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A total of 98 patients with chronic obstructive pulmonary disease, arterial hypertension and combined flow of both chronic obstructive pulmonary disease and arterial hypertension were examined. The patients were divided into 3 groups. The first group included patients with arterial hypertension, the second consisted of patients with COPD, the third of patients with combined flow of COPD and AH. ELISA method was used to determine serum concentrations of interleukin-6 and tumor necrosis factor-α. Immunoturbidimetric method was used to measure the concentration of C-reactive protein. Spectrophotometrically markers of oxidative stress, the levels of oxidative protein modifications were measured. It was found that there was a significant increase in levels of interleukin-6, tumor necrosis factor-α and C-reactive protein in patients with combined flow of chronic obstructive pulmonary disease and arterial hypertension while comparing with other groups. In patients with comorbid disorders COPD and AH an increase in products of oxidative modification of proteins, spontaneous and iron induced aldehydephenylhydrazone's and ketondinitrophenylhydrazone's were also observed. Significant correlations between biomarkers of systemic inflammation and oxidative stress were found. Source


Voskoboynik O.Y.,Zaporizhia State Medical University | Kovalenko S.I.,Zaporizhia State Medical University | Shishkina S.V.,Ukrainian Academy of Sciences
Heterocyclic Communications | Year: 2016

The synthesis and antitumor activity of substituted benzo[e][1,2,4]triazino[2,3-c][1,2,3]triazin-2-ones-novel electro-deficient tricyclic compounds-are described. These compounds were prepared by treatment of 3-(2-amino-3-R2-5-R3-phenyl)-6-R1-1,2,4-triazin-5(2H)-ones with sodium nitrite in acetic acid. Spectral properties of synthesized compounds were studied and compared with spectral data of known 3-R-8-R1-10-R2-2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones. These compounds are promising antitumor agents. The most active anticancer compound 3d was studied in dose-depended anticancer activity assay and its selective growth inhibition against breast cancer MDA-MB-468 cell line was established (GI50=0.41 μm). © 2016 by De Gruyter. Source


Makra L.,University of Szeged | Matyasovszky I.,Eotvos Lorand University | Tusnady G.,Hungarian Academy of Sciences | Wang Y.,Chinese Academy of Meteorological Sciences | And 26 more authors.
Agricultural and Forest Meteorology | Year: 2016

Long-distance pollen transport can substantially raise local pollen levels, but their relative contribution has not yet been quantified temporally or spatially in ragweed infested regions. Using common ragweed (Ambrosia artemisiifolia) pollen accumulation at a ragweed infested area, Szeged, Hungary as a test case, this study attempted to: (1) identify, using cluster analysis, biogeographical regions that contribute to long-range transport of ragweed pollen to Szeged; (2) quantify the relative contribution of ragweed pollen from these regions; (3) determine the relative contribution of "local" and "transported" pollen for Szeged. Using the HYSPLIT model, three-dimensional backward trajectories were produced daily over a 5-year period, 2009-2013 for ragweed pollen accumulation at Szeged. A k-means clustering algorithm using the Mahalanobis distance was applied in order to develop trajectory types. Nine back-trajectory clusters were identified. Cluster 1 (direction: from the Channel area south of Great Britain) and cluster 5 (direction: from Northern Mediterranean) were found the most relevant potential long-distance sources for Ambrosia pollen transport to Szeged. Potential source contribution function (PSCF) and concentration weighted trajectory (CWT) values indicated additional potential source areas including the central and eastern part of France, the northern part of Italy and the Carpathian Basin. For Szeged on non-rainy days, medium-range transport is important, while on rainy days the two transport ranges have equal weights. Based on the Granger causality, annual pollen amount transported by the atmospheric circulation is 27.8% of the annual total pollen at Szeged. From this quantity, 7.5% is added to (due to transport), while 20.3% is subtracted from (e.g. because of wash-out by frontal rainfalls going towards Szeged) local sources. © 2016 Elsevier B.V. Source


Gromov I.A.,Ukrainian Academy of Sciences | Belenichev I.F.,Zaporizhia State Medical University | Gonchar-Cherdakli I.G.,Ukrainian Academy of Sciences | Zhernovaja G.A.,Zaporizhia State Medical University
Ukrain'skyi Biokhimichnyi Zhurnal | Year: 2013

The effect of phenobarbital, carbamazepine, valproate sodium, depakine, topiramate and lamo-trigine on the content of NO and NO-synthase activity in white rat brain tissues has been studied. It was established that the action of carbamazepine, valproate sodium, topiramate and lamotrigine decreases the activity of NO-synthase and the level of NO in the brain tissues. The amount of NO does not change while NO-synthase activity increases with the introduction of phenobarbital. The involvement of nitric oxide in the mechanism of action of the studied anticonvulsant drugs is discussed. Source


Zubatyuk R.I.,Ukrainian Academy of Sciences | Shishkina S.V.,Ukrainian Academy of Sciences | Kucherenko L.I.,Zaporizhia State Medical University | Mazur I.A.,Zaporizhia State Medical University | Shishkin O.V.,Ukrainian Academy of Sciences
Structural Chemistry | Year: 2012

Crystal and molecular structure of lysine (5-methyl-1H-[1,2,4]triazol-3- ylsulfanyl)-acetate was determined and intermolecular interactions between ions in crystal were investigated by quantum-chemical methods (MP2 and B3LYP-D). COSMO solvation method was used to account crystal field effects. While the gas-phase calculations significantly overestimate attraction between similarly charged and repulsion between oppositely charged ions, COSMO method provides results which are consistent with interaction energies estimated from AIM analysis of electron density distribution. Also, all hydrogen- bonded dimers found in crystal are intrinsically stable if modeled with COSMO method, contrary to gas phase calculations. © Springer Science+Business Media, LLC 2011. Source

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