Central Psychiatric Center

Amersfoort, Netherlands

Central Psychiatric Center

Amersfoort, Netherlands
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Korfage I.J.,Erasmus Medical Center | de Kwaadsteniet E.W.,Leiden University | van Voorst A.,Central Psychiatric Center | Stiggelbout A.M.,Leiden University | And 2 more authors.
Patient Education and Counseling | Year: 2017

Objectives: Implicit associations influence behaviour, but their impact on cancer screening intentions is unknown. Methods: We assessed implicit associations with cervical cancer screening using an evaluative priming task. Participants were shown primes ('Pap test', neutral or non-word) followed by positive or negative target words. The test is based on the assumption that response times are shorter if primes and targets are strongly associated in the participant's mind. The Dutch screening program targets women aged 30-60, 226 of them completed online assessments twice. Prior to the second assessment participants were randomized to reading versus not reading the leaflet about the cervical screening program. Results: After controlling for knowledge and screen history, response times for 'Pap test' no longer differed between positive and negative targets. Implicit associations were not correlated with explicit attitudes or screening intentions. Reading the screening leaflet resulted in improved knowledge levels (p. <. 0.001), but implicit associations, explicit attitudes, and screening intentions remained similar. Conclusion: Cervical cancer screening intentions were related to explicit attitudes, but not to implicit associations. The screening leaflet did not affect screening intentions. Practice implications: We recommend achieving a deepened interest in the screening program among risk groups, e.g. by adapting the information leaflet. © 2017 Elsevier B.V.


Roke Y.,Central Psychiatric Center | Van Harten P.N.,Central Psychiatric Center | Van Harten P.N.,Maastricht University | Franke B.,Radboud University Nijmegen | And 5 more authors.
Pharmacogenetics and Genomics | Year: 2013

Objective: To investigate the effect of the Taq1A variant in the Dopamine D2 receptor gene (DRD2) and common functional genetic variants in the cytochrome P450 2D6 gene (CYP2D6) on prolactin levels in risperidone-treated boys with autism spectrum disorders and disruptive behavior disorders. Methods: Forty-seven physically healthy 10-year-old to 19-year-old boys with autism spectrum disorders and/or disruptive behavior disorders, chronically treated (mean 52 months, range 16-126 months) with an antipsychotic, were recruited into this observational study. Prolactin levels, hyperprolactinemia, risperidone levels, and 9-hydroxyrisperidone levels were assessed and the participants were genotyped for common CYP2D6 polymorphisms and the Taq1A allele of the dopamine D2 receptor gene. Group differences were tested using Student's t-test, χ, and logistic regression analysis. Results: Prolactin levels were associated positively and significantly with risperidone levels (P=0.05), 9-hydroxyrisperidone levels (P≤0.0001), and with the oral risperidone dose in milligrams per kilogram (P≤0.0001). Furthermore, multiple regression analysis showed no correlations between prolactin level and the presence of at least one Taq1A A1 allele of the DRD2 gene (P=0.12). Conclusion: Although CYP2D6 might have an effect, the presence of at least one Taq1A A1 allele of the D2DR gene did not contribute toward susceptibility to risperidone-induced hyperprolactinemia, and as a result, toward prolactin-related adverse events such as amenorrhea, galactorrhea, and sexual dysfunctioning. © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.

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