,Zekai Tahir Burak Maternity | Altug N.,Zekai Tahir Burak Maternity
Cardiology in the Young | Year: 2014

Persistent pulmonary hypertension of the newborn is a source of considerable mortality and morbidity. Anomalous origin of one pulmonary artery, an uncommon congenital cardiac malformation, is a rare cause of persistent pulmonary hypertension. Here, we report the case of a patient with an anomalous origin of one pulmonary artery from the innominate artery who presented with persistent pulmonary hypertension refractory to treatment. © Cambridge University Press 2013. Source

Oncel M.Y.,Zekai Tahir Burak Maternity | Celen S.,Zekai Tahir Burak Maternity | Demirel G.,Zekai Tahir Burak Maternity | Canpolat F.E.,Zekai Tahir Burak Maternity | And 7 more authors.
Clinical and Experimental Obstetrics and Gynecology | Year: 2015

Purpose: To evaluate and compare the morbidity and mortality of neonates born to pregnant women with positive and negative cervical cultures. Materials and Methods: The demographic and clinical features of mothers included in this study, along with details of the microorganisms isolated on maternal cervical cultures and the number of days between a positive cervical culture and delivery were recorded. Neonates were stratified into two groups based on cervical culture results of their mothers - Group 1, positive cervical culture; Group 2, negative cervical culture. Results: A total of 216 women who delivered 242 infants were included in the study. Group 1 consisted of 90 neonates while Group 2 had 152 newborns. The difference between the groups with demographic characteristics was statistically insignificant. Mean levels of the acute phase reactants, CRE, and IL-6, obtained six hours after delivery were significantly higher in Group 1 compared to Group 2 (p < 0.05 for C-reactive protein (CRP) and p < 0.001 for IL-6). Although there was no difference between groups in terms of duration of respiratory support, mean duration of hospitalization, as well as mortality rate were significantly higher in Group 1 (p < 0.001, p < 0.05, respectively). Conclusions: Women diagnosed with a high-risk pregnancy should be treated with antibiotics immediately after a positive cervical culture result, and delivery should be delayed until the success of antibiotic treatment can be evaluated. Early initiation of maternal antibiotic therapy is associated with shorter durations of hospital stay for newborns. Close follow-up of mothers with high-risk pregnancies and extension of treatment duration are critical for determining prognosis in newborn infants. Source

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