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Marii, Poland

Multiple simultaneous ipsilateral breast cancer incidence is some 10% of new breast cancer cases. Update of clinical- -pathological view of multitumor breast cancer in the context of 7th Edition of AJCC Classification is the main aim of this article. 7th Edition of AJCC Classification does not apply terms multifocal and multicentric for multitumor breast carcinomas. Term multiple carcinoma is used instead for all cases of multiple unilateral breast carcinomas. 7th Edition of AJCC Classification defines multiple carcinomas as follows: multiple tumors grossly presented in the same breast, tumors are separated by at least 0.5 cm, invasion is confirmed by microscopic evaluation, microscopically confirmed absents of invasion in breast tissue between tumors. 7th Edition of AJCC Classification considers mainly the dimension of the largest invasive tumor in cases of multiple carcinomas. Presence of additional tumors with invasive histology is reported only by parameter "m"(e.g., pT(m)1c) or by a parameter considering number of tumors (e.g., pT(3)1c - for three invasive breast carcinoma tumors, in which the largest one is more than 1cm and up to 2 cm in diameter. © Polskie Towarzystwo Onkologiczne.

Nowikiewicz T.,Oddzial Kliniczny Nowotworow Piersi i Chirurgii Rekonstrukcyjnej | Biedka M.,Oddzial Radioterapii I | Krajewski E.,Oddzial Kliniczny Nowotworow Piersi i Chirurgii Rekonstrukcyjnej | Koper K.,Katedra i Klinika Ginekologii Onkologicznej i Pielegniarstwa Ginekologicznego CM UMK W Bydgoszczy | Windorbska W.,Zaklad Teleradioterapii
Current Gynecologic Oncology | Year: 2012

Sentinel lymph node biopsy in patients with early-stage breast cancer is an example of a surgical procedure which, despite its long history, has had no uniform standard of performance implemented. This is a problem which concerns both the indications and limitations of this method as well as many of the technical aspects connected with the procedure. This paper is an attempt to resolve some of the controversies mentioned above based on the clinical experience of the authors. Material and method: The group consisted of 974 patients suffering from breast cancer and treated from January 2004 through October 2011 in the Clinical Department of Breast Cancer and Reconstructive Surgery of the Oncology Center in Bydgoszcz who were also scheduled for sentinel lymph node removal. Data regarding the preoperative diagnosis of the primary tumor, such as minimally invasive methods (FNAB, core biopsy, and mammotome biopsy) or open surgical biopsy (tumorectomy, quadrantectomy, or past breast operations with no relation to the current treatment) of the location of the lesion and the sentinel lymph node identification method (combined isotope-dye, isotope, or dye method) was analyzed. Results: Ninety-four point five percent of all sought nodes were detected. The detection rate for the combined SLN marking and isotope methods amounted to 94.4% each, whereas in the case of the dye method, it amounted to 100%. Of all the patients who underwent surgery for the first time, 95.0% had the sentinel lymph node location isolated during the operation, whereas in the case of patients who had previously undergone surgical treatment of the breast or surgical biopsy of a tumor it was 92.1%. Moreover, the location of the tumor within the breast did not have a significant impact on the success of the sentinel lymph node biopsy. Conclusions: The surgical biopsy of the primary lesion preceding the removal of the sentinel lymph node does not have a significant impact on the possibility of the detection of the node sought. The situation is similar with regard to the selected method of sentinel lymph node detection and the location of the primary tumor. As a result, it is possible to extend the usage of the sentinel lymph node biopsy into a wider range of cases. © Curr. Gynecol. Oncol. 2012.

Aim of the study. The analysis of early and late toxicity was assessed comparing two schedules of irradiation - conventional fractionation (CF) and accelerated fractionation (AF). Our population of patients had squamous cell carcinoma of the larynx stage T1-T3N0M0. All were treated with radical intent. Material and method. Patients treated 1995-1998 in the Centre of Oncology in Warsaw were separately analyzed in a phase III multicentre clinical trial. Patients were irradiated with Co-60, in the CF arm to a total dose of 66 Gy in 33 fractions with an overall treatment time of 45 days. In the AF arm the overall treatment time was 7 days shorter but the rest of parameters were not changed. Results. A higher percentage of acute post-irradiation reactions was observed in patients who underwent AF. The early reactions settled down after termination in 5 to 8 weeks in both fractionation methods. There were no serious late post-irradiation complications stated in both group of patients examined. © Polskie Towarzystwo Onkologiczne.

Gottwald L.,University of Lodz | Spych M.,University Medyczny | Moszynska-Zielinska M.,Oddzial Brachyterapii | Misiewicz P.,Pracownia Medycyny Nuklearnej | And 4 more authors.
Przeglad Menopauzalny | Year: 2012

Background: Breast cancer is the most common malignant neoplasm in women. Metastases to the central nervous system (CNS) are diagnosed in 15% of metastatic diseases. Aim of the study: The aim of the study was to investigate the clinical features in patients with breast cancer metastasized to the CNS. Material and methods: 54 patients were studied retrospectively. Clinical and pathologic data were analyzed. The time from primary diagnosis to relapse in the CNS was evaluated. The CNS tumors were characterized. Results: At the diagnosis of primary cancer, patients were aged 34-87 (54.8 ±10.0). The histology was ductal adenocarcinoma (88.9%) and lobular adenocarcinoma (11.1%). The interval from diagnosis of primary cancer to the CNS relapse was 2-96 months (35.6 ±23.8). The CNS metastases were less often solitary (27.8%) than multifocal (72.2%). 25.9% of metastatic tumors were diagnosed only in the CNS, and 74.1% of patients had extracranial metastases. The synchronous metastases were located most commonly in the lungs, liver, bones, and the lymphatic system. The treatment of relapse in the brain was in 25.9% - the surgery followed by radiotherapy, in 61.1% of patients - radiotherapy alone, in 3.7% - radiotherapy followed by chemotherapy and in 9.3% - palliative care only. Conclusions: The development of the CNS metastases from breast cancer occurs commonly in patients with an inoperable primary tumor, 2-3 years after primary diagnosis. The tumors are usually multiple and are diagnosed in patients with synchronous extracranial metastases. The development of the CNS metastases, despite oncologic treatment, is related to poor prognosis and most patients die during the first year of the follow-up.

Introduction. In the last 20 years, anthracycline and taxanes (AT) have been implemented in breast cancer treatment. The aim of this work is to estimate the prognostic factors and long-term disease-free survival in breast cancer patients after radical mastectomy and postoperative radiotherapy before implementation of AT.

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