Zaporizhzhia State Medical University

Zaporizhzhia, Ukraine

Zaporizhzhia State Medical University

Zaporizhzhia, Ukraine
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Sincha K.,Zaporizhzhia State Medical University
Psychiatry, Psychotherapy and Clinical Psychology | Year: 2016

The paper traces the alexithymic, anhedonics and alarming phenomena in the structure depressive and paradepression symptoms in patients with schizophrenia and schizoaffective disorder. Observed correlations between alexithymia, anhedonia, anxiety, and depressive symptoms of patients with schizophrenia and schizoaffective disorder.


Tsybulskaya T.E.,Zaporizhzhia State Medical University | Zavgorodnyaya N.E.,Zaporizhzhia State Medical University | Pashkova E.E.,Zaporizhzhia State Medical University
Oftalmologicheskii Zhurnal | Year: 2017

Background: Myopia can be caused by structural and functional alterations in the connective tissue. Purpose: To evaluate the phenotypic markers of the syndrome of unspecified connective tissue dysplasia (SUCTD) in a cohort of children with acquired myopia. Materials and Methods: Two hundred and thirty 7-15-year-old children with acquired myopia of low or moderate degree were involved in the study. They were divided into two age groups, junior (7-11 years; 102 individuals) and senior school children (12-15 years; 128 individuals). Odds ratios (OR) and 95% confidence intervals (CI) were used to assess the risk of myopia progression. Results: The major phenotypic risk factors for developing moderate myopia in children of 7-11 years were prominent venous network of the skin (OR, 7.8; 95% CI, 2.9-20.7; p < 0.05), asthenic habitus (OR, 4.9; 95% CI, 2.1-11.8; p < 0.05), and flat foot (OR, 4.0; 95% CI, 1.7-9.5; p < 0.05), whereas in children of 12-15 years, these factors were moderate or severe connective tissue dysplasia (OR, 7.9; 95% CI, 3.2-19.3; p < 0.05), asthenic habitus (OR, 7.1; 95% CI, 3.2-15.7), cardiac valve prolapse and other minor cardiac anomalies (OR, 6.9; 95% CI, 3.1-15.3; p < 0.05), hypermobility of the joints (OR, 6.1; 95% CI, 2.7-13.6; p < 0.05), postural anomalies and scoliosis (OR, 5.6; 95% CI, 2.5-12.4; p < 0.05), and hyperelasticity of the skin (OR, 5.3; 95% CI, 2.3-12.5; p < 0.05). Conclusions: Low myopic children with a moderate or severe connective tissue dysplasia are at risk for developing moderate myopia. The major SUCTD-related risk factors for developing moderate myopia in children of 7-11 years were prominent venous network of the skin, asthenic habitus, and flat foot, whereas in children of 12-15 years, these factors were asthenic habitus, cardiac valve prolapse and other minor cardiac anomalies, hypermobility of the joints, postural anomalies and scoliosis, and hyperelasticity of the skin. © 2017, Phosphen Ltd. All rights reserved.


Nosulenko I.S.,Zaporizhzhia State Medical University | Voskoboynik Y.U.,Zaporizhzhia State Medical University | Berest G.G.,Post University | Safronyuk S.L.,Crimean State Medical University | And 5 more authors.
Scientia Pharmaceutica | Year: 2014

Potassium 8-R1-9-R2-10-R3-3-R-2-oxo-2Н-[1,2,4]triazino [2,3-с]quinazoline-6- thiolates 2.1-2.26 were synthesized via cyclocondensation of 6-R-3-(3-R1-4-R2- 5-R3-aminophenyl)-1,2,4-triazin-5-ones 1.1-1.26 with carbon disulfide, potassium hydroxide, and ethanol or with potassium O-ethyl dithiocarbonate in 2-propanol. The corresponding thiones 3.1-3.26 were obtained by treatment of 2.1-2.26 with hydrochloric acid. It was found that the nature of the substituents in positions 3, 4, and 5 of the corresponding 6-R-3-(3-R1-4-R2-5-R3-aminophenyl)-1,2,4-triazin-5-ones were affected on the terms of the reaction. The structures of compounds were proven by a complex of physicochemical methods (1H,13C NMR, LC-MS, and EI-MS). The results of the antibacterial and antifungal activity assay allowed the determination of the high sensitivity of Staphylococcus aureus ATCC 25923 (MIC 6.25-100 µg/mL, MBC 12.5-200 µg/mL) to the synthesized compounds. © Nosulenko et al.


