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Rogoźno, Poland

Szybiak B.,University Im Karola Marcinkowskiego znaniu | Korski K.,Zaklad Patologii Nowotworow | Golusinski W.,University Im Karola Marcinkowskiego znaniu
Otolaryngologia Polska | Year: 2015

Introduction: Oral cancer is the second most prevalent head and neck malignancy in Poland. The incidence of these types of cancer is constantly growing. A reason for treatment failure of oral cancer is local recurrence. Aim of the study: To find out why the rate of recurrence of oral cancer is so high despite radical surgical treatment combined with radiochemotherapy. Materials and methods: The study comprised a group of 160 oral cancer patients. Thirty patients who showed local recurrence were subjected to an extended histopathological examination in keeping to the guidelines of the Royal College of Pathologists. Results: In 9 patients, primary tumours were found to be histologically aggressive as indicated by the proliferation of the vessels, nerves and muscles. In next 9 cases, the cancer infiltrated both the vessels and nerves or the vessels and muscles, and in the other 8 cases, just one of those structures. The tumours which were found to penetrate the vessels, nerves and muscles were also characterised with peri- and intraneural infiltration. The aggressiveness of invasion measured by the extent of damage to the muscles, vessels and nerves correlated with the depth of invasion from the mucous membrane, the occurrence of embolisms in blood vessels, and a high (score 4) risk according to the assessment proposed by Margaret Brandwein-Gensler. Conclusion: The progression of cancer depends strongly on histopathological features. The incidence of penetration of the vessels, nerves and muscles correlates with aggressiveness of the front of tumour and few other histological features. © 2015 Polish Society of Otorhinolaryngologists Head and Neck Surgeons. Published by Index Copernicus Sp. z o.o. All rights reserved. Source


Sas-Korczynska B.,Klinika Onkologii Oddzial Nowotworow Piersi i Klatki Piersiowej | Mitus J.,Klinika Chirurgii Onkologicznej | Stelmach A.,Klinika Chirurgii Onkologicznej | Rys J.,Zaklad Patologii Nowotworow | Martynow D.,Klinika Onkologii Oddzial Nowotworow Piersi i Klatki Piersiowej
Ginekologia Polska | Year: 2013

Apocrine breast cancer is a rare type of neoplasm and accounts for approximately 0.3-4% of all breast cancers. It most frequently diagnosed in women over the age of 50. Objectives: The purpose of the study was to present the clinical characteristics and treatment outcomes of 53 patients treated from apocrine breast cancer at the Oncology Center in Kraków between 1955 and 2002. Material and Methods: Stage I or II carcinomas were found in 37 patients (69.8%) of the study group and 16 patients (30.2%) were classified as stage III. Node metastases were observed in 27 patients (50.9%). Surgery constituted the primary method of treatment and was used in all patients. Forty-nine patients underwent mastectomy and 4 underwent breast conserving surgery. Post-operative radiotherapy was given to 16 patients. Chemotherapy and hormonal therapy were also used-in 20 and 26 cases, respectively. Results: The follow-up period in the study group was maximum 207 months. The 10-year survival rates were as follows: 75.9% (overall survival) and 58.1% (disease-free survival). It was shown that positive lymph nodes highly affected symptoms-free free survival. During follow-up, 7 patients developed local recurrence, 16 patients developed distant metastases. Second primary malignancies were found in 5 patients. Conclusions: Our findings confirm good prognosis in patients treated for apocrine breast cancer, similar to invasive ductal carcinoma. © Polskie Towarzystwo Ginekologiczne. Source


Jodkiewicz Z.,Pracownia Przygotowania | Kozakiewicz B.,Pracownia Przygotowania | Roszkowska-Purska K.,Zaklad Patologii Nowotworow | Trzaska B.,Pracownia Przygotowania
Nowotwory | Year: 2014

A case is described of angiosarcoma in the irradiated area in a 71 year old patient treated with breast conserving therapy 16 years ago for cancer of the left breast. These rare tumours of soft tissues account for about 1-2% of all types of sarcomas. In the irradiated area breast cancer occurs less often and is found only in 0.4% of patients. An analysis of the course of the disease, and review of literature with regard to methods of treatment and prognostic factors were carried out. © Polskie Towarzystwo Onkologiczne. Source


Mrochen-Domin I.,Klinika Onkologii Klinicznej i Doswiadczalnej | Chmielik E.,Zaklad Patologii Nowotworow | Starzyczny-Slota D.,Klinika Onkologii Klinicznej i Doswiadczalnej | Nowara E.,Klinika Onkologii Klinicznej i Doswiadczalnej | Sikora M.,Klinika Onkologii Klinicznej i Doswiadczalnej
Pneumonologia i Alergologia Polska | Year: 2011

Thymomas are thymic epithelial neoplasms. Surgery plays a major role in thymoma treatment but chemotherapy can significantly improve prognoses for this group of patients. Neoadjuvant chemotherapy (before surgery), adjuvant chemotherapy (after surgery), chemotherapy combined with radiotherapy and palliative chemotherapy in dissemination stage could be required in effective therapy. The aim of this paper is description of the effective systemic second line treatment in the case of 66 years old patient with advanced thymoma. © 2011 Via Medica. Source


Ejduk A.,Klinika Hematologii | Nasilowska-Adamska B.,Klinika Transplantacji Komorek Krwiotworczych | Kolkowska-Lesniak A.,Klinika Hematologii | Borg K.,Pracownia Genetyki | And 7 more authors.
Hematologia | Year: 2013

Aberrant rearrangements in the 3q26 and 3q21 regions on the long arm of chromosome 3 have been observed in many conditions, including de novo acute myeloid leukemia (AML), in AML with antecedent myelodysplastic syndrome (MDS), as well as in MDS itself, the blastic phase of chronic myelogenous leukemia (BP-CML) and also in other myeloproliferative neoplasms (MPN). Such cytogenetic aberrations lead to abnormal expression of the RPN1-EVI1 fusion gene transcripts which involve the ecotropic viral integration site-1 (EVI1) at 3q26 and ribophorin I (RPN1) at 3q21; these playing important roles in leukemogenesis and disease progression. Three case studies are presented of patients with the selfsame rearrangements on the long arm of chromosome 3. The fi rst patient presented with de novo AML and t(3;3) (q21;q26) who, in spite of having double allogeneic hematopoietic stem cell transplantations, had fatal outcome. The other two patients had MPN. One was initially diagnosed with CML and whilst being treated with imatinib, the t(3;3) abnormality was nevertheless acquired even though at fi rst the treatment had been effective. Despite subsequent second line treatment with dasatinab, the leukemia progressed with the appearance of extramedullary infi ltration. The second patient developed AML with inv(3) after essential thrombocythaemia had been diagnosed 10 years ago. At fi rst, the patient went into complete remission following induction chemotherapy with daunorubicine and cytarabine. This therapy was however re-implemented, when disease progression had again occurred during further observation. The patient then unfortunately developed pneumonia and died before hematopoietic recovery. These clinical fi ndings thus indicate that cytogenetic aberrations on the long arm of chromosome 3 predict a poor outcome in patients with myeloid neoplasms. © 2013 Via Medica. Source

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