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Zaozhuang, China

Li Y.Q.,Zaozhuang Municipal Hospital
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery | Year: 2011

To improve the recognition of clinical manifestation of human immunodeficiency virus(HIV) infection and acquired immunodeficiency syndrome (AIDS) in otorhinolaryngology head and neck surgery, and to emphasize the early diagnosis, correct treatment and effective protection. Fifty-five patients with HIV infection and AIDS encountered in the department of otorhinolaryngology head and neck surgery in Tanzania were included in this study. There were 23 males and 32 female with age ranged from 3 - 67 years, medium 31 year. The clinical manifestation and prognosis of the patients were analyzed and summed up. Parotid glands swelling was the most commonly seen clinical manifestation in the 55 cases. Among the cases reported here, 17 (30.9%) showed parotid glands swelling, 19 (34.5%) had Kaposi's sarcoma in nasal cavity or oral cavity or pharynx, 12(21.8%) were accompanied with chronic suppurative otitis media, 11 (20.0%) had masses in the neck, 7 (12.7%) had masses in the pharynx, 6 (10.9%) were seen to have ulcer in oral and pharyngeal mucosa, 2 (3.6%) showed infection due to candidaalbicans. The infection in most cases could be controlled and symptoms relieved, but recurrence could occur over time and got worse gradually. Many patients with HIV infection and AIDS first see a doctor in otorhinolaryngology head and neck surgery. Patients who had the above clinical manifestations in repeated poor results should be observed carefully, early diagnosis and treatment are important to prevent transmission, prolong life and maximize the quality of life of the patients. Source

Yang B.T.,Capital Medical University | Li S.P.,Zaozhuang Municipal Hospital | Wang Y.Z.,Capital Medical University | Dong J.Y.,Capital Medical University | Wang Z.C.,Capital Medical University
American Journal of Neuroradiology | Year: 2013

BACKGROUND AND PURPOSE: Lobular capillary hemangioma is an uncommon lesion, and its MR imaging appearance has not been fully characterized. The purpose of this study was to determine the MR imaging features of nasal lobular capillary hemangioma and contrast its imaging characteristics to inverting papilloma. MATERIALS AND METHODS: The MR imaging signals of 32 patients with histopathologically proven nasal lobular capillary hemangiomas and 53 patients with nasal inverted papillomas were retrospectively studied. The findings of dynamic contrast-enhanced MR imaging in 24 lobular capillary hemangiomas and in 53 inverted papillomas were also analyzed. The Monte Carlo exact test was used for comparison of the time-intensity curve patterns of lobular capillary hemangioma and inverted papilloma. RESULTS: All lobular capillary hemangiomas appeared to be homogeneously isointense to gray matter on T1-weighted images. On T2-weighted images, all lesions showed heterogeneous hyperintensity, and a thin peripheral isointense or hypointense ring was seen in 28 patients. All lesions showed marked enhancement on enhanced images, with the exception of enhancement of the T2 isointense or hypointense ring. Forty-three (81.1%) inverted papillomas had moderate heterogeneous T2 signal intensity, and a characteristic "cerebriform"appearance was detected in 45 (84.91%) of 53 inverted papillomas. The time-intensity curves showed a washout pattern in 18 and a plateau pattern in 6 patients, whereas inverted papillomas showed a washout pattern in 12, a plateau pattern in 35, and a persistent pattern in 6 patients. There was a statistically significant difference as to time-intensity curve pattern between the 2 groups (P < .05). CONCLUSIONS: Hyperintensity on T2-weighted images, marked enhancement of tumor with a nonenhancing thin peripheral ring, and a washout time-intensity curve pattern are characteristic MR imaging features of nasal lobular capillary hemangiomas. Source

Yang B.T.,Capital Medical University | Song Z.L.,Zaozhuang Municipal Hospital | Wang Y.Z.,Capital Medical University | Dong J.Y.,Capital Medical University | Wang Z.C.,Capital Medical University
American Journal of Neuroradiology | Year: 2013

SFT is a rare lesion of the sinonasal cavity. We retrospectively reviewed 5 patients with histopathologically proved sinonasal SFTs to determine their CT and MR imaging features. All patients underwent paranasal sinus CT and MR imaging. Four SFTs occurred in the nasal cavity, and 1, in the maxillary sinus. All SFTs had well-defined margins, and the mean maximum diameter was 55 mm. On nonenhanced CT, 5 SFTs appeared homogeneously isoattenuating to gray matter. The most common manifestations of bony involvement were bony remodeling and thinning. On MR imaging, 5 SFTs were isointense to gray matter on T1-weighted images, and the lesions were isointense in 3 and hypointense in 2 patients on T2-weighted images. The lesions showed heterogeneously marked enhancement on postenhanced MR images. Four patients underwent dynamic contrast-enhanced MR imaging, and the TICs showed a washout pattern. A familiarity with the imaging findings of sinonasal SFT may help to diagnose this entity. Source

Zhu Z.,Shandong University | Wang C.-P.,Zaozhuang Municipal Hospital | Zhang Y.-F.,Zaozhuang Shizhong Peoples Hospital | Nie L.,Shandong University
Asian Pacific Journal of Cancer Prevention | Year: 2014

Chondrosarcomas are malignant cartilage-forming tumors of bone which exhibit resistance to both chemotherapy and radiation treatment. miRNAs have been well demonstrated to regulate gene expression and play essential roles in a variety of biological processes, including proliferation, differentiation, migration, cell cycling and apoptosis. In this study, we obtained evidence that miR-100 acts as a tumor suppressor in human chondrosarcomas. Interestingly, cisplatin resistant chondrosarcoma cells exhibit decreased expression of miR-100 compared with parental cells. In addition, we identified mTOR as a direct target of miR-100. Overexpression of miR-100 complementary pairs to the 3' untranslated region (UTR) of mTOR, resulted in sensitization of cisplatin resistant cells to cisplatin. Moreover, recovery of the mTOR pathway by overexpression of S6K desensitized the chondrosarcoma cells to cisplatin, suggesting the miR-100-mediated sensitization to cisplatin dependent on inhibition of mTOR. In summary, the present studies highlight miR-100 as a tumor suppressor in chondrosarcoma contributing to anti-chemoresistance. Overexpression of miR-100 might be exploited as a therapeutic strategy along with cisplatin-based combined chemotherapy for the treatment of clinical chondrosarcoma patients. Source

Zhong W.,Cadre Ward | Huan X.-D.,Cadre Ward | Cao Q.,Zaozhuang Hospital of Traditional Chinese Medicine | Yang J.,Zaozhuang Municipal Hospital
Experimental and Therapeutic Medicine | Year: 2015

Cardiovascular diseases are closely associated with a highcholesterol or highfat diet. The aim of the present study was to investigate the cadioprotective effect of epigallocatechin3gallate (EGCG) in highfat dietfed rats, with special emphasis on myocardial infarction. A highfat diet was administered to male Wistar rats for 45 days and the rats of the treatment group were administered EGCG via intraperitoneal injection for the last 15 days. The serum lipid profile, antioxidant enzyme activity, lipid peroxidation, lipid metabolic proteins and cardiac tissue markers were assessed. The myocardium and aorta were also histopathologically examined. The highfat dietfed rats were found to be hyper­cholesterolemic or exhibited abnormal values in the selected parameters. However, these abnormalities were reversed to nearnormal values in the rats administered EGCG. Similarly, the enzymatic antioxidant activity and nonenzymatic antioxi­dant levels were improved with EGCG treatment in highfat dietfed rats. In addition, EGCG activated sirtuin 1, endothe­lial nitric oxide synthase and AMP-activated protein kinase α, which suggests that its protective effect is mediated through the stimulation of lipid metabolism. The histopathological exami­nation further revealed that EGCG significantly prevented the development of tissue abnormalities and improved the morphology of myocardial tissue. Taken together, our results suggested that EGCG plays a significant role in the protection of the cardiovascular system against the highfat diet. This is a preliminary study, emphasizing on the cardioprotective properties of EGCG. We are currently analyzing the molecular mechanism underlying the protective effects of EGCG. © 2015, Spandidos Publications. All rights reserved. Source

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