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Khazaee-Pool M.,Zanjan University of Medical Sciences
Asian Pacific journal of cancer prevention : APJCP | Year: 2016

BACKGROUND: Breast cancer risk assessment is a helpful method for estimating development of breast cancer at the population level.MATERIALS AND METHODS: In this cross-sectional study, participants consisted of a group of 3,847 volunteers (mean ± SD age: 463 ± 7.59 years) in a convenience sample of women referred to health centers af liated to Tehran University of Medical Sciences in Tehran, Iran. The risk of breast cancer was estimated by applying the National Cancer Institute's online version of the Gail Risk Assessment Tool.RESULTS: Some 24.9% of women reported having one rst-degree female relative with breast cancer, with 8.05% of them having two or more rst-degree relatives with breast cancer. The mean five-year risk of breast cancer for all participants was 1.61±0.73%, and 9.36% of them had a five-year risk of breast cancer >1.66%. The mean lifetime risk of breast cancer was 11.7±3.91%.CONCLUSIONS: The Gail model is useful for assessing probability of breast cancer in Iranian women. Based on the their breast cancer risk, women may decide to accept further screening services.


Soltanpour S.,Zanjan University of Medical Sciences | Jouyban A.,Tabriz University of Medical Sciences | Jouyban A.,University of Tehran
Journal of Molecular Liquids | Year: 2013

The solubility of lamotrigine in binary and ternary mixtures of N-methyl pyrrolidone and water with polyethylene glycols 200, 400, and 600 at 25 C is determined and mathematically represented using two cosolvency models, i.e. the log-linear model of Yalkowsky (method I), the Jouyban-Acree model (method II), and a combined version of the Jouyban-Acree model with Hansen partial solubility parameters (method III). The density of the solute free solvent mixtures is measured and employed to train the Jouyban-Acree model and subsequently the density of the saturated solutions is predicted. For methods I and II, the overall mean relative deviations (OMRDs) for fitting the solubility data of lamotrigine in binary mixtures are 39.1% and 5.1%, respectively. Further, the OMRDs for fitting the solubilities in ternary solvent mixtures for lamotrigine are 42.9% and 22.1% for methods I and II, respectively. In method III, the OMRD value for fitting all 122 data points by means of the combined version of the Jouyban-Acree model with Hansen solubility parameters is 12.7%. The trained version of the Jouyban-Acree model was produced by using the density of the solute free solutions, and the prediction of OMRD for the density of saturated solutions is 1.6%. © 2012 Elsevier B.V.


Hamidi M.,Zanjan University of Medical Sciences | Shahbazi M.-A.,Shiraz University of Medical Sciences | Rostamizadeh K.,Zanjan University of Medical Sciences
Macromolecular Bioscience | Year: 2012

Copolymers are among the most promising substances used in the preparation of drug/gene delivery systems. Different categories of copolymers, including block copolymers, graft copolymers, star copolymers and crosslinked copolymers, are of interest in drug delivery. A variety of nanostructures, including polymeric micelles, polymersomes and hydrogels, have been prepared from copolymers and tested successfully for their drug delivery potential. The most recent area of interest in this field is smart nanostructures, which benefit from the stimuli-responsive properties of copolymeric moieties to achieve novel targeted drug delivery systems. Different copolymer applications in drug/gene delivery using nanotechnology-based approaches with particular emphasis on smart nanoparticles are reviewed. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Mohammadi A.,Zanjan University of Medical Sciences
Indian journal of public health | Year: 2012

To assess quality of health services in Zanjan health centres based on clients' expectations and perceptions. The study was conducted by using service quality (SERVQUAL) scale on a sample of 300 females, clients of health care centres in the district of Zanjan, selected by cluster sampling. The results indicated that there were negative quality gaps at five SERVQUAL dimensions. The most and least negative quality gap mean scores were in reliability dimension (-2.1) and tangible (-1.13) respectively. There was statistically significant difference between clients' perceptions and expectations mean scores at all of the five service quality dimensions (P<0.001). The negative quality gap level in health service dimensions can be used as a guideline for redistribution of resources and managerial attempts to reduce quality gaps and improvement of health care quality.


