Zaporozhye State Medical University
Zaporizhia, Ukraine

Zaporozhye State Medical University is a medical university in the city of Zaporizhia, Ukraine.It is one of the leading educational establishments of Ukraine. Wikipedia.

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Rekalov D.,Zaporozhye State Medical University
Georgian medical news | Year: 2016

The aim of the research was to study biomarkers of osteochondral lesions on early stages of rheumatoid arthritis (RA). The data showed the prognostic value of indicators of the erosive and destructive changes of joints in early and in the advanced stage of RA. Indicators that determine how directly, inflammatory process activity and markers associated with the speed and staging damage of articular surfaces is analyzed. That can adequately justify individualized clinical strategy in patients with early RA.

Samura B.,Zaporozhye State Medical University
Georgian medical news | Year: 2016

THE AIM OF THE STUDY: to investigate an interrelationship between pre-treatment galcetin-3 (Gal-3) level and one-year survival rate, cardiovascular events in subjects with multiple myeloma. Eighty nine subjects with full or partial remission of multiple myeloma were enrolled in the study. Patients were divided into 2 groups based on whether or not statins were included in their treatment: a statin group (n=43) and a no statin group (n=46). Among the 43 patients in the statin group, 31 patients received 20mg/day atorvastatin and 12 patients received 40-mg/day atorvastatin. None of the patients had received any lipid-modulating medications, including statins or fibrates, before enrollment. Observation period was up to 1 year. Blood samples for biomarkers measurements were collected. ELISA method for measurements of circulating level of galectin-3, interleukin-6 and NT-pro-brain natriuretic peptide were used. Lipid lowering effect in statin user was associates with declined serum Gal-3 level, whereas in not statin users similar response was not appeared. No any changes in hemodynamics and other biomarkers between both cohorts were found. Univariate logistic regression had exhibited that galtctin-3 (odds ratio [OR] = 1.17; 95% CI = 1.07-1.29; P = 0.002), NT-pro-brain natriuretic peptide (OR=1.04; 95% CI=1.02-1.10; P<0.05) and statin therapy (OR=1.07; 95% CI = 1.02-1.11; P = 0.001) predicted one-year cumulative CV events. After adjustment on statin therapy, galectin-3 remained independent predictor one-year cumulative cardiovascular events (OR=1.08; 95% CI=1.06-1.11; P=0.001). When initial serum galectin-3 level has incorporated into prediction model, statin therapy was found as predictor for improving survival in multiple myeloma patients with elevated serum galectin-3 level (>14 ng/ml). Elevated pre-treatment galectin-3 level was found a powerful predictor of positive effect of statins on survival in patients with regression of multiple myeloma.

Sulaieva O.,Zaporozhye State Medical University | Wallace J.L.,University of Calgary | Wallace J.L.,University Camilo Castelo Branco
Current Opinion in Pharmacology | Year: 2015

Among the most commonly used drugs, nonsteroidal anti-inflammatory drugs (NSAIDs) remain problematic because of their propensity to cause serious adverse events, principally affecting the gastrointestinal tract. In recent years, the discovery of potent anti-inflammatory and cytoprotective effects of endogenous gaseous mediators (nitric oxide, hydrogen sulfide, carbon monoxide) stimulated efforts to develop novel, combination NSAIDs that suppress prostaglandin synthesis (producing anti-inflammatory and analgesic effects) and release one or more of the cytoprotective gaseous mediators. Gaseous mediator-based anti-inflammatory drugs have reached the human clinical trial stage and show considerable promise as a safer option for treating chronic inflammatory diseases. © 2015 Elsevier Ltd. All rights reserved.

Berezin A.E.,Zaporozhye State Medical University
Advances in Clinical Chemistry | Year: 2017

Heart failure (HF) continues to have a sufficient impact on morbidity, mortality, and disability in developed countries. Growing evidence supports the hypothesis that microparticles (MPs) might contribute to the pathogenesis of the HF development playing a pivotal role in the regulation of the endogenous repair system, thrombosis, coagulation, inflammation, immunity, and metabolic memory phenomenon. Therefore, there is a large body of data clarifying the predictive value of MP numerous in circulation among subjects with HF. Although the determination of MP signature is better than measurement of single MP circulating level, there is not yet close confirmation that immune phenotype of cells produced MPs are important for HF prediction and development. The aim of the chapter is to summarize knowledge regarding the role of various MPs in diagnosis and prognosis of HF. The role of MPs as a delivery vehicle for drugs attenuated cardiac remodeling is considered. © 2017 Elsevier Inc.

