Al-Sha'er M.A.,Zarqa University
Der Pharma Chemica | Year: 2014
Antimicrobial activities of novel synthesized pyridinium derivatives showed prospective broad spectrum antimicrobial effect. The synthetic compounds were examined using agar well and dilution method. The antimicrobial effect was measured and represented as minimum inhibitory concentration (MIC). Halogentated pyridinium derivatives showed significant antimicrobial effect with MIC values ranged from 7.5 μg/ml to 180 μg/ml aganist ATCC strains and clinically isolated gram positive and gram negative microbes. P-flouro-derivative (79) was the broadest antimicrobial agent with MIC value = 7.5 μg/ml against Strep. B. Although, S.aureus, B.subtilis and C.albican are the most sensitive microbes , P.auregenosa, P.mirabilis and K.pneumoniae are the most challenging one.
Al-Sha'er M.A.,Zarqa University |
Taha M.O.,University of Jordan
Journal of Molecular Modeling | Year: 2012
Heat shock protein (Hsp90α) has been recently implicated in cancer, prompting several attempts to discover and optimize new Hsp90α inhibitors. Towards this end, we docked 83 diverse Hsp90α inhibitors into the ATP-binding site of this chaperone using several docking-scoring settings. Subsequently, we applied our newly developed computational tool-docking-based comparative intramolecular contacts analysis (dbCICA)-to assess the different docking conditions and select the best settings. dbCICA is based on the number and quality of contacts between docked ligands and amino acid residues within the binding pocket. It assesses a particular docking configuration based on its ability to align a set of ligands within a corresponding binding pocket in such a way that potent ligands come into contact with binding site spots distinct from those approached by low-affinity ligands, and vice versa. The optimal dbCICA models were translated into valid pharmacophore models that were used as 3D search queries to mine the National Cancer Institute's structural database for new inhibitors of Hsp90α that could potentially be used as anticancer agents. The process culminated in 15 micromolar Hsp90α ATPase inhibitors. © Springer-Verlag 2012.
Fei W.,Cranfield University |
Luk P.C.K.,Cranfield University |
El-Hasan T.S.,Zarqa University
IEEE Transactions on Industrial Electronics | Year: 2011
The rotor integrity design for a high-speed modular air-cored axial-flux permanent-magnet (AFPM) generator is presented. The main focus is on the mechanical parametric optimization of the rotor, which becomes a more dominating design issue over electromagnetic optimization at high operational speeds. Approximate analytical formulas are employed for preliminary sizing of the mechanical parameters of the rotor, which consists of the permanent magnets, retainment ring, and back iron. Two-dimensional (2-D) finite-element analysis (FEA) models are used to optimize the values of the parameters. Then, 3-D FEA models are developed to verify the final design. Finally, based on the final design, an AFPM prototype is built for experimental validation, and mechanical integrity tests for the rotor are undertaken. The results confirm the validity of the analytical and FEA models, as well as the overall design approach. © 2010 IEEE.
Abojaradeh M.,Zarqa University
Jordan Journal of Civil Engineering | Year: 2013
Fatigue in hot-mix asphalt is the accumulation of damage under the effect of repeated loading. Flexural beam fatigue testing in the laboratory has been used for several decades and is expected to be an integral part of the new superpave advanced characterization procedure. Current fatigue failure criteria are based on a simple relation between the tensile strain in the beam versus the number of load repetitions to failure. Failure in the beam has relied on an arbitrary criterion such as 50 percent reduction of stiffness. This method does not provide a consistent indication of the onset of failure when different modes of loading are used. The dissipated energy approach is a promising technique for fatigue characterization, since it provides a consistent indication of the level of deterioration in the specimen in terms of behavior, accumulated damage or remaining life. As a part of the superpave advanced characterization research, a new fatigue failure criterion for flexure fatigue test was developed in this study using the dissipated energy approach. This approach makes it possible to predict the fatigue behavior of hot-mix asphalt in the laboratory over a wide range of conditions from the results of a few simple fatigue tests. A fundamental energy-based fatigue failure criteria methodology was developed using the dissipated energy approach, which is independent of the type of load control, temperature and mix and binder type. © 2013 JUST All Rights Reserved.
Eshah N.F.,Zarqa University
Nursing and Health Sciences | Year: 2013
Risk factor reduction and modification of patient lifestyle have become the focus of secondary prevention and cardiac rehabilitation programs. Considering the scarcity of resources in developing countries, nurses can potentially provide great benefit to acute coronary syndrome patients by utilizing hospital time to teach the patients how to lower their risk for recurrence and adopt healthier lifestyles after discharge. The purpose of this study was to identify the effectiveness of a predischarge education on acute coronary syndrome patients' lifestyles. Quasi-experimental pretest-post-test design was used. The patients assigned to the experimental group were offered predischarge education that stimulates lifestyle modification and adoption of a healthier lifestyle. The experimental group scored significantly higher than the control group in three lifestyle components - health responsibilities, nutrition, and interpersonal relations. In conclusion, predischarge education helps motivate acute coronary syndrome patients to adhere to a healthy lifestyle postdischarge. Therefore, nurses must be educated and prepared to be qualified health educators, and health education should continue as one of the most important daily nursing practices, thus it is invested in the preparation of acute coronary patients' discharge plan. © 2012 Wiley Publishing Asia Pty Ltd.
