Zaporizhia, Ukraine

Zaporozhye State Medical University is a medical university in the city of Zaporizhia, Ukraine.It is one of the leading educational establishments of Ukraine. Wikipedia.


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Rekalov D.,Zaporozhye State Medical University
Georgian medical news | Year: 2016

The aim of the research was to study biomarkers of osteochondral lesions on early stages of rheumatoid arthritis (RA). The data showed the prognostic value of indicators of the erosive and destructive changes of joints in early and in the advanced stage of RA. Indicators that determine how directly, inflammatory process activity and markers associated with the speed and staging damage of articular surfaces is analyzed. That can adequately justify individualized clinical strategy in patients with early RA.


Samura B.,Zaporozhye State Medical University
Georgian medical news | Year: 2016

THE AIM OF THE STUDY: to investigate an interrelationship between pre-treatment galcetin-3 (Gal-3) level and one-year survival rate, cardiovascular events in subjects with multiple myeloma. Eighty nine subjects with full or partial remission of multiple myeloma were enrolled in the study. Patients were divided into 2 groups based on whether or not statins were included in their treatment: a statin group (n=43) and a no statin group (n=46). Among the 43 patients in the statin group, 31 patients received 20mg/day atorvastatin and 12 patients received 40-mg/day atorvastatin. None of the patients had received any lipid-modulating medications, including statins or fibrates, before enrollment. Observation period was up to 1 year. Blood samples for biomarkers measurements were collected. ELISA method for measurements of circulating level of galectin-3, interleukin-6 and NT-pro-brain natriuretic peptide were used. Lipid lowering effect in statin user was associates with declined serum Gal-3 level, whereas in not statin users similar response was not appeared. No any changes in hemodynamics and other biomarkers between both cohorts were found. Univariate logistic regression had exhibited that galtctin-3 (odds ratio [OR] = 1.17; 95% CI = 1.07-1.29; P = 0.002), NT-pro-brain natriuretic peptide (OR=1.04; 95% CI=1.02-1.10; P<0.05) and statin therapy (OR=1.07; 95% CI = 1.02-1.11; P = 0.001) predicted one-year cumulative CV events. After adjustment on statin therapy, galectin-3 remained independent predictor one-year cumulative cardiovascular events (OR=1.08; 95% CI=1.06-1.11; P=0.001). When initial serum galectin-3 level has incorporated into prediction model, statin therapy was found as predictor for improving survival in multiple myeloma patients with elevated serum galectin-3 level (>14 ng/ml). Elevated pre-treatment galectin-3 level was found a powerful predictor of positive effect of statins on survival in patients with regression of multiple myeloma.


Bolli G.B.,University of Perugia | Munteanu M.,Victor Babes University of Medicine and Pharmacy Timisoara | Dotsenko S.,Zaporozhye State Medical University | Niemoeller E.,Sanofi S.A. | And 3 more authors.
Diabetic Medicine | Year: 2014

Aims: To assess the efficacy and safety of one- and two-step dose-increase regimens of lixisenatide once daily in participants with Type 2 diabetes mellitus insufficiently controlled with metformin. Methods: This was a randomized, double-blind, placebo-controlled, parallel-group, multi-centre study enrolling participants with Type 2 diabetes (n = 484) treated with metformin. Participants were randomized to receive either lixisenatide in a one-step dose increase or a two-step dose increase vs. placebo for 24 weeks, followed by a ≥ 52-week variable double blind period. Primary outcome was HbA1c reduction at week 24. Results: Lixisenatide one-/two-step once daily significantly improved HbA1c at week 24 compared with placebo (P < 0.0001) and allowed more participants to achieve HbA1c < 53 mmol/mol (< 7.0%) (P ≤ 0.0005). Improvements were observed in fasting plasma glucose (-0.5/-0.6 vs. +0.1 mmol/l; P < 0.001) and body weight (-2.6/-2.7 vs. -1.6 kg; P < 0.005). At week 24, adverse events were reported by 67.7/70.8/65.6% of participants treated with lixisenatide one-/two-step/placebo, respectively-nausea and vomiting being reported most frequently. Symptomatic hypoglycaemia occurred in 1.9/2.5% of participants on one-/two-step lixisenatide and 0.6% with placebo, with no severe episodes. Lixisenatide continued to be efficacious and well tolerated during the variable double-blind extension period of at least 52 weeks. Conclusions: Lixisenatide one- or two-step dose-increase regimens significantly improved glycaemic control and decreased body weight over 24 weeks and during a long-term extension period without increasing hypoglycaemia. The study confirmed that tolerability in the one-step group was at least similar to the two-step dose increase, with nausea/vomiting and hypoglycaemia frequency being lower in the one-step regimen. © 2013 Diabetes UK.