Romanenko N.I.,Zaporizhzhia State Medical University | Nazarenko M.V.,Crimea State Medical University | Kornienko V.I.,Kharkov State Zooveterinary Academy | Samura B.A.,Zaporizhzhia State Medical University | Pakhomova O.A.,University of Kharkiv
Pharmaceutical Chemistry Journal | Year: 2014

Asimple laboratory method for preparing 8-amino-substituted 7-(2-aryl-2-oxoethyl)xanthines by reacting the corresponding 8-bromo derivatives with primary and secondary amines in ethoxyethanol was developed. The structures of the synthesized compounds were confirmed by PMR spectroscopy. The analgesic and anti-inflammatory activities of the synthesized compounds were studied in laboratory animal tests. It was established that the majority of the tested compounds possessed moderate or strong analgesic and anti-inflammatory activities. Several compounds exhibited activity stronger than or comparable to that of metamizole sodium (analgin) and diclofenac. 7-(2-Oxo-2-phenylethyl)-8-(4-methylpiperidinyl-1)theophylline (XIV) and 7-(2-oxo-2-phenylethyl)-8-(4-ethylpiperazinyl-1)-3-methylxanthine (XVII) could be introduced as analgesic and anti-inflammatory agents after detailed pharmacological testing. © 2014, Springer Science+Business Media New York.


Voskoboynik O.Y.,Zaporizhzhia State Medical University | Kolomoets O.S.,Zaporizhzhia State Medical University | Berest G.G.,Zaporizhzhia State Medical University | Nosulenko I.S.,Zaporizhzhia State Medical University | And 2 more authors.
Chemistry of Heterocyclic Compounds | Year: 2017

[Figure not available: see fulltext.] The known methods for synthesis of thioxopyrimidines and their condensed analogs with exocyclic sulfur atom are summarized and discussed. The most popular approaches are based on [3+3], [4+2], [5+1] cyclization processes or domino reactions. The literature data analysis shows that the title compounds possess diverse biological activities, such as antioxidant, radioprotective, analgesic, antiinflammatory, antihypertensive, anxiolytic, anamnestic, anticonvulsant, antimicrobial, fungicidal, herbicidal, antiviral, and anticancer. © 2017 Springer Science+Business Media New York


Antypenko O.M.,Zaporizhzhia State Medical University | Kholodnyak S.V.,Zaporizhzhia State Medical University | Schabelnyk K.P.,Zaporizhzhia State Medical University | Antypenko L.M.,Zaporizhzhia State Medical University | Kovalenko S.I.,Zaporizhzhia State Medical University
Chemistry of Heterocyclic Compounds | Year: 2017

[Figure not available: see fulltext.] This review offers summary and analysis of the data on the synthesis of 2-(azolyl)anilines published from 1942 to 2016. It is shown, that they act as effective 1,5-nucleophiles in cyclocondensation reactions. Besides, biological activity data on 2-(azolyl)anilines and their derivatives are reported. © 2017 Springer Science+Business Media New York


Komykhov S.A.,Ukrainian Academy of Sciences | Komykhov S.A.,University of Kharkiv | Bondarenko A.A.,Ukrainian Academy of Sciences | Musatov V.I.,Ukrainian Academy of Sciences | And 4 more authors.
Chemistry of Heterocyclic Compounds | Year: 2017

[Figure not available: see fulltext.] (5S,7R)-5-Aryl-7-methyl-4,5,6,7-tetrahydro[1, 2, 4]triazolo[1,5-a]pyrimidin-7-ols were synthesized by three-component reactions of 1H-1,2,4-triazol-3-amine with aromatic aldehydes and acetone in the presence of TsOH. Antimicrobial and antifungal activities of these new substances were investigated in vitro. © 2017 Springer Science+Business Media New York


