ZaCh System SpA

Lonigo, Italy

ZaCh System SpA

Lonigo, Italy

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Patent
Zach System S.P.A. | Date: 2014-06-13

A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine hydrochloride salt of formula (I) i.e. Cinacalcet hydrochloride and its intermediates of formulae (VII) and (VIII) wherein Z is chloride or another pharmaceutically acceptable anionic counterion.


Patent
Zach System S.P.A. | Date: 2014-06-20

The present invention relates to a process for the cyclopropanation with ethylene carbonate or ethylene sulfate of a compound of formula (II): wherein G is CN or COOR in which R is a C_(1)-C_(4 )straight or branched alkyl X and Y are independently selected from the group consisting of hydrogen, fluorine, chlorine, bromine, iodine, R_(1)O and R_(1)S wherein R_(1 )is C1-C4 straight or branched alkyl chain.


Patent
Zach System S.P.A. | Date: 2012-05-16

A method of detecting polymorphs using X-ray produced by a synchrotron source is described. In particular, the method allows to detect particular polymorphs present in small amounts in mixtures of polymorphic compounds present in a prevailing amount. The method offers a powerful resolution of mixtures of polymorph and finds application particularly in the pharmaceutical field.


Patent
ZaCh System S.p.A. | Date: 2013-09-18

The present invention relates to a process for preparing a ketosulfone derivative and, more particularly, to an improved method for synthesising 1-(6-methylpyridin-3-yl)-2-[(4-methylsulfonyl)-phenyl]-ethanone by means of Pd-catalysed alpha arylation process of a heteroaromatic ketone derivative.


Patent
ZaCh System S.p.A. | Date: 2014-12-31

The present invention relates to a process for the cyclopropanation with ethylene carbonate or ethylene sulfate of a compound of formula (II):_(1)-C_(4) straight or branched alkyl X and Y are independently selected from the group consisting of hydrogen, fluorine, chlorine, bromine, iodine, R_(1)O- and R_(1)S- wherein R_(1) is C1-C4 straight or branched alkyl chain.


Patent
Zach System S.P.A. | Date: 2014-10-21

The present invention relates to a process for preparing gabapentin and, more particularly, it relates to a process for the direct extraction of gabapentin from an aqueous solution derived from the Hofmann rearrangement of 1,1-cyclohexanediacetic acid monoamide.


Patent
Zach System S.P.A. | Date: 2013-06-28

The present invention relates to a chiral oxamide of formula (I) useful as an intermediate in the preparation of dorzolamide, and to the preparation thereof. The invention also relates to the preparation of dorzolamide, to the hydrochloride salt thereof, and to the active ingredient contained in a drug useful in the treatment of glaucoma, by means of the intermediate of formula (I).


Patent
Zach System Spa | Date: 2011-09-22

The present invention relates to a process for preparing Bosentan Monohydrate; in particular, the present invention provides the preparation of the novel 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(2-pyrimidinyl)-pyrimidin-4-yl]-benzenesulfonamide sodium salt as an ethylene glycol solvate (Bosentan sodium salt ethylene glycol solvate), which is a useful intermediate for obtaining Bosentan Monohydrate in a pure form.


Patent
Zach System S.P.A. | Date: 2013-03-08

The present invention relates to a process for preparing a ketosulfone derivative and, more particularly, to an improved method for synthesising 1-(6-methylpyridin-3-yl)-2-[(4-methylsulfonyl)-phenyl]ethanone by means of Pd-catalysed alpha arylation process of a heteroaromatic ketone derivative.


Patent
Zach System S.P.A. | Date: 2012-03-08

The present invention relates to a stereoselective reduction procedure to obtain, by means of catalytic asymmetric hydrogenation by hydrogen transfer, a compound of formula (I) in which X is S or SO_(2 )and R_(4 )is hydrogen or an SO_(2)NH_(2 )group, from the corresponding ketone precursor, said compound of formula (I) being useful as an intermediate in the preparation of dorzolamide or of the hydrochloride salt thereof.

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