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Aleksandrova E.V.,Zaporozhe State Medical University | Kravchenko A.N.,RAS N. D. Zelinsky Institute of Organic Chemistry | Kochergin P.M.,RAS Institute of Chemistry
Chemistry of Heterocyclic Compounds | Year: 2011

Published information on methods for the synthesis of haloimidazoles is summarized and classified. © 2011 Springer Science+Business Media, Inc.


Romanenko N.I.,Zaporozhe State Medical University | Nazarenko M.V.,Crimea State Medical University | Ivanchenko D.G.,Zaporozhe State Medical University | Cherchesova A.Yu.,Zaporozhe State Medical University | Aleksandrova E.V.,Zaporozhe State Medical University
Chemistry of Natural Compounds | Year: 2014

A simple preparative synthetic method for previously undescribed 8-bromo-7-[2-hydroxy-3-(4-tertbutyl) phenoxypropyl-1]-3-methylxanthine derivatives, potential biologically active compounds and convenient synthons for further synthetic investigations, was developed. The spectral properties of the synthesized compounds were studied. © 2014 Springer Science+Business Media New York.


Romanenko N.I.,Zaporozhe State Medical University | Pakhomova O.A.,Zaporozhe State Medical University | Vasyuk S.A.,Zaporozhe State Medical University | Borodina N.I.,Crimea State Medical University
Chemistry of Natural Compounds | Year: 2013

A preparative synthetic method for 3-methyl-7-R-hydroxyethylxanthinyl-8- aminoalkanoic acids, potential bioactive compounds and convenient synthons for further synthetic research (synthesis of salts, amides, peptides, hydrazides, ylenhydrazides, esters, etc.), was developed. The spectral characteristics of the synthesized compounds were studied. © 2013 Springer Science+Business Media New York.


Romanenko N.I.,Zaporozhe State Medical University | Nazarenko M.V.,Crimea State Medical University | Kornienko V.I.,University of Kharkiv | Rak T.N.,Crimea State Medical University | And 2 more authors.
Chemistry of Natural Compounds | Year: 2013

A method for preparing previously undescribed derivatives of imidazo[1,2-f]-, 1,3-oxazolo[2,3-f]-, and 1,2,4-triazino[3,4-f]xanthine, potential biologically active compounds, was developed. Their physicochemical properties and biological activity were studied. © 2013 Springer Science+Business Media New York.


Romanenko N.I.,Zaporozhe State Medical University | Rak T.N.,Crimea State Medical University | Pakhomova O.A.,Zaporozhe State Medical University | Ivanchenko D.G.,Zaporozhe State Medical University | Mylova A.A.,Zaporozhe State Medical University
Chemistry of Natural Compounds | Year: 2014

A simple preparative method for the synthesis of imidazo[1,2-f]xanthine derivatives, promising synthons for further modification of the xanthine molecule, was developed. The spectral characteristics of the synthesized compounds were studied. © 2014 Springer Science+Business Media New York.


Shishkina S.V.,Ukrainian Academy of Sciences | Zubatyuk R.I.,Ukrainian Academy of Sciences | Kucherenko L.I.,Zaporozhe State Medical University | Parnyuk N.V.,Zaporozhe State Medical University | And 4 more authors.
Russian Chemical Bulletin | Year: 2013

The character of intermolecular interactions of the bromide anion and organic cation in crystal of 4-amino-1-(β-phenylethyl)-1,2,4-triazolium bromide was studied by a combination of X-ray diffraction data and M06-2X/cc-pvtz quantum chemical calculations. The existence of binding anion···π-system interactions was shown, and their characteristics were studied. © 2013 Springer Science+Business Media, Inc.