PubMed | Zaporizhzhia State Medical University, Post University and Crimean State Medical University
Type: Journal Article | Journal: Scientia pharmaceutica | Year: 2015

Potassium 8-R(1)-9-R(2)-10-R(3)-3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazoline-6-thiolates 2.1-2.26 were synthesized via cyclocondensation of 6-R-3-(3-R(1)-4-R(2)-5-R(3)-aminophenyl)-1,2,4-triazin-5-ones 1.1-1.26 with carbon disulfide, potassium hydroxide, and ethanol or with potassium O-ethyl dithiocarbonate in 2-propanol. The corresponding thiones 3.1-3.26 were obtained by treatment of 2.1-2.26 with hydrochloric acid. It was found that the nature of the substituents in positions 3, 4, and 5 of the corresponding 6-R-3-(3-R(1)-4-R(2)-5-R(3)-aminophenyl)-1,2,4-triazin-5-ones were affected on the terms of the reaction. The structures of compounds were proven by a complex of physicochemical methods ((1)H, (13)C NMR, LC-MS, and EI-MS). The results of the antibacterial and antifungal activity assay allowed the determination of the high sensitivity of Staphylococcus aureus ATCC 25923 (MIC 6.25-100 g/mL, MBC 12.5-200 g/mL) to the synthesized compounds.


Pogorielov M.V.,Sumy State University | Mishchenko O.N.,Zaporizhzhia State Medical University | Zaitseva N.V.,Zircon Prior Private Enterprise Eksima' | Babich I.N.,Sumy State University | Nikulin A.M.,Zaporizhzhia State Medical University
New Armenian Medical Journal | Year: 2014

Osteointegration is a key factor for successful implant ingrowth. It depends on quality of bone, lack of initial stability, excessive loading, loosening or fracture of screw, and fracture of implant itself. Other factors that can affect osteointegration are implant composition and features of implant surface. There are a lot of research data showing better results of implantation in alloys combined with Ti, Co, Ni and Zr. But the mechanism of combined, as well as Zr-based alloys’ influence on bone ingrowth around implant is still not known. The aim of this research was an in vivo evaluation of β (Zr-Ti)-alloy compared to the traditional TiVT-6 dental implant. In the experiment 30 rabbits were used for implantation of β (Zr-Ti)-alloys (experimental group) and TiVT6 dental implants (control group) in distal epiphysis of the femur. We analyzed bone/implant interface and controlled ion content (Ca and P) 1, 3, and 6 months after implantation by Scanning Electron Microscope with X-Ray analysis REMMA-102 (“Selmy”, Ukraine). After implantation of TiVT6-alloy we can see formation of connective tissue “cuff” that being tightly connected with implant does not turn into bone tissue. These processes lead to hypermobility and overloud of implant, and simultaneously decrease mechanical forces on surrounding bone tissue, which can lead to implant failure and complications in surrounding bone tissue. At the same time β (Zr-Ti)-alloy with modified surface is surrounding with woven bone tissue one month after the implantation that turns into lamellar bone in three months. Summarizing our data, we can suggest that β (Zr-Ti)-alloy is more suitable for implant material due to its osteostimulatory potential. © 2014, Yerevan State Medical University. All rights reserved.


Gubsky Y.I.,Ukrainian Academy of Sciences | Belenichev I.F.,Zaporizhzhia State Medical University | Kovalenko C.I.,Zaporizhzhia State Medical University | Goryushko G.G.,Ukrainian Academy of Sciences | And 5 more authors.
Ukrain'skyi Biokhimichnyi Zhurnal | Year: 2012

Under modelling of brain ischemia in rats the antioxidant and cerebroprotective action of new N-,S-chinazolone derivative-compound NC-224 has been established. The compensation of pathobiochemical abnormalities in the system "LPOantioxidant protection" is observed, indicators of carbohydrate metabolism and energy-supply, and morpho-functional status of brain cells are improved under administration of the compound NC-224. Administration of the compound NC-224 to rats promoted a decrease of the lethality index and signs of neurological deficiency.

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