Berezin A.E.,Zaporozhye State Medical University | Kremzer A.A.,Zaporozhye State Medical University
Atherosclerosis | Year: 2013

Objective: To evaluate the interrelation between circulating osteopontin (OPN) and coronary atherosclerosis and calcification in type 2 diabetes mellitus patients (T2DM). Design and methods: 126 subjects (46 patients with T2DM) with previously documented asymptomatic coronary artery disease (CAD) were enrolled in the study. CAD was determined by contrast multispiral CT-angiography. OPN plasma levels were measured by ELISA. Results: Analysis of the results showed that in a patient cohort the mean value of circulating OPN was 43.55ng/mL (95% CI=31.5-57.0ng/mL). OPN plasma levels were correlated with Agatston score index (r=0.418, P=0.009), T2DM (r=0.411, P=0.006), gender (r=0.395, P<0.001 for male), TC (r=0.405, P=0.006), hsC-RP (r=0.368, P=0.008), age (r=0.256, P=0.001), smoking (r=0.255, P=0.001) and inversely to LVEF (r=-0.579, P=0.001). Cox-regression analyzes showed that in T2DM patients upper quartile OPN compared with the lowest quartile are associated with Agatston score index (adjusted OR=3.23, 95% CI=1.09-5.20; P=0.044), numerous of damaged coronary arteries (adjusted OR=2.60, 95% CI=1.10-9.20, P=0.005). The findings suggest that the predictive power of the model for asymptomatic CAD patients with T2DM, the estimated AUC (area under curve) was 0.788. In this case, the concentration of OPN that had the best predict potential on the risk of coronary atherosclerosis was 48.5ng/mL.In conclusions, we believe that elevated OPN in plasma can be considered as an independent predictor of coronary calcification in T2DM patients with known CAD. © 2013 Elsevier Ireland Ltd.

Berezin A.E.,Zaporozhye State Medical University | Kremzer A.A.,Zaporozhye State Medical University
Journal of Cardiac Failure | Year: 2014

Introduction Despite a high potential of endothelial progenitor cells (EPCs) for diagnostic purposes, the EPC role in developing ischemic chronic heart failure (CHF) has not been determined obviously. The objective of this study was to assess the counts of CD45+CD34+, CD45 -CD34+, CD14+CD309+, and CD14 +CD309+Tie2+ phenotyped circulating EPCs of various subpopulations in patients with ischemic CHF. Methods and Results The study involved 153 patients (86 male), aged 48-62 years, with angiographically proven coronary artery disease (CAD) and 25 healthy volunteers. CHF was diagnosed in 109 patients (71.2%). Mononuclear cell populations were phenotyped by flow cytofluorimetry. Cardiovascular risk factors, such as type 2 diabetes mellitus, hyperlipidemia, arterial hypertension, and adherence to smoking, may have a negative effect on circulating EPC counts in CAD patients regardless of the presence of CHF. The depletion of the CD14+CD309+- and CD14+CD309+Tie2+-phenotyped circulating EPC counts is associated with the severity of left ventricular dysfunction, whereas the CD45+CD34+- and CD45-CD34 +-mononuclear cell counts are more representative of the severity of atherosclerotic coronary artery lesions. Conclusion The authors found that New York Heart Association functional class of CHF, left ventricular ejection fraction <42%, the N-terminal pro-B-type natriuretic peptide level >554 pg/mL, and E/Em ratio >15 U had the highest predictive value for the depletion of the EPC count in CAD patients. © 2014 Elsevier Inc. All rights reserved.

