Zaklad Patomorfologii


Zaklad Patomorfologii

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Fijolaw J.,III Klinika Chorob Pluc | Wiatr E.,III Klinika Chorob Pluc | Gawryluk D.,III Klinika Chorob Pluc | Langfort R.,Zaklad Patomorfologii | And 3 more authors.
Pneumonologia i Alergologia Polska | Year: 2012

Introduction: The diagnosis of Churg-Strauss syndrome (CSS) is difficult because pathological criteria are present in minority of patients and in advanced stages. Several centers elaborated criteria which allowed to suspect CSS in patients with asthma, hypereosinophilia and clinical manifestations consistent with systemic vasculitis with or without histologic evidence. The aim of the study is the presentation of the basis of CSS diagnosis in our material. Material and methods: The analysis included 38 patients. Blood and biochemical analysis, radiological examinations of the chest and sinuses, echocardiography were performed in all patients. In 22/23 patients with cardiac symptoms magnetic resonance of the heart was performed. In two patients mediastinoscopy was performed, in 4 - laparotomy. Results: Only in 13/38 patients vasculitis was histologically proven, in the rest the diagnosis was established mainly on clinical ground. In 23 patients the diagnosis was established on the clinical cardiac symptoms - in all of them the cardiac involvement was confirmed by magnetic resonance. In 9 cases skin leasions were cause of further diagnostic procedures, 6 patients presented gastrointestinal symptoms, in 15 - paralysis of peroneal nerve was observed, and 1 patient had polyneuropathy and symptoms of central nervous system. Conclusions: The diagnosis of CSS in our material was established mainly on clinical ground, because histologic material was difficult to obtain (it needs invasive procedures). Only in 13 from 38 patients vasculitis was histologically proven. The presence of asthma, sinusitis associated with peripheral eosinophilia and organ symptoms suggesting a vasculitis could support the diagnosis, without histologic evidence. © 2012 Via Medica.

Kruk M.,Szkola Glowna Gospodarstwa Wiejskiego | Osowski S.,Military University of Technology | Osowski S.,Warsaw University of Technology | Koktysz R.,Zaklad Patomorfologii
Przeglad Elektrotechniczny | Year: 2010

The paper presents the algorithm of extraction and parameterization of the histological structures existing in the images of the prostate cancer. It is first part of research directed to the semiautomatic, diagnostic system able to recognize the Gleason scale of the image. The extraction algorithm is based on the mathematical morphological operations and geometrical characterization of the segmented structures. Its successful operation has been verified on the examples of 32 images corresponding to different stages of development of the prostate cancer.

Stoklosa A.,II Klinika Chorob Pluc | Radzikowska E.,III Klinika Chorob Pluc | Baranska I.,Zaklad Radiologii | Langfort R.,Zaklad Patomorfologii | And 3 more authors.
Pneumonologia i Alergologia Polska | Year: 2012

Autoimmunological pulmonary alveolar proteinosis (APAP) is a rare interstitial lung disease with abnormal surfactant homeostasis. Autoimmunological pulmonary alveolar proteinosis is diagnosed most often in the third or fourth decade of life. Predominant symptoms are dyspnea and cough. In most cases, disease is mild but in more severe cases when dyspnea limits patient physical activity a treatment is required. The most common treatment procedure is a whole-lung lavage. We present a case study of 37 years old woman with the patchy consolidations in the chest radiograph. High resolution computed tomography (HRCT) image suggested hipersensivity pneumonitis. At the beginning due to limited disease symptoms no specific proceedings was implemented. After two year follow-up of non-resolving pulmonary changes the decision about open lung biopsy was made. On the basis of histological examination of samples and presence of anty GM-CSF antibodies the diagnosis of autoimmunological pulmonary alveolar proteinosis was established. © 2012 Via Medica.

