Labenska I.B.,Zaporizhia State University |
Shapoval G.A.,Ukrainian Academy of Sciences |
Kruglyak O.S.,Ukrainian Academy of Sciences |
Omeljanchik L.A.,Zaporizhia State University |
And 2 more authors.
Ukrain'skyi Biokhimichnyi Zhurnal | Year: 2010
The influence of substituents in the sixth position of N-acyl derivatives of 2-methyl-4-mercaptoquinoline on hepatoprotective and antioxidant effect was investigated. It was also determined that alcoxy-derivatives show hepatoprotective, antiradical, antioxidant activity and can act as preventive antioxidants. Introduction of the ethoxy-group into the sixth position of azoheterocycle potentiates activity. Symbasis of intensities of hepatoprotective and antioxidant actions of the investigated compounds was proved.