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Byun J.S.,Andrology Unit | Byun J.S.,Zaii Urological Institute | Yoon T.K.,CHA Medical University | Rhee H.W.,Andrology Unit | And 7 more authors.
Journal of Andrology

Chronic prostatitis/chronic pelvic pain syndrome (CP/ CPPS) is a common condition that adversely affects men across a wide range of ages. A number of pharmacologic and nonpharmacologic therapies for CP/CPPS have been investigated. Our study aimed to evaluate the prevalence of CPPS in Korean men in their thirties and to investigate the effect of CPPS and medical treatment on semen quality. Of 314 men with prostatitis, 74 patients with CPPS class IIIA (23.6%) were eligible for the study; these patients underwent combined α-blocker and cyclo-oxygenase 2 inhibitor therapy. These 74 men were prospectively studied at a medical center in Seoul, Korea. A number of parameters, including ejaculations per month, semen variables, and the levels of hormones (such as follicle-stimulating hormone, estradiol [E2], luteinizing hormone [LH], testosterone, and prolactin) were evaluated. The mean number of ejaculations per month, the mean number of daily hours spent sitting at work, smoking, body mass index, LH and E2 levels, and semen parameters all showed significant differences (P < .0001) between the study patients and the controls. The combined regimen was effective in improving all aspects of semen quality except morphology (P < .05). CPPS class IIIA, which is notably prevalent among Korean men in the fourth decade of life, affects semen quality and poses a challenge to fertility. Proper treatment of CPPS class IIIA results in improved semen quality. Men with CPPS therefore require proper evaluation and treatment by andrologists/ urologists before planning a natural conception. © American Society of Andrology. Source

Bak C.W.,Center for Reproductive Medicine | Bak C.W.,Zaii Urological Institute | Bak C.W.,CHA Medical University | Byun J.S.,Center for Reproductive Medicine | And 6 more authors.
International Journal of Urology

Objectives: To investigate the characteristics of Klinefelter syndrome in a consecutive series of men consulting for sexual as well as fertility problems in Korea. Methods: A total of 179 men with non-mosaic 47,XXY Klinefelter syndrome of the 1876 azoospermic males who visited the fertility center of our university hospital between January 2002 and January 2010 were included in this analysis. Their semen characteristics, hormone profiles, size of the prostate gland, and education level were assessed and compared with an age-matched control group of 218 fertile males. Additionally, a histological evaluation was carried out. Results: Prostate size, testicular volume, semen volume and symptom severity showed statistically significant differences in both groups (P<0.0001). As the severity of signs and symptoms worsened, the education level decreased. Each degree of signs and symptoms was associated with a different level of education, as well as with significant differences in the level of testosterone and testicular volume (P<0.05). Spearman's correlation coefficient showed the severity of signs and symptoms was associated with testosterone (P<0.0001). Conclusions: Testosterone has the strongest negative association with the severity of signs and symptoms in patients with Klinefelter syndrome. It influences the reproductive capacity, as well as the manifested signs and symptoms of hypogonadism. Furthermore, it is also associated with various aspects of life in these patients. © 2012 The Japanese Urological Association. Source

Byun J.S.,Chungnam National University | Byun J.S.,Center for Male Reproductive Medicine | Byun J.S.,Zaii Urological Institute | Lyu S.W.,CHA Medical University | And 6 more authors.
BJU International

What's known on the subject? and What does the study add? It is known that timed intercourse that is planned to coincide with ovulation causes stress in women. In men premature ejaculation is more common than delayed ejaculation. Timed intercourse imposes a substantial degree of stress on men. None of our study participants reported premature ejaculation, whereas delayed ejaculation was noted by 5.92% of the participants. Timed intercourse elevates anxiety levels, which leads to aggression. The men who required high doses of tadalafil had significantly higher scores on both the Beck Anxiety Inventory and the Buss Perry Aggression Questionnaire subscales (P< 0.001). OBJECTIVE To understand the effect of stress incurred by timed intercourse (TI) on sexual dysfunction in relation to anxiety and aggression in men facing TI. PATIENTS AND METHODS This study involved 439 men and was conducted during a 3-year period between 1 July 2008 and 30 June 2011. Various characteristics were evaluated, including newly acquired erectile dysfunction (ED), ejaculatory dysfunction (EjD), anxiety levels (using the Beck Anxiety Inventory [BAI]), self-reported aggression (using the Buss Perry Aggression Questionnaire [BPAQ]), hormone levels (such as follicle-stimulating hormone, luteinizing hormone, testosterone, prolactin and oestradiol) and semen parameters. RESULTS A total of 188 men (42.8%) and 26 men (5.92%) experienced ED and EjD, respectively. Luteinizing hormone, testosterone and oestradiol were significantly lower in men with ED (P< 0.05). The men who required high doses of tadalafil had significantly higher scores on both the BAI and the BPAQ subscales (P< 0.001). BAI and subscales of BPAQ were higher in males with delayed ejaculation (P< 0.001). CONCLUSIONS TI imposes a great deal of stress on male partners, potentially causing ED and EjD, and elevates anxiety levels, which leads to aggression. Physicians and clinicians should acknowledge the potentially harmful effects of TI on men. Furthermore, both female and male patients should be cautioned about the increased likelihood of ED and EjD as the number of incidents of TI increases. © 2012 BJU INTERNATIONAL. Source

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