Zaporizhia State Medical University


Zaporizhia State Medical University

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Matyasovszky I.,Eötvös Loránd University | Makra L.,University of Szeged | Tusnady G.,Hungarian Academy of Sciences | Csepe Z.,Optin Ltd | And 32 more authors.
Theoretical and Applied Climatology | Year: 2017

The drivers of spatial variation in ragweed pollen concentrations, contributing to severe allergic rhinitis and asthma, are poorly quantified. We analysed the spatiotemporal variability in 16-year (1995–2010) annual total (66 stations) and annual total (2010) (162 stations) ragweed pollen counts and 8 independent variables (start, end and duration of the ragweed pollen season, maximum daily and calendar day of the maximum daily ragweed pollen counts, last frost day in spring, first frost day in fall and duration of the frost-free period) for Europe (16 years, 1995–2010) as a function of geographical coordinates. Then annual total pollen counts, annual daily peak pollen counts and date of this peak were regressed against frost-related variables, daily mean temperatures and daily precipitation amounts. To achieve this, we assembled the largest ragweed pollen data set to date for Europe. The dependence of the annual total ragweed pollen counts and the eight independent variables against geographical coordinates clearly distinguishes the three highly infected areas: the Pannonian Plain, Western Lombardy and the Rhône-Alpes region. All the eight variables are sensitive to longitude through its temperature dependence. They are also sensitive to altitude, due to the progressively colder climate with increasing altitude. Both annual total pollen counts and the maximum daily pollen counts depend on the start and the duration of the ragweed pollen season. However, no significant changes were detected in either the eight independent variables as a function of increasing latitude. This is probably due to a mixed climate induced by strong geomorphological inhomogeneities in Europe. © 2017 Springer-Verlag Wien

Makra L.,University of Szeged | Matyasovszky I.,Eötvös Loránd University | Tusnady G.,Hungarian Academy of Sciences | Wang Y.,Chinese Academy of Meteorological Sciences | And 25 more authors.
Agricultural and Forest Meteorology | Year: 2016

Long-distance pollen transport can substantially raise local pollen levels, but their relative contribution has not yet been quantified temporally or spatially in ragweed infested regions. Using common ragweed (Ambrosia artemisiifolia) pollen accumulation at a ragweed infested area, Szeged, Hungary as a test case, this study attempted to: (1) identify, using cluster analysis, biogeographical regions that contribute to long-range transport of ragweed pollen to Szeged; (2) quantify the relative contribution of ragweed pollen from these regions; (3) determine the relative contribution of "local" and "transported" pollen for Szeged. Using the HYSPLIT model, three-dimensional backward trajectories were produced daily over a 5-year period, 2009-2013 for ragweed pollen accumulation at Szeged. A k-means clustering algorithm using the Mahalanobis distance was applied in order to develop trajectory types. Nine back-trajectory clusters were identified. Cluster 1 (direction: from the Channel area south of Great Britain) and cluster 5 (direction: from Northern Mediterranean) were found the most relevant potential long-distance sources for Ambrosia pollen transport to Szeged. Potential source contribution function (PSCF) and concentration weighted trajectory (CWT) values indicated additional potential source areas including the central and eastern part of France, the northern part of Italy and the Carpathian Basin. For Szeged on non-rainy days, medium-range transport is important, while on rainy days the two transport ranges have equal weights. Based on the Granger causality, annual pollen amount transported by the atmospheric circulation is 27.8% of the annual total pollen at Szeged. From this quantity, 7.5% is added to (due to transport), while 20.3% is subtracted from (e.g. because of wash-out by frontal rainfalls going towards Szeged) local sources. © 2016 Elsevier B.V.

Voskoboynik O.Y.,Zaporizhia State Medical University | Kovalenko S.I.,Zaporizhia State Medical University | Shishkina S.V.,Ukrainian Academy of Sciences
Heterocyclic Communications | Year: 2016

The synthesis and antitumor activity of substituted benzo[e][1,2,4]triazino[2,3-c][1,2,3]triazin-2-ones-novel electro-deficient tricyclic compounds-are described. These compounds were prepared by treatment of 3-(2-amino-3-R2-5-R3-phenyl)-6-R1-1,2,4-triazin-5(2H)-ones with sodium nitrite in acetic acid. Spectral properties of synthesized compounds were studied and compared with spectral data of known 3-R-8-R1-10-R2-2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones. These compounds are promising antitumor agents. The most active anticancer compound 3d was studied in dose-depended anticancer activity assay and its selective growth inhibition against breast cancer MDA-MB-468 cell line was established (GI50=0.41 μm). © 2016 by De Gruyter.