Berezin A.E.,Zaporozhye State Medical University | Kremzer A.A.,Zaporozhye State Medical University
Atherosclerosis | Year: 2013

Objective: To evaluate the interrelation between circulating osteopontin (OPN) and coronary atherosclerosis and calcification in type 2 diabetes mellitus patients (T2DM). Design and methods: 126 subjects (46 patients with T2DM) with previously documented asymptomatic coronary artery disease (CAD) were enrolled in the study. CAD was determined by contrast multispiral CT-angiography. OPN plasma levels were measured by ELISA. Results: Analysis of the results showed that in a patient cohort the mean value of circulating OPN was 43.55ng/mL (95% CI=31.5-57.0ng/mL). OPN plasma levels were correlated with Agatston score index (r=0.418, P=0.009), T2DM (r=0.411, P=0.006), gender (r=0.395, P<0.001 for male), TC (r=0.405, P=0.006), hsC-RP (r=0.368, P=0.008), age (r=0.256, P=0.001), smoking (r=0.255, P=0.001) and inversely to LVEF (r=-0.579, P=0.001). Cox-regression analyzes showed that in T2DM patients upper quartile OPN compared with the lowest quartile are associated with Agatston score index (adjusted OR=3.23, 95% CI=1.09-5.20; P=0.044), numerous of damaged coronary arteries (adjusted OR=2.60, 95% CI=1.10-9.20, P=0.005). The findings suggest that the predictive power of the model for asymptomatic CAD patients with T2DM, the estimated AUC (area under curve) was 0.788. In this case, the concentration of OPN that had the best predict potential on the risk of coronary atherosclerosis was 48.5ng/mL.In conclusions, we believe that elevated OPN in plasma can be considered as an independent predictor of coronary calcification in T2DM patients with known CAD. © 2013 Elsevier Ireland Ltd.


Berezin A.E.,Zaporozhye State Medical University | Kremzer A.A.,Zaporozhye State Medical University
Journal of Cardiac Failure | Year: 2014

Introduction Despite a high potential of endothelial progenitor cells (EPCs) for diagnostic purposes, the EPC role in developing ischemic chronic heart failure (CHF) has not been determined obviously. The objective of this study was to assess the counts of CD45+CD34+, CD45 -CD34+, CD14+CD309+, and CD14 +CD309+Tie2+ phenotyped circulating EPCs of various subpopulations in patients with ischemic CHF. Methods and Results The study involved 153 patients (86 male), aged 48-62 years, with angiographically proven coronary artery disease (CAD) and 25 healthy volunteers. CHF was diagnosed in 109 patients (71.2%). Mononuclear cell populations were phenotyped by flow cytofluorimetry. Cardiovascular risk factors, such as type 2 diabetes mellitus, hyperlipidemia, arterial hypertension, and adherence to smoking, may have a negative effect on circulating EPC counts in CAD patients regardless of the presence of CHF. The depletion of the CD14+CD309+- and CD14+CD309+Tie2+-phenotyped circulating EPC counts is associated with the severity of left ventricular dysfunction, whereas the CD45+CD34+- and CD45-CD34 +-mononuclear cell counts are more representative of the severity of atherosclerotic coronary artery lesions. Conclusion The authors found that New York Heart Association functional class of CHF, left ventricular ejection fraction <42%, the N-terminal pro-B-type natriuretic peptide level >554 pg/mL, and E/Em ratio >15 U had the highest predictive value for the depletion of the EPC count in CAD patients. © 2014 Elsevier Inc. All rights reserved.


Berezin A.E.,Zaporozhye State Medical University
Asian cardiovascular & thoracic annals | Year: 2013

The aim of this study was to compare the prognostic value of matrix metalloproteinase-3 and -9, and NT-pro-natriuretic peptide for fatal and nonfatal complications in Q-wave myocardial infarction patients in the acute and postinfarction periods. 85 men and women with documented Q-wave myocardial infarction were observed for 1 year after hospitalization. Clinical endpoints were identified through the hospital patient-tracking system, with a review of medical records for each recorded endpoint. Left ventricular ejection fraction and wall motion index were calculated. Measurements of matrix metalloproteinases and NT-pro-natriuretic peptide were performed by an enzyme-linked immunosorbent assay. A cutoff value of 9.7 ng·mL(-1) for matrix metalloproteinase-3 showed the best discriminatory power (sensitivity = 77.8%, specificity = 90.8%). The optimal cutoff value of matrix metalloproteinase-9 was 18.1 ng·mL(-1) (sensitivity, 70.5%; specificity, 75%), and the cutoff for NT-pro-natriuretic peptide was 885 pmol·L(-1) (sensitivity, 58%; specificity, 68.6%). Matrix metalloproteinase-3 and -9 were strongly related with a positive prognostic value of 70% (sensitivity and specificity, 84% and 82%, respectively). These data may be helpful for further stratification of patients into cardiovascular mortality risk groups.