Belenichev I.F.,Zaporozhe State Medical University | Mazur I.A.,Zaporozhe State Medical University | Abramov A.V.,Zaporozhe State Medical University | Kucherenko L.I.,Zaporozhe State Medical University | And 4 more authors.
Neurochemical Journal | Year: 2013

We modeled acute disruption of the brain blood circulation (ADBC) by bilateral ligature of the common carotids in white outbred rats. This resulted in the formation of endothelial dysfunction of capillary network in the IV-V layers of the cortex and the vessels of the pia mater, choroids plexuses, and the branches of the middle cerebral and ophthalmic arteries, which was seen as a considerable decrease in the density of nuclei of endotheliocytes, a decrease in the RNA concentration in them, expression of vascular endothelial growth factor (VEGF), and a substantial decrease in the index of the proliferative activity of endotheliocytes. Intraperitoneal treatment of rats with ADBC with lysinium for 21 days at a dose of 50 mg/kg led on the 4th day to an increase in the density of endotheliocytes in the capillary network of the brain cortex and the walls of cerebral vessels and an increase in the RNA content in endothelial nuclei. At the end of the lysinium treatment, we observed an increase in the density of endotheliocytes in the capillary network of the brain cortex and the walls of cerebral vessels, an increase in the RNA content in nuclei of endotheliocytes, and an increase in the density of proliferating endotheliocytes in these vessels, which was associated with increased VEGF concentration. Administration of the control drug piracetam had no endothelium-protective effect. © 2013 Pleiades Publishing, Ltd.


Demchenko A.V.,Zaporozhe State Medical University | Belenichev I.F.,Zaporozhe State Medical University
Neurochemical Journal | Year: 2016

Chronic brain ischemia was accompanied by decreased activities of glutathione-dependent enzymes and an increased content of nitrotyrosine in the rat brain, which indicates the development of oxidative and nitrosative stress and a decline of cognitive functions. Treatment with cortexin normalized the activities of glutathione-dependent enzymes, increased the contents of intermediates of the thiol–disulfide system, decreased the level of nitrotyrosine, which is a marker of nitrosative stress, and improved memory. © 2016, Pleiades Publishing, Ltd.


Pavlov S.V.,Zaporozhe State Medical University | Belenichev I.F.,Zaporozhe State Medical University
Neurochemical Journal | Year: 2014

We studied the neurochemical aspects of the neuroprotective action of a selective modulator of the estrogen receptors, tamoxifen citrate, in a model of acute cerebral ischemia (ACI). It was shown that modeling of cerebral ischemia is followed by pathobiochemical changes in the brain tissue: a rapid shift of thioldisulfide homeostasis, intensification of free radical oxidation, and impaired synthesis of the cytoprotective protein Hsp70. A course of the 1 mg/kg tamoxifen citrate led to the normalization of the thiol-disulfide system due to an increase of the glutathione level in the brain tissue which, in turn, restricted the development of oxidative and nitrosative stress. In addition, Western blot analysis showed that treatment with tamoxifen citrate increased the Hsp70 level in the brain tissue, which resulted from genomic and non-genomic actions. The neuroprotective profile of tamoxifen citrate that we found here opens the future perspective of the studies in this field for introduction of this agent as a neuroprotective drug into clinical practice. © 2014 Pleiades Publishing, Ltd.


Aleksandrova E.V.,Zaporozhe State Medical University | Levich S.V.,Zaporozhe State Medical University | Romanenko N.I.,Zaporozhe State Medical University | Shkoda A.S.,Zaporozhe State Medical University | Mikhalchenko E.K.,Zaporozhe State Medical University
Chemistry of Natural Compounds | Year: 2014

A preparative method for producing of 3-(4′-methylphenyl)-8- methylxanthine, its 7-substituted derivatives, 3-(4′-methylphenyl)-8- methylxanthinyl-7-acetic acid, its ester, amide, hydrazide, ylidenehydrazides, and N-phenylhydrazinocarbothiamide was developed. The structure of the cyclization product of the last, 3-(4′-methylphenyl)-7-[2-(4″- phenyl-5″-thio-4″H-[1″,2″,4″]triazol-3″-yl) methyl]xanthine, was confirmed by elemental analysis and PMR spectroscopy. © 2014 Springer Science+Business Media New York.

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