Zubatyuk R.I.,Ukrainian Academy of Sciences | Shishkina S.V.,Ukrainian Academy of Sciences | Kucherenko L.I.,Zaporizhia State Medical University | Mazur I.A.,Zaporizhia State Medical University | Shishkin O.V.,Ukrainian Academy of Sciences
Structural Chemistry | Year: 2012

Crystal and molecular structure of lysine (5-methyl-1H-[1,2,4]triazol-3- ylsulfanyl)-acetate was determined and intermolecular interactions between ions in crystal were investigated by quantum-chemical methods (MP2 and B3LYP-D). COSMO solvation method was used to account crystal field effects. While the gas-phase calculations significantly overestimate attraction between similarly charged and repulsion between oppositely charged ions, COSMO method provides results which are consistent with interaction energies estimated from AIM analysis of electron density distribution. Also, all hydrogen- bonded dimers found in crystal are intrinsically stable if modeled with COSMO method, contrary to gas phase calculations. © Springer Science+Business Media, LLC 2011.

A total of 98 patients with chronic obstructive pulmonary disease, arterial hypertension and combined flow of both chronic obstructive pulmonary disease and arterial hypertension were examined. The patients were divided into 3 groups. The first group included patients with arterial hypertension, the second consisted of patients with COPD, the third of patients with combined flow of COPD and AH. ELISA method was used to determine serum concentrations of interleukin-6 and tumor necrosis factor-α. Immunoturbidimetric method was used to measure the concentration of C-reactive protein. Spectrophotometrically markers of oxidative stress, the levels of oxidative protein modifications were measured. It was found that there was a significant increase in levels of interleukin-6, tumor necrosis factor-α and C-reactive protein in patients with combined flow of chronic obstructive pulmonary disease and arterial hypertension while comparing with other groups. In patients with comorbid disorders COPD and AH an increase in products of oxidative modification of proteins, spontaneous and iron induced aldehydephenylhydrazone's and ketondinitrophenylhydrazone's were also observed. Significant correlations between biomarkers of systemic inflammation and oxidative stress were found.

Komykhov S.A.,Ukrainian Academy of Sciences | Komykhov S.A.,University of Kharkiv | Tkachenko I.G.,Ukrainian Academy of Sciences | Musatov V.I.,Ukrainian Academy of Sciences | And 5 more authors.
Arkivoc | Year: 2016

Simple, efficient and eco-friendly method for preparation of 7-unsubstituted 4,7-dihydro-1,2,4-triazolo[1,5-a]pyrimidines was elaborated, which presumes the three-component reaction of 3-amino-1,2,4-triazole with paraformaldehyde and different 1,3-dicarbonyl compounds in hot-water by either conventional heating or microwave irradiation without any catalyst. The target compounds showed antimicrobial and antifungal activity. ©ARKAT-USA, Inc.

Gromov I.A.,Ukrainian Academy of Sciences | Belenichev I.F.,Zaporizhia State Medical University | Gonchar-Cherdakli I.G.,Ukrainian Academy of Sciences | Zhernovaja G.A.,Zaporizhia State Medical University
Ukrain'skyi Biokhimichnyi Zhurnal | Year: 2013

The effect of phenobarbital, carbamazepine, valproate sodium, depakine, topiramate and lamo-trigine on the content of NO and NO-synthase activity in white rat brain tissues has been studied. It was established that the action of carbamazepine, valproate sodium, topiramate and lamotrigine decreases the activity of NO-synthase and the level of NO in the brain tissues. The amount of NO does not change while NO-synthase activity increases with the introduction of phenobarbital. The involvement of nitric oxide in the mechanism of action of the studied anticonvulsant drugs is discussed.

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