Berezin A.E.,Zaporozhye State Medical University
Asian cardiovascular & thoracic annals | Year: 2013

The aim of this study was to compare the prognostic value of matrix metalloproteinase-3 and -9, and NT-pro-natriuretic peptide for fatal and nonfatal complications in Q-wave myocardial infarction patients in the acute and postinfarction periods. 85 men and women with documented Q-wave myocardial infarction were observed for 1 year after hospitalization. Clinical endpoints were identified through the hospital patient-tracking system, with a review of medical records for each recorded endpoint. Left ventricular ejection fraction and wall motion index were calculated. Measurements of matrix metalloproteinases and NT-pro-natriuretic peptide were performed by an enzyme-linked immunosorbent assay. A cutoff value of 9.7 ng·mL(-1) for matrix metalloproteinase-3 showed the best discriminatory power (sensitivity = 77.8%, specificity = 90.8%). The optimal cutoff value of matrix metalloproteinase-9 was 18.1 ng·mL(-1) (sensitivity, 70.5%; specificity, 75%), and the cutoff for NT-pro-natriuretic peptide was 885 pmol·L(-1) (sensitivity, 58%; specificity, 68.6%). Matrix metalloproteinase-3 and -9 were strongly related with a positive prognostic value of 70% (sensitivity and specificity, 84% and 82%, respectively). These data may be helpful for further stratification of patients into cardiovascular mortality risk groups.

Berezin A.E.,Zaporozhye State Medical University | Kremzer A.A.,Zaporozhye State Medical University
Cardiology Research and Practice | Year: 2013

Objective. To evaluate the interrelation between serum uric acid and artery calcification in asymptomatic coronary artery disease subjects. Design and Methods. 126 subjects with previously documented asymptomatic coronary artery disease were enrolled in the study. Results. Mean value of serum uric acid level was 23.84 mmol/L (95% confidence interval (CI) = 15.75-31.25 mmol/L). In multivariate Cox regression analysis, the results showed that serum uric acid levels (odds ratio OR = 1.42, 95% CI = 1.20-1.82; P < 0.001), osteopontin (OR = 1.14, 95% CI = 1.12-1.25; P < 0.001), osteoprotegerin (OR = 1.45, 95% CI = 1.20-1.89; P < 0.001), type 2 diabetes mellitus (OR = 1.41, 95% CI = 1.20-1.72; P < 0.001), and total cholesterol (OR = 1.13, 95% CI = 1.10-1.22; P < 0.001) were factors that independently associated with coronary artery calcification. The Cox models suggested that high quartile of serum uric acid level is very significant in predicting Agatston score index. In conclusion, we suggested that high quartile of serum uric acid level (cutoff point equaled 35.9 mmol/L) was a very significant predictor of coronary calcification examined by Agatston score index in subjects with asymptomatic coronary artery disease. © 2013 A. E. Berezin and A. A. Kremzer.

Berezin A.,Zaporozhye State Medical University
Diabetes and Metabolic Syndrome: Clinical Research and Reviews | Year: 2016

Diabetes mellitus (DM) exhibits raised prevalence worldwide. There is a large body of evidence regarding the incidence of DM closely associates with cardiovascular (CV) complications. In this context, hyperglycaemia, oxidant stress, and inflammation are key factors that contribute in CV events and disease in type1 and type 2 DM, even when metabolic control was optimal and/or intensive glycemic control was implemented. It has been suggested that the effect of poor metabolic control or even transient episodes of hyperglycemia in DM associates in particularly with worsening ability of endogenous vasoreparative systems that are mediated epigenetic changes in several cells (progenitor cells, stem cells, mononuclears, immune cells), and thereby lead to so called "vascular glycemic memory" or "metabolic memory". Both terms are emphasized the fact that prior glucose control has sustained effects that persist even after return to more usual glycemic control. The mechanisms underlying the cellular "metabolic memory" induced by high glucose remain unclear. The review is discussed pathophysiology and clinical relevance of "metabolic" memory phenomenon in DM. The role of oxidative stress, inflammation, and epigenetics in DM and its vascular complications are highlighted. The effects of several therapeutic approaches are discussed. © 2016 Diabetes India.

Furyk E.,Zaporozhye State Medical University
Georgian medical news | Year: 2013

The article presents information obtained during the survey in 64 patients with acute hepatitis B. We show that acute hepatitis B in patients with concomitant chronic toxic liver characterized by a marked imbalance of cytokine status due to a lower level of interleukin-2 and a higher content of interleukin-8, the highest levels of nitrite content, spontaneous oxidative modifications of blood proteins and the lowest content of L -arginine in the blood serum in the dynamics of disease compared with patients without this concomitant factor. In the period of convalescence these changes in patients with acute hepatitis B with concomitant chronic toxic liver characterized combined with higher cytolysis of liver cells, often circulating in the blood of HBsAg seroconversion and less frequently with the advent of anti-HBeAg.

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