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Cukrowska B.,Zaklad Patologii | Ceregra A.,Klinika Pediatrii Instytutu Pomnika | Klewicka E.,Zaklad Mikrobiologii Technicznej Politechniki LO dzkiej | Slizewska K.,Zaklad Mikrobiologii Technicznej Politechniki LO dzkiej | And 2 more authors.
Przeglad Pediatryczny | Year: 2010

Introduction: Probiotics have been used both in the prevention and treatment of allergic diseases. Aim of the study: The evaluation of the activity of probiotic strains Lactobacillus (L.) casei ŁOCK 0900, L. casei ŁOCK 0908 and L. paracasei ŁOCK 0919 in children with food allergy demonstrating as atopic eczema (AE) in a 2-year observation. Material and methods: The randomized double blind placebo controlled clinical trial included 60 children in with cow's milk protein allergy under 2 years of age. Bacteria were applied per orally for 3 months in daily dose of 109 cells. AE symptoms were evaluated by SCORAD index before treatment, at the end of bacteria in-take, then 5 and at least 21 months later. Results: Probiotic application induced statistically significant clinical improvement (a decrease in SCORAD more than 50%), mainly in children with IgE-dependent AE. Two-year observation showed that irrespective of eczema type SCORAD index significantly decreased in comparison with 5 months after probiotic in-take only in group supplemented with probiotics. After 2 years 81% of children tolerated cow's milk proteins in probiotic group whereas in the control group this percentage was lower (68.5%). Conclusions: Application of probiotic strains L. casei and L. paracasei induces clinical improvment of AE in children and affects the developmnet of tolerance to cow's milk proteins in long term observation.

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