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Aleksandrova E.V.,Zaporozhe State Medical University | Kravchenko A.N.,RAS N. D. Zelinsky Institute of Organic Chemistry | Kochergin P.M.,RAS Institute of Chemistry
Chemistry of Heterocyclic Compounds | Year: 2011

Published information on methods for the synthesis of haloimidazoles is summarized and classified. © 2011 Springer Science+Business Media, Inc. Source


Pavlov S.V.,Zaporozhe State Medical University | Belenichev I.F.,Zaporozhe State Medical University
Neurochemical Journal | Year: 2014

We studied the neurochemical aspects of the neuroprotective action of a selective modulator of the estrogen receptors, tamoxifen citrate, in a model of acute cerebral ischemia (ACI). It was shown that modeling of cerebral ischemia is followed by pathobiochemical changes in the brain tissue: a rapid shift of thioldisulfide homeostasis, intensification of free radical oxidation, and impaired synthesis of the cytoprotective protein Hsp70. A course of the 1 mg/kg tamoxifen citrate led to the normalization of the thiol-disulfide system due to an increase of the glutathione level in the brain tissue which, in turn, restricted the development of oxidative and nitrosative stress. In addition, Western blot analysis showed that treatment with tamoxifen citrate increased the Hsp70 level in the brain tissue, which resulted from genomic and non-genomic actions. The neuroprotective profile of tamoxifen citrate that we found here opens the future perspective of the studies in this field for introduction of this agent as a neuroprotective drug into clinical practice. © 2014 Pleiades Publishing, Ltd. Source


Romanenko N.I.,Zaporozhe State Medical University | Nazarenko M.V.,Crimea State Medical University | Kornienko V.I.,University of Kharkiv | Rak T.N.,Crimea State Medical University | And 2 more authors.
Chemistry of Natural Compounds | Year: 2013

A method for preparing previously undescribed derivatives of imidazo[1,2-f]-, 1,3-oxazolo[2,3-f]-, and 1,2,4-triazino[3,4-f]xanthine, potential biologically active compounds, was developed. Their physicochemical properties and biological activity were studied. © 2013 Springer Science+Business Media New York. Source


Shishkina S.V.,Ukrainian Academy of Sciences | Zubatyuk R.I.,Ukrainian Academy of Sciences | Kucherenko L.I.,Zaporozhe State Medical University | Parnyuk N.V.,Zaporozhe State Medical University | And 4 more authors.
Russian Chemical Bulletin | Year: 2013

The character of intermolecular interactions of the bromide anion and organic cation in crystal of 4-amino-1-(β-phenylethyl)-1,2,4-triazolium bromide was studied by a combination of X-ray diffraction data and M06-2X/cc-pvtz quantum chemical calculations. The existence of binding anion···π-system interactions was shown, and their characteristics were studied. © 2013 Springer Science+Business Media, Inc. Source


Romanenko N.I.,Zaporozhe State Medical University | Nazarenko M.V.,Crimea State Medical University | Ivanchenko D.G.,Zaporozhe State Medical University | Cherchesova A.Yu.,Zaporozhe State Medical University | Aleksandrova E.V.,Zaporozhe State Medical University
Chemistry of Natural Compounds | Year: 2014

A simple preparative synthetic method for previously undescribed 8-bromo-7-[2-hydroxy-3-(4-tertbutyl) phenoxypropyl-1]-3-methylxanthine derivatives, potential biologically active compounds and convenient synthons for further synthetic investigations, was developed. The spectral properties of the synthesized compounds were studied. © 2014 Springer Science+Business Media New York. Source

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