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Medhat N.I.,National Research Institute of Geophysics | Atya M.,National Research Institute of Geophysics | Ragab E.A.,National Research Institute of Geophysics | Ali A.,Zagazige University | Abdelzaher M.,National Research Institute of Geophysics
Near Surface Geoscience 2015 - 21st European Meeting of Environmental and Engineering Geophysics | Year: 2015

The reason for implementation of this research is the prevalent of incidences of structural damage around the area of investigation causing large number of casualties and loose of souls. The location of the district is very close to the quarry blasting operations that can intensely produce stresses in the ground due to continuous artificial explosions and ultimately result in the instability of the area. Geophysical reconnaissance surveys using seismic refraction, electrical resistivity and ground penetrating radar were carried out to measure near surface structure setting and follow up its activity upon time by delineating the major fault and other minor features such as cracks, fissures and water saturated zone. Integration of the geophysical data shows that the main reason of fractures in the study area is the swelling of marly clay layer due to retention of the drainage water. Also, there is a near surface major fault cuts the southern part of the study area causing variation in thickness of the marly clay layer and consequently affect on the inhabitant buildings. © (2015) by the European Association of Geoscientists & Engineers (EAGE). Source


Abdulla M.M.,Saco Pharm. Co. | Amr A.E.-G.E.,King Saud University | Amr A.E.-G.E.,National Research Center of Egypt | Al-Omar M.A.,King Saud University | And 2 more authors.
Digest Journal of Nanomaterials and Biostructures | Year: 2014

In the present study, forty one steroid candidates containing a pyrazole ring were screened for their anti-androgenic and anti-prostate cancer activities. Also, in the same time these compounds were screened for their EGFR and VEGFR-2 kinase inhibitor potencies comparable to that of the Delphinidin. Initially, all the candidates were less toxic than the reference drug concerning LD50 values. Some of the compounds exhibited better antiandrogenic, anti-prostate cancer and EGFR and VEGFR-2 kinase inhibitor activities than the reference drugs Bicalutamide and Delphinidin, respectively. The detailed antiandrogenic, anti-prostate cancer and EGFR and VEGFR-2 kinase inhibitor activities and toxicity (LD50) of the synthesized compounds were reported. Source


Abdulla M.M.,Research Unit | Amr A.E.-G.E.,King Saud University | Amr A.E.-G.E.,National Research Center of Egypt | Al-Omar M.A.,King Saud University | And 2 more authors.
Journal of Pure and Applied Microbiology | Year: 2014

We herein report the androgenic-anabolic activities of some synthesized substituted androstano[17,16-c]pyrazoline (steroidal structure). Twenty six steroid derivatives 1-11 containing acetyl, ester, methoxy and oxazole moieties attached to a steroid moiety were conveniently synthesized and screened for their androgenic anabolic activities. Synthetic steroid structures linked to a different function groups seem to be a promising approach in the search for novel leads for potent androgenic agents. The detailed synthetic pathways of obtained compounds and androgenic activities were reported. Source


Abdalla M.M.,Saco Pharm. Co. | Amr A.E.-G.E.,King Saud University | Amr A.E.-G.E.,National Research Center of Egypt | Al-Omar M.A.,King Saud University | And 2 more authors.
Russian Journal of Bioorganic Chemistry | Year: 2014

In continuation of our previous work, fused steroidal derivatives with pyrane, pyridine, pyrimidine moieties were synthesized and evaluated as androgenic-anabolic agents. Some of the newly synthesized compounds are exhibited pronounced androgenic-anabolic activities. © 2014 Pleiades Publishing, Ltd. Source


Abdulla M.M.,Saco Pharm. Co. | Amr A.E.-G.E.,King Saud University | Amr A.E.-G.E.,National Research Center of Egypt | Al-Omar M.A.,King Saud University | And 2 more authors.
Life Science Journal | Year: 2013

A series of androstano[17,16-c] pyrazoline derivatives were synthesized using arylmethylene of 3β-hydroxyandrostan-17-one derivatives 1a-e, which were protected by stirring with acetyl chloride to give acetate derivatives 2a-e. Compounds 2a-d was treated with hydrazine hydrate to afford the 17-hydrazino-androstane derivatives 3a-d and 4a-d, which were cyclized by trifluoroborane-etherate to yield androstanopyrazolines 5a-d. Treatment of 2a-d with refluxing hydrazine hydrate in propionic acid gave N-propionylpyrazoline derivatives 6a-d. Similarly, compounds 1a,c,e were protected by stirring with trifluoroacetic anhydride to give 3p-trifluoroacetate derivatives 7a-c, which was treated with hydrazine hydrate in refluxing ethanol or methanol to afford 17-hydrazino-androstane derivatives 8a-c and 9a-c. Compounds 8a-c and 9a-c were cyclized in refluxing trifluoroborane-etherate to yield androstanopyrazoline derivatives 10a-c. Finally, condensation of 7a-c with refluxing hydrazine hydrate in propionic acid gave N-propionyl pyrazoline derivatives 11a-c, respectively. Source

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