Azadi A.,Tehran University of Medical Sciences | Hamidi M.,Zanjan University of Medical Sciences | Rouini M.-R.,Tehran University of Medical Sciences
International Journal of Biological Macromolecules | Year: 2013

Methotrexate-loaded hydrogel nanoparticles were prepared and after in vitro characterization, their transport across blood-brain barrier was investigated in vivo in intact animals in this study. The ionic gelation method was used for preparation of drug-loaded nanogels, after optimized by a systematic multi-objective optimization approach. After surface-modification with polysorbate 80, nanoparticles with the final particle size, poly-dispersity index (PDI), loading efficiency (LE) and loading capacity (LC) of 118.54. ±. 15.93. nm, 0.35. ±. 0.05, 61.82. ±. 6.84%, and 53.68. ±. 3.09% were obtained, respectively. The in vitro drug release study indicated non-Fickian diffusion kinetic, apparently governed by both diffusion of the drug out of the nanoparticles and swelling/disintegration of the polymeric network as characterized by a Weibull model for both surface-treated and untreated nanogels. After intravenous administration of surface-modified and unmodified nanogels compared to the free drug, all with the same dose of 25. mg/kg, remarkably higher brain concentrations of methotrexate were achieved with the nanogel formulations in comparison to the free drug (in some cases, more than 10-fold); but there were no significant differences between the surface-modified and unmodified nanogels in all the time points tested. © 2013 Elsevier B.V.


Zarrin A.,Shiraz University of Medical Sciences | Foroozesh M.,Persian Care Inc. | Hamidi M.,Zanjan University of Medical Sciences
Expert Opinion on Drug Delivery | Year: 2014

Introduction: Carrier erythrocytes, thanks to their main advantages, including biocompatibility, biodegradability, immunocompatibility, simple and well-known structure and physiology, availability for sampling and versatility in loading and use, have been studied as cellular carriers for delivery of drugs and other bioactive agents for more than three decades. Based on this body of knowledge and recent advances in this field, and with the help of novel multidisciplinary sciences and technologies, it seems that this field is becoming renowned and experiencing an outstanding turning point in its developmental history. Areas covered: In this trendy and timely review, following a short historical review of the story of erythrocytes from oxygen delivery to drug delivery and evaluation of the present status of these biocarriers, recent advances and current experimental, technological and clinical trends, as well as future horizons, and, in particular, translation-prone strategies, are going to be discussed in detail. Expert opinion: Despite the challenging developmental history of carrier erythrocytes, they now stand closer to clinical use and market entrance due to their unique advantages in drug delivery, proven by recently reported success stories in late-stage clinical trials and progresses made in biotechnology, nanotechnology and biomaterials fields. Translation-prone approaches, like in vivo loading of circulating erythrocytes or semiautomatic loading of erythrocytes, and more realistic study designs by focusing on clinical needs that have not been responded to or erythrocyte biology/fate-inspired study design are among the main trends being focused on by pioneer research groups active in this field of drug delivery. © 2014 Informa UK, Ltd.


Soltanpour Sh.,Zanjan University of Medical Sciences | Jouyban A.,Tabriz University of Medical Sciences
Chemical and Pharmaceutical Bulletin | Year: 2010

Experimental solubilities of acetaminophen and ibuprofen in polyethylene glycol 600-water, ethanol-polyethylene glycol 600, and polyethylene glycol 600-water-ethanol mixtures at 25°C are reported. The solubilities of drugs in the presence of ethanol and polyethylene glycol 600 were increased. The Jouyban-Acree model was used to fit the solubility data of each drug in the binary mixtures in which the overall mean relative deviations (OMRDs) for acetaminophen and ibuprofen were 2.9% and 4.3%, respectively. The OMRDs for ternary solvent mixtures for acetaminophen and ibuprofen were 16.8% and 22.4%, respectively. Generally, the errors associated with ibuprofen are larger than that of acetaminophen in both binary and ternary solvent mixtures. The solubilities were predicted using previously trained versions of the Jouyban-Acree and log-linear models with the OMRDs of 38.8% and 52.1%, respectively. Density of the mixed solvents in the absence of the solute was measured and used to train the model and then the density of the saturated solutions was predicted using the trained model and the density of the saturated solutions in mono-solvent systems with the OMRD of 3.2%. © 2010 Pharmaceutical Society of Japan.


