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Lesiak D.,Zaklad Biologii Molekularnej Wirusow | Brzozowska A.,Zaklad Biologii Molekularnej Wirusow | Bienkowska-Szewczyk K.,Zaklad Biologii Molekularnej Wirusow | Lipinska A.D.,Zaklad Biologii Molekularnej Wirusow
Postepy Mikrobiologii | Year: 2013

Phosphorylation by protein kinases modulates the function of target proteins by interfering with their enzymatic activity, cellular location and/or association with other proteins. Viruses have evolved complex interactions with their hosts and often mimic cellular proteins in order to usurp the cellular machinery for their own benefit, so it is not surprising that vast number of viruses encode protein kinases. Alphaherpesvirus kinase US3 is a conserved multifunctional protein, regulating the egress of viral particles, but also responsible for alterations in cell morphology resulting from the breakdown of actin stress fibers and formation of cell projections. US3 homologs control the trafficking of viral and cellular proteins and inhibit apoptosis. The current review provides an overview of the properties and functions of alphaherpesvirus US3 protein kinase orthologues.

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