Kolacinska A.,University of Lodz | Blasinska-Morawiec M.,Oddzial Chorob Rozrostowych WSS Im. M. Kopernika | Dowgier-Witczak I.,Oddzial Chemioterapii WSS Im. M. Kopernika | Kordek R.,Zaklad Patomorfologii | Morawiec Z.,University of Lodz
Przeglad Menopauzalny | Year: 2010

Objectives: Pathological complete response (pCR) after neoadjuvant systemic treatment, used in inoperable locally advanced breast cancers or resectable tumours with the intent to reduce their size, is defined as no residual cancer in the breast and axilla reported by the pathologist. Aim: The aim of the study is to characterize breast cancer patients who achieved pathological complete response after neoadjuvant systemic treatment. Material and methods: 101 consecutive patients with locally advanced breast cancer, operated on after adjuvant systemic treatment, were enrolled in the study. Results: 8.91% of patients achieved a pCR. Conclusions: The highest rate of pCR was observed in triple negative breast cancer patients, G3, with invasive ductal carcinoma, receiving a combination of anthracycline- and taxane-based chemotherapy.

Langfort R.,Zaklad Patomorfologii | Rudzinski P.,Klinika Chirurgii Instytutu Gruzlicy i Chorob Pluc | Burakowska B.,Zaklad Radiologii Instytutu Gruzlicy i Chorob Pluc
Pneumonologia i Alergologia Polska | Year: 2010

Neuroendocrine tumors of the lung represent a broad spectrum of morphologic types that share specific morphologic, immunohistochemical, ultrastructural, and molecular characteristics. The classification of neuroendocrine lung tumors has changed over the last decades and currently four categories are distinguished: typical carcinoid tumor, atypical carcinoid tumor, large cell neuroendocrine carcinoma and small cell carcinoma. Neuroendocrine tumors of the lung comprise approximately 20% of all primary lung cancers. Among them, the most frequent is small cell carcinoma (13-17%). Because of differences in clinical behavior, therapy, and prognosis, a reliable histological diagnosis, as well as clinical and pathological staging system are essential for an appropriate medical proceedings. The most effective treatment of bronchial carcinoids and large cell neuroendocrine carcinoma in an early stage is complete surgical resection, whereas chemotherapy remains the primary treatment for small cell carcinoma. All carcinoids are malignant tumors with the potential to metastasize. The majority of patients with pulmonary carcinoid have an excellent survival, even if they present with lymph node metastases. Large cell neuroendocrine and small cell carcinoma progress rapidly and are generally widespread at the moment of diagnosis. Their overall prognosis is poor. Increased knowledge about pulmonary neuroendocrine tumors biology and the genetic characteristics, imply that carcinoid tumors appear to have a different etiology and pathogenesis than large cell neuroendocrine and small cell carcinoma. In practice, it could be easiest to conceptualize this group of pulmonary tumors as a spectrum of malignancy ranging from the low grade typical carcinoid to the highly malignant large cell neuroendocrine and small cell carcinoma. Typical carcinoid tumors associated with a fairly benign behavior should be classified as low-grade neuroendocrine tumor/carcinoma (G1) and atypical carcinoid tumors as intermediate-grade tumor/carcinoma (G2). Whereas, large cell neuroendocrine and small cell carcinoma should be grouped together under the designation of high-grade neuroendocrine tumor/carcinoma (G3). © 2010 Via Medica.

Samulak D.,Klinika Ginekologii Operacyjnej | Romanowicz-Makowska H.,Pracownia Biologii Molekularnej | Smolarz B.,Pracownia Biologii Molekularnej | Polac I.,Klinika Ginekologii | And 3 more authors.
Przeglad Menopauzalny | Year: 2012

Background: Mutations in the hMSH2 gene predispose to a number of tumorigenic conditions, including breast cancer. hMSH2 encodes a protein in the mismatch repair (MMR) pathway which is involved in the removal of mispairs originating during replication or from damaged DNA. Material and methods: The genotype analysis of Gly322Asp and Asn127Ser hMSH2 gene polymorphisms for 205 breast cancer patients and 180 controls of cancer-free subjects in the Polish population was performed using the PCR-based restriction fragment length polymorphism (PCR-RFLP). Results: The distribution of genotypes of the Gly322Asp polymorphism of hMSH2 in patients differed significantly (p < 0.05) from those predicted by the Hardy-Weinberg equilibrium. There were significant differences in the frequencies of alleles between breast cancer subjects and controls (p < 0.05). The Asp/Asp genotype of hMSH2 increased the risk of breast cancer occurrence (OR 2.60, 95% CI 1.03-6.53, p = 0.043). Conclusion: The results support the hypothesis that the Gly322Asp polymorphism of the hMSH2 gene may be associated with the incidence of sporadic breast cancer in Polish women.