Daoud E.A.,Zarqa University |
Turabieh H.,Zarqa University
Applied Soft Computing Journal | Year: 2013
Despite the excellent applicability of kernel methods, there seems to be no systematic way of choosing appropriate kernel functions or the optimum parameters. Therefore, the performance of support vector machines (SVMs) cannot be easily optimized. To address this problem, a general procedure is suggested to produce nonparametric and efficient kernels. This is achieved by finding an empirical and theoretical connection between positive semidefinite matrices and certain metric space properties. The Gaussian kernel turns out to be a special case of the new framework. Comprehensive experiments on eleven real-world datasets and seven synthetic datasets demonstrate a clear advantage in favor of the proposed kernels. However, several important problems remain unresolved. © 2013 Elsevier B.V.
Obeidat R.,Zarqa University
Supportive Care in Cancer | Year: 2015
Purpose: The purpose of the study was to determine Jordanian women’s preferences regarding participation in decision-making related to their breast cancer treatment. Methods: A cross-sectional survey design was used in this study. A convenience sample of 156 Jordanian women, who had a confirmed, first-time diagnosis of breast cancer within 18 months prior to the study and had undergone treatment at three hospitals in Central and Northern Jordan, was recruited for the study. A modified version of the Control Preferences Scale was used for data collection. Results: More than half of the participants (57 %) wanted the physician to make the decision about the appropriate treatment, approximately 33 % wanted to share the decision with the physician, and only 10 % wanted to make their own decisions. Participants aged more than 50 years, those with secondary school education or less, and those who were undergoing treatment at the public or teaching hospital under study were more likely to prefer a passive role in decision-making regarding treatment. Conclusions: Although more than half of the participants involved in this study preferred to play a passive role, their preferences in this regard varied. This highlighted the importance of individually assessing patients’ preferences regarding participation in the decision-making process and provision of information that is tailored according to each patient’s needs. © 2015, Springer-Verlag Berlin Heidelberg.
Aljamal A.,Zarqa University
Research Journal of Medicinal Plant | Year: 2011
The aim of this study was to determine if bay leaves maybe important in the prevention and/or alleviation of type2 diabetes. Sixty five people with type 2 diabetes were divided into two groups, 50 given capsules containing 2 g of bay leaves per day for 30 days and 15 given a placebo capsules. All the patients consumed bay leaves shows reduced plasma glucose with significant decreases 30% after 30 days. Total cholesterol decreased, 22%, after 30 days with larger decreases in Low Density Lipoprotein (LDL) 24%. High-Density lipoprotein (HDL) increased 18% and Triglycerides also decreased 25%. There were no significant changes in the placebo group. In conclusion, this study demonstrates that consumption of bay leaves, 2 g d-1 for 30 days, decreases risk factors for diabetes and cardiovascular diseases and suggests that bay leaves may be beneficial for people with type 2 diabetes. © 2011 Academic Journals Inc.
Hasan L.,Zarqa University
International Conference on Communications and Information Technology - Proceedings | Year: 2012
This research evaluated the usability of educational websites. In particular, it focused on nine Jordanian university websites. Evaluation criteria for assessing the usability of educational websites were developed; these consisted of five categories: navigation, architecture / organisation, ease of use and communication, design and content. Then 237 students were asked to provide ratings for nine Jordanian university websites using the developed usability criteria and their categories. Students were also asked to report qualitatively what they liked and disliked regarding the design of the tested websites. The results provided detailed information for each tested website regarding their conformance with the developed usability criteria. The results showed that the majority of the students were satisfied with the usability of the Jordanian university websites. Specifically, the results showed that the students were satisfied with the content and navigation (ease of use) issues of the tested websites, but were dissatisfied with the design of the websites. Common and unique strengths and weaknesses related to design issues of the investigated websites were identified based on the quantitative results and the qualitative data obtained from the open-ended questions. © 2012 IEEE.
Adwan M.A.,Zarqa University
Global journal of health science | Year: 2013
Diabetes is a chronic disease that requires routine and complicated self care. Although self care can be managed by most diabetes patients, there are many variables that may make diabetes self-management difficult. The study examined the relationship between clients' demographic variables and diabetes self-management in diabetic clients in Amman city/Jordan. The data were collected through a self-completed questionnaire developed by the researchers and combined with the perceived diabetes self-management scale (PDSMS). The sampling of the investigation comprised 178 diabetes clients from Amman city/Jordan. There was proportional little relationship between income level and diabetes self management, and reversely proportional low relationship between duration of diabetes and diabetes self management. Other variables had no relationship with diabetes self management. The demographic variables related to diabetes self-management in this study are income level and duration of diabetes. As income level increases, diabetes self-management become better, and the longer the duration of diabetes, the worse is diabetes self-management.