Berezin A.,Zaporozhye State Medical University
Diabetes and Metabolic Syndrome: Clinical Research and Reviews | Year: 2016

Fetuin-A and osteoprotegerin (OPG) are considered biomarkers of atherosclerosis, vascular calcification, inflammation in subjects with type 2 diabetes mellitus (T2DM) with possible predictive value. Recent clinical studies have been shown that fetuin-A and OPG could be helpful for cardiovascular risk stratification in T2DM. Therefore, fetuin-A and OPG may offer protection against atherosclerosis and vascular calcification. However, clinical implication of decreased serum concentrations of these biomarkers in T2DM during treatment with thiazolidinediones, in particular pioglitazone, and metformin is not fully understood. The relation of thiazolidinediones- and metformin- induced post-treatment serum levels of fetuin-A and OPG to changes in CV risk requires more investigations. © 2016 Diabetes India


Berezin A.E.,Zaporozhye State Medical University | Kremzer A.A.,Zaporozhye State Medical University
Cardiology Research and Practice | Year: 2013

Objective. To evaluate the interrelation between serum uric acid and artery calcification in asymptomatic coronary artery disease subjects. Design and Methods. 126 subjects with previously documented asymptomatic coronary artery disease were enrolled in the study. Results. Mean value of serum uric acid level was 23.84 mmol/L (95% confidence interval (CI) = 15.75-31.25 mmol/L). In multivariate Cox regression analysis, the results showed that serum uric acid levels (odds ratio OR = 1.42, 95% CI = 1.20-1.82; P < 0.001), osteopontin (OR = 1.14, 95% CI = 1.12-1.25; P < 0.001), osteoprotegerin (OR = 1.45, 95% CI = 1.20-1.89; P < 0.001), type 2 diabetes mellitus (OR = 1.41, 95% CI = 1.20-1.72; P < 0.001), and total cholesterol (OR = 1.13, 95% CI = 1.10-1.22; P < 0.001) were factors that independently associated with coronary artery calcification. The Cox models suggested that high quartile of serum uric acid level is very significant in predicting Agatston score index. In conclusion, we suggested that high quartile of serum uric acid level (cutoff point equaled 35.9 mmol/L) was a very significant predictor of coronary calcification examined by Agatston score index in subjects with asymptomatic coronary artery disease. © 2013 A. E. Berezin and A. A. Kremzer.


Berezin A.,Zaporozhye State Medical University
Diabetes and Metabolic Syndrome: Clinical Research and Reviews | Year: 2016

Diabetes mellitus (DM) exhibits raised prevalence worldwide. There is a large body of evidence regarding the incidence of DM closely associates with cardiovascular (CV) complications. In this context, hyperglycaemia, oxidant stress, and inflammation are key factors that contribute in CV events and disease in type1 and type 2 DM, even when metabolic control was optimal and/or intensive glycemic control was implemented. It has been suggested that the effect of poor metabolic control or even transient episodes of hyperglycemia in DM associates in particularly with worsening ability of endogenous vasoreparative systems that are mediated epigenetic changes in several cells (progenitor cells, stem cells, mononuclears, immune cells), and thereby lead to so called "vascular glycemic memory" or "metabolic memory". Both terms are emphasized the fact that prior glucose control has sustained effects that persist even after return to more usual glycemic control. The mechanisms underlying the cellular "metabolic memory" induced by high glucose remain unclear. The review is discussed pathophysiology and clinical relevance of "metabolic" memory phenomenon in DM. The role of oxidative stress, inflammation, and epigenetics in DM and its vascular complications are highlighted. The effects of several therapeutic approaches are discussed. © 2016 Diabetes India.


Furyk E.,Zaporozhye State Medical University
Georgian medical news | Year: 2013

The article presents information obtained during the survey in 64 patients with acute hepatitis B. We show that acute hepatitis B in patients with concomitant chronic toxic liver characterized by a marked imbalance of cytokine status due to a lower level of interleukin-2 and a higher content of interleukin-8, the highest levels of nitrite content, spontaneous oxidative modifications of blood proteins and the lowest content of L -arginine in the blood serum in the dynamics of disease compared with patients without this concomitant factor. In the period of convalescence these changes in patients with acute hepatitis B with concomitant chronic toxic liver characterized combined with higher cytolysis of liver cells, often circulating in the blood of HBsAg seroconversion and less frequently with the advent of anti-HBeAg.

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