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Zarqa, Jordan

Fatigue in hot-mix asphalt is the accumulation of damage under the effect of repeated loading. Flexural beam fatigue testing in the laboratory has been used for several decades and is expected to be an integral part of the new superpave advanced characterization procedure. Current fatigue failure criteria are based on a simple relation between the tensile strain in the beam versus the number of load repetitions to failure. Failure in the beam has relied on an arbitrary criterion such as 50 percent reduction of stiffness. This method does not provide a consistent indication of the onset of failure when different modes of loading are used. The dissipated energy approach is a promising technique for fatigue characterization, since it provides a consistent indication of the level of deterioration in the specimen in terms of behavior, accumulated damage or remaining life. As a part of the superpave advanced characterization research, a new fatigue failure criterion for flexure fatigue test was developed in this study using the dissipated energy approach. This approach makes it possible to predict the fatigue behavior of hot-mix asphalt in the laboratory over a wide range of conditions from the results of a few simple fatigue tests. A fundamental energy-based fatigue failure criteria methodology was developed using the dissipated energy approach, which is independent of the type of load control, temperature and mix and binder type. © 2013 JUST All Rights Reserved. Source

Fei W.,Cranfield University | Luk P.C.K.,Cranfield University | El-Hasan T.S.,Zarqa University
IEEE Transactions on Industrial Electronics

The rotor integrity design for a high-speed modular air-cored axial-flux permanent-magnet (AFPM) generator is presented. The main focus is on the mechanical parametric optimization of the rotor, which becomes a more dominating design issue over electromagnetic optimization at high operational speeds. Approximate analytical formulas are employed for preliminary sizing of the mechanical parameters of the rotor, which consists of the permanent magnets, retainment ring, and back iron. Two-dimensional (2-D) finite-element analysis (FEA) models are used to optimize the values of the parameters. Then, 3-D FEA models are developed to verify the final design. Finally, based on the final design, an AFPM prototype is built for experimental validation, and mechanical integrity tests for the rotor are undertaken. The results confirm the validity of the analytical and FEA models, as well as the overall design approach. © 2010 IEEE. Source

Heat shock protein (Hsp90α) has been recently implicated in cancer, prompting several attempts to discover and optimize new Hsp90α inhibitors. Towards this end, we docked 83 diverse Hsp90α inhibitors into the ATP-binding site of this chaperone using several docking-scoring settings. Subsequently, we applied our newly developed computational tool-docking-based comparative intramolecular contacts analysis (dbCICA)-to assess the different docking conditions and select the best settings. dbCICA is based on the number and quality of contacts between docked ligands and amino acid residues within the binding pocket. It assesses a particular docking configuration based on its ability to align a set of ligands within a corresponding binding pocket in such a way that potent ligands come into contact with binding site spots distinct from those approached by low-affinity ligands, and vice versa. The optimal dbCICA models were translated into valid pharmacophore models that were used as 3D search queries to mine the National Cancer Institute's structural database for new inhibitors of Hsp90α that could potentially be used as anticancer agents. The process culminated in 15 micromolar Hsp90α ATPase inhibitors. © Springer-Verlag 2012. Source

Al-Sha'er M.A.,Zarqa University
Der Pharma Chemica

Antimicrobial activities of novel synthesized pyridinium derivatives showed prospective broad spectrum antimicrobial effect. The synthetic compounds were examined using agar well and dilution method. The antimicrobial effect was measured and represented as minimum inhibitory concentration (MIC). Halogentated pyridinium derivatives showed significant antimicrobial effect with MIC values ranged from 7.5 μg/ml to 180 μg/ml aganist ATCC strains and clinically isolated gram positive and gram negative microbes. P-flouro-derivative (79) was the broadest antimicrobial agent with MIC value = 7.5 μg/ml against Strep. B. Although, S.aureus, B.subtilis and C.albican are the most sensitive microbes , P.auregenosa, P.mirabilis and K.pneumoniae are the most challenging one. Source

Obeidat R.,Zarqa University
Supportive Care in Cancer

Purpose: The purpose of the study was to determine Jordanian women’s preferences regarding participation in decision-making related to their breast cancer treatment. Methods: A cross-sectional survey design was used in this study. A convenience sample of 156 Jordanian women, who had a confirmed, first-time diagnosis of breast cancer within 18 months prior to the study and had undergone treatment at three hospitals in Central and Northern Jordan, was recruited for the study. A modified version of the Control Preferences Scale was used for data collection. Results: More than half of the participants (57 %) wanted the physician to make the decision about the appropriate treatment, approximately 33 % wanted to share the decision with the physician, and only 10 % wanted to make their own decisions. Participants aged more than 50 years, those with secondary school education or less, and those who were undergoing treatment at the public or teaching hospital under study were more likely to prefer a passive role in decision-making regarding treatment. Conclusions: Although more than half of the participants involved in this study preferred to play a passive role, their preferences in this regard varied. This highlighted the importance of individually assessing patients’ preferences regarding participation in the decision-making process and provision of information that is tailored according to each patient’s needs. © 2015, Springer-Verlag Berlin Heidelberg. Source

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