Behroozy A.,Zanjan University of Medical Sciences
International Journal of Occupational and Environmental Medicine | Year: 2013

Hazardous chemicals may enter the body by inhalation, ingestion, injection or dermal absorption. These exposure routes constitute the overall exposure burden on the body. Most occupational exposure studies have focused on measurement of the concentration of air-borne contaminants and other possible routes of exposure are often overlooked. Several studies have already highlighted the importance of dermal absorption. However, less development occurred in the assessment of dermal exposures to occupational and environmental contaminants compared to air sampling techniques. This paper intends to highlight the importance of dermal exposure and looks at the methods currently used for its assessment. Advantages and disadvantages of each method in the context of occupational dermal exposure assessment are also outlined. Dermal exposure models, as an easy-to-use and low-cost tool to predict dermal uptake, especially when few or no actual data are available, are also included in this review.


Momtazi S.,Zanjan University of Medical Sciences | Rawson R.,University of California at Los Angeles
Current Opinion in Psychiatry | Year: 2010

Purpose of review In this study, we reviewed data on drug use among high school students in Iran. Recent findings Published epidemiological studies in international and domestic journals show that drug use/abuse is a serious mental health problem in Iran. There is cultural support for opium in Iran and also there is cultural tolerance for tobacco smoking, especially as water pipe smoking in Iranian families. Alcohol, opium and cannabis are the most frequently used illicit drugs, but there are new emerging problems with anabolic steroids, ecstasy and stimulant substances, such as crystal methamphetamine. Summary There is a serious drug abuse problem among Iranian high school students. It could be due to role modeling by parents - mainly fathers - and also cultural tolerance of some substances. Early onset of tobacco smoking, with a daily use rate between 4.4 and 12.8% in high school students, is an important risk factor for other drug abuse problems. Use of all types of drugs, except prescription drugs, is more prevalent among boys. Alcohol is the most frequently abused substance, with a lifetime rate of at least 9.9%. Lifetime rates of opiate use - mostly opium - was between 1.2 and 8.6% in different parts of the country. As drug abuse is a frequent problem among Iranian high school students, it is necessary to design and implement drug prevention programs to protect them. Such programs, including life skills training and drug education, have been operating in recent years for Iranian students from kindergarten to the university level.. © 2010 Wolters Kluwer Health π Lippincott Williams & Wilkins 0951-7367.


Aghahosseini M.,Zanjan University of Medical Sciences
Journal of assisted reproduction and genetics | Year: 2011

This study was designed to evaluate the effects of adding Estradiol (E2) supplementation to progesterone (P) on improvement of pregnancy outcomes in poor responder patients who underwent in vitro fertilization (IVF). In a prospective randomized clinical trial, 118 poor responder patients, older than 38 years without contraindications of estradiol consumption from Infertility clinic of a university hospital were randomly divided (by computerized software) into two groups. Control group (59 patients) received only P and intervention group (59 patients) received P and E2 (4 mg/d). Supplementation was done with 4 mg E2 in the luteal phase. Fertilization rate, implantation rate, biochemical and clinical pregnancy rates, abortion rate, ongoing pregnancy, multiple pregnancy and ectopic pregnancy rates were documented for those who completed the study protocol in each group (per protocol analysis) and compared between groups. Fifty five patients in control group and 53 patients in intervention group successfully completed the study protocol. Treatment outcomes were not significantly different between two groups. For poor responder women who underwent IVF, addition of E2 to P supplementation could not significantly improve pregnancy outcomes.

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