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Langfort R.,Zaklad Patomorfologii | Rudzinski P.,Klinika Chirurgii Instytutu Gruzlicy i Chorob Pluc | Burakowska B.,Zaklad Radiologii Instytutu Gruzlicy i Chorob Pluc
Pneumonologia i Alergologia Polska | Year: 2010

Neuroendocrine tumors of the lung represent a broad spectrum of morphologic types that share specific morphologic, immunohistochemical, ultrastructural, and molecular characteristics. The classification of neuroendocrine lung tumors has changed over the last decades and currently four categories are distinguished: typical carcinoid tumor, atypical carcinoid tumor, large cell neuroendocrine carcinoma and small cell carcinoma. Neuroendocrine tumors of the lung comprise approximately 20% of all primary lung cancers. Among them, the most frequent is small cell carcinoma (13-17%). Because of differences in clinical behavior, therapy, and prognosis, a reliable histological diagnosis, as well as clinical and pathological staging system are essential for an appropriate medical proceedings. The most effective treatment of bronchial carcinoids and large cell neuroendocrine carcinoma in an early stage is complete surgical resection, whereas chemotherapy remains the primary treatment for small cell carcinoma. All carcinoids are malignant tumors with the potential to metastasize. The majority of patients with pulmonary carcinoid have an excellent survival, even if they present with lymph node metastases. Large cell neuroendocrine and small cell carcinoma progress rapidly and are generally widespread at the moment of diagnosis. Their overall prognosis is poor. Increased knowledge about pulmonary neuroendocrine tumors biology and the genetic characteristics, imply that carcinoid tumors appear to have a different etiology and pathogenesis than large cell neuroendocrine and small cell carcinoma. In practice, it could be easiest to conceptualize this group of pulmonary tumors as a spectrum of malignancy ranging from the low grade typical carcinoid to the highly malignant large cell neuroendocrine and small cell carcinoma. Typical carcinoid tumors associated with a fairly benign behavior should be classified as low-grade neuroendocrine tumor/carcinoma (G1) and atypical carcinoid tumors as intermediate-grade tumor/carcinoma (G2). Whereas, large cell neuroendocrine and small cell carcinoma should be grouped together under the designation of high-grade neuroendocrine tumor/carcinoma (G3). © 2010 Via Medica. Source


Stoklosa A.,II Klinika Chorob Pluc | Radzikowska E.,III Klinika Chorob Pluc | Baranska I.,ZakLad Radiologii | Langfort R.,Zaklad Patomorfologii | And 3 more authors.
Pneumonologia i Alergologia Polska | Year: 2012

Autoimmunological pulmonary alveolar proteinosis (APAP) is a rare interstitial lung disease with abnormal surfactant homeostasis. Autoimmunological pulmonary alveolar proteinosis is diagnosed most often in the third or fourth decade of life. Predominant symptoms are dyspnea and cough. In most cases, disease is mild but in more severe cases when dyspnea limits patient physical activity a treatment is required. The most common treatment procedure is a whole-lung lavage. We present a case study of 37 years old woman with the patchy consolidations in the chest radiograph. High resolution computed tomography (HRCT) image suggested hipersensivity pneumonitis. At the beginning due to limited disease symptoms no specific proceedings was implemented. After two year follow-up of non-resolving pulmonary changes the decision about open lung biopsy was made. On the basis of histological examination of samples and presence of anty GM-CSF antibodies the diagnosis of autoimmunological pulmonary alveolar proteinosis was established. © 2012 Via Medica. Source


Smoter M.,Klinika Onkologii Kobiet | Bodnar L.,Klinika Onkologii Kobiet | Duchnowska R.,Klinika Onkologii Kobiet | Stec R.,Klinika Onkologii Kobiet | And 2 more authors.
Cancer Chemotherapy and Pharmacology | Year: 2011

Resistance to taxanes, related to limited efficacy of systemic therapy in cancer patients, is multifactorial. Among mechanisms of resistance to taxanes, those related to microtubule-associated proteins (MAP), including protein Tau, are of great importance. Protein Tau (50-64 kD) binds to beta-tubulin in the same place as paclitaxel. In preclinical studies, low expression of Tau in cancer cells was associated with increased sensitivity to paclitaxel. High expression of Tau protein in ER-positive breast cancers indicates resistance to taxane-containing chemotherapy and sensitivity to hormonal treatment. This article reviews current knowledge on predictive value of protein Tau in response to taxanes. Better understanding of its role may facilitate patients selection to this sort of treatment and lead to treatment optimization. © 2011 The Author(s). Source


Malgorzata K.,Oddzial Polozniczo Ginekologiczny | Jaroslaw J.,Oddzial Polozniczo Ginekologiczny | Malgorzata T.,Zaklad Patomorfologii | Marek G.,Kliniczny Oddzial ChorobWewnetrznych
Ginekologia Polska | Year: 2010

Hormonally active, associated with pregnancy ovarian tumors can cause some diagnostic and therapeutic problems. In the following work we present a 28-year-old primigravida in the 21st week of pregnancy who was admitted to hospital with acute abdominal pain and virilizing symptoms. Bilateral luteinized thecoma of a considerable size, secreting testosterone, was diagnosed and the woman received surgical treatment. During the operation a rupture of the left tumor was discovered. Bilateral adnexectomy was performed. After the operation the symptoms subsided. The pregnancy continued until 38 weeks gestation. A normal female fetus without virilizing symptoms was delivered by caesarean section. © Polskie Towarzystwo Ginekologiczne. Source


Swietlik E.M.,Klinika Pulmonologii | Doboszynska A.,Klinika Pulmonologii | Kupis W.,Klinika Chirurgii | Szolkowska M.,Zaklad Patomorfologii | Opoka L.,LUX MED Diagnostyka Sp.z.o.o
Pneumonologia i Alergologia Polska | Year: 2014

Here we present a 65-year old ex-smoker with history of recent surgery for vocal cord tumor (histology: moderate grade intraepithelial neoplasia), who reported to the pulmonary outpatient clinic for the nodular lesions in the left lung seen on chest X-ray. Subsequent chest CT scan revealed focal lesion of 18 mm in diameter with spicular margins located in the right upper lobe, another irregular cyst with septa, 62 × 58 mm in the right lower lobe, and calcified nodule in the left lung, no enlarged lymph nodes or pleural effusion was seen. He underwent upper right lobe resection and wedge resection of the lower right lobe. Histological examination revealed adenocarcinoma in the right upper lobe with lymph node metastasis (pT2aN2M0). Examination of the right lower lobe showed squamous cell carcinoma (pT2bN0M0). He was subsequently treated with adjuvant chemotherapy and radiotherapy. During 20 months of the follow-up, he remained in good health with no signs of the disease progression. Patients with synchronous multiple primary lung cancers have significantly less favorable outcome than those with single primary lung malignancies, although it can be considerably improved with radical surgical treatment. Basing on the above case report, we discussed diagnostic and therapeutical scheme in patients with the primary multiple lung cancers, and have analyzed epidemiological data and some aspects of MPM etiology. © 2014 PTChP. Source

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