Malgorzata K.,Oddzial Polozniczo Ginekologiczny | Jaroslaw J.,Oddzial Polozniczo Ginekologiczny | Malgorzata T.,Zaklad Patomorfologii | Marek G.,Kliniczny Oddzial ChorobWewnetrznych
Ginekologia Polska | Year: 2010

Hormonally active, associated with pregnancy ovarian tumors can cause some diagnostic and therapeutic problems. In the following work we present a 28-year-old primigravida in the 21st week of pregnancy who was admitted to hospital with acute abdominal pain and virilizing symptoms. Bilateral luteinized thecoma of a considerable size, secreting testosterone, was diagnosed and the woman received surgical treatment. During the operation a rupture of the left tumor was discovered. Bilateral adnexectomy was performed. After the operation the symptoms subsided. The pregnancy continued until 38 weeks gestation. A normal female fetus without virilizing symptoms was delivered by caesarean section. © Polskie Towarzystwo Ginekologiczne.

Swietlik E.M.,Klinika Pulmonologii | Doboszynska A.,Klinika Pulmonologii | Kupis W.,Klinika Chirurgii | Szolkowska M.,Zaklad Patomorfologii | Opoka L.,LUX MED Diagnostyka Sp.z.o.o
Pneumonologia i Alergologia Polska | Year: 2014

Here we present a 65-year old ex-smoker with history of recent surgery for vocal cord tumor (histology: moderate grade intraepithelial neoplasia), who reported to the pulmonary outpatient clinic for the nodular lesions in the left lung seen on chest X-ray. Subsequent chest CT scan revealed focal lesion of 18 mm in diameter with spicular margins located in the right upper lobe, another irregular cyst with septa, 62 × 58 mm in the right lower lobe, and calcified nodule in the left lung, no enlarged lymph nodes or pleural effusion was seen. He underwent upper right lobe resection and wedge resection of the lower right lobe. Histological examination revealed adenocarcinoma in the right upper lobe with lymph node metastasis (pT2aN2M0). Examination of the right lower lobe showed squamous cell carcinoma (pT2bN0M0). He was subsequently treated with adjuvant chemotherapy and radiotherapy. During 20 months of the follow-up, he remained in good health with no signs of the disease progression. Patients with synchronous multiple primary lung cancers have significantly less favorable outcome than those with single primary lung malignancies, although it can be considerably improved with radical surgical treatment. Basing on the above case report, we discussed diagnostic and therapeutical scheme in patients with the primary multiple lung cancers, and have analyzed epidemiological data and some aspects of MPM etiology. © 2014 PTChP.

Smoter M.,Klinika Onkologii Kobiet | Bodnar L.,Klinika Onkologii Kobiet | Duchnowska R.,Klinika Onkologii Kobiet | Stec R.,Klinika Onkologii Kobiet | And 2 more authors.
Cancer Chemotherapy and Pharmacology | Year: 2011

Resistance to taxanes, related to limited efficacy of systemic therapy in cancer patients, is multifactorial. Among mechanisms of resistance to taxanes, those related to microtubule-associated proteins (MAP), including protein Tau, are of great importance. Protein Tau (50-64 kD) binds to beta-tubulin in the same place as paclitaxel. In preclinical studies, low expression of Tau in cancer cells was associated with increased sensitivity to paclitaxel. High expression of Tau protein in ER-positive breast cancers indicates resistance to taxane-containing chemotherapy and sensitivity to hormonal treatment. This article reviews current knowledge on predictive value of protein Tau in response to taxanes. Better understanding of its role may facilitate patients selection to this sort of treatment and lead to treatment optimization. © 2011 The Author(s).

There are conducted several different prophylactic programs with the target to decrease the incidence as well as mortality according neoplastic diseases. In Poland since 2005 early detection of cervical cancer program have been held. It is directed to women between 25 and 59 years of age. Beside the cytological examination of the uterine cervix smear, for better definition of risk groups, all patients are requested to fill the questionnaire. Among factors that could be related to development of cancer in this localization is tobacco smoking. In this studies authors analized the changes of cervical cytology in respect of tobacco smoking by female patients. The results revealed a significant increase of high grade squamous intraepithelial lesion (HSIL) in smokers than in nonsmokers. In Non-smoking females or those who quite smoking the preneoplastic lesion of low or high